ATE178056T1 - Substituierte tertiäre amine und deren salze - Google Patents
Substituierte tertiäre amine und deren salzeInfo
- Publication number
- ATE178056T1 ATE178056T1 AT93909428T AT93909428T ATE178056T1 AT E178056 T1 ATE178056 T1 AT E178056T1 AT 93909428 T AT93909428 T AT 93909428T AT 93909428 T AT93909428 T AT 93909428T AT E178056 T1 ATE178056 T1 AT E178056T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted tertiary
- salts
- tertiary amine
- mastopathy
- endometriosis
- Prior art date
Links
- 150000003512 tertiary amines Chemical class 0.000 title 1
- 102000014654 Aromatase Human genes 0.000 abstract 1
- 108010078554 Aromatase Proteins 0.000 abstract 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 abstract 1
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 201000009273 Endometriosis Diseases 0.000 abstract 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 abstract 1
- 208000030270 breast disease Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 201000004240 prostatic hypertrophy Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- -1 tertiary amino compound Chemical class 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/20—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13776292 | 1992-04-28 | ||
| JP23429892 | 1992-08-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE178056T1 true ATE178056T1 (de) | 1999-04-15 |
Family
ID=26470979
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93909428T ATE178056T1 (de) | 1992-04-28 | 1993-04-27 | Substituierte tertiäre amine und deren salze |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5538976A (de) |
| EP (1) | EP0640595B1 (de) |
| JP (1) | JP2682741B2 (de) |
| KR (1) | KR0163624B1 (de) |
| CN (1) | CN1039228C (de) |
| AT (1) | ATE178056T1 (de) |
| AU (1) | AU4023093A (de) |
| CA (1) | CA2118138A1 (de) |
| DE (1) | DE69324141T2 (de) |
| DK (1) | DK0640595T3 (de) |
| ES (1) | ES2130258T3 (de) |
| GR (1) | GR3030472T3 (de) |
| TW (1) | TW345577B (de) |
| WO (1) | WO1993022290A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6756367B2 (en) | 1998-02-03 | 2004-06-29 | Novartis Ag | Benzo-oxadiazoles, -thiadiazoles and -1,4-diazines, pharmaceutical compositions containing them and a process for preparing them |
| GB9802251D0 (en) * | 1998-02-03 | 1998-04-01 | Ciba Geigy Ag | Organic compounds |
| CA2327543A1 (en) * | 1998-05-06 | 1999-11-11 | Duke University | Method of treating bladder and lower urinary tract syndromes |
| AU6589801A (en) * | 2000-04-28 | 2001-11-12 | F. Hoffmann-La Roche Ag | P-(sulfonyl)aryl and heteroaryls |
| GB0120147D0 (en) * | 2001-08-17 | 2001-10-10 | Metris Therapeutics Ltd | Treatment method |
| GB0127923D0 (en) | 2001-11-21 | 2002-01-16 | Sterix Ltd | Compound |
| US6737433B1 (en) | 2002-12-16 | 2004-05-18 | Laboratoire Theramex | 1-N-phenylamino-1H-imidazole derivatives as aromatase inhibitors and pharmaceutical compositions containing them |
| WO2007089735A2 (en) * | 2006-02-01 | 2007-08-09 | Merck & Co., Inc. | Potassium channel inhibitors |
| DE202009014107U1 (de) | 2009-10-16 | 2010-02-25 | HOKWANG INDUSTRIES CO., LTD., Rueifang | Druckmechanismus eines Seifenspenders mit der Möglichkeit zur Einstellung der Dosiermenge der flüssigen Seife |
| ES2694582T3 (es) * | 2011-01-31 | 2018-12-21 | Lucolas-M.D. Ltd. | Combinaciones de inhibidores de aromatasa y antioxidantes |
| CN103183669B (zh) * | 2011-12-27 | 2015-11-18 | 湖南化工研究院 | 噻唑甲胺基吡啶类化合物及其制备方法 |
| CN105190317B (zh) | 2013-03-15 | 2018-05-04 | 雅培制药有限公司 | 具有预处理转盘的诊断分析机及相关方法 |
| CN107831324B (zh) | 2013-03-15 | 2021-11-19 | 雅培制药有限公司 | 具有后面可进入轨道系统的自动化诊断分析仪及相关方法 |
| CN105378487B (zh) | 2013-03-15 | 2018-08-21 | 雅培制药有限公司 | 具有竖直布置的圆盘传送带的自动化诊断分析仪及相关方法 |
| CN104387377B (zh) * | 2014-10-14 | 2017-03-29 | 湖南海利常德农药化工有限公司 | 一种噻唑甲胺基吡啶类化合物的制备方法 |
| CN105777741B (zh) * | 2014-12-18 | 2019-02-01 | 湖南化工研究院有限公司 | 噻唑烷基吡啶胺类化合物及其制备方法与应用 |
| CN104770374B (zh) * | 2015-04-02 | 2017-10-17 | 湖南化工研究院有限公司 | 一种杀菌组合物 |
| CN113387894B (zh) * | 2021-06-22 | 2023-02-24 | 首都医科大学脑重大疾病研究中心(北京脑重大疾病研究院) | 1-n-苯乙腈基氨基-三氮唑和嘧啶衍生物及其制备方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4762836A (en) * | 1983-02-02 | 1988-08-09 | Eli Lilly And Company | Aromatase inhibitors |
| US4774251A (en) * | 1984-06-18 | 1988-09-27 | Eli Lilly And Company | Method of inhibiting aromatase |
| US4727060A (en) * | 1984-11-13 | 1988-02-23 | Ciba-Geigy Corporation | Novel 5-amino-4-hydroxyvaleryl derivatives |
| DD239210A5 (de) * | 1984-11-13 | 1986-09-17 | Ciba-Geigy Ag,Ch | Verfahren zur herstellung neuer 5-amino-4-hydroxyvaleryl-derivate |
| AU4717889A (en) * | 1988-12-29 | 1990-07-05 | Ciba-Geigy Ag | Amino-substituted hydroxamic acids |
| DE3905364A1 (de) * | 1989-02-22 | 1990-08-23 | Hoechst Ag | Substituierte pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als tool |
-
1993
- 1993-04-27 KR KR1019940703846A patent/KR0163624B1/ko not_active Expired - Fee Related
- 1993-04-27 WO PCT/JP1993/000548 patent/WO1993022290A1/ja not_active Ceased
- 1993-04-27 DK DK93909428T patent/DK0640595T3/da active
- 1993-04-27 JP JP5519125A patent/JP2682741B2/ja not_active Expired - Fee Related
- 1993-04-27 CA CA002118138A patent/CA2118138A1/en not_active Abandoned
- 1993-04-27 AU AU40230/93A patent/AU4023093A/en not_active Abandoned
- 1993-04-27 US US08/325,383 patent/US5538976A/en not_active Expired - Fee Related
- 1993-04-27 DE DE69324141T patent/DE69324141T2/de not_active Expired - Fee Related
- 1993-04-27 EP EP93909428A patent/EP0640595B1/de not_active Expired - Lifetime
- 1993-04-27 TW TW082103252A patent/TW345577B/zh active
- 1993-04-27 ES ES93909428T patent/ES2130258T3/es not_active Expired - Lifetime
- 1993-04-27 AT AT93909428T patent/ATE178056T1/de not_active IP Right Cessation
- 1993-04-28 CN CN93105330A patent/CN1039228C/zh not_active Expired - Fee Related
-
1999
- 1999-06-09 GR GR990401545T patent/GR3030472T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK0640595T3 (da) | 1999-10-11 |
| KR950701321A (ko) | 1995-03-23 |
| EP0640595A1 (de) | 1995-03-01 |
| AU4023093A (en) | 1993-11-29 |
| US5538976A (en) | 1996-07-23 |
| EP0640595B1 (de) | 1999-03-24 |
| TW345577B (en) | 1998-11-21 |
| ES2130258T3 (es) | 1999-07-01 |
| WO1993022290A1 (fr) | 1993-11-11 |
| DE69324141D1 (de) | 1999-04-29 |
| KR0163624B1 (ko) | 1998-12-01 |
| CN1079962A (zh) | 1993-12-29 |
| DE69324141T2 (de) | 1999-08-26 |
| EP0640595A4 (de) | 1995-04-12 |
| CA2118138A1 (en) | 1993-10-29 |
| JP2682741B2 (ja) | 1997-11-26 |
| CN1039228C (zh) | 1998-07-22 |
| GR3030472T3 (en) | 1999-10-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |