ATE172183T1 - Ester und kombinationen von einem organischen nitrat und einem salicyclat - Google Patents

Ester und kombinationen von einem organischen nitrat und einem salicyclat

Info

Publication number: ATE172183T1
Authority: AT; Austria
Prior art keywords: organic nitrate; salicyclate; esters; combinations; image
Prior art date: 1992-07-30

Application number

AT93916129T

Other languages

English (en)

Inventor

William Byrne

Andrew Rynne

Original Assignee

Cal Int Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-07-30

Filing date

1993-07-26

Publication date

1998-10-15

1993-07-26 Application filed by Cal Int Ltd filed Critical Cal Int Ltd

1998-10-15 Application granted granted Critical

1998-10-15 Publication of ATE172183T1 publication Critical patent/ATE172183T1/de

Links

229910002651 NO3 Inorganic materials 0.000 title abstract 4
NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 title abstract 4
BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 abstract 2
229960001138 acetylsalicylic acid Drugs 0.000 abstract 2
239000002775 capsule Substances 0.000 abstract 2
230000004888 barrier function Effects 0.000 abstract 1
239000011248 coating agent Substances 0.000 abstract 1
238000000576 coating method Methods 0.000 abstract 1
239000012729 immediate-release (IR) formulation Substances 0.000 abstract 1
YWXYYJSYQOXTPL-SLPGGIOYSA-N isosorbide mononitrate Chemical compound [O-][N+](=O)O[C@@H]1CO[C@@H]2[C@@H](O)CO[C@@H]21 YWXYYJSYQOXTPL-SLPGGIOYSA-N 0.000 abstract 1
229960003827 isosorbide mononitrate Drugs 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/618—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate
- A61K31/621—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate having the hydroxy group in position 2 esterified, e.g. benorylate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/625—Salicylic acid; Derivatives thereof having heterocyclic substituents, e.g. 4-salicycloylmorpholine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C203/00—Esters of nitric or nitrous acid
- C07C203/02—Esters of nitric acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C203/00—Esters of nitric or nitrous acid
- C07C203/02—Esters of nitric acid
- C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C203/00—Esters of nitric or nitrous acid
- C07C203/02—Esters of nitric acid
- C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
- C07C203/06—Glycerol trinitrate
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Saccharide Compounds (AREA)

AT93916129T 1992-07-30 1993-07-26 Ester und kombinationen von einem organischen nitrat und einem salicyclat ATE172183T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IE922474		1992-07-30

Publications (1)

Publication Number	Publication Date
ATE172183T1 true ATE172183T1 (de)	1998-10-15

Family

ID=11039709

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93916129T ATE172183T1 (de)	1992-07-30	1993-07-26	Ester und kombinationen von einem organischen nitrat und einem salicyclat

Country Status (11)

Country	Link
US (1)	US5665766A (de)
EP (2)	EP0676204A1 (de)
JP (1)	JPH07509484A (de)
AT (1)	ATE172183T1 (de)
AU (2)	AU673846B2 (de)
CA (1)	CA2141435A1 (de)
DE (1)	DE69321596T2 (de)
DK (1)	DK0656881T3 (de)
ES (1)	ES2125342T3 (de)
GB (1)	GB2284350B (de)
WO (1)	WO1994003421A2 (de)

