ATE179982T1 - Modifizierte, phosphor enthaltende zwischenprodukte zur erzeugung von funktionalen gruppen am 5' ende von oligonucleotiden - Google Patents
Modifizierte, phosphor enthaltende zwischenprodukte zur erzeugung von funktionalen gruppen am 5' ende von oligonucleotidenInfo
- Publication number
- ATE179982T1 ATE179982T1 AT92306477T AT92306477T ATE179982T1 AT E179982 T1 ATE179982 T1 AT E179982T1 AT 92306477 T AT92306477 T AT 92306477T AT 92306477 T AT92306477 T AT 92306477T AT E179982 T1 ATE179982 T1 AT E179982T1
- Authority
- AT
- Austria
- Prior art keywords
- carbon atoms
- group
- oligonucleotide
- atoms
- oligonucleotides
- Prior art date
Links
- 108091034117 Oligonucleotide Proteins 0.000 title abstract 4
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 6
- 125000002228 disulfide group Chemical group 0.000 abstract 3
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001787 chalcogens Chemical group 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 150000002009 diols Chemical group 0.000 abstract 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
- 125000000743 hydrocarbylene group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 238000002515 oligonucleotide synthesis Methods 0.000 abstract 1
- 150000008300 phosphoramidites Chemical class 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/12—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/20—Free hydroxyl or mercaptan
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2408—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73105591A | 1991-07-15 | 1991-07-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE179982T1 true ATE179982T1 (de) | 1999-05-15 |
Family
ID=24937868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92306477T ATE179982T1 (de) | 1991-07-15 | 1992-07-15 | Modifizierte, phosphor enthaltende zwischenprodukte zur erzeugung von funktionalen gruppen am 5' ende von oligonucleotiden |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0523978B1 (de) |
| JP (3) | JP2899111B2 (de) |
| AT (1) | ATE179982T1 (de) |
| AU (3) | AU664184B2 (de) |
| CA (1) | CA2073846C (de) |
| DE (1) | DE69229149T2 (de) |
| DK (1) | DK0523978T3 (de) |
| ES (1) | ES2131060T3 (de) |
| GR (1) | GR3030260T3 (de) |
| IE (1) | IE922292A1 (de) |
| PT (1) | PT100691B (de) |
| WO (1) | WO1993002093A1 (de) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5268454A (en) | 1991-02-08 | 1993-12-07 | La Jolla Pharmaceutical Company | Composition for inducing humoral anergy to an immunogen comprising a t cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic carrier |
| JP2899111B2 (ja) | 1991-07-15 | 1999-06-02 | ラ ホヤ ファーマシューティカル カンパニー | オリゴヌクレオチドの５’末端へ官能基を提供するための修飾された亜リン酸中間体 |
| KR100361933B1 (ko) | 1993-09-08 | 2003-02-14 | 라 졸라 파마슈티칼 컴파니 | 화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트 |
| US6344330B1 (en) * | 1998-03-27 | 2002-02-05 | The Regents Of The University Of California | Pharmacophore recombination for the identification of small molecule drug lead compounds |
| AU2003200284B2 (en) * | 1998-03-27 | 2006-11-02 | The Regents Of The University Of California | Pharmacophore recombination for the identification of small molecule drug lead compounds |
| US6858210B1 (en) | 1998-06-09 | 2005-02-22 | La Jolla Pharmaceutical Co. | Therapeutic and diagnostic domain 1 β2GPI polypeptides and methods of using same |
| EP0967217B1 (de) * | 1998-06-22 | 2005-12-21 | Affymetrix, Inc. (a California Corporation) | Reagenz und Verfahren zu fester Phase Synthese |
| US6458953B1 (en) | 1998-12-09 | 2002-10-01 | La Jolla Pharmaceutical Company | Valency platform molecules comprising carbamate linkages |
| US6399578B1 (en) | 1998-12-09 | 2002-06-04 | La Jolla Pharmaceutical Company | Conjugates comprising galactose α1,3 galactosyl epitopes and methods of using same |
| MXPA02005236A (es) | 1999-11-28 | 2004-03-19 | Jolla Pharma | Metodos de tratamiento de lupus con base en la afinidad de anticuerpos y metodos de separacion por exclusion y composiciones para el uso de los mismos. |
| DE10013600A1 (de) * | 2000-03-18 | 2002-01-10 | Aventis Res & Tech Gmbh & Co | Reaktive Monomere für die Oligonucleotid- und Polynucleotidsynthese, modifizierte Oligonucleotide und Polynucleotiden und ein Verfahren zu deren Herstellung |
| EP2423335B1 (de) | 2001-06-21 | 2014-05-14 | Dynavax Technologies Corporation | Chimäre immunmodulierende Verbindungen und Verwendungsverfahren dafür |
| DE10163836A1 (de) | 2001-12-22 | 2003-07-10 | Friz Biochem Gmbh | Multifunktionales Reagenz zur Synthese von thiolmodifizierten Oligomeren |
| JP4495670B2 (ja) * | 2005-12-27 | 2010-07-07 | 三井化学株式会社 | メルカプトアルキルホスホニウム化合物の製造法 |
| EP2478013B1 (de) | 2009-09-16 | 2018-10-24 | F.Hoffmann-La Roche Ag | Coiled-coil- und/oder tether-haltige proteinkomplexe und verwendungen davon |
| TW201138821A (en) | 2010-03-26 | 2011-11-16 | Roche Glycart Ag | Bispecific antibodies |
| WO2012085064A1 (en) | 2010-12-23 | 2012-06-28 | Roche Diagnostics Gmbh | Detection of a posttranslationally modified polypeptide by a bi-valent binding agent |
| EP2655414B1 (de) | 2010-12-23 | 2018-08-29 | Roche Diagniostics GmbH | Bispezifisches bindungsmolekül |
| SG191153A1 (en) | 2010-12-23 | 2013-07-31 | Hoffmann La Roche | Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery |
| CA2861124A1 (en) | 2012-02-10 | 2013-08-15 | Genentech, Inc. | Single-chain antibodies and other heteromultimers |
| FR2989086B1 (fr) | 2012-04-04 | 2017-03-24 | Centre Nat De La Rech Scient (Cnrs) | Composes thiol et leur utilisation pour la synthese d'oligonucleotides modifies |
| FR2989089B1 (fr) * | 2012-04-04 | 2020-02-07 | Etablissement Francais Du Sang | Oligonucleotides modifies comprenant des fonctions thiol et leur utilisation pour la detection d'acides nucleiques |
| RU2639287C2 (ru) | 2012-06-27 | 2017-12-20 | Ф. Хоффманн-Ля Рош Аг | Способ отбора и получения высокоселективных и мультиспецифичных нацеливающих групп с заданными свойствами, включающих по меньшей мере две различные связывающие группировки, и их применения |
| KR20150030744A (ko) | 2012-06-27 | 2015-03-20 | 에프. 호프만-라 로슈 아게 | 표적에 특이적으로 결합하는 하나 이상의 결합 단위를 포함하는 항체 Ｆｃ－영역 접합체의 제조 방법 및 그의 용도 |
| EP2928877B1 (de) * | 2012-12-06 | 2020-01-22 | Merck Sharp & Dohme Corp. | Disulfidmaskierte prodrug-zusammensetzungen und verfahren |
| EP3227332B1 (de) | 2014-12-03 | 2019-11-06 | F.Hoffmann-La Roche Ag | Multispezifische antikörper |
| JP2022535717A (ja) | 2019-05-24 | 2022-08-10 | エンピリコ インク． | アンジオポエチン様７（ａｎｇｐｔｌ７）関連疾患の処置 |
| AU2023245603A1 (en) * | 2022-03-28 | 2024-11-07 | Empirico Inc. | Modified oligonucleotides |
| US20250197859A1 (en) * | 2022-03-28 | 2025-06-19 | Empirico Inc. | Compositions and methods for the treatment of angiopoietin like 7 (angptl7) related diseases |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3225063A (en) * | 1962-05-21 | 1965-12-21 | Scott Paper Co | Organic cyclic carbonates |
| US4191668A (en) * | 1977-02-03 | 1980-03-04 | Scripps Clinic And Research Foundation | Induction of immunological tolerance |
| US4220565A (en) * | 1979-01-18 | 1980-09-02 | Scripps Clinic & Research Foundation | Immunochemical conjugates: method and composition |
| US4650675A (en) * | 1983-08-18 | 1987-03-17 | The Children's Medical Center Corporation | Oligonucleotide conjugates |
| DK160818C (da) * | 1983-12-30 | 1991-10-07 | Hoffmann La Roche | N-ring-holdige glycerolderivater, fremgangsmaade til fremstilling deraf, anvendelse deraf til fremstilling af et blodpladeaktiveringsfaktorhaemmende middel samt laegemidler indeholdende en saadan forbindelse |
| US4575558A (en) * | 1984-02-15 | 1986-03-11 | American Hospital Supply Corporation | Preparation of optically active 1,3-dioxolane-4-methanol compounds |
| US4751181A (en) * | 1984-12-31 | 1988-06-14 | Duke University | Methods and compositions useful in the diagnosis and treatment of autoimmune diseases |
| EP0282482B1 (de) * | 1985-10-24 | 1992-01-22 | Medical Research Council | Biochemisches reagenzmittel |
| DE3811005A1 (de) * | 1988-03-31 | 1989-10-19 | Bayer Ag | Thionophosphor(phosphon)saeureamidester |
| EP0354323A3 (de) * | 1988-08-12 | 1990-06-13 | American Cyanamid Company | Antidiabetische Phosphate |
| DE3916871A1 (de) * | 1989-05-24 | 1990-11-29 | Boehringer Mannheim Gmbh | Modifiziertes phosphoramidit-verfahren zur herstellung von modifizierten nukleinsaeuren |
| EP0478686B1 (de) * | 1989-06-22 | 1993-08-11 | Applications Et Transferts De Technologies Avancees Atta | Fluor- und phosphorhaltige amphiphilische moleküle mit oberflächenaktiven eigenschaften |
| DE3937116A1 (de) * | 1989-11-03 | 1991-05-08 | Dainippon Ink & Chemicals | Verfahren zur herstellung cyclocarbonathaltiger ester |
| JP2899111B2 (ja) | 1991-07-15 | 1999-06-02 | ラ ホヤ ファーマシューティカル カンパニー | オリゴヌクレオチドの５’末端へ官能基を提供するための修飾された亜リン酸中間体 |
-
1992
- 1992-07-14 JP JP5502916A patent/JP2899111B2/ja not_active Expired - Fee Related
- 1992-07-14 WO PCT/US1992/005897 patent/WO1993002093A1/en not_active Ceased
- 1992-07-14 CA CA002073846A patent/CA2073846C/en not_active Expired - Fee Related
- 1992-07-14 IE IE229292A patent/IE922292A1/en not_active IP Right Cessation
- 1992-07-14 AU AU19685/92A patent/AU664184B2/en not_active Ceased
- 1992-07-15 ES ES92306477T patent/ES2131060T3/es not_active Expired - Lifetime
- 1992-07-15 DE DE69229149T patent/DE69229149T2/de not_active Expired - Fee Related
- 1992-07-15 AT AT92306477T patent/ATE179982T1/de not_active IP Right Cessation
- 1992-07-15 PT PT100691A patent/PT100691B/pt not_active IP Right Cessation
- 1992-07-15 EP EP92306477A patent/EP0523978B1/de not_active Expired - Lifetime
- 1992-07-15 DK DK92306477T patent/DK0523978T3/da active
-
1995
- 1995-12-20 AU AU40580/95A patent/AU686911B2/en not_active Ceased
-
1997
- 1997-11-12 AU AU45202/97A patent/AU703715B2/en not_active Ceased
-
1998
- 1998-12-02 JP JP34324698A patent/JP3188243B2/ja not_active Expired - Fee Related
-
1999
- 1999-05-19 GR GR990401353T patent/GR3030260T3/el unknown
-
2001
- 2001-03-08 JP JP2001065808A patent/JP3488435B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2131060T3 (es) | 1999-07-16 |
| AU4058095A (en) | 1996-03-14 |
| JPH07500576A (ja) | 1995-01-19 |
| GR3030260T3 (en) | 1999-08-31 |
| CA2073846C (en) | 2007-09-18 |
| EP0523978B1 (de) | 1999-05-12 |
| JP2001302684A (ja) | 2001-10-31 |
| AU4520297A (en) | 1998-02-19 |
| JPH11228592A (ja) | 1999-08-24 |
| AU703715B2 (en) | 1999-04-01 |
| IE922292A1 (en) | 1993-01-27 |
| DE69229149D1 (de) | 1999-06-17 |
| DK0523978T3 (da) | 1999-11-01 |
| PT100691B (pt) | 1999-06-30 |
| AU686911B2 (en) | 1998-02-12 |
| HK1014369A1 (en) | 1999-09-24 |
| EP0523978A1 (de) | 1993-01-20 |
| JP3488435B2 (ja) | 2004-01-19 |
| PT100691A (pt) | 1993-10-29 |
| AU1968592A (en) | 1993-01-21 |
| JP3188243B2 (ja) | 2001-07-16 |
| JP2899111B2 (ja) | 1999-06-02 |
| AU664184B2 (en) | 1995-11-09 |
| CA2073846A1 (en) | 1993-01-16 |
| WO1993002093A1 (en) | 1993-02-04 |
| DE69229149T2 (de) | 1999-12-09 |
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