ATE177149T1 - Expression von menschlichen serum-albuminen in pichia pastoris - Google Patents

Expression von menschlichen serum-albuminen in pichia pastoris

Info

Publication number
ATE177149T1
ATE177149T1 AT92107062T AT92107062T ATE177149T1 AT E177149 T1 ATE177149 T1 AT E177149T1 AT 92107062 T AT92107062 T AT 92107062T AT 92107062 T AT92107062 T AT 92107062T AT E177149 T1 ATE177149 T1 AT E177149T1
Authority
AT
Austria
Prior art keywords
pichia pastoris
hsa
regulatory region
structural gene
expression
Prior art date
Application number
AT92107062T
Other languages
English (en)
Inventor
Kotikanyad Sreekrishna
Kathryn Ann Barr
Russell A Brierley
Gregory P Thill
Juerg F Tschopp
Original Assignee
Res Corp Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Res Corp Technologies Inc filed Critical Res Corp Technologies Inc
Application granted granted Critical
Publication of ATE177149T1 publication Critical patent/ATE177149T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT92107062T 1991-04-25 1992-04-24 Expression von menschlichen serum-albuminen in pichia pastoris ATE177149T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US69160491A 1991-04-25 1991-04-25

Publications (1)

Publication Number Publication Date
ATE177149T1 true ATE177149T1 (de) 1999-03-15

Family

ID=24777211

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92107062T ATE177149T1 (de) 1991-04-25 1992-04-24 Expression von menschlichen serum-albuminen in pichia pastoris

Country Status (8)

Country Link
US (1) US5707828A (de)
EP (1) EP0510693B1 (de)
JP (2) JP3583791B2 (de)
AT (1) ATE177149T1 (de)
CA (1) CA2058820C (de)
DE (1) DE69228497T2 (de)
DK (1) DK0510693T3 (de)
ES (1) ES2127734T3 (de)

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CN1103374C (zh) * 1999-03-04 2003-03-19 上海贸基生物工程科技有限公司 重组dna技术生产人血清白蛋白的方法
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US7625756B2 (en) 2000-06-28 2009-12-01 GycoFi, Inc. Expression of class 2 mannosidase and class III mannosidase in lower eukaryotic cells
US7598055B2 (en) * 2000-06-28 2009-10-06 Glycofi, Inc. N-acetylglucosaminyltransferase III expression in lower eukaryotes
US8697394B2 (en) * 2000-06-28 2014-04-15 Glycofi, Inc. Production of modified glycoproteins having multiple antennary structures
US7449308B2 (en) 2000-06-28 2008-11-11 Glycofi, Inc. Combinatorial DNA library for producing modified N-glycans in lower eukaryotes
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US7507413B2 (en) 2001-04-12 2009-03-24 Human Genome Sciences, Inc. Albumin fusion proteins
US6645739B2 (en) * 2001-07-26 2003-11-11 Phoenix Pharmacologies, Inc. Yeast expression systems, methods of producing polypeptides in yeast, and compositions relating to same
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WO2005003296A2 (en) 2003-01-22 2005-01-13 Human Genome Sciences, Inc. Albumin fusion proteins
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US7118901B2 (en) * 2002-12-18 2006-10-10 Roche Diagnostics Operations, Inc. Recombinant bovine pancreatic desoxyribonuclease I with high specific activity
EP1433842B1 (de) * 2002-12-18 2011-01-05 Roche Diagnostics GmbH Rekombinante Desoxyribonuclease I aus Rinder-Pankreas mit hoher spezifischer Aktivität
US7332299B2 (en) 2003-02-20 2008-02-19 Glycofi, Inc. Endomannosidases in the modification of glycoproteins in eukaryotes
WO2004108890A2 (en) * 2003-05-30 2004-12-16 New Century Pharmaceuticals, Inc. Dilute methanol -or ethanol- induced production of polypeptides in microorganisms
AT501955B1 (de) * 2005-02-23 2007-08-15 Univ Graz Tech Mutierte aox1-promotoren
RU2306333C2 (ru) * 2005-05-27 2007-09-20 Общество с ограниченной ответственностью научно-производственная компания "Генные и клеточные технологии" ШТАММ ДРОЖЖЕЙ Pichia pastoris Х-33/2albumin ДЛЯ СЕКРЕЦИИ ЧЕЛОВЕЧЕСКОГО АЛЬБУМИНА
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US11345891B2 (en) 2017-04-05 2022-05-31 Asgard Therapeutics Ab Compositions for reprogramming cells into dendritic cells or antigen presenting cells, methods and uses thereof
US20220000976A1 (en) 2018-11-09 2022-01-06 The Children's Medical Center Corporation Methods and compositions for treating or preventing the development of food allergies
CN113056554A (zh) * 2018-11-19 2021-06-29 巴斯夫欧洲公司 重组酵母细胞
US20240115607A1 (en) 2021-01-26 2024-04-11 Cytocares (Shanghai) Inc. Chimeric antigen receptor (car) constructs and nk cells expressing car constructs
EP4486764A4 (de) 2022-02-28 2026-03-18 Childrens Medical Ct Corp Regulatorische t-zellen mit chimärem antigenrezeptor zum targeting costimulatorischer moleküle zur vorbeugung und/oder behandlung von entzündlichen erkrankungen
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Also Published As

Publication number Publication date
JPH0646858A (ja) 1994-02-22
DE69228497D1 (de) 1999-04-08
DE69228497T2 (de) 1999-07-15
CA2058820A1 (en) 1992-10-26
JP2004166711A (ja) 2004-06-17
EP0510693A3 (de) 1994-01-12
DK0510693T3 (da) 1999-09-27
JP3583791B2 (ja) 2004-11-04
EP0510693A2 (de) 1992-10-28
ES2127734T3 (es) 1999-05-01
CA2058820C (en) 2003-07-15
US5707828A (en) 1998-01-13
EP0510693B1 (de) 1999-03-03
JP3786662B2 (ja) 2006-06-14

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