ATE182628T1 - Ein protein, das spezifische dna-strukturen erkennt, und seine verwendungen - Google Patents

Ein protein, das spezifische dna-strukturen erkennt, und seine verwendungen

Info

Publication number
ATE182628T1
ATE182628T1 AT93901926T AT93901926T ATE182628T1 AT E182628 T1 ATE182628 T1 AT E182628T1 AT 93901926 T AT93901926 T AT 93901926T AT 93901926 T AT93901926 T AT 93901926T AT E182628 T1 ATE182628 T1 AT E182628T1
Authority
AT
Austria
Prior art keywords
protein
dna
specific dna
recognition protein
specific recognition
Prior art date
Application number
AT93901926T
Other languages
English (en)
Inventor
Brian A Donahue
Jeffrey H Toney
John M Essigmann
Stephen J Lippard
Pieter M Pil
Suzanne L Bruhn
Steven J Brown
Patti J Kellett
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Application granted granted Critical
Publication of ATE182628T1 publication Critical patent/ATE182628T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C07K14/43577—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies
    • C07K14/43581—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies from Drosophila
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/142—Toxicological screening, e.g. expression profiles which identify toxicity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Insects & Arthropods (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT93901926T 1991-12-26 1992-12-18 Ein protein, das spezifische dna-strukturen erkennt, und seine verwendungen ATE182628T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/814,964 US5359047A (en) 1988-09-22 1991-12-26 Nucleic acids encoding DNA structure-specific recognition protein and uses therefor

Publications (1)

Publication Number Publication Date
ATE182628T1 true ATE182628T1 (de) 1999-08-15

Family

ID=25216483

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93901926T ATE182628T1 (de) 1991-12-26 1992-12-18 Ein protein, das spezifische dna-strukturen erkennt, und seine verwendungen

Country Status (7)

Country Link
US (2) US5359047A (de)
EP (1) EP0621902B1 (de)
JP (1) JPH07502415A (de)
AT (1) ATE182628T1 (de)
CA (1) CA2125673C (de)
DE (1) DE69229681T2 (de)
WO (1) WO1993013222A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5705334A (en) * 1988-09-22 1998-01-06 Massachusetts Institute Of Technology Uses for DNA structure-specific recognition protein
US5874218A (en) * 1990-06-11 1999-02-23 Nexstar Pharmaceuticals, Inc. Method for detecting a target compound in a substance using a nucleic acid ligand
US5874283A (en) * 1995-05-30 1999-02-23 John Joseph Harrington Mammalian flap-specific endonuclease
US5912332A (en) * 1996-07-26 1999-06-15 Hybridon, Inc. Affinity-based purification of oligonucleotides using soluble multimeric oligonucleotides
US6030783A (en) * 1997-01-31 2000-02-29 Massachusetts Institute Of Technology Photo-potentiation of cisplatin chemotherapy
WO2000000605A1 (en) * 1998-06-29 2000-01-06 Myriad Genetics, Inc. Tmprss2 is a tumor suppressor
US7960540B2 (en) 1999-04-08 2011-06-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
JP2002541264A (ja) 1999-04-08 2002-12-03 ユーエイビー・リサーチ・ファウンデーション 冨ｇオリゴヌクレオチドの抗増殖活性およびヌクレオリンに結合するためのその使用方法
US20080318889A1 (en) * 1999-04-08 2008-12-25 Antisoma Research Limited Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US20080318890A1 (en) * 1999-04-08 2008-12-25 Antisoma Research Limited Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US8114850B2 (en) 1999-04-08 2012-02-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US6573050B1 (en) 1999-10-29 2003-06-03 Sunnybrook & Women's College Health Sciences Centre Treatment, diagnosis and evaluation of anti-cancer therapy resistance in melanoma
FR2809417B1 (fr) * 2000-05-24 2004-07-30 Commissariat Energie Atomique Detection et caracterisation de l'activite de proteines impliquees dans la reparation de lesions de l'adn
DE10030452A1 (de) * 2000-06-21 2002-01-24 Max Planck Gesellschaft Assay zur Detektion von primären DNA-Schäden
US6806289B1 (en) 2000-07-14 2004-10-19 Stephen J. Lippard Coordination complexes, and methods for preparing by combinatorial methods, assaying and using the same
JP2004534955A (ja) * 2001-07-12 2004-11-18 エクセリクシス・インコーポレイテッド ｐ２１経路のモディファイヤーとしてのＨＡＤＨｓおよび使用方法
ITTO20010762A1 (it) * 2001-07-31 2003-01-31 Consiglio Nazionale Ricerche Anticorpi monoclonali anti-ssrp-1 ed ibridomi producenti tali anticorpi.
JP4007000B2 (ja) * 2001-12-25 2007-11-14 富士ゼロックス株式会社 導電性有機高分子
WO2003064698A1 (en) * 2002-01-25 2003-08-07 Board Of Regents, The University Of Texas System Electrophoretic assay to predict risk of cancer and the efficacy and toxicity of cancer therapy
US7153691B2 (en) * 2002-11-13 2006-12-26 G6 Science Corp. Method of identifying and assessing DNA euchromatin in biological cells for detecting disease, monitoring wellness, assessing bio-activity, and screening pharmacological agents
US20090148958A1 (en) * 2006-04-27 2009-06-11 Onecell Inc. Nucleotide-transition metal complex catalyst

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4407942A (en) * 1981-01-29 1983-10-04 Atomic Energy Of Canada Limited Fluorescent detection of DNA damage
US4670388A (en) * 1982-12-30 1987-06-02 Carnegie Institution Of Washington Method of incorporating DNA into genome of drosophila
JPS6343931A (ja) * 1986-08-12 1988-02-25 Diafoil Co Ltd 磁気記録媒体用ポリエステルフイルム
JPH04505150A (ja) * 1988-09-22 1992-09-10 マサチューセッツ・インステチュート・オブ・テクノロジー Ｄｎａ損傷結合因子およびその使用

Also Published As

Publication number Publication date
US5670621A (en) 1997-09-23
DE69229681D1 (de) 1999-09-02
EP0621902A1 (de) 1994-11-02
JPH07502415A (ja) 1995-03-16
US5359047A (en) 1994-10-25
CA2125673A1 (en) 1993-07-08
EP0621902B1 (de) 1999-07-28
WO1993013222A1 (en) 1993-07-08
DE69229681T2 (de) 2000-04-06
CA2125673C (en) 2001-03-13

Similar Documents

Publication Publication Date Title
ATE182628T1 (de) Ein protein, das spezifische dna-strukturen erkennt, und seine verwendungen
NO973933L (no) Vaskulær endotelvekstfaktor B
NO972455L (no) Cytokin betegnet LERK-7
PT770088E (pt) Nova citoquina designada lerk-5
DE69638077D1 (de) Bakterielle Produktion von Interferon-beta Polypeptiden
BRPI0315666B8 (pt) dna de a34 e a33 do tipo 3, proteínas, seus anticorpos e métodos de tratamento usando os mesmos
ATE353906T1 (de) Cd27 ligand
ATE405650T1 (de) Produktion von ganzen antikörpern in prokaryontischen zellen
NO963371L (no) Hematopoietisk protein samt materialer og fremgangsmåter for fremstilling av det
EP0575546A4 (en) Prad1 cyclin and its cdna
CA2413156A1 (en) Expression vectors
NO961115L (no) Humane metabotrope glutamatreseptorsubtyper (HMR4, HMR6, HMR7) og relaterte DNA forbindelser
DE69433552D1 (de) An den zelloberflächenrezeptor hek bindendes cytokin
DK1005540T3 (da) IKK-beta-proteiner, nukleinsyrer og fremgangsmåder
BG46598A3 (bg) Метод за получаване на алфа-хетероциклично заместени толунитрили
DK130690B (da) Fremgangsmåde til udførelse af diffusionsprøver i mikrobiologiske, immunologiske og lignende laboratoriearbejder samt bærelegeme til udførelse af fremgangsmåden.
SE9301270D0 (sv) Biosensor
ATE135371T1 (de) Mit akuter pankreatitis assoziiertes protein, mittel zur diagnose von akuter pankreatitis
DE69129034D1 (de) Molekulare klone von hiv-1 und deren verwendung
ATE291086T1 (de) An entzündlichen darmerkrankungen beteiligte gene und deren verwendung
DE3853718D1 (de) Menschliche gamma, delta-t-zellen-antigen-rezeptor-polypeptide und nukleinsäuren.
ATE110074T1 (de) Quinolyloxazol-2-one, nützlich als proteinkinase- c-inhibitoren.
DE69028095D1 (de) M-csf-monoklonale antikörper, die ein neutralisierendes konformationales epitop erkennen
ES2085329T3 (es) Agente anticanceroso proteico.
DE68919387D1 (de) DNS- und RNS-Proben, Methoden und Testsätze zum Nachweis von Salmonella.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties