ATE173476T1 - 1-(4-(imidazol-1-yl)benzoyl>piperidin-derivate als antiarrhythmica - Google Patents

1-(4-(imidazol-1-yl)benzoyl>piperidin-derivate als antiarrhythmica

Info

Publication number: ATE173476T1
Authority: AT; Austria
Prior art keywords: antiarrhythmics; benzoyl; imidazole; piperidine derivatives; agents
Prior art date: 1990-06-20

Application number

AT91911396T

Other languages

English (en)

Inventor

You-Ling Chou

Paul William Erhardt

Alfred Arthur Hagedorn

John W Lampe

William Carl Lumma Jr

Thomas Kenneth Morgan

Jay Ross Wiggins

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-20

Filing date

1991-06-19

Publication date

1998-12-15

1991-06-19 Application filed by Schering Ag filed Critical Schering Ag

1998-12-15 Application granted granted Critical

1998-12-15 Publication of ATE173476T1 publication Critical patent/ATE173476T1/de

Links

239000003416 antiarrhythmic agent Substances 0.000 title abstract 2
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical class C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 1
230000003288 anthiarrhythmic effect Effects 0.000 title 1
239000002327 cardiovascular agent Substances 0.000 abstract 1
229940125692 cardiovascular agent Drugs 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)

AT91911396T 1990-06-20 1991-06-19 1-(4-(imidazol-1-yl)benzoyl>piperidin-derivate als antiarrhythmica ATE173476T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/540,980 US5189036A (en)	1990-06-20	1990-06-20	Imidazolylbenzoyl substituted heterocycles

Publications (1)

Publication Number	Publication Date
ATE173476T1 true ATE173476T1 (de)	1998-12-15

Family

ID=24157703

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91911396T ATE173476T1 (de)	1990-06-20	1991-06-19	1-(4-(imidazol-1-yl)benzoyl>piperidin-derivate als antiarrhythmica

Country Status (6)

Country	Link
US (1)	US5189036A (de)
EP (1)	EP0537201B1 (de)
JP (1)	JPH05509303A (de)
AT (1)	ATE173476T1 (de)
DE (1)	DE69130505D1 (de)
WO (1)	WO1991019709A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1996019475A1 (en) *	1994-12-22	1996-06-27	Smithkline Beecham Corporation	Fibrinogen receptor antagonists
GB2327418A (en) *	1997-07-18	1999-01-27	Rhone Poulenc Agriculture	Derivatives of 2-benzoylcyclohexane-1,3-dione
US5977376A (en) *	1997-07-18	1999-11-02	Rhone-Poulenc Agriculture Limited	Herbicidal 2-benzoylcyclohexane-1,3-diones and related compounds
US6376514B1 (en)	2000-10-17	2002-04-23	The Procter & Gamble Co.	Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof
WO2002068409A1 (en)	2001-02-23	2002-09-06	Merck & Co., Inc.	N-substituted nonaryl-heterocyclic nmda/nr2b antagonists
US7259157B2 (en)	2001-04-03	2007-08-21	Merck & Co., Inc.	N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists
AU2002322720B2 (en)	2001-07-25	2008-11-13	Raptor Pharmaceutical Inc.	Compositions and methods for modulating blood-brain barrier transport
CN102379684B (zh)	2005-04-28	2014-11-19	普罗透斯数字保健公司	药物信息系统
AR059826A1 (es) *	2006-03-13	2008-04-30	Univ California	Inhibidores de urea conformacionalmente restringidos de epoxido hidrolasa soluble
KR20090071598A (ko)	2006-09-18	2009-07-01	랩터 파마슈티컬 인코포레이티드	수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
JP2010507587A (ja) *	2006-10-20	2010-03-11	アレテセラピューティクス，インコーポレイテッド	可溶性エポキシドヒドロラーゼ阻害剤
MX2009004089A (es) *	2006-10-20	2009-07-10	Arete Therapeutics Inc	Inhibidores de epoxido hidrolasa soluble.
EP2132176A1 (de) *	2007-03-13	2009-12-16	Arete Therapeutics, Inc.	4-piperidinylharnstoffverbindungen als lösliche epoxidhydrolaseinhibitoren
EP2398500B1 (de)	2009-02-20	2019-03-13	2-BBB Medicines B.V.	Arzneiabgabesystem auf glutathion-basis
ES2942923T3 (es)	2009-05-06	2023-06-07	Laboratory Skin Care Inc	Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
US20120077778A1 (en)	2010-09-29	2012-03-29	Andrea Bourdelais	Ladder-Frame Polyether Conjugates

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4804662A (en) *	1987-05-05	1989-02-14	Schering A.G.	Substituted 4-(1H-imidazol-1-yl)benzamides as antiarrhythmic agents
US4851526A (en) *	1987-09-04	1989-07-25	Schering A.G.	1-(4-Substituted phenyl)-1H-imidazoles compounds
US4868194A (en) *	1988-09-23	1989-09-19	Merrell Dow Pharmaceuticals Inc.	Imidazole antiarrhythmics

1990
- 1990-06-20 US US07/540,980 patent/US5189036A/en not_active Expired - Fee Related
1991
- 1991-06-19 DE DE69130505T patent/DE69130505D1/de not_active Expired - Lifetime
- 1991-06-19 AT AT91911396T patent/ATE173476T1/de not_active IP Right Cessation
- 1991-06-19 WO PCT/EP1991/001137 patent/WO1991019709A1/en not_active Ceased
- 1991-06-19 JP JP3510921A patent/JPH05509303A/ja active Pending
- 1991-06-19 EP EP91911396A patent/EP0537201B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JPH05509303A (ja)	1993-12-22
EP0537201B1 (de)	1998-11-18
US5189036A (en)	1993-02-23
WO1991019709A1 (en)	1991-12-26
DE69130505D1 (de)	1998-12-24
EP0537201A1 (de)	1993-04-21

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Legal Events

Date	Code	Title	Description
1999-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties