ATE175875T1 - Tirilazad parentale formulierung mit einem co- lösungsmittel - Google Patents

Tirilazad parentale formulierung mit einem co- lösungsmittel

Info

Publication number
ATE175875T1
ATE175875T1 AT95931566T AT95931566T ATE175875T1 AT E175875 T1 ATE175875 T1 AT E175875T1 AT 95931566 T AT95931566 T AT 95931566T AT 95931566 T AT95931566 T AT 95931566T AT E175875 T1 ATE175875 T1 AT E175875T1
Authority
AT
Austria
Prior art keywords
pct
formulation
parentale
tirilazad
solvent
Prior art date
Application number
AT95931566T
Other languages
English (en)
Inventor
Ching-Chiang Su
David S Baker
Susan M Machkovech
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of ATE175875T1 publication Critical patent/ATE175875T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
AT95931566T 1994-09-01 1995-08-29 Tirilazad parentale formulierung mit einem co- lösungsmittel ATE175875T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29937094A 1994-09-01 1994-09-01
US38225695A 1995-02-01 1995-02-01

Publications (1)

Publication Number Publication Date
ATE175875T1 true ATE175875T1 (de) 1999-02-15

Family

ID=26971187

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95931566T ATE175875T1 (de) 1994-09-01 1995-08-29 Tirilazad parentale formulierung mit einem co- lösungsmittel

Country Status (23)

Country Link
US (1) US5858999A (de)
EP (1) EP0778775B1 (de)
JP (1) JPH10505063A (de)
KR (1) KR100359556B1 (de)
CN (1) CN1156962A (de)
AT (1) ATE175875T1 (de)
AU (1) AU696856B2 (de)
BR (1) BR9508655A (de)
CA (1) CA2196063A1 (de)
CZ (1) CZ283875B6 (de)
DE (1) DE69507493T2 (de)
DK (1) DK0778775T3 (de)
ES (1) ES2128761T3 (de)
FI (1) FI970858L (de)
GR (1) GR3029396T3 (de)
HU (1) HUT76808A (de)
MX (1) MX9701342A (de)
NO (1) NO311405B1 (de)
NZ (1) NZ292690A (de)
PL (1) PL181244B1 (de)
RU (1) RU2152789C2 (de)
SK (1) SK280278B6 (de)
WO (1) WO1996006618A1 (de)

Families Citing this family (42)

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US6254564B1 (en) 1998-09-10 2001-07-03 Percardia, Inc. Left ventricular conduit with blood vessel graft
US6017948A (en) * 1998-10-30 2000-01-25 Supergen, Inc. Water-miscible pharmaceutical compositions
ES2232195T3 (es) * 1999-01-28 2005-05-16 Dinesh Shantilal Patel Solucion parenteral de propofol (2,6-diisopropilfenol) y 2,5-di-o-metil-1,4;3,6-dianhidro-d-glucitol como solvente.
DE10010073B4 (de) 2000-02-28 2005-12-22 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verankerung für implantierbare Herzklappenprothesen
DE10010074B4 (de) 2000-02-28 2005-04-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung zur Befestigung und Verankerung von Herzklappenprothesen
FR2828263B1 (fr) 2001-08-03 2007-05-11 Philipp Bonhoeffer Dispositif d'implantation d'un implant et procede d'implantation du dispositif
US20040058895A1 (en) * 2002-09-18 2004-03-25 Bone Care International, Inc. Multi-use vessels for vitamin D formulations
US20040053895A1 (en) * 2002-09-18 2004-03-18 Bone Care International, Inc. Multi-use vessels for vitamin D formulations
US7148211B2 (en) * 2002-09-18 2006-12-12 Genzyme Corporation Formulation for lipophilic agents
JP2007514732A (ja) * 2003-12-18 2007-06-07 バイオマス リミテッド 神経変性過程の予防及び治療のためのテルル誘導体
ES2312012T3 (es) 2004-09-17 2009-02-16 Biomas Ltd. Nuevos compuestos de telurio y su uso como inmunomodulares.
AU2005330504B2 (en) * 2004-09-29 2010-10-28 Harbor Biosciences, Inc. Steroid analogs and characterization and treatment methods
DE102005003632A1 (de) 2005-01-20 2006-08-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Katheter für die transvaskuläre Implantation von Herzklappenprothesen
DE102005051849B4 (de) 2005-10-28 2010-01-21 JenaValve Technology Inc., Wilmington Vorrichtung zur Implantation und Befestigung von Herzklappenprothesen
DE102005052628B4 (de) 2005-11-04 2014-06-05 Jenavalve Technology Inc. Selbstexpandierendes, flexibles Drahtgeflecht mit integrierter Klappenprothese für den transvaskulären Herzklappenersatz und ein System mit einer solchen Vorrichtung und einem Einführkatheter
US20070213813A1 (en) 2005-12-22 2007-09-13 Symetis Sa Stent-valves for valve replacement and associated methods and systems for surgery
US9138315B2 (en) 2007-04-13 2015-09-22 Jenavalve Technology Gmbh Medical device for treating a heart valve insufficiency or stenosis
US7896915B2 (en) 2007-04-13 2011-03-01 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
CA2683193A1 (en) 2007-05-15 2008-11-20 Jenavalve Technology Inc. Handle for manipulating a catheter tip, catheter system and medical insertion system for inserting a self-expandable heart valve stent
US8317858B2 (en) 2008-02-26 2012-11-27 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US8398704B2 (en) 2008-02-26 2013-03-19 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US9044318B2 (en) 2008-02-26 2015-06-02 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis
US8465540B2 (en) 2008-02-26 2013-06-18 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis
BR112012021347A2 (pt) 2008-02-26 2019-09-24 Jenavalve Tecnology Inc stent para posicionamento e ancoragem de uma prótese valvular em um local de implantação no coração de um paciente
US9168130B2 (en) 2008-02-26 2015-10-27 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
DK2444092T3 (en) 2008-05-28 2015-09-28 Reveragen Biopharma Inc Non-hormonal steroidmodulatorer of NF-? B for the treatment of disease
US20100292779A1 (en) 2009-05-15 2010-11-18 Helmut Straubinger Device for compressing a stent and a system as well as a method for loading a stent into a medical delivery system
EP2556083A4 (de) 2010-04-05 2013-12-04 Validus Biopharma Inc Nichthormonale steroide modulatoren von nf-kappa-b zur krankheitsbehandlung
US11278406B2 (en) 2010-05-20 2022-03-22 Jenavalve Technology, Inc. Catheter system for introducing an expandable heart valve stent into the body of a patient, insertion system with a catheter system and medical device for treatment of a heart valve defect
US10856978B2 (en) 2010-05-20 2020-12-08 Jenavalve Technology, Inc. Catheter system
CA2799459A1 (en) 2010-05-25 2011-12-01 Jenavalve Technology Inc. Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent
JP6005168B2 (ja) 2011-10-21 2016-10-12 イエナバルブ テクノロジー インク 患者の身体への拡張型心臓弁ステント導入用カテーテルシステム、カテーテルシステムを備えた挿入システムおよび心臓弁欠陥治療用医療機器
EP2849678B1 (de) 2012-05-16 2022-08-10 JenaValve Technology, Inc. Katheterverabreichungssystem zur einführung einer dehnbaren herzklappenprothese sowie medizinische vorrichtung zur behandlung eines herzklappendefekts
CN103861090B (zh) * 2012-12-18 2017-06-13 美迪思生物科技(北京)有限公司 含蛋白或多肽的疏水溶液、其制备方法及用途
WO2015028209A1 (en) 2013-08-30 2015-03-05 Jenavalve Technology Gmbh Radially collapsible frame for a prosthetic valve and method for manufacturing such a frame
EP4353203B1 (de) 2015-03-20 2026-08-19 JenaValve Technology, Inc. Herzklappenprotheseneinführungssystem
EP3632378B1 (de) 2015-05-01 2024-05-29 JenaValve Technology, Inc. Vorrichtung mit reduzierter herzschrittmacherrate bei herzklappenersatz
WO2017004205A1 (en) 2015-06-29 2017-01-05 Reveragen Biopharma, Inc. NON-HORMONAL STEROID MODULATORS OF NF-κB FOR TREATMENT OF DISEASE
WO2017195125A1 (en) 2016-05-13 2017-11-16 Jenavalve Technology, Inc. Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath and loading system
EP3573579B1 (de) 2017-01-27 2023-12-20 JenaValve Technology, Inc. Herzklappennachahmung
US11382922B2 (en) 2019-03-07 2022-07-12 Reveragen Biopharma, Inc. Aqueous oral pharmaceutical suspension compositions
WO2024102411A1 (en) 2022-11-09 2024-05-16 Jenavalve Technology, Inc. Catheter system for sequential deployment of an expandable implant

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU573321B2 (en) * 1984-03-14 1988-06-02 Jerome Corbiere Process for solubilizing active principles and pharmaceuticalcompositions thus obtained
US5175281A (en) * 1985-09-12 1992-12-29 The Upjohn Company Pharmaceutically active pyrimidinylpiperazinylsterioids
WO1987001706A2 (en) * 1985-09-12 1987-03-26 The Upjohn Company C20 through c26 amino steroids
US4968675A (en) * 1988-10-28 1990-11-06 Upjohn Non-hemolytic lazaroid parenteral formulation
US5124154A (en) * 1990-06-12 1992-06-23 Insite Vision Incorporated Aminosteroids for ophthalmic use
JP2002500616A (ja) * 1994-07-21 2002-01-08 ファルマシア・アンド・アップジョン・カンパニー 神経学的に活性なアミノステロイド
US5614515A (en) * 1994-11-17 1997-03-25 University Of Southern California Lazaroid-based compositions and method for preventing adhesion formation using the same

Also Published As

Publication number Publication date
NZ292690A (en) 1998-06-26
WO1996006618A1 (en) 1996-03-07
KR100359556B1 (ko) 2002-12-18
PL181244B1 (pl) 2001-06-29
RU2152789C2 (ru) 2000-07-20
MX9701342A (es) 1997-05-31
AU696856B2 (en) 1998-09-17
DE69507493T2 (de) 1999-06-10
NO311405B1 (no) 2001-11-26
PL318901A1 (en) 1997-07-21
SK26297A3 (en) 1997-09-10
GR3029396T3 (en) 1999-05-28
BR9508655A (pt) 1997-08-12
NO970935D0 (no) 1997-02-28
JPH10505063A (ja) 1998-05-19
CA2196063A1 (en) 1996-03-07
HUT76808A (en) 1997-11-28
EP0778775B1 (de) 1999-01-20
NO970935L (no) 1997-04-11
CZ283875B6 (cs) 1998-06-17
FI970858A7 (fi) 1997-02-28
FI970858A0 (fi) 1997-02-28
CZ55997A3 (en) 1997-06-11
FI970858L (fi) 1997-02-28
DK0778775T3 (da) 1999-09-13
DE69507493D1 (de) 1999-03-04
AU3493895A (en) 1996-03-22
SK280278B6 (sk) 1999-10-08
EP0778775A1 (de) 1997-06-18
ES2128761T3 (es) 1999-05-16
CN1156962A (zh) 1997-08-13
US5858999A (en) 1999-01-12

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Legal Events

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REN Ceased due to non-payment of the annual fee