ATE183741T1 - 2-piperazinylbenzimidazolderivate - Google Patents

2-piperazinylbenzimidazolderivate

Info

Publication number: ATE183741T1
Authority: AT; Austria
Prior art keywords: group; hydrogen atom; piperazinylbenzimidazole; derivatives; piperazinylbenzimidazole derivatives
Prior art date: 1991-05-10

Application number

AT92500056T

Other languages

English (en)

Inventor

Aurelio Orjales-Venero

Neftali Garcia-Dominguez

Victor Rubio-Royo

Rosa Rodes-Solanes

Original Assignee

Espanola Prod Quimicos

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-05-10

Filing date

1992-05-08

Publication date

1999-09-15

1992-05-08 Application filed by Espanola Prod Quimicos filed Critical Espanola Prod Quimicos

1999-09-15 Application granted granted Critical

1999-09-15 Publication of ATE183741T1 publication Critical patent/ATE183741T1/de

Links

NZXGDKLTTHIYTB-UHFFFAOYSA-N 2-piperazin-1-yl-1h-benzimidazole Chemical class C1CNCCN1C1=NC2=CC=CC=C2N1 NZXGDKLTTHIYTB-UHFFFAOYSA-N 0.000 title abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
102000035037 5-HT3 receptors Human genes 0.000 abstract 1
108091005477 5-HT3 receptors Proteins 0.000 abstract 1
CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000005982 diphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
-1 hydroxymetyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229940076279 serotonin Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT92500056T 1991-05-10 1992-05-08 2-piperazinylbenzimidazolderivate ATE183741T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ES9101147A ES2038532B1 (es)	1991-05-10	1991-05-10	Procedimiento de preparacion de nuevos derivados de 2-piperacinilbecimidazol.

Publications (1)

Publication Number	Publication Date
ATE183741T1 true ATE183741T1 (de)	1999-09-15

Family

ID=8272328

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92500056T ATE183741T1 (de)	1991-05-10	1992-05-08	2-piperazinylbenzimidazolderivate

Country Status (14)

Country	Link
EP (1)	EP0512939B1 (de)
JP (1)	JPH072795A (de)
KR (1)	KR100227458B1 (de)
AT (1)	ATE183741T1 (de)
AU (1)	AU666477B2 (de)
CA (1)	CA2068292A1 (de)
DE (1)	DE69229845T2 (de)
DK (1)	DK0512939T3 (de)
ES (1)	ES2038532B1 (de)
GR (1)	GR3031930T3 (de)
MX (1)	MX9202178A (de)
PT (1)	PT97882B (de)
TW (1)	TW200478B (de)
ZA (1)	ZA923319B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW201744B (de) *	1991-07-02	1993-03-11	Kanebou Textile Co Ltd
JP3193560B2 (ja) *	1993-04-16	2001-07-30	明治製菓株式会社	新規ベンゾオキサゾール誘導体
ES2072193B1 (es) *	1993-05-21	1996-02-16	Espanola Prod Quimicos	Nuevos derivados del1-fenilmetil bencimidazol piperacinas.
FR2731707B1 (fr) *	1995-03-13	1997-04-30	Synthelabo	Derives de benzimidazole, leur preparation et leur application en therapeutique
JP3520177B2 (ja) *	1996-05-09	2004-04-19	明治製菓株式会社	セロトニン５−ｈｔ３受容体部分活性薬
MX2009007912A (es) *	2007-01-25	2009-07-31	Janssen Pharmaceutica Nv	Derivados de 2-piperazin-1-il-3h-imidazo[4,5-b]piridina.
CA2996717A1 (en)	2015-09-11	2017-03-16	Chase Pharmaceuticals Corporation	Muscarinic combination and its use for combating hypocholinergic disorders of the central nervous system

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4351832A (en) *	1980-04-18	1982-09-28	American Home Products Corporation	2-(Piperazinyl)-4-pyrimidinamines
JPS5879983A (ja) *	1981-11-06	1983-05-13	Kanebo Ltd	新規なベンズイミダゾ−ル誘導体、その製造法およびその医薬組成物
US4634704A (en) *	1983-10-06	1987-01-06	Janssen Pharmaceutica, N.V.	Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines
AU7997091A (en) *	1990-05-30	1991-12-31	American Home Products Corporation	Substituted arylsulfonamides and benzamides

1991
- 1991-05-10 ES ES9101147A patent/ES2038532B1/es not_active Expired - Fee Related
- 1991-06-06 PT PT97882A patent/PT97882B/pt not_active IP Right Cessation
1992
- 1992-05-01 AU AU15970/92A patent/AU666477B2/en not_active Ceased
- 1992-05-07 KR KR1019920007702A patent/KR100227458B1/ko not_active Expired - Fee Related
- 1992-05-07 ZA ZA923319A patent/ZA923319B/xx unknown
- 1992-05-08 DK DK92500056T patent/DK0512939T3/da active
- 1992-05-08 DE DE69229845T patent/DE69229845T2/de not_active Expired - Fee Related
- 1992-05-08 EP EP92500056A patent/EP0512939B1/de not_active Expired - Lifetime
- 1992-05-08 AT AT92500056T patent/ATE183741T1/de not_active IP Right Cessation
- 1992-05-08 CA CA002068292A patent/CA2068292A1/en not_active Abandoned
- 1992-05-11 MX MX9202178A patent/MX9202178A/es not_active IP Right Cessation
- 1992-05-11 JP JP4144877A patent/JPH072795A/ja active Pending
- 1992-05-27 TW TW081104137A patent/TW200478B/zh active
1999
- 1999-11-24 GR GR990403022T patent/GR3031930T3/el unknown

Also Published As

Publication number	Publication date
MX9202178A (es)	1992-11-01
DE69229845T2 (de)	2000-04-27
ZA923319B (en)	1994-02-07
KR100227458B1 (ko)	1999-11-01
GR3031930T3 (en)	2000-03-31
AU666477B2 (en)	1996-02-15
CA2068292A1 (en)	1992-11-11
TW200478B (de)	1993-02-21
ES2038532A1 (es)	1993-07-16
EP0512939B1 (de)	1999-08-25
ES2038532B1 (es)	1994-02-16
AU1597092A (en)	1992-11-12
PT97882A (pt)	1993-04-30
KR920021527A (ko)	1992-12-18
DE69229845D1 (de)	1999-09-30
DK0512939T3 (da)	2000-03-13
PT97882B (pt)	1998-10-30
JPH072795A (ja)	1995-01-06
EP0512939A1 (de)	1992-11-11

Legal Events

Date	Code	Title	Description
2000-03-15	UEP	Publication of translation of european patent specification
2004-02-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DK0452873T3 (da)	1996-07-29	1,8-naphthyridin-2-on-derivater
DK0386675T3 (da)	1996-06-24	Xanthinderivater
DE69529418D1 (de)	2003-02-20	Cyclopropachromencarbonsäure derivate
ATE144511T1 (de)	1996-11-15	Tetrahydrobenzimidazol-derivate
DK0459505T3 (da)	1996-11-18	Imidazonaphthyridinderivater
DE68911773D1 (de)	1994-02-10	Benzimidazol-Derivate mit pharmakologischer Aktivität.
DE69229845D1 (de)	1999-09-30	2-Piperazinylbenzimidazolderivate
MY101261A (en)	1991-08-17	New 4-pyridone derivatives, method of their production and their pharmaceutical compositions.
DE69031111D1 (de)	1997-09-04	Indolderivate
ES2072193B1 (es)	1996-02-16	Nuevos derivados del1-fenilmetil bencimidazol piperacinas.
ATE78254T1 (de)	1992-08-15	Indol-derivate.
NO173276C (no)	1993-12-01	Analogifremgangsm}te for fremstilling av terapeutisk aktive 1,4-disubstituerte-piperidinylderivater
ATE151750T1 (de)	1997-05-15	3-(indol-3-yl) propensäurderivate, die als nmda- antagonisten nützlich sind
DE69128272D1 (de)	1998-01-08	Piperazinderivate
EA200500922A1 (ru)	2005-12-29	Производные имидазола, обладающие аффиностью по отношению к альфа2 рецепторам
ATE268769T1 (de)	2004-06-15	Pyrimidinderivate mit antitumor-wirkung