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US5703073A (en) *	1995-04-19	1997-12-30	Nitromed, Inc.	Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
DE19515970A1 (de) *	1995-05-02	1996-11-07	Bayer Ag	Acetylsalicylsäurenitrate
US5674894A (en) *	1995-05-15	1997-10-07	G.D. Searle & Co.	Amidine derivatives useful as platelet aggregation inhibitors and vasodilators
WO1997005128A1 (en) *	1995-07-27	1997-02-13	Cal International Limited	Cardioactive aspirinates
WO1997004757A1 (en) *	1995-07-27	1997-02-13	Cal International Limited	Transdermal nitrate formulation
AU6709096A (en) *	1995-07-27	1997-02-26	Cal International Limited	Pharmaceutical preparation for percutaneous absorbtion
US5707984A (en) *	1995-12-08	1998-01-13	G. D. Searle & Co.	Steroid nitrite/nitrate ester derivatives useful as anti-inflammatory drugs
US5792758A (en) *	1995-12-08	1998-08-11	G. D. Searle & Co.	Steroid nitrite ester derivatives useful as anti-inflammatory drugs
US5837698A (en) *	1996-05-02	1998-11-17	G. D. Searle & Co.	Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs
US5985862A (en) *	1996-05-02	1999-11-16	G.D. Searle & Co.	Pharmaceutical compositions having steroid nitrate ester derivatives useful as anti-inflammatory drugs
WO1998005306A1 (en) *	1996-08-02	1998-02-12	Cal International Limited	Controlled release tablet formulation of isosorbide-5-mononitrate
GB9713549D0 (en) *	1996-10-18	1997-09-03	Euro Celtique Sa	Pharmaceutical combination formulation
ZA979404B (en) *	1996-10-21	1998-06-01	Cal Internat Ltd	Aspirinate compounds.
US6117911A (en)	1997-04-11	2000-09-12	Neorx Corporation	Compounds and therapies for the prevention of vascular and non-vascular pathologies
ES2142773B1 (es)	1998-10-07	2001-01-01	Lacer Sa	Derivados de mononitrato de isosorbida y su empleo como agentes vasodilatadores con tolerancia desminuida.
BR9905261A (pt) *	1999-09-30	2001-07-24	Libbs Farmaceutica Ltda	Uma nova associação medicamentosa de liberação programada
US7086397B2 (en) *	2002-02-16	2006-08-08	Graham Lindley Spruiell	Patient usable emergency medical kit
AU2003247792B2 (en)	2002-07-03	2009-09-24	Nicox S.A.	Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
US7244753B2 (en)	2002-07-29	2007-07-17	Nitromed, Inc.	Cyclooxygenase-2 selective inhibitors, compositions and methods of use
ES2258365B1 (es) *	2003-10-03	2007-12-01	Lacer, S.A.	Derivados de disulfuro, sulfuro, sulfoxido y sulfona de azucares ciclicos y sus usos.
WO2006041855A2 (en)	2004-10-04	2006-04-20	Nitromed, Inc.	Compositions and methods using apocynin compounds and nitric oxide donors
EP2149576A1 (de) *	2008-07-22	2010-02-03	Lacer, S.A.	Isosorbitnitrate mit vasodilatierender Wirksamkeit
CN102757444B (zh) *	2011-04-29	2016-02-10	南京信诺泰医药有限公司	具有一氧化氮供体性质的苯并呋喃类化合物
CN102241687A (zh) *	2011-05-23	2011-11-16	中国人民解放军第四军医大学	抗缺血/再灌注损伤的药物
US20150132371A1 (en)	2012-04-23	2015-05-14	University Of Oslo	Use of tomato extract as antihypertensive agent and process for making water soluble sugar free tomato extract
GB201223365D0 (en) *	2012-12-24	2013-02-06	Provexis Natural Products Ltd	Compositions
US10905733B2 (en)	2016-11-02	2021-02-02	Provexis Natural Products Limited	Water soluble tomato extract protects against adverse effects of air pollution
WO2026061429A1 (zh) *	2024-09-18	2026-03-26	南京宁丹新药技术股份有限公司	一类单硝酸异山梨酯衍生物的盐类化合物及其用途

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FR2187315B1 (de) *	1972-06-05	1975-06-20	Fabre Sa Pierre
GB1540463A (en) *	1976-10-07	1979-02-14	Ici Ltd	Alkanolamine derivatives
FR2368272A1 (fr) *	1976-10-20	1978-05-19	Theramex	Compositions therapeutiques solides pour combattre l'agregation plaquettaire
CA1248450A (en) *	1984-04-05	1989-01-10	Kazuo Kigasawa	Soft patch
DE3421072A1 (de) *	1984-06-06	1985-12-12	Heinrich Mack Nachf., 7918 Illertissen	1,4:3,6-dianhydro-hexit-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
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US5133974A (en) *	1989-05-05	1992-07-28	Kv Pharmaceutical Company	Extended release pharmaceutical formulations
IE64128B1 (en) *	1990-02-26	1995-07-12	Byrne Rynne Holdings Ltd	A pharmaceutical composition
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1993
- 1993-07-26 WO PCT/IE1993/000040 patent/WO1994003421A2/en not_active Ceased
- 1993-07-26 JP JP6505156A patent/JPH07509484A/ja not_active Ceased
- 1993-07-26 AT AT93916129T patent/ATE172183T1/de active
- 1993-07-26 EP EP95201369A patent/EP0676204A1/de not_active Withdrawn
- 1993-07-26 GB GB9501785A patent/GB2284350B/en not_active Expired - Fee Related
- 1993-07-26 AU AU45812/93A patent/AU673846B2/en not_active Ceased
- 1993-07-26 US US08/374,650 patent/US5665766A/en not_active Expired - Fee Related
- 1993-07-26 ES ES93916129T patent/ES2125342T3/es not_active Expired - Lifetime
- 1993-07-26 EP EP93916129A patent/EP0656881B1/de not_active Expired - Lifetime
- 1993-07-26 CA CA002141435A patent/CA2141435A1/en not_active Abandoned
- 1993-07-26 DK DK93916129T patent/DK0656881T3/da active
- 1993-07-26 DE DE69321596T patent/DE69321596T2/de not_active Expired - Fee Related
1995
- 1995-02-14 AU AU12257/95A patent/AU1225795A/en not_active Abandoned

