ATE176280T1 - Enzymatisches verfahren zur herstellung von morphin-6-glucuroniden oder substituierten morphin-6-glucuroniden - Google Patents

Enzymatisches verfahren zur herstellung von morphin-6-glucuroniden oder substituierten morphin-6-glucuroniden

Info

Publication number: ATE176280T1
Authority: AT; Austria
Prior art keywords: morphin; glucuronides; substituted; producing; enzymatic process
Prior art date: 1993-12-07

Application number

AT95902183T

Other languages

English (en)

Inventor

Feodor Scheinmann

Nicholas John Turner

Richard Talbot Brown

Neil Edward Carter

Original Assignee

Salford Ultrafine Chem & Res

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-12-07

Filing date

1994-11-29

Publication date

1999-02-15

1994-11-29 Application filed by Salford Ultrafine Chem & Res filed Critical Salford Ultrafine Chem & Res

1999-02-15 Application granted granted Critical

1999-02-15 Publication of ATE176280T1 publication Critical patent/ATE176280T1/de

Links

230000002255 enzymatic effect Effects 0.000 title abstract 2
GNJCUHZOSOYIEC-GAROZEBRSA-N Morphine-6-glucuronide Chemical compound O([C@H]1C=C[C@H]2[C@H]3CC=4C5=C(C(=CC=4)O)O[C@@H]1[C@]52CCN3C)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O GNJCUHZOSOYIEC-GAROZEBRSA-N 0.000 abstract 2
238000003776 cleavage reaction Methods 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
230000007017 scission Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
- C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
- C12N11/087—Acrylic polymers

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Zoology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT95902183T 1993-12-07 1994-11-29 Enzymatisches verfahren zur herstellung von morphin-6-glucuroniden oder substituierten morphin-6-glucuroniden ATE176280T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB939325065A GB9325065D0 (en)	1993-12-07	1993-12-07	An enzymatic process for making morphine-6-glucuronide or substituted morphine-6-glucuronide

Publications (1)

Publication Number	Publication Date
ATE176280T1 true ATE176280T1 (de)	1999-02-15

Family

ID=10746262

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95902183T ATE176280T1 (de)	1993-12-07	1994-11-29	Enzymatisches verfahren zur herstellung von morphin-6-glucuroniden oder substituierten morphin-6-glucuroniden

Country Status (9)

Country	Link
US (1)	US5750381A (de)
EP (1)	EP0733120B1 (de)
JP (1)	JPH09505999A (de)
AT (1)	ATE176280T1 (de)
AU (1)	AU1112695A (de)
CA (1)	CA2178082A1 (de)
DE (1)	DE69416325D1 (de)
GB (1)	GB9325065D0 (de)
WO (1)	WO1995016050A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5977326A (en) *	1991-08-06	1999-11-02	Salford Ultrafine Chemicals And Research Limited	Process for making morphine-6-glucuronide or substituted morphine-6-glucuronide
GB9116909D0 (en) *	1991-08-06	1991-09-18	Salford Ultrafine Chem & Res	Morphine derivatives
ATE242257T1 (de) *	1997-04-14	2003-06-15	Ufc Ltd	Morphin-derivate
ES2185350T3 (es) *	1998-06-06	2003-04-16	Cenes Ltd	Sintesis de morfina-6-glucuronido.
GB9914382D0 (en) *	1999-06-21	1999-08-18	Ufc Limited	New process for the manufacture of morphine-6-glucuronide and its analogues and also to a manufacture of new intermediaries
GB2553142B (en)	2016-08-26	2021-06-02	La Piedra Biotecnologia Spa	Method for detecting products derived from glucuronide metabolites with the enzyme beta-glucuronidase, and a reagent comprising said enzyme

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE839799C (de) *		1952-04-17	Muri Bern Dr. Paul Casparis (Schweiz)	Verfahren zur Herstellung von Morphin-6-glycosiden
FR1023058A (fr) *	1949-08-12	1953-03-13		Procédé pour la préparation de morphino-6-glucosides
ES2058243T3 (es) *	1988-01-12	1994-11-01	Baker Norton Pharma	Derivados del acido glucuronico de antagonistas de opiaceos.
US4774230A (en) *	1988-03-26	1988-09-27	Ivax Laboratories, Inc.	Glucuronic acid derivatives of opioid antagonists
GB9116909D0 (en) *	1991-08-06	1991-09-18	Salford Ultrafine Chem & Res	Morphine derivatives
FR2680786B1 (fr) *	1991-09-04	1995-03-10	Irepa	Procede de synthese de glucuronides d'epoxy-4,5 morphinanes.

1993
- 1993-12-07 GB GB939325065A patent/GB9325065D0/en active Pending
1994
- 1994-11-29 JP JP7516023A patent/JPH09505999A/ja active Pending
- 1994-11-29 WO PCT/GB1994/002605 patent/WO1995016050A1/en not_active Ceased
- 1994-11-29 AU AU11126/95A patent/AU1112695A/en not_active Abandoned
- 1994-11-29 DE DE69416325T patent/DE69416325D1/de not_active Expired - Lifetime
- 1994-11-29 CA CA002178082A patent/CA2178082A1/en not_active Abandoned
- 1994-11-29 EP EP95902183A patent/EP0733120B1/de not_active Expired - Lifetime
- 1994-11-29 AT AT95902183T patent/ATE176280T1/de active
1996
- 1996-06-03 US US08/659,047 patent/US5750381A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0733120B1 (de)	1999-01-27
WO1995016050A1 (en)	1995-06-15
AU1112695A (en)	1995-06-27
EP0733120A1 (de)	1996-09-25
US5750381A (en)	1998-05-12
CA2178082A1 (en)	1995-06-15
JPH09505999A (ja)	1997-06-17
DE69416325D1 (de)	1999-03-11
GB9325065D0 (en)	1994-02-02

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