ATE183398T1 - Eine cyclosporin enthaltende zubereitung und ein verfahren für ihre herstellung - Google Patents

Eine cyclosporin enthaltende zubereitung und ein verfahren für ihre herstellung

Info

Publication number: ATE183398T1
Authority: AT; Austria
Prior art keywords: pct; production; preparation containing; containing cyclosporin; sec
Prior art date: 1994-06-01

Application number

AT95920275T

Other languages

English (en)

Inventor

Hyun Soo Kim

Jae Yoon Choi

Hye Weon Lee

Young Keun Park

Sung Wook Choi

Original Assignee

Yuhan Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-06-01

Filing date

1995-05-19

Publication date

1999-09-15

1995-05-19 Application filed by Yuhan Corp filed Critical Yuhan Corp

1999-09-15 Application granted granted Critical

1999-09-15 Publication of ATE183398T1 publication Critical patent/ATE183398T1/de

Links

229930105110 Cyclosporin A Natural products 0.000 title abstract 2
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 2
108010036949 Cyclosporine Proteins 0.000 title abstract 2
229960001265 ciclosporin Drugs 0.000 title abstract 2
229930182912 cyclosporin Natural products 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
229920001353 Dextrin Polymers 0.000 abstract 1
239000004375 Dextrin Substances 0.000 abstract 1
235000019425 dextrin Nutrition 0.000 abstract 1
238000004090 dissolution Methods 0.000 abstract 1
239000003995 emulsifying agent Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Dispersion Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Transplantation (AREA)
Organic Chemistry (AREA)
Inorganic Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Cosmetics (AREA)
Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)

AT95920275T 1994-06-01 1995-05-19 Eine cyclosporin enthaltende zubereitung und ein verfahren für ihre herstellung ATE183398T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
KR19940012288		1994-06-01

Publications (1)

Publication Number	Publication Date
ATE183398T1 true ATE183398T1 (de)	1999-09-15

Family

ID=19384450

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95920275T ATE183398T1 (de)	1994-06-01	1995-05-19	Eine cyclosporin enthaltende zubereitung und ein verfahren für ihre herstellung

Country Status (13)

Country	Link
US (1)	US5739105A (de)
EP (1)	EP0756489B1 (de)
JP (1)	JP2936209B2 (de)
KR (1)	KR0163212B1 (de)
CN (1)	CN1148224C (de)
AT (1)	ATE183398T1 (de)
AU (1)	AU2577295A (de)
DE (1)	DE69511539T2 (de)
DK (1)	DK0756489T3 (de)
ES (1)	ES2137516T3 (de)
GR (1)	GR3031568T3 (de)
RU (1)	RU2119351C1 (de)
WO (1)	WO1995032726A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9618952D0 (en) *	1996-09-11	1996-10-23	Sandoz Ltd	Process
KR100241652B1 (ko) *	1997-07-07	2000-03-02	김충섭	이푸리플라본의 경구 투여용 제제의 제조 방법
CA2306448A1 (en)	1997-10-16	1999-04-22	Board Of Regents, The University Of Texas System	Models and treatments for cardiac hypertrophy in relation with nf-at3 function
TW581681B (en)	1998-02-20	2004-04-01	Nektar Therapeutics	Liquid crystal forms of cyclosporin
DE19859910C2 (de) *	1998-12-23	2001-03-22	Ratiopharm Gmbh	Orales Arzneimittel
IL143604A0 (en)	1998-12-30	2002-04-21	Dexcel Ltd	Dispersable concentrate for the delivery of cyclosporin
EP1058539A1 (de) *	1999-01-06	2000-12-13	Korea Research Institute Of Chemical Technology	Methode zur herstellung eines pharmazeutisch aktiven bestandteils beinhaltend einen wasserunlöslichen wirkstoff sowie eine pharmazeutische zusammensetzung zur oralen verabreichung die diesen bestandteil enthält
US7732404B2 (en)	1999-12-30	2010-06-08	Dexcel Ltd	Pro-nanodispersion for the delivery of cyclosporin
PT1142566E (pt) *	2000-04-07	2004-02-27	Medidom Lab	Formulacao oftalmica topica na forma de uma solucao aquosa e uso de uma ciclosporina em associacao com acido hialuronico ou um de seus sais e com polisorbato 80
GB0008785D0 (en) *	2000-04-10	2000-05-31	Novartis Ag	Organic compounds
RU2207870C2 (ru) *	2000-11-10	2003-07-10	Панацея Биотек Лимитед	Фармацевтическая композиция, включающая циклоспорин в качестве активного ингредиента
EP1435910B9 (de) *	2001-10-19	2010-02-03	Isotechnika Inc.	Neue cyclosporin-analoge mikroemulsionsvorkonzentrate
US6979672B2 (en) *	2002-12-20	2005-12-27	Polichem, S.A.	Cyclosporin-based pharmaceutical compositions
US20050059583A1 (en)	2003-09-15	2005-03-17	Allergan, Inc.	Methods of providing therapeutic effects using cyclosporin components
PT1802650E (pt) *	2004-10-01	2011-12-30	Scynexis Inc	Derivados da ciclosporina 3-éter e 3-tioéter substituída para o tratamento e prevenção da infecção de hepatite c
EP1655021B1 (de) *	2004-11-09	2008-10-29	Novagali Pharma SA	Öl-in-Wasser-Emulsion mit niedriger Konzentration des kationischen Mittels und positivem Zetapotential
US7151085B2 (en)	2004-11-15	2006-12-19	Allergan, Inc.	Therapeutic methods using cyclosporine components
US7135455B2 (en) *	2004-11-15	2006-11-14	Allergan, Inc	Methods for the therapeutic use of cyclosporine components
EP1843724B1 (de)	2005-02-02	2018-07-25	Össur hf	Messsysteme und verfahren zur überwachung der gangdynamik
GB0921528D0 (en)	2009-12-09	2010-01-27	Mast Carbon Internat Ltd	Carbon and its use in blood cleansing applications
JP6200698B2 (ja) *	2013-06-18	2017-09-20	ニュートリー株式会社	嚥下造影検査食
WO2022098121A1 (ko) *	2020-11-09	2022-05-12	주식회사 스카이테라퓨틱스	고상의 물질 및 이를 포함하는 분산 조성물
CN116390762B (zh) *	2020-11-09	2026-05-08	思凯制药有限公司	固体环孢菌素a和包含其的分散组合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI65914C (fi) *	1978-03-07	1984-08-10	Sandoz Ag	Foerfarande foer framstaellning av farmaceutiska kompositionerinnehaollande cyklosporin a
GB8903804D0 (en) *	1989-02-20	1989-04-05	Sandoz Ltd	Improvements in or relating to organic compounds
JP2577049B2 (ja) *	1987-06-04	1997-01-29	三共株式会社	シクロスポリン製剤
US4963362A (en) *	1987-08-07	1990-10-16	Regents Of The University Of Minnesota	Freeze-dried liposome mixture containing cyclosporin
GB8807505D0 (en) *	1988-03-29	1988-05-05	Glaxo Group Ltd	Pharmaceutical combinations
CZ278863B6 (en) *	1992-09-07	1994-07-13	Galena	Medicinal preparations with n-methylated cyclic undecapeptides

1995
- 1995-05-19 WO PCT/KR1995/000059 patent/WO1995032726A1/en not_active Ceased
- 1995-05-19 AT AT95920275T patent/ATE183398T1/de not_active IP Right Cessation
- 1995-05-19 CN CNB951933647A patent/CN1148224C/zh not_active Expired - Fee Related
- 1995-05-19 EP EP95920275A patent/EP0756489B1/de not_active Expired - Lifetime
- 1995-05-19 AU AU25772/95A patent/AU2577295A/en not_active Abandoned
- 1995-05-19 RU RU96120199A patent/RU2119351C1/ru not_active IP Right Cessation
- 1995-05-19 JP JP8500680A patent/JP2936209B2/ja not_active Expired - Lifetime
- 1995-05-19 DE DE69511539T patent/DE69511539T2/de not_active Expired - Fee Related
- 1995-05-19 US US08/732,377 patent/US5739105A/en not_active Expired - Fee Related
- 1995-05-19 ES ES95920275T patent/ES2137516T3/es not_active Expired - Lifetime
- 1995-05-19 DK DK95920275T patent/DK0756489T3/da active
- 1995-05-30 KR KR1019950013737A patent/KR0163212B1/ko not_active Expired - Fee Related
1999
- 1999-10-20 GR GR990402665T patent/GR3031568T3/el unknown

Also Published As

Publication number	Publication date
JP2936209B2 (ja)	1999-08-23
JPH09510733A (ja)	1997-10-28
KR960000247A (ko)	1996-01-25
DK0756489T3 (da)	1999-12-06
EP0756489B1 (de)	1999-08-18
GR3031568T3 (en)	2000-01-31
CN1149834A (zh)	1997-05-14
WO1995032726A1 (en)	1995-12-07
CN1148224C (zh)	2004-05-05
EP0756489A1 (de)	1997-02-05
US5739105A (en)	1998-04-14
RU2119351C1 (ru)	1998-09-27
DE69511539T2 (de)	2000-03-30
KR0163212B1 (ko)	1998-12-01
AU2577295A (en)	1995-12-21
ES2137516T3 (es)	1999-12-16
DE69511539D1 (de)	1999-09-23

Legal Events

Date	Code	Title	Description
2007-02-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69511539D1 (de)	1999-09-23	Eine cyclosporin enthaltende zubereitung und ein verfahren für ihre herstellung
DE3783007D1 (de)	1993-01-21	9-alpha-hydroxysteroide, verfahren zu ihrer herstellung und verfahren zur herstellung der entsprechenden 9(11)-dehydro-derivate.
DE69725608D1 (de)	2003-11-20	Indolin-2-one derivate, verfahren zu ihrer herstellung und dieseenthaltende arzneimittel
DE3766160D1 (de)	1990-12-20	Hochreines titan und verfahren zu seiner herstellung.
DE59104377D1 (de)	1995-03-09	Copolyamide, Verfahren zu ihrer Herstellung und ihre Verwendung.
ATE73758T1 (de)	1992-04-15	2,2-difluorcyclopropylethanderivate, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel.
PL311122A1 (en)	1996-02-05	Water-solublederivatives of camptotectin, method of obtaining them and their application as anticarcinogenic agents
ATE266030T1 (de)	2004-05-15	1,4,7,10-tetraazabicyclo(8.2.2)tetradecan-2-on, verfahren zu ihrer herstellung und ihrer verwendung für die herstellung von tetraazamacrocyclen
DE3675931D1 (de)	1991-01-10	Thiadiazabicyclononanderivate, verfahren zu ihrer herstellung und herbizide zusammensetzungen.
EP1089968A4 (de)	2002-08-21	Thyroidhormon-analoga und verfahren zu ihrer herstellung
DE3784401D1 (de)	1993-04-08	Karbostyril-derivate und ihre salze, verfahren zu ihrer herstellung und diese enthaltende kardiotonische zusammensetzung.
DE3674582D1 (de)	1990-10-31	(s)-(-)-1-propyl-2',6'-pipecoloxylidid-hydrochloridmonohydrat, verfahren zu seiner herstellung und es enthaltendes pharmazeutisches praeparat.
GB9126725D0 (en)	1992-02-12	Process
ATE40826T1 (de)	1989-03-15	4'-demethyl-4-epipodophyllotoxinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
EP0297378A3 (de)	1989-05-10	2,5-Dihydropyrrole
ATE79121T1 (de)	1992-08-15	Iodierte polymere, verfahren zu ihrer herstellung und ihre verwendung als kontrastmittel.
DE68908459D1 (de)	1993-09-23	Prepolymerzusammensetzung, verfahren zu ihrer herstellung und ihre verwendung.
DE69007047D1 (de)	1994-04-07	Lagerstabile feste Isocyanatzusammensetzungen, ihre Herstellung und Verfahren zu ihrer Verwendung.
DE3789466D1 (de)	1994-05-05	3,7-Disubstituierte-3-Cephemverbindungen und Verfahren zu ihrer Herstellung.
DE3574706D1 (de)	1990-01-18	Chartreusin-derivate, ihre salze, antitumorale zusammensetzungen und verfahren zu ihrer herstellung.
HUP9702480A3 (en)	1999-06-28	New polymorphous form of doxazosin-mesylate (form. i.), process for it's preparation and pharmaceutical compositions containing the same
DE58904404D1 (de)	1993-06-24	Substituierte 4-sulfonylamino-2-azinyl-1,2,4-triazol-3-one, verfahren sowie zwischenprodukte zu ihrer herstellung und ihre verwendung als herbizide.
DE68912944D1 (de)	1994-03-17	Phenylpyrole, verwendbar als arzneimittel, verfahren zu ihrer herstellung und ihre verwendung.
DE69514122D1 (de)	2000-01-27	Lösungsmittelfreies verfahren zur herstellung von 2,6 difluorbenzonitril
DE59002382D1 (de)	1993-09-23	Alkadiennitrile, verfahren zu ihrer herstellung und ihre verwendung.