Also Published As

Publication number	Publication date
AU1225795A (en)	1995-05-04
GB9501785D0 (en)	1995-03-22
DK0656881T3 (da)	1999-06-23
WO1994003421A3 (en)	1994-03-31
EP0656881B1 (de)	1998-10-14
DE69321596T2 (de)	1999-04-22
AU673846B2 (en)	1996-11-28
US5665766A (en)	1997-09-09
CA2141435A1 (en)	1994-02-17
EP0656881A1 (de)	1995-06-14
DE69321596D1 (de)	1998-11-19
JPH07509484A (ja)	1995-10-19
EP0676204A1 (de)	1995-10-11
GB2284350A (en)	1995-06-07
GB2284350B (en)	1996-08-28
WO1994003421A2 (en)	1994-02-17
AU4581293A (en)	1994-03-03
ES2125342T3 (es)	1999-03-01

Publication	Publication Date	Title
ATE172183T1 (de)	1998-10-15	Ester und kombinationen von einem organischen nitrat und einem salicyclat
ES2117146T3 (es)	1998-08-01	Tableta farmaceutica capaz de liberar una o varias sustancias medicamentosas a diferentes velocidades.
PT90120A (pt)	1989-11-10	Processo para a preparacao de uma composicao farmaceutica contendo deprenil para administracao sistemica transdermica
ATE151285T1 (de)	1997-04-15	Orale arzneimittel mit kolonspezifischer freisetzung
ATE128863T1 (de)	1995-10-15	Arzneimittelformulierungen mit verzögerter wirkstoffabgabe.
DE3686483D1 (de)	1992-09-24	Arzneimittel.
PH25905A (en)	1991-12-19	A controlled release pharmaceutical dosage form
IT1215726B (it)	1990-02-22	Formulazioni galeniche a cessione programmata.
JPS5793911A (en)	1982-06-11	Drug composition
PH12363A (en)	1979-01-29	Oral pharmaceutical compositions of nandrolone-17 esters with a non-steroidal lipoid
ZA905861B (en)	1991-07-31	Pharmaceutical composition for oral administration containing nac
RU93045145A (ru)	1996-06-20	Замещенные производные циклогексана и их применение для лечения заболеваний, содержащее их лекарственное средство
DE58905681D1 (de)	1993-10-28	Pharmazeutische Präparate zur verbesserten Resorption antibakterieller Verbindungen.
GB8812653D0 (en)	1988-06-29	Pharmaceutical composition based on high concentration esters of docosahexaenoic acid
IL88403A0 (en)	1989-06-30	Esters of pharmacologically active carboxylic acids,their manufacture and pharmaceutical compositions containing them
PT88634A (pt)	1988-10-01	A process for the preparation of catechol carboxylic acid derivatives and of pharmaceutical compositions containing the same
ES2063446T3 (es)	1995-01-01	Compuesto farmaceutico.
NZ182046A (en)	1979-03-16	9-0-ethers of clavulanic acid,saltd and esters and pharmaceutical compositions
GB8812621D0 (en)	1988-06-29	Pharmaceutical composition containing combination of analgesic agents
MX9203575A (es)	1992-07-01	Esteres de oximas de propenonas y composiciones farmaceuticas que los contienen.
DK152987D0 (da)	1987-03-25	Dosageform for nonimmediate release of one or more drugs
IT1223097B (it)	1990-09-12	Formulazione farmaceutica contenente gemfibrozil microincapsulato