ATE172966T1 - 3-phenylisochinolin-1(2h)-one-derivate als liganden der mit gabaa rezeptoren verbundenen benzodiazepine rezeptoren - Google Patents

3-phenylisochinolin-1(2h)-one-derivate als liganden der mit gabaa rezeptoren verbundenen benzodiazepine rezeptoren

Info

Publication number
ATE172966T1
ATE172966T1 AT95402842T AT95402842T ATE172966T1 AT E172966 T1 ATE172966 T1 AT E172966T1 AT 95402842 T AT95402842 T AT 95402842T AT 95402842 T AT95402842 T AT 95402842T AT E172966 T1 ATE172966 T1 AT E172966T1
Authority
AT
Austria
Prior art keywords
receptors
phenylisoquinoline
ligands
derivatives
linked
Prior art date
Application number
AT95402842T
Other languages
English (en)
Inventor
Mireille Sevrin
Benoit Marabout
Jacques Froissant
Catherine Guinot
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Application granted granted Critical
Publication of ATE172966T1 publication Critical patent/ATE172966T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
AT95402842T 1994-12-29 1995-12-18 3-phenylisochinolin-1(2h)-one-derivate als liganden der mit gabaa rezeptoren verbundenen benzodiazepine rezeptoren ATE172966T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9415837A FR2728900B1 (fr) 1994-12-29 1994-12-29 Derives de 3-phenylisoquinolein-1(2h)-one, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
ATE172966T1 true ATE172966T1 (de) 1998-11-15

Family

ID=9470390

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95402842T ATE172966T1 (de) 1994-12-29 1995-12-18 3-phenylisochinolin-1(2h)-one-derivate als liganden der mit gabaa rezeptoren verbundenen benzodiazepine rezeptoren

Country Status (22)

Country Link
US (1) US5665733A (de)
EP (1) EP0719764B1 (de)
JP (1) JPH08239365A (de)
KR (1) KR960022472A (de)
CN (1) CN1131150A (de)
AR (1) AR002016A1 (de)
AT (1) ATE172966T1 (de)
AU (1) AU698595B2 (de)
BR (1) BR9506106A (de)
CA (1) CA2166234A1 (de)
CO (1) CO4700298A1 (de)
CZ (1) CZ348995A3 (de)
DE (1) DE69505780D1 (de)
FI (1) FI956298L (de)
FR (1) FR2728900B1 (de)
HU (1) HU215394B (de)
IL (1) IL116590A0 (de)
NO (1) NO955326L (de)
NZ (1) NZ280765A (de)
PL (1) PL312079A1 (de)
SK (1) SK165795A3 (de)
ZA (1) ZA9511046B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2750427B1 (fr) * 1996-06-28 1998-08-07 Synthelabo Derives de 1-oxo-1, 2-dihydroisoquinoleine-4-propanamide, leur preparation et leur application en therapeutique
FR2772758B1 (fr) * 1997-12-22 2000-02-04 Synthelabo Derives de 1-oxo-1,2-dihydroisoquinoleine-4-propanamide, leur preparation et leur application en therapeutique
WO2004058717A1 (en) * 2002-12-20 2004-07-15 X-Ceptor Therapeutics, Inc. Isoquinolinone derivatives and their use as therapeutic agents
GB0420722D0 (en) * 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
EP1886996A1 (de) * 2006-08-10 2008-02-13 Ferrer Internacional, S.A. 1H-Chinolin-4-on Verbindungen mit Affinität für den GABA Rezeptor, Prozesse, Verwendungen und Zusammensetzungen
JP2010500330A (ja) * 2006-08-10 2010-01-07 フエルレル インターナショナル，ソシエダッド アノニマ Ｇａｂａａ受容体に対して親和性を有する１ｈ−キノリン−４−オン化合物、方法、使用及び組成物
CA2751892A1 (en) 2009-01-15 2010-07-22 Rutgers, The State University Of New Jersey Benzo [c] phenanthridines as antimicrobial agents
CA2760526A1 (en) 2009-04-30 2010-11-04 Rutgers, The State University Of New Jersey Antimicrobial agents
FR2956816B1 (fr) * 2010-03-01 2012-05-18 Univ Joseph Fourier Utilisation de quinolones pour la preparation de medicaments, nouvelles quinolones et leur procede de synthese
US8933096B2 (en) 2010-06-09 2015-01-13 Rugers, The State University of New Jersey Antimicrobial agents
WO2011163610A2 (en) 2010-06-25 2011-12-29 Rutgers, The State University Of New Jersey Antimicrobial agents
WO2013106756A2 (en) 2012-01-13 2013-07-18 Rutgers, The State University Of New Jersey Antimicrobial agents
EP2828245A1 (de) 2012-03-21 2015-01-28 Rutgers, The State University of New Jersey Antimikrobiotika
US9458150B2 (en) 2013-11-08 2016-10-04 Rutgers, The State University Of New Jersey Antimicrobial agents
WO2017147316A1 (en) 2016-02-25 2017-08-31 Taxis Pharmaceuticals, Inc. Synthetic processes and intermediates
CN110891566B (zh) 2017-03-30 2023-12-19 塔克西斯医药股份有限公司 合成方法和合成中间体
TWI901650B (zh) * 2020-03-26 2025-10-21 匈牙利商羅特格登公司 啶及吡啶并〔３，４－ｃ〕嗒衍生物
US12649738B2 (en) 2020-03-26 2026-06-09 Richter Gedeon Nyrt. 1,3-dihydro-2H-pyrrolo[3,4-c]pyridine derivatives as GABAA α5 receptor modulators

Also Published As

Publication number Publication date
HU9503848D0 (en) 1996-02-28
SK165795A3 (en) 1996-07-03
NO955326D0 (no) 1995-12-28
BR9506106A (pt) 1997-12-23
DE69505780D1 (de) 1998-12-10
EP0719764B1 (de) 1998-11-04
FR2728900B1 (fr) 1997-01-31
HU215394B (hu) 1998-12-28
NZ280765A (en) 1996-08-27
CZ348995A3 (en) 1996-07-17
EP0719764A1 (de) 1996-07-03
US5665733A (en) 1997-09-09
AU4071295A (en) 1996-07-04
FR2728900A1 (fr) 1996-07-05
CN1131150A (zh) 1996-09-18
FI956298A7 (fi) 1996-06-30
FI956298L (fi) 1996-06-30
IL116590A0 (en) 1996-03-31
HUT74187A (en) 1996-11-28
AR002016A1 (es) 1998-01-07
CO4700298A1 (es) 1998-12-29
JPH08239365A (ja) 1996-09-17
ZA9511046B (en) 1996-07-11
NO955326L (no) 1996-07-01
AU698595B2 (en) 1998-11-05
FI956298A0 (fi) 1995-12-28
CA2166234A1 (en) 1996-06-30
PL312079A1 (en) 1996-07-08
KR960022472A (ko) 1996-07-18

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Legal Events

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