ATE172966T1 - 3-phenylisochinolin-1(2h)-one-derivate als liganden der mit gabaa rezeptoren verbundenen benzodiazepine rezeptoren - Google Patents

3-phenylisochinolin-1(2h)-one-derivate als liganden der mit gabaa rezeptoren verbundenen benzodiazepine rezeptoren

Info

Publication number: ATE172966T1
Authority: AT; Austria
Prior art keywords: receptors; phenylisoquinoline; ligands; derivatives; linked
Prior art date: 1994-12-29

Application number

AT95402842T

Other languages

English (en)

Inventor

Mireille Sevrin

Benoit Marabout

Jacques Froissant

Catherine Guinot

Original Assignee

Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-12-29

Filing date

1995-12-18

Publication date

1998-11-15

1995-12-18 Application filed by Synthelabo filed Critical Synthelabo

1998-11-15 Application granted granted Critical

1998-11-15 Publication of ATE172966T1 publication Critical patent/ATE172966T1/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)

AT95402842T 1994-12-29 1995-12-18 3-phenylisochinolin-1(2h)-one-derivate als liganden der mit gabaa rezeptoren verbundenen benzodiazepine rezeptoren ATE172966T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9415837A FR2728900B1 (fr)	1994-12-29	1994-12-29	Derives de 3-phenylisoquinolein-1(2h)-one, leur preparation et leur application en therapeutique

Publications (1)

Publication Number	Publication Date
ATE172966T1 true ATE172966T1 (de)	1998-11-15

Family

ID=9470390

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95402842T ATE172966T1 (de)	1994-12-29	1995-12-18	3-phenylisochinolin-1(2h)-one-derivate als liganden der mit gabaa rezeptoren verbundenen benzodiazepine rezeptoren

Country Status (22)

Country	Link
US (1)	US5665733A (de)
EP (1)	EP0719764B1 (de)
JP (1)	JPH08239365A (de)
KR (1)	KR960022472A (de)
CN (1)	CN1131150A (de)
AR (1)	AR002016A1 (de)
AT (1)	ATE172966T1 (de)
AU (1)	AU698595B2 (de)
BR (1)	BR9506106A (de)
CA (1)	CA2166234A1 (de)
CO (1)	CO4700298A1 (de)
CZ (1)	CZ348995A3 (de)
DE (1)	DE69505780D1 (de)
FI (1)	FI956298L (de)
FR (1)	FR2728900B1 (de)
HU (1)	HU215394B (de)
IL (1)	IL116590A0 (de)
NO (1)	NO955326L (de)
NZ (1)	NZ280765A (de)
PL (1)	PL312079A1 (de)
SK (1)	SK165795A3 (de)
ZA (1)	ZA9511046B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2750427B1 (fr) *	1996-06-28	1998-08-07	Synthelabo	Derives de 1-oxo-1, 2-dihydroisoquinoleine-4-propanamide, leur preparation et leur application en therapeutique
FR2772758B1 (fr) *	1997-12-22	2000-02-04	Synthelabo	Derives de 1-oxo-1,2-dihydroisoquinoleine-4-propanamide, leur preparation et leur application en therapeutique
WO2004058717A1 (en) *	2002-12-20	2004-07-15	X-Ceptor Therapeutics, Inc.	Isoquinolinone derivatives and their use as therapeutic agents
GB0420722D0 (en) *	2004-09-17	2004-10-20	Addex Pharmaceuticals Sa	Novel allosteric modulators
EP1886996A1 (de) *	2006-08-10	2008-02-13	Ferrer Internacional, S.A.	1H-Chinolin-4-on Verbindungen mit Affinität für den GABA Rezeptor, Prozesse, Verwendungen und Zusammensetzungen
CA2660421A1 (en) *	2006-08-10	2008-02-14	Ferrer Internacional S.A.	1h-quinolin-4-one compounds, with affinity for the gaba receptor, processes, uses and compositions
US8741917B2 (en)	2009-01-15	2014-06-03	Rutgers, The State University Of New Jersey	Benzo [C] phenanthridines as antimicrobial agents
US20120059026A1 (en) *	2009-04-30	2012-03-08	University Of Medicine And Dentistry Of New Jersey	Antimicrobial agents
FR2956816B1 (fr) *	2010-03-01	2012-05-18	Univ Joseph Fourier	Utilisation de quinolones pour la preparation de medicaments, nouvelles quinolones et leur procede de synthese
WO2011156626A1 (en)	2010-06-09	2011-12-15	Rutgers, The State University Of New Jersey	Antimicrobial agents
CA2803890A1 (en)	2010-06-25	2011-12-29	Rutgers, The State University Of New Jersey	Antimicrobial agents
US9822108B2 (en)	2012-01-13	2017-11-21	Rutgers, The State University Of New Jersey	Antimicrobial agents
US9475783B2 (en)	2012-03-21	2016-10-25	Rutgers, The State University Of New Jersey	Antimicrobial agents
US9458150B2 (en)	2013-11-08	2016-10-04	Rutgers, The State University Of New Jersey	Antimicrobial agents
WO2017147316A1 (en)	2016-02-25	2017-08-31	Taxis Pharmaceuticals, Inc.	Synthetic processes and intermediates
US10774093B2 (en)	2017-03-30	2020-09-15	Taxis Pharmaceuticals, Inc.	Synthetic processes and synthetic intermediates
EP4126858B1 (de) *	2020-03-26	2026-03-18	Richter Gedeon Nyrt.	Dihydro-2-pyrrolo[3,4-c pyridin-derivate als gabaa a5 rezeptormodulatoren
TWI901650B (zh) *	2020-03-26	2025-10-21	匈牙利商羅特格登公司	啶及吡啶并〔３，４－ｃ〕嗒衍生物

