ATE174899T1 - Zytotoxische stilben-derivate und diese enthaltende pharmazeutische zusammensetzungen - Google Patents

Zytotoxische stilben-derivate und diese enthaltende pharmazeutische zusammensetzungen

Info

Publication number
ATE174899T1
ATE174899T1 AT94306522T AT94306522T ATE174899T1 AT E174899 T1 ATE174899 T1 AT E174899T1 AT 94306522 T AT94306522 T AT 94306522T AT 94306522 T AT94306522 T AT 94306522T AT E174899 T1 ATE174899 T1 AT E174899T1
Authority
AT
Austria
Prior art keywords
cytotoxic
pharmaceutical compositions
compositions containing
containing same
carbon atoms
Prior art date
Application number
AT94306522T
Other languages
English (en)
Inventor
Koji Ohsumi
Takashi Tsuji
Yoshihiro Morinaga
Kazuo Ohishi
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Application granted granted Critical
Publication of ATE174899T1 publication Critical patent/ATE174899T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
    • C07C255/43—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
    • C07C217/84—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/164—Unsaturated ethers containing six-membered aromatic rings
    • C07C43/166—Unsaturated ethers containing six-membered aromatic rings having unsaturation outside the aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Laminated Bodies (AREA)
AT94306522T 1993-09-08 1994-09-05 Zytotoxische stilben-derivate und diese enthaltende pharmazeutische zusammensetzungen ATE174899T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP22357393 1993-09-08
JP32283293 1993-12-21

Publications (1)

Publication Number Publication Date
ATE174899T1 true ATE174899T1 (de) 1999-01-15

Family

ID=26525559

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94306522T ATE174899T1 (de) 1993-09-08 1994-09-05 Zytotoxische stilben-derivate und diese enthaltende pharmazeutische zusammensetzungen

Country Status (13)

Country Link
US (1) US5525632A (de)
EP (1) EP0641767B1 (de)
JP (1) JP3045017B2 (de)
KR (1) KR100308463B1 (de)
CN (1) CN1035996C (de)
AT (1) ATE174899T1 (de)
CA (1) CA2131683C (de)
DE (1) DE69415445T2 (de)
DK (1) DK0641767T3 (de)
ES (1) ES2126068T3 (de)
GR (1) GR3029603T3 (de)
SI (1) SI0641767T1 (de)
TW (1) TW325458B (de)

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TW334418B (en) * 1995-03-07 1998-06-21 Ajinomoto Kk Stilbene derivatives and pharmaceutical compositions
WO1999051246A1 (en) * 1998-04-03 1999-10-14 Ajinomoto Co., Inc. Antitumor agents
US6331633B1 (en) 1998-05-08 2001-12-18 Calyx Therapeutics Inc. Heterocyclic analogs of diphenylethylene compounds
US7105552B2 (en) 1998-05-08 2006-09-12 Theracos, Inc. Heterocyclic analogs of diphenylethylene compounds
US6245814B1 (en) 1998-05-08 2001-06-12 Calyx Therapeutics, Inc. Diphenylethylene compounds
US6624197B1 (en) 1998-05-08 2003-09-23 Calyx Therapeutics, Inc. Diphenylethylene compounds
GB9903403D0 (en) 1999-02-16 1999-04-07 Angiogene Pharm Ltd Substituted stilbene compounds with vascular damaging activity
US7407978B2 (en) * 1999-04-06 2008-08-05 Theracos, Inc. Heterocyclic analogs of diphenylethylene compounds
GB9918912D0 (en) * 1999-08-12 1999-10-13 Angiogene Pharm Ltd New stilbenes with vascular damaging activity
US6849656B1 (en) * 1999-09-17 2005-02-01 Baylor University Indole-containing and combretastatin-related anti-mitotic and anti-tubulin polymerization agents
US20020002200A1 (en) * 2000-02-04 2002-01-03 Bishwagit Nag Novel diphenylethylene compounds
US20080108825A1 (en) * 1999-11-08 2008-05-08 Theracos, Inc. Compounds for treatment of inflammation, diabetes and related disorders
US7323496B2 (en) * 1999-11-08 2008-01-29 Theracos, Inc. Compounds for treatment of inflammation, diabetes and related disorders
US6525093B1 (en) 1999-11-08 2003-02-25 Calyx Therapeutics Inc. Compounds to treat diabetes and associated conditions
US20080103302A1 (en) * 2000-02-04 2008-05-01 Theracos, Inc. Compounds for treatment of inflammation, diabetes and related disorders
NZ520829A (en) * 2000-02-04 2004-12-24 Calyx Therapeutics Inc Diphenylethylene compounds for treating diabetes and related conditions
CA2407967C (en) 2000-03-10 2010-10-05 Baylor University Tubulin binding ligands and corresponding prodrug constructs
US20040122083A1 (en) * 2000-05-09 2004-06-24 Pettit George R Antitubulin assembly and cell growth inhibitor denominated "dioxostatin"
AU1602902A (en) * 2000-10-27 2002-05-06 Aventis Pharma Sa A combination comprising camptothecin and a stilbene derivative for the treatment of cancer
EP1351912A2 (de) 2000-12-21 2003-10-15 Cancer Research Ventures Limited Substituierte stilbene, ihre reaktionen und antikrebsaktivität
US20020183266A1 (en) * 2001-03-15 2002-12-05 Aventis Pharma, S.A. Combination comprising combretastatin and anticancer agents
WO2003000645A1 (en) * 2001-06-22 2003-01-03 Ajinomoto Co., Inc. Method for producing aminostilbene derivative
PT1407784E (pt) * 2001-06-25 2011-03-03 Ajinomoto Kk Agentes antitumorais
CN1299777C (zh) * 2001-08-27 2007-02-14 宾夕法尼亚州大学理事会 茋衍生物及其用于结合和成像淀粉样蛋白斑的用途
EP1438281A4 (de) * 2001-10-26 2006-04-26 Oxigene Inc Funktionalisierte stilbenderivate als verbesserte, auf das gefässsystem zielende mittel
FR2838437B1 (fr) * 2002-04-11 2004-06-04 Aventis Pharma Sa Procedes de preparation de combretastatines
US6759555B2 (en) * 2002-04-11 2004-07-06 Aventis Pharma S.A. Process for the preparation of combretastatins
EP1591117A4 (de) * 2003-02-04 2006-04-26 Yakult Honsha Kk Bcrp (breast cancer resistance protein) inhibitor
EP1601348A4 (de) * 2003-02-28 2008-12-10 Oxigene Inc Zusammensetzungen und verfahren mit verbesserter therapeutischer aktivität
CN1723884A (zh) * 2004-07-21 2006-01-25 中国人民解放军军事医学科学院放射医学研究所 顺式－1，2－取代的二苯乙烯衍生物用于制备治疗或预防糖尿病的药物的用途
US7858072B2 (en) * 2004-12-17 2010-12-28 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
EP2213652B1 (de) * 2004-12-17 2014-10-22 The Trustees of The University of Pennsylvania Stilbenderivate und ihre Verwendung zum Binden und Abbilden von Amyloidplaques
FR2895258B1 (fr) * 2005-12-22 2008-03-21 Aventis Pharma Sa Combinaison comprenant de la combretastatine et des agents anticancereux
CN101139358B (zh) * 2006-09-07 2011-10-12 浙江大德药业集团有限公司 乙氧基康普立停及其前药的制备和用途
TW200819409A (en) 2006-10-19 2008-05-01 Univ Taipei Medical Z-stilbenes derivatives and the pharmaceutical composition thereof
CN100532353C (zh) * 2006-12-06 2009-08-26 中国科学院广州化学研究所 (z)-3＇-氨基-3,4,4＇,5-四甲氧基二苯乙烯的制备方法
WO2009067706A1 (en) 2007-11-21 2009-05-28 Oxigene, Inc. Method for treating hematopoietic neoplasms
CN101450889B (zh) * 2007-12-03 2012-05-30 中国科学院理化技术研究所 光催化1,2-二苯乙烯类似物发生顺反异构化反应的方法
FR2928148B1 (fr) 2008-02-28 2013-01-18 Sanofi Aventis Procede de preparation de combretastatine
CN101723813A (zh) * 2008-10-15 2010-06-09 上海华理生物医药有限公司 一种乙氧基二苯乙烷衍生物及其制备方法和用途
FR2953518B1 (fr) * 2009-12-03 2012-01-20 Sanofi Aventis Procede de preparation d'un derive de combretastatine
FR2968557A1 (fr) 2010-12-09 2012-06-15 Sanofi Aventis Combinaison antitumorale comprenant un derive de la famille des combretastatines et le cetuximab
CN110015962B (zh) * 2011-01-28 2022-03-15 肯塔基大学研究基金会 茋类似物和治疗癌症的方法
WO2013003112A1 (en) 2011-06-27 2013-01-03 The Jackson Laboratory Methods and compositions for treatment of cancer and autoimmune disease
CN103288701B (zh) * 2012-02-24 2016-01-27 中南大学 1，5-二芳基吡咯衍生物、制备方法及其抗肿瘤应用
WO2014089177A2 (en) 2012-12-04 2014-06-12 Massachusetts Institute Of Technology Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines
EP2972394A4 (de) 2013-03-15 2016-11-02 Sloan Kettering Inst Cancer Hsp90-anzielende herzbildgebung und -therapie
US11419934B2 (en) 2015-08-18 2022-08-23 Oncotelic Therapeutics, Inc. Use of VDAS to enhance immunomodulating therapies against tumors
WO2017197045A1 (en) 2016-05-11 2017-11-16 Movassaghi Mohammad Convergent and enantioselective total synthesis of communesin analogs
CN108727222B (zh) * 2017-04-24 2020-12-08 延边大学 一种选择性抗癌活性的tyd1608及其制备及用途
US11932650B2 (en) 2017-05-11 2024-03-19 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
US11535634B2 (en) 2019-06-05 2022-12-27 Massachusetts Institute Of Technology Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
WO2022182415A1 (en) 2021-02-24 2022-09-01 Massachusetts Institute Of Technology Himastatin derivatives, and processes of preparation thereof, and uses thereof

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DE3832204A1 (de) * 1988-09-22 1990-03-29 Basf Ag Neue stilbenverbindungen und deren verwendung bei der anionischen polymerisation
AU4385293A (en) * 1992-05-21 1993-12-13 Research Corporation Technologies, Inc. Stilbene derivatives as anticancer agents
US5430062A (en) * 1992-05-21 1995-07-04 Research Corporation Technologies, Inc. Stilbene derivatives as anticancer agents

Also Published As

Publication number Publication date
JP3045017B2 (ja) 2000-05-22
GR3029603T3 (en) 1999-06-30
DE69415445T2 (de) 1999-07-22
US5525632A (en) 1996-06-11
EP0641767B1 (de) 1998-12-23
SI0641767T1 (en) 1999-04-30
KR100308463B1 (ko) 2001-12-01
CN1035996C (zh) 1997-10-01
CA2131683A1 (en) 1995-03-09
ES2126068T3 (es) 1999-03-16
JPH07228558A (ja) 1995-08-29
DK0641767T3 (da) 1999-08-23
CN1105967A (zh) 1995-08-02
EP0641767A1 (de) 1995-03-08
TW325458B (en) 1998-01-21
CA2131683C (en) 2005-01-25
KR950008476A (ko) 1995-04-17
DE69415445D1 (de) 1999-02-04

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