ATE179182T1 - Arginin ahnliche derivate als enzym-inhibitoren - Google Patents

Arginin ahnliche derivate als enzym-inhibitoren

Info

Publication number: ATE179182T1
Authority: AT; Austria
Prior art keywords: arginine; enzyme inhibitors; similar derivatives; pharmaceutically acceptable; group
Prior art date: 1994-06-17

Application number

AT95924618T

Other languages

English (en)

Inventor

Odile Esther Levy

Susan Y Tamura

Ruth F Nutt

William C Ripka

Original Assignee

Corvas Int Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-06-17

Filing date

1995-06-19

Publication date

1999-05-15

1994-06-17 Priority claimed from US08/261,478 external-priority patent/US5637599A/en

1995-06-19 Application filed by Corvas Int Inc filed Critical Corvas Int Inc

1999-05-15 Application granted granted Critical

1999-05-15 Publication of ATE179182T1 publication Critical patent/ATE179182T1/de

Links

239000004475 Arginine Substances 0.000 title abstract 2
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 title abstract 2
239000002532 enzyme inhibitor Substances 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
241000124008 Mammalia Species 0.000 abstract 1
108090000190 Thrombin Proteins 0.000 abstract 1
208000007536 Thrombosis Diseases 0.000 abstract 1
230000002159 abnormal effect Effects 0.000 abstract 1
150000001299 aldehydes Chemical class 0.000 abstract 1
-1 amidinophenyl Chemical group 0.000 abstract 1
125000002393 azetidinyl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
230000003278 mimic effect Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
QUUYRYYUKNNNNS-UHFFFAOYSA-N piperidine-1-carboximidamide Chemical compound NC(=N)N1CCCCC1 QUUYRYYUKNNNNS-UHFFFAOYSA-N 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1
229960004072 thrombin Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Diabetes (AREA)
Hematology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT95924618T 1994-06-17 1995-06-19 Arginin ahnliche derivate als enzym-inhibitoren ATE179182T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/261,478 US5637599A (en)	1994-06-17	1994-06-17	Arginine mimic derivatives as enzyme inhibitors
US08/487,611 US5883107A (en)	1994-06-17	1995-06-07	Arginine mimic derivatives as enzyme inhibitors

Publications (1)

Publication Number	Publication Date
ATE179182T1 true ATE179182T1 (de)	1999-05-15

Family

ID=26948633

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95924618T ATE179182T1 (de)	1994-06-17	1995-06-19	Arginin ahnliche derivate als enzym-inhibitoren

Country Status (5)

Country	Link
US (1)	US5883107A (de)
EP (1)	EP0765338B1 (de)
AT (1)	ATE179182T1 (de)
CA (1)	CA2192686A1 (de)
DE (1)	DE69509235D1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6677473B1 (en)	1999-11-19	2004-01-13	Corvas International Inc	Plasminogen activator inhibitor antagonists
WO2006005667A2 (en) *	2004-07-08	2006-01-19	Novo Nordisk A/S	Polypeptide protracting tags comprising a tetrazole moiety

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5754157A (en) *	1980-09-19	1982-03-31	Nippon Kayaku Co Ltd	L-argininal derivative and its preparation
CA2075154A1 (en) *	1991-08-06	1993-02-07	Neelakantan Balasubramanian	Peptide aldehydes as antithrombotic agents
WO1994017817A1 (en) *	1993-02-12	1994-08-18	Corvas International, Inc.	Inhibitors of thrombosis
US5637599A (en) *	1994-06-17	1997-06-10	Corvas International, Inc.	Arginine mimic derivatives as enzyme inhibitors

1995
- 1995-06-07 US US08/487,611 patent/US5883107A/en not_active Expired - Lifetime
- 1995-06-19 EP EP95924618A patent/EP0765338B1/de not_active Expired - Lifetime
- 1995-06-19 AT AT95924618T patent/ATE179182T1/de active
- 1995-06-19 DE DE69509235T patent/DE69509235D1/de not_active Expired - Lifetime
- 1995-06-19 CA CA002192686A patent/CA2192686A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CA2192686A1 (en)	1995-12-28
EP0765338A1 (de)	1997-04-02
EP0765338B1 (de)	1999-04-21
US5883107A (en)	1999-03-16
DE69509235D1 (de)	1999-05-27

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