1994
- 1994-12-29 FR FR9415837A patent/FR2728900B1/fr not_active Expired - Fee Related
1995
- 1995-12-18 EP EP95402842A patent/EP0719764B1/de not_active Expired - Lifetime
- 1995-12-18 DE DE69505780T patent/DE69505780D1/de not_active Expired - Lifetime
- 1995-12-18 AT AT95402842T patent/ATE172966T1/de not_active IP Right Cessation
- 1995-12-21 NZ NZ280765A patent/NZ280765A/en unknown
- 1995-12-27 AR ARP950100767A patent/AR002016A1/es unknown
- 1995-12-27 JP JP7340607A patent/JPH08239365A/ja active Pending
- 1995-12-28 BR BR9506106A patent/BR9506106A/pt not_active Application Discontinuation
- 1995-12-28 KR KR1019950061341A patent/KR960022472A/ko not_active Withdrawn
- 1995-12-28 CN CN95120638A patent/CN1131150A/zh active Pending
- 1995-12-28 US US08/579,677 patent/US5665733A/en not_active Expired - Fee Related
- 1995-12-28 IL IL11659095A patent/IL116590A0/xx unknown
- 1995-12-28 NO NO955326A patent/NO955326L/no unknown
- 1995-12-28 ZA ZA9511046A patent/ZA9511046B/xx unknown
- 1995-12-28 CA CA002166234A patent/CA2166234A1/en not_active Abandoned
- 1995-12-28 SK SK1657-95A patent/SK165795A3/sk unknown
- 1995-12-28 CO CO95062144A patent/CO4700298A1/es unknown
- 1995-12-28 HU HU9503848A patent/HU215394B/hu not_active IP Right Cessation
- 1995-12-28 AU AU40712/95A patent/AU698595B2/en not_active Ceased
- 1995-12-28 PL PL95312079A patent/PL312079A1/xx unknown
- 1995-12-28 CZ CZ953489A patent/CZ348995A3/cs unknown
- 1995-12-28 FI FI956298A patent/FI956298L/fi not_active Application Discontinuation

Also Published As

Publication number	Publication date
CZ348995A3 (en)	1996-07-17
CA2166234A1 (en)	1996-06-30
NO955326L (no)	1996-07-01
ZA9511046B (en)	1996-07-11
FI956298A7 (fi)	1996-06-30
DE69505780D1 (de)	1998-12-10
NO955326D0 (no)	1995-12-28
HU215394B (hu)	1998-12-28
FR2728900B1 (fr)	1997-01-31
FR2728900A1 (fr)	1996-07-05
HU9503848D0 (en)	1996-02-28
US5665733A (en)	1997-09-09
FI956298A0 (fi)	1995-12-28
IL116590A0 (en)	1996-03-31
AU698595B2 (en)	1998-11-05
JPH08239365A (ja)	1996-09-17
PL312079A1 (en)	1996-07-08
AR002016A1 (es)	1998-01-07
EP0719764B1 (de)	1998-11-04
CN1131150A (zh)	1996-09-18
AU4071295A (en)	1996-07-04
EP0719764A1 (de)	1996-07-03
CO4700298A1 (es)	1998-12-29
FI956298L (fi)	1996-06-30
BR9506106A (pt)	1997-12-23
HUT74187A (en)	1996-11-28
SK165795A3 (en)	1996-07-03
KR960022472A (ko)	1996-07-18
NZ280765A (en)	1996-08-27

Legal Events

Date	Code	Title	Description
1999-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE172966T1 (de)	1998-11-15	3-phenylisochinolin-1(2h)-one-derivate als liganden der mit gabaa rezeptoren verbundenen benzodiazepine rezeptoren
DE69628334D1 (de)	2003-06-26	Chinolin derivate als nk3 antagoniste
DE69829192D1 (de)	2005-04-07	Neue substituierte imidazolverbindungen
ATE229940T1 (de)	2003-01-15	3-spiro-indolin-2-onderivate als liganden der vasopressin und/oder der ocytocin rezeptoren
FI970148A7 (fi)	1997-01-14	Heterosyklisten yhdisteiden käyttö dopamiini-D3-ligandeina
DE69605430D1 (de)	2000-01-05	Chinolin-2-on derivate als serotonin antagonisten
LV10099A (lv)	1994-05-10	Bicikliski heterocikliski atvasinajumi
PL317381A1 (en)	1997-04-01	Derivatives of quinoline as antagonists of tachykynin receptors nk3
IL154310A0 (en)	2003-09-17	Heterocyclic compounds as ligands of the gabaa receptor
DE69612852D1 (de)	2001-06-21	BENZO[g]CHINOLINDERIVATE
FI913048A7 (fi)	1991-12-22	Bisykliset heterosykliset yhdisteet
FI914476A7 (fi)	1992-04-09	Trisyklisiä heterosyklisiä yhdisteitä
DK0804440T3 (da)	2008-03-31	Tricykliske benzazapin-vasopressionantagonister
ATE251166T1 (de)	2003-10-15	Bicyclische benzazepin-derivate als vasopressin- antagonisten
PT861248E (pt)	2002-05-31	Derivados indolealquilo de benzodioxanometilamina como ligandos do receptor 5-ht1a
NO932344D0 (no)	1993-06-25	Kinoksalinderivater med affinitet for quisqualatreseptorer
DE69819903D1 (de)	2003-12-24	Bizyklische verbindungen als liganden der 5-ht1 rezeptoren
DE69626416D1 (de)	2003-04-03	Salze von chinolinderivaten als nk3 antagonisten
NO994516D0 (no)	1999-09-17	Brönnhodeelement for opptak av faste bestanddeler i produksjonsfluid
FI932928A7 (fi)	1993-06-24	Uudet bentsodiatsepiinijohdokset
ATE232869T1 (de)	2003-03-15	Tricyclische delta3-piperidine als alpha2- antagonisten
FI943808A7 (fi)	1994-10-24	Triatsolopyrimidiinijohdannaisia angiotensiini II:n reseptoreiden vast avaikuttajina
KR970013921U (ko)	1997-04-28	건축용 다용도 브라켓
ATE172973T1 (de)	1998-11-15	8-oxo-5,8-dihydro-6h-dibenzo(a,g>chinolizin-13- propansäure-derivate als liganden der mit gabaa rezeptoren verbundenen benzodiazepine rezeptoren
DE69527785D1 (de)	2002-09-19	Chinuclidin-n-oxidderivate als muscarin rezeptor liganden