ATE174064T1 - Sonden system zur hla-dr charakterisierung und sie verwendendes charakterisierungs-verfahren - Google Patents
Sonden system zur hla-dr charakterisierung und sie verwendendes charakterisierungs-verfahrenInfo
- Publication number
- ATE174064T1 ATE174064T1 AT92916146T AT92916146T ATE174064T1 AT E174064 T1 ATE174064 T1 AT E174064T1 AT 92916146 T AT92916146 T AT 92916146T AT 92916146 T AT92916146 T AT 92916146T AT E174064 T1 ATE174064 T1 AT E174064T1
- Authority
- AT
- Austria
- Prior art keywords
- probes
- characterization
- hla
- solid support
- types
- Prior art date
Links
- 239000000523 sample Substances 0.000 title abstract 7
- 102000006354 HLA-DR Antigens Human genes 0.000 title abstract 3
- 108010058597 HLA-DR Antigens Proteins 0.000 title abstract 3
- 238000012512 characterization method Methods 0.000 title 2
- 239000002773 nucleotide Substances 0.000 abstract 2
- 125000003729 nucleotide group Chemical group 0.000 abstract 2
- 239000007787 solid Substances 0.000 abstract 2
- 108091034117 Oligonucleotide Proteins 0.000 abstract 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Tests Of Electronic Circuits (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Testing Or Measuring Of Semiconductors Or The Like (AREA)
- Particle Formation And Scattering Control In Inkjet Printers (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Polyamides (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Graft Or Block Polymers (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9109058A FR2679252B1 (fr) | 1991-07-17 | 1991-07-17 | Systeme de sondes permettant d'effectuer le typage hla dr, et procede de typage utilisant lesdites sondes. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE174064T1 true ATE174064T1 (de) | 1998-12-15 |
Family
ID=9415244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92916146T ATE174064T1 (de) | 1991-07-17 | 1992-07-17 | Sonden system zur hla-dr charakterisierung und sie verwendendes charakterisierungs-verfahren |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0549776B9 (de) |
| JP (1) | JPH06501622A (de) |
| AT (1) | ATE174064T1 (de) |
| AU (1) | AU659866B2 (de) |
| CA (1) | CA2091775C (de) |
| DE (1) | DE69227756T3 (de) |
| DK (1) | DK0549776T4 (de) |
| ES (1) | ES2126597T5 (de) |
| FR (1) | FR2679252B1 (de) |
| WO (1) | WO1993002213A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5976789A (en) * | 1991-07-17 | 1999-11-02 | Bio Merieux | System of probes enabling HLA-DR typing to be performed, and typing method using said probes |
| FR2749308B1 (fr) * | 1996-06-03 | 1998-07-24 | Bio Merieux | Sondes nucleotidiques et procede pour determiner le typage hla dqb1 |
| AU6223098A (en) * | 1997-02-14 | 1998-09-08 | Medical Research Council | Method of determining susceptibility to late-onset alzheimer's disease and dementia with lewy bodies |
| FR2793808B1 (fr) * | 1999-05-20 | 2003-09-19 | Biomerieux Sa | Procede d'analyse de la predisposition genetique d'un patient a au moins une maladie |
| FR2793809B1 (fr) * | 1999-05-20 | 2006-07-28 | Biomerieux Sa | Procede d'analyse de la predisposition genetique d'un patient a au moins une maladie et amplification adaptee a un tel procede |
| DE10032529A1 (de) * | 2000-06-30 | 2002-02-07 | Epigenomics Ag | Diagnose von bedeutenden genetischen Parametern innerhalb des Major Histocompatibility Complex (MHC) |
| GB0016836D0 (en) * | 2000-07-07 | 2000-08-30 | Lee Helen | Improved dipstick assays (1) |
| EP1536021A1 (de) * | 2003-11-27 | 2005-06-01 | Consortium National de Recherche en Genomique (CNRG) | Methode zur Typisierung von HLA |
| JP6734011B2 (ja) * | 2014-06-06 | 2020-08-05 | 古河電気工業株式会社 | 生体分子検出用試験キット、及びこれを用いた生体分子の検出方法、並びにこれらに用いられる生体分子検出用試験片及び生体分子検出用標識試薬 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6194561B1 (en) * | 1986-03-13 | 2001-02-27 | Roche Molecular Systems, Inc. | Characterization and detection of sequences associated with autoimmune diseases |
| CA1284931C (en) * | 1986-03-13 | 1991-06-18 | Henry A. Erlich | Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids |
| US5310893A (en) * | 1986-03-31 | 1994-05-10 | Hoffmann-La Roche Inc. | Method for HLA DP typing |
| US4965189A (en) * | 1986-07-01 | 1990-10-23 | University Of Massachusetts Medical School | Probes for the determination of the proclivity for development of autoimmune diseases |
| JPH03164180A (ja) * | 1989-08-10 | 1991-07-16 | Noboru Kashiwagi | 新規なdna塩基配列およびその用途 |
| GB9002625D0 (en) * | 1990-02-06 | 1990-04-04 | Univ Singapore | Human leukocyte antigen typing |
| US5387505A (en) * | 1990-05-04 | 1995-02-07 | Eastman Kodak Company | Preparation and isolation of single-stranded biotinylated nucleic acids by heat avidin-biotin cleavage |
| DE69112309T2 (de) † | 1990-06-28 | 1996-01-25 | Wakunaga Seiyaku Kk | Verfahren zum Nukleinsäurenachweis. |
| CA2049449C (en) † | 1990-08-20 | 1999-08-10 | Fumiya Obata | Hla-dr antigen gene and its nucleotide sequence and its use |
| ATE164630T1 (de) * | 1990-12-06 | 1998-04-15 | Hoffmann La Roche | Verfahren und reagenzien für die karakterisierung von hla-drbeta-dns |
| WO1993009245A1 (en) † | 1991-10-31 | 1993-05-13 | University Of Pittsburgh | Reverse dot blot hybridization using tandem head-to-tail monomers containing probes synthesized by staggered complementary primers |
-
1991
- 1991-07-17 FR FR9109058A patent/FR2679252B1/fr not_active Expired - Fee Related
-
1992
- 1992-07-17 AU AU23885/92A patent/AU659866B2/en not_active Ceased
- 1992-07-17 ES ES92916146T patent/ES2126597T5/es not_active Expired - Lifetime
- 1992-07-17 AT AT92916146T patent/ATE174064T1/de not_active IP Right Cessation
- 1992-07-17 DK DK92916146T patent/DK0549776T4/da active
- 1992-07-17 DE DE69227756T patent/DE69227756T3/de not_active Expired - Fee Related
- 1992-07-17 WO PCT/FR1992/000702 patent/WO1993002213A1/fr not_active Ceased
- 1992-07-17 JP JP5502642A patent/JPH06501622A/ja active Pending
- 1992-07-17 CA CA002091775A patent/CA2091775C/fr not_active Expired - Fee Related
- 1992-07-17 EP EP92916146A patent/EP0549776B9/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH06501622A (ja) | 1994-02-24 |
| CA2091775C (fr) | 2003-02-25 |
| FR2679252A1 (fr) | 1993-01-22 |
| AU2388592A (en) | 1993-02-23 |
| EP0549776B9 (de) | 2003-03-12 |
| EP0549776A1 (de) | 1993-07-07 |
| DE69227756T3 (de) | 2002-11-21 |
| ES2126597T3 (es) | 1999-04-01 |
| CA2091775A1 (fr) | 1993-01-18 |
| DK0549776T4 (da) | 2002-07-29 |
| DK0549776T3 (da) | 1999-08-16 |
| ES2126597T5 (es) | 2002-11-01 |
| EP0549776B1 (de) | 1998-12-02 |
| FR2679252B1 (fr) | 1993-12-10 |
| WO1993002213A1 (fr) | 1993-02-04 |
| EP0549776B2 (de) | 2002-03-27 |
| AU659866B2 (en) | 1995-06-01 |
| DE69227756D1 (de) | 1999-01-14 |
| DE69227756T2 (de) | 1999-07-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties | ||
| EEK | Proclamation as to paragraph 128 patent law | ||
| UEP | Publication of translation of european patent specification | ||
| UEP | Publication of translation of european patent specification |
Ref document number: 0549776 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |