ATE178613T1 - Zyklische peptide mit aggregationshemmenden eigenschaften - Google Patents

Zyklische peptide mit aggregationshemmenden eigenschaften

Info

Publication number: ATE178613T1
Authority: AT; Austria
Prior art keywords: arg; alk; min min; phe; lys
Prior art date: 1989-10-23

Application number

AT90311537T

Other languages

English (en)

Inventor

Fadia El-Fehail Ali

James Martin Samanen

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-10-23

Filing date

1990-10-22

Publication date

1999-04-15

1990-10-22 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

1999-04-15 Application granted granted Critical

1999-04-15 Publication of ATE178613T1 publication Critical patent/ATE178613T1/de

Links

102000001189 Cyclic Peptides Human genes 0.000 title 1
108010069514 Cyclic Peptides Proteins 0.000 title 1
230000002401 inhibitory effect Effects 0.000 abstract 3
ODKSFYDXXFIFQN-UHFFFAOYSA-N Arginine Chemical compound OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 2
241000124008 Mammalia Species 0.000 abstract 1
206010038563 Reocclusion Diseases 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
210000004204 blood vessel Anatomy 0.000 abstract 1
230000035602 clotting Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000003527 fibrinolytic agent Substances 0.000 abstract 1
230000003480 fibrinolytic effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
- C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1019—Tetrapeptides with the first amino acid being basic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
- C07K5/123—Tripeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT90311537T 1989-10-23 1990-10-22 Zyklische peptide mit aggregationshemmenden eigenschaften ATE178613T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US42590689A	1989-10-23	1989-10-23

Publications (1)

Publication Number	Publication Date
ATE178613T1 true ATE178613T1 (de)	1999-04-15

Family

ID=23688530

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90311537T ATE178613T1 (de)	1989-10-23	1990-10-22	Zyklische peptide mit aggregationshemmenden eigenschaften

Country Status (13)

Country	Link
EP (1)	EP0425212B1 (de)
JP (1)	JP2922281B2 (de)
KR (1)	KR910007964A (de)
AT (1)	ATE178613T1 (de)
AU (1)	AU6470590A (de)
CA (1)	CA2027936C (de)
CZ (1)	CZ397991A3 (de)
DE (1)	DE69033038T2 (de)
ES (1)	ES2130118T3 (de)
IE (1)	IE903775A1 (de)
NZ (1)	NZ235767A (de)
PT (1)	PT95661B (de)
ZA (1)	ZA908426B (de)

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US6019958A (en) *	1991-02-08	2000-02-01	Diatide, Inc.	Technetium-99m labeled peptides for imaging inflammation
US5830856A (en) *	1991-02-08	1998-11-03	Diatide, Inc.	Radiolabeled compounds for thrombus imaging
US5645815A (en) *	1991-02-08	1997-07-08	Diatide, Inc.	Radiolabled compounds for thrombus imaging
US5736122A (en) *	1991-02-08	1998-04-07	Diatide, Inc.	Technetium-99m labeled peptides for thrombus imaging
DE69230525T2 (de) *	1991-02-08	2000-06-21	Diatide, Inc.	Technetium-99m markierte Polypeptide zur Bildformung
US5561220A (en) *	1991-02-08	1996-10-01	Diatech, Inc.	Technetium-99m labeled peptides for imaging inflammation
US5635477A (en) *	1991-09-30	1997-06-03	The Dupont Merck Pharmaceutical Company	Cyclic compounds useful as inhibitors of platelet glycoprotein IIB/IIIA
IL103252A (en)	1991-09-30	1997-03-18	Du Pont Merck Pharma	CYCLIC COMPOUNDS USEFUL AS INHIBITORS OF PLATELET GLYCOPROTEIN IIb/IIIa AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US5250679A (en) *	1991-10-18	1993-10-05	Genentech, Inc.	Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor
US5674863A (en) *	1991-10-18	1997-10-07	Genentech, Inc.	Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa receptor
US5968476A (en) *	1992-05-21	1999-10-19	Diatide, Inc.	Technetium-99m labeled peptides for thrombus imaging
US5338725A (en) *	1992-06-30	1994-08-16	The Research Foundation Of The State University Of New York	Anti-aggregatory agents for platelets
CA2101599A1 (en) *	1992-08-31	1994-03-01	Wilhelm Bannwarth	Tri- and tetracyclic compounds
DE69332203T2 (de) *	1992-10-02	2003-05-28	Diatide, Inc.	Multimerische mehrzweckwirkstoffe gegen thrombose
JPH08503217A (ja) *	1992-11-18	1996-04-09	ザ・デュポン・メルク・ファーマシュウティカル・カンパニー	血小板糖タンパク質▲ＩＩ▼ｂ／▲ＩＩＩ▼ａの阻害剤として有用な複素環式環により結合された環状化合物
JPH08509708A (ja) *	1993-03-29	1996-10-15	ザ・デュポン・メルク・ファーマシュウティカル・カンパニー	血小板糖蛋白▲ＩＩ▼ｂ／▲ＩＩＩ▼ａ抑制剤の調製のための新規な方法および中間体化合物
AU6415894A (en) *	1993-03-29	1994-10-24	Du Pont Merck Pharmaceutical Company, The	Cyclic compounds useful as inhibitors of platelet glycoprotein iib/iiia
US5879657A (en) *	1993-03-30	1999-03-09	The Dupont Merck Pharmaceutical Company	Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
US6056940A (en) *	1993-04-08	2000-05-02	Diatide, Inc.	Radiolabeled compounds for thrombus imaging
US5770565A (en) *	1994-04-13	1998-06-23	La Jolla Cancer Research Center	Peptides for reducing or inhibiting bone resorption
US6635738B2 (en)	1996-03-04	2003-10-21	The Trustees Of Columbia University In The City Of New York	Compounds which prevent neuronal cell death and uses thereof
US6808698B1 (en)	1999-03-26	2004-10-26	Bristol-Myers Squibb Pharma Company	Method for localization of blood clots
US6685914B1 (en)	1999-09-13	2004-02-03	Bristol-Myers Squibb Pharma Company	Macrocyclic chelants for metallopharmaceuticals
AU2001236065A1 (en) *	2000-03-03	2001-09-12	Nobutaka Fujii	Antiviral compounds
US7319149B2 (en)	2003-06-13	2008-01-15	Bristol-Myers Squibb Pharma Company	Chelants and macrocyclic metal complex radiopharmaceuticals thereof
US7317104B2 (en)	2003-06-13	2008-01-08	Bristol-Myers Squibb Pharma Company	Chelants and macrocyclic metal complex radiopharmaceuticals thereof
US8926945B2 (en)	2005-10-07	2015-01-06	Guerbet	Compounds comprising a biological target recognizing part, coupled to a signal part capable of complexing gallium
US8986650B2 (en)	2005-10-07	2015-03-24	Guerbet	Complex folate-NOTA-Ga68
CN103327996B (zh) *	2010-11-01	2016-06-15	延世大学校产学协力团	血栓溶解用组合物及包含其的血管狭窄或闭塞性疾病的治疗用药剂学组合物
FR2968999B1 (fr)	2010-12-20	2013-01-04	Guerbet Sa	Nanoemulsion de chelate pour irm
FR2980364B1 (fr)	2011-09-26	2018-08-31	Guerbet	Nanoemulsions et leur utilisation comme agents de contraste
FR3001154B1 (fr)	2013-01-23	2015-06-26	Guerbet Sa	Magneto-emulsion vectorisee
CN105152989B (zh) *	2015-09-16	2017-05-10	复旦大学	一种(1r,2r)‑1‑取代苯基‑2‑氨基‑1,3‑丙二醇的制备方法
CN107540728A (zh) *	2017-07-07	2018-01-05	安徽工程大学	环（Phe‑Pro‑lle‑Phe‑Pro‑Pro‑Leu‑Val）肽的制备方法
WO2020007822A1 (en)	2018-07-02	2020-01-09	Conservatoire National Des Arts Et Metiers (Cnam)	Bismuth metallic (0) nanoparticles, process of manufacturing and uses thereof
CN112125953B (zh) *	2020-07-23	2022-09-16	昆明医科大学第一附属医院	一种抗血小板聚集的多肽
CN113429457B (zh) *	2021-06-16	2022-07-26	昆明医科大学第一附属医院	一种抗血小板聚集的多肽及其应用

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US5192746A (en) *	1990-07-09	1993-03-09	Tanabe Seiyaku Co., Ltd.	Cyclic cell adhesion modulation compounds

1990
- 1990-10-18 CA CA002027936A patent/CA2027936C/en not_active Expired - Fee Related
- 1990-10-18 AU AU64705/90A patent/AU6470590A/en not_active Abandoned
- 1990-10-19 NZ NZ235767A patent/NZ235767A/en unknown
- 1990-10-22 EP EP90311537A patent/EP0425212B1/de not_active Expired - Lifetime
- 1990-10-22 DE DE69033038T patent/DE69033038T2/de not_active Expired - Fee Related
- 1990-10-22 AT AT90311537T patent/ATE178613T1/de not_active IP Right Cessation
- 1990-10-22 ZA ZA908426A patent/ZA908426B/xx unknown
- 1990-10-22 ES ES90311537T patent/ES2130118T3/es not_active Expired - Lifetime
- 1990-10-22 IE IE377590A patent/IE903775A1/en unknown
- 1990-10-23 JP JP2286930A patent/JP2922281B2/ja not_active Expired - Lifetime
- 1990-10-23 KR KR1019900017122A patent/KR910007964A/ko not_active Ceased
- 1990-10-23 PT PT95661A patent/PT95661B/pt not_active IP Right Cessation
1991
- 1991-12-20 CZ CS913979A patent/CZ397991A3/cs unknown

Also Published As

Publication number	Publication date
CA2027936C (en)	2001-07-24
EP0425212B1 (de)	1999-04-07
DE69033038D1 (de)	1999-05-12
DE69033038T2 (de)	1999-11-11
KR910007964A (ko)	1991-05-30
JPH03161498A (ja)	1991-07-11
EP0425212A2 (de)	1991-05-02
ZA908426B (en)	1991-07-31
AU6470590A (en)	1991-04-26
NZ235767A (en)	1992-08-26
EP0425212A3 (en)	1991-09-18
CZ397991A3 (en)	1993-06-16
ES2130118T3 (es)	1999-07-01
IE903775A1 (en)	1991-04-24
CA2027936A1 (en)	1991-04-24
PT95661A (pt)	1991-09-13
JP2922281B2 (ja)	1999-07-19
PT95661B (pt)	1998-03-31

Legal Events

Date	Code	Title	Description
1999-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE178613T1 (de)	1999-04-15	Zyklische peptide mit aggregationshemmenden eigenschaften
HUT49891A (en)	1989-11-28	Process for production of peptides with antiaggregation effect and medical compositions containing them
Ljungqvist et al.	1988	Antide and related antagonists of luteinizing hormone release with long action and oral activity.
CA2050300A1 (en)	1990-11-10	Tnf-inhibiting proteins and the preparation thereof
EP0333356A3 (de)	1990-12-19	Hirudin-Peptide
DK413986A (da)	1987-03-01	Syntetisk peptid og farmaceutisk middel indeholdende peptidet
DE69133591D1 (de)	2008-03-27	CNP-Gen und Vorläuferprotein aus Schwein
KR0173976B1 (ko)	1999-02-01	브라디키닌에 대하여 길항작용을 하는 펩타이드
AU3764195A (en)	1996-05-06	Neurotrophic peptides of activity dependent neurotrophic factor
ES2054365T3 (es)	1994-08-01	Inhibicion de la via de la regla del n final en celulas vivas.
EP0352014A3 (de)	1991-07-03	Zyklische GRF-Analoge
KR880013977A (ko)	1988-12-22	항응고제인 사이클릭 펩타이드
AU641215B2 (en)	1993-09-16	Stabilized sulfonate, sulfate, phosphonate and phosphate derivatives of hirudin
NZ334714A (en)	2000-08-25	Liver proteins as agents against autoimmune diseases
ITMI951670A1 (it)	1997-01-28	Peptidi ciclici analoghi della somatostatina ad attivita' inibitrice dell'ormone della crescita
CA2202496C (en)	2010-01-05	Neurotrophic peptides of activity dependent neurotrophic factor
KR920018074A (ko)	1992-10-21	사이클릭 항-응집성 펩티드
KR880006262A (ko)	1988-07-22	펩티드
HU910508D0 (en)	1991-09-30	Process for producing peptide-analogues and pharmaceutical preparatives containing them
SI9300595B (sl)	2003-04-30	Peptidi z organo-protektivno aktivnostjo, postopki za njihovo pripravo in njihova uporaba v terapiji
TH35998A (th)	1999-11-30	Lh-rh เป็ปไทด์ อะนาล็อก ประโยชน์ของสิ่งเหล่านั้นและองค์ประกอบทางเภสัชกรรมซึ่งประกอบด้วยสิ่งเหล่านั้น
LT3872B (en)	1996-04-25	Novel peptides and pharmaceutical compositions containing them