ATE175113T1 - Verwendung von 4-amino-1-(2-pyridyl)piperidinen als 5-ht3-agonisten zur behandlung und verhütung von serotoninergen dysfunktionen - Google Patents

Verwendung von 4-amino-1-(2-pyridyl)piperidinen als 5-ht3-agonisten zur behandlung und verhütung von serotoninergen dysfunktionen

Info

Publication number: ATE175113T1
Authority: AT; Austria
Prior art keywords: serotoninergic; piperidines; pyridyl; amino; dysfunctions
Prior art date: 1991-03-27

Application number

AT92400792T

Other languages

English (en)

Inventor

Fur Gerard Le

Alberto Bianchetti

Antonina Giudice

Tiziano Croct

Philippe Soubrie

Original Assignee

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-03-27

Filing date

1992-03-24

Publication date

1999-01-15

1991-03-27 Priority claimed from FR9103735A external-priority patent/FR2674435B1/fr

1991-09-03 Priority claimed from FR9110890A external-priority patent/FR2674752B1/fr

1992-03-24 Application filed by Sanofi Sa filed Critical Sanofi Sa

1999-01-15 Application granted granted Critical

1999-01-15 Publication of ATE175113T1 publication Critical patent/ATE175113T1/de

Links

230000002295 serotoninergic effect Effects 0.000 title abstract 3
230000004064 dysfunction Effects 0.000 title abstract 2
150000003053 piperidines Chemical class 0.000 title 1
239000000198 serotonin 5-HT3 receptor agonist Substances 0.000 title 1
125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
125000004455 (C1-C3) alkylthio group Chemical group 0.000 abstract 1
CZINLSYKXBADTA-UHFFFAOYSA-N 1-pyridin-2-ylpiperidin-4-amine Chemical class C1CC(N)CCN1C1=CC=CC=N1 CZINLSYKXBADTA-UHFFFAOYSA-N 0.000 abstract 1
102000035037 5-HT3 receptors Human genes 0.000 abstract 1
108091005477 5-HT3 receptors Proteins 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
229940126601 medicinal product Drugs 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1
125000005034 trifluormethylthio group Chemical group FC(S*)(F)F 0.000 abstract 1
-1 trifluoromethoxy, 2,2,2-trifluoroethoxy, methylthio Chemical group 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)

AT92400792T 1991-03-27 1992-03-24 Verwendung von 4-amino-1-(2-pyridyl)piperidinen als 5-ht3-agonisten zur behandlung und verhütung von serotoninergen dysfunktionen ATE175113T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR9103735A FR2674435B1 (fr)	1991-03-27	1991-03-27	Utilisation de 4-amino-1-(2-pyridyl) piperidines pour la preparation d'agents psychotropes.
FR9110890A FR2674752B1 (fr)	1991-09-03	1991-09-03	Utilisation de 4-amino-1-(2-pyridyl)piperidines pour la preparation de medicaments pour le traitement et la prophylaxie des etats decoulant d'un dysfonctionnement du systeme serotoninergique.
EP91402753		1991-10-15

Publications (1)

Publication Number	Publication Date
ATE175113T1 true ATE175113T1 (de)	1999-01-15

Family

ID=27234263

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92400792T ATE175113T1 (de)	1991-03-27	1992-03-24	Verwendung von 4-amino-1-(2-pyridyl)piperidinen als 5-ht3-agonisten zur behandlung und verhütung von serotoninergen dysfunktionen

Country Status (9)

Country	Link
US (1)	US5604245A (de)
EP (1)	EP0506545B1 (de)
JP (1)	JP2603023B2 (de)
AT (1)	ATE175113T1 (de)
AU (1)	AU656563B2 (de)
CA (1)	CA2063941A1 (de)
DE (1)	DE69228017D1 (de)
HU (1)	HUT61465A (de)
SG (1)	SG47477A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2106840A1 (en) *	1992-09-25	1994-03-26	Marco Baroni	Heteroarylazetidines and -pyrrolidines, process for their preparation and pharmaceutical compositions containing them
EP0591030A3 (de) *	1992-09-25	1994-04-27	Sanofi	1-Heteroaryl-azetidine und -pyrrolidine als 5-HT3-Agoniste
CA2133855A1 (en) *	1993-10-11	1995-04-12	Marco Baroni	Heteroarylpiperidines, process for their preparation and pharmaceutical compositions in which they are present
EP0647639A1 (de) *	1993-10-11	1995-04-12	Sanofi	Heteroarylpiperidinen, Verfahren zu deren Herstellung und diese enthaltende pharmazeutischen Zusammenstellungen
FR2780057B1 (fr) *	1998-06-18	2002-09-13	Sanofi Sa	Phenoxypropanolamines, procede pour leur preparation et compositions pharmaceutiques les contenant
US6833370B1 (en) *	1999-05-21	2004-12-21	Abbott Laboratories	Heterocycle substituted aminoazacycles useful as central nervous system agents
KR100715344B1 (ko) *	1999-11-23	2007-05-08	얀센 파마슈티카 엔.브이.	기저부 이완을 위한 5ｈｔ3 효능제의 용도
WO2001053288A1 (en) *	2000-01-20	2001-07-26	Eisai Co., Ltd.	Novel piperidine compounds and drugs containing the same
US20040191312A1 (en) *	2002-12-31	2004-09-30	Donna Oksenberg	5-HT3 receptor agonists as neuroprotectors
US11446290B2 (en)	2017-06-28	2022-09-20	Osaka University	Treatment of pain with serotonin-3 receptor agonist
JPWO2022118783A1 (de) *	2020-12-04	2022-06-09
TW202508584A (zh)	2023-05-25	2025-03-01	日商丸石製藥股份有限公司	癌性疼痛預防或治療用組成物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2459240A1 (fr) *	1979-06-21	1981-01-09	Cm Ind	Aminopiperidines anorexigenes, procede pour leur preparation, intermediaires dans ledit procede et medicaments qui les contiennent

1992
- 1992-03-24 DE DE69228017T patent/DE69228017D1/de not_active Expired - Lifetime
- 1992-03-24 AT AT92400792T patent/ATE175113T1/de not_active IP Right Cessation
- 1992-03-24 EP EP92400792A patent/EP0506545B1/de not_active Expired - Lifetime
- 1992-03-24 SG SG1996002112A patent/SG47477A1/en unknown
- 1992-03-25 AU AU13168/92A patent/AU656563B2/en not_active Ceased
- 1992-03-25 CA CA002063941A patent/CA2063941A1/en not_active Abandoned
- 1992-03-26 JP JP4068374A patent/JP2603023B2/ja not_active Expired - Lifetime
- 1992-03-26 HU HU929200940A patent/HUT61465A/hu unknown
- 1992-03-27 US US07/858,483 patent/US5604245A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2063941A1 (en)	1992-09-28
JP2603023B2 (ja)	1997-04-23
HUT61465A (en)	1993-01-28
HU9200940D0 (en)	1992-05-28
DE69228017D1 (de)	1999-02-11
US5604245A (en)	1997-02-18
JPH07145166A (ja)	1995-06-06
AU656563B2 (en)	1995-02-09
EP0506545A2 (de)	1992-09-30
EP0506545B1 (de)	1998-12-30
EP0506545A3 (en)	1993-01-27
SG47477A1 (en)	1998-04-17
AU1316892A (en)	1992-10-01

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Legal Events

Date	Code	Title	Description
1999-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties