ATE174586T1 - Auf das cardiovaskuläre system wirksame 1,5- disubstituierte 7a-methylperhydroinden-3a-ol- derivate, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen - Google Patents

Auf das cardiovaskuläre system wirksame 1,5- disubstituierte 7a-methylperhydroinden-3a-ol- derivate, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen

Info

Publication number
ATE174586T1
ATE174586T1 AT95830452T AT95830452T ATE174586T1 AT E174586 T1 ATE174586 T1 AT E174586T1 AT 95830452 T AT95830452 T AT 95830452T AT 95830452 T AT95830452 T AT 95830452T AT E174586 T1 ATE174586 T1 AT E174586T1
Authority
AT
Austria
Prior art keywords
disubstituted
methylperhydroindene
production
pharmaceutical compositions
compositions containing
Prior art date
Application number
AT95830452T
Other languages
English (en)
Inventor
Alberto Cerri
Nicoletta Almirante
Giuseppe Bianchi
Patrizia Ferrari
Piero Melloni
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Application granted granted Critical
Publication of ATE174586T1 publication Critical patent/ATE174586T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08Hydroxylamino compounds or their ethers or esters
    • C07C239/20Hydroxylamino compounds or their ethers or esters having oxygen atoms of hydroxylamino groups etherified
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32Oximes
    • C07C251/34Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/36Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32Oximes
    • C07C251/34Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/36Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C251/38Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a saturated carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32Oximes
    • C07C251/50Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals
    • C07C251/58Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/08Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/10Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by doubly-bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16Compounds containing any of the groups, e.g. aminoguanidine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44Nitrogen atoms not forming part of a nitro radical
    • C07D233/52Nitrogen atoms not forming part of a nitro radical with hetero atoms directly attached to said nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09Geometrical isomers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14All rings being cycloaliphatic
    • C07C2602/24All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT95830452T 1994-11-07 1995-10-27 Auf das cardiovaskuläre system wirksame 1,5- disubstituierte 7a-methylperhydroinden-3a-ol- derivate, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen ATE174586T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT94RM000715A IT1279386B1 (it) 1994-11-07 1994-11-07 1,5 derivati di 7a-metilperidroinden-3a-oli, attivi sul sistema cardiovascolare, procedimenti per la loro preparazione e composizioni

Publications (1)

Publication Number Publication Date
ATE174586T1 true ATE174586T1 (de) 1999-01-15

Family

ID=11402799

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95830452T ATE174586T1 (de) 1994-11-07 1995-10-27 Auf das cardiovaskuläre system wirksame 1,5- disubstituierte 7a-methylperhydroinden-3a-ol- derivate, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen

Country Status (10)

Country Link
US (1) US5705531A (de)
EP (1) EP0710646B1 (de)
JP (1) JP3776153B2 (de)
AT (1) ATE174586T1 (de)
CA (1) CA2161936A1 (de)
DE (1) DE69506671T2 (de)
DK (1) DK0710646T3 (de)
ES (1) ES2126865T3 (de)
GR (1) GR3029466T3 (de)
IT (1) IT1279386B1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19633376A1 (de) * 1996-08-19 1998-02-26 Sigma Tau Ind Farmaceuti Neue Seco-D-Steroide, die auf das kardiovaskuläre System wirken, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2669927B1 (fr) * 1990-11-29 1994-04-08 Adir Cie Nouveaux derives de guanidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
DE4222404C1 (de) * 1992-07-08 1993-12-02 Sigma Tau Ind Farmaceuti Verwendung von Iminoderivaten von Etianaldehyd zur Behandlung von Hypertonie
DE4227605C2 (de) * 1992-08-20 1995-02-16 Sigma Tau Ind Farmaceuti 17-Hydroxyiminomethyl-14beta-hydroxy-5ß-androstan-Derivate, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die dieselben enthalten
DE4227626C2 (de) * 1992-08-20 1994-11-17 Sigma Tau Ind Farmaceuti 17-Hydrazonomethyl-14ß-hydroxy-5ß-androstanderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
DE4232681C2 (de) * 1992-09-29 1994-11-24 Sigma Tau Ind Farmaceuti 17-Phenyl- und 17-Furyl-14beta,5alpha-androstan- und androsten- Derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzung

Also Published As

Publication number Publication date
ITRM940715A0 (it) 1994-11-07
DE69506671D1 (de) 1999-01-28
IT1279386B1 (it) 1997-12-10
US5705531A (en) 1998-01-06
JP3776153B2 (ja) 2006-05-17
DE69506671T2 (de) 1999-05-27
JPH08245537A (ja) 1996-09-24
DK0710646T3 (da) 1999-06-23
ITRM940715A1 (it) 1996-05-07
CA2161936A1 (en) 1996-05-08
ES2126865T3 (es) 1999-04-01
EP0710646A1 (de) 1996-05-08
EP0710646B1 (de) 1998-12-16
GR3029466T3 (en) 1999-05-28

Similar Documents

Publication Publication Date Title
ATE132496T1 (de) 3-desmethyl-mevalonsäurederivate, verfahren zu ihrer herstellung, pharmazeutische präparate auf basis dieser verbindungen, ihre verwendung sowie zwischenprodukte
GR3034821T3 (en) New 6-hydroxy and 6-oxo-anstro-stane derivatives active on the cardiovascular system and pharmaceutical compositions containing same
IT1275935B1 (it) Derivato di aminotetralina per la terapia di malattie cardiovascolari
DE3770726D1 (de) Decahydrochinolinderivate, verfahren zu ihrer herstellung und zwischenprodukte davon, ihre verwendung als arzneimittel und ihre pharmazeutischen zusammensetzungen.
ATE147077T1 (de) Kardioaktive 17b-aryl und 17b-heterozyklyl-5- beta,14-beta-androstan-derivate,ein verfahren zu ihrer herstellung und pharmazeutische phäparate davon
DE59008921D1 (de) Dibenzo(1,5)dioxocin-5-one-Derivate, ihre Verwendung in Arzneimitteln und Verfahren zu ihrer Herstellung.
ATE174586T1 (de) Auf das cardiovaskuläre system wirksame 1,5- disubstituierte 7a-methylperhydroinden-3a-ol- derivate, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen
ATE156490T1 (de) Neue hydrazino und hydroxyamino-14-beta- hydroxyandrostan-derivate mit kardiotonischer aktivität, ein verfahren zu ihrer herstellung und pharmaceutische präparate davon
ATE191462T1 (de) Im kardiovaskulären system aktive seco-d- steroide, verfahren zu deren herstellung und diese enthaltende pharmazeutische zubereitungen
DE69306513D1 (de) Neue kardioaktive Zyklopentaperhydrophenanthrene-17-beta-(hydroxy oder alkoxy)-17-alpha-(aryl oder heterozyklyl)-3-beta Derivate, ein Verfahren zu ihrer Herstellung und pharmazeutische Präparate davon
DE59200566D1 (de) Aryl-Chinolyl-substituierte 1,4-Dihydropyridin-dicarbonsäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln.
ATE183512T1 (de) Kardioaktive 17-hydroxyiminoalkyl- und 17- hydroxyiminomethylalkenyl-steroid-derivate, ein verfahren zu ihrer herstellung und pharmazeutische präparate davon
DE3881132D1 (de) Kondensierte piperidinderivate, zwischenprodukte und verfahren zu ihrer herstellung, ihre verwendung als arzneimittel und pharmazeutische zusammensetzungen davon.
DK0714908T3 (da) Nye 17-(3-imino-2-alkylproenyl)-5beta, 14beta-androstanderivater, der er aktive i det cardiovaskulære system, fremgansmåder
DE59206959D1 (de) Arzneimittel enthaltend azacyclodiphosphonsäurederivate, neue azacyclodiphosphonsäurederivate sowie verfahren zu deren herstellung
ATE43606T1 (de) Verbindungen mit cardiotropischer aktivitaet, verfahren zu ihrer herstellung und die sie enthaltenden pharmazeutischen zusammensetzungen.
GR3024707T3 (en) Digitoxigenin and dihydrodigitoxigenin 3beta-derivatives and pharmaceutical compositions comprising same for the treatment of cardiovascular disorders
ATE64384T1 (de) Decahydrochinolinderivate, verfahren zu ihrer herstellung und zwischenprodukte davon, ihre verwendung als arzneimittel und ihre pharmazeutischen zusammensetzungen.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee