ATE184194T1 - Immunsuppressive und antiallergische verbindungen; z.b. n-(3-oxohexanoyl)- homoserinlacton - Google Patents

Immunsuppressive und antiallergische verbindungen; z.b. n-(3-oxohexanoyl)- homoserinlacton

Info

Publication number: ATE184194T1
Authority: AT; Austria
Prior art keywords: oxohexanoyl; immunosupressive; homoserine lactone; antiallergic compounds; antiallergic
Prior art date: 1993-07-02

Application number

AT94919750T

Other languages

English (en)

Inventor

Barrie Walsham Bycroft

Herbert Fitzgerald Sewell

Gordon Sydney Anderson Stewart

Paul Williams

Original Assignee

Univ Nottingham

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-07-02

Filing date

1994-07-01

Publication date

1999-09-15

1994-07-01 Application filed by Univ Nottingham filed Critical Univ Nottingham

1999-09-15 Application granted granted Critical

1999-09-15 Publication of ATE184194T1 publication Critical patent/ATE184194T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 2
YRYOXRMDHALAFL-UHFFFAOYSA-N N-(3-oxohexanoyl)homoserine lactone Chemical compound CCCC(=O)CC(=O)NC1CCOC1=O YRYOXRMDHALAFL-UHFFFAOYSA-N 0.000 title 1
230000003266 anti-allergic effect Effects 0.000 title 1
230000001506 immunosuppresive effect Effects 0.000 title 1
125000006702 (C1-C18) alkyl group Chemical group 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/39—Heterocyclic compounds having sulfur as a ring hetero atom having oxygen in the same ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pulmonology (AREA)
Virology (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Transplantation (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Hydrogenated Pyridines (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT94919750T 1993-07-02 1994-07-01 Immunsuppressive und antiallergische verbindungen; z.b. n-(3-oxohexanoyl)- homoserinlacton ATE184194T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP93305221		1993-07-02

Publications (1)

Publication Number	Publication Date
ATE184194T1 true ATE184194T1 (de)	1999-09-15

Family

ID=8214462

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94919750T ATE184194T1 (de)	1993-07-02	1994-07-01	Immunsuppressive und antiallergische verbindungen; z.b. n-(3-oxohexanoyl)- homoserinlacton

Country Status (11)

Country	Link
US (2)	US5776974A (de)
EP (1)	EP0706393B1 (de)
JP (1)	JP3434824B2 (de)
AT (1)	ATE184194T1 (de)
AU (1)	AU7077894A (de)
CA (1)	CA2166289A1 (de)
DE (1)	DE69420564T2 (de)
DK (1)	DK0706393T3 (de)
ES (1)	ES2139079T3 (de)
GR (1)	GR3032083T3 (de)
WO (1)	WO1995001175A1 (de)

Families Citing this family (36)

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US6936447B1 (en)	2000-04-03	2005-08-30	University Of Iowa Research Foundation	Autoinducer molecule
DE69836218T2 (de) *	1997-06-18	2007-09-06	Montana State University - Bozeman	Homoserinlactone zum regulieren von biofilmen und methoden zur anwendung
JP2002514092A (ja) *	1997-06-18	2002-05-14	ザリサーチアンドデヴェロップメントインスティテュート，インク．	ホモセリンラクトンバイオフィルム調節化合物及びそれらの利用法
US6455031B1 (en) *	1997-06-18	2002-09-24	David G Davies	Methods and compositions for controlling biofilm development
US6054595A (en) *	1999-06-30	2000-04-25	Baylor University	Method for synthesis of N-homocysteine thiolactonyl retinamide
GB9924195D0 (en) *	1999-10-13	1999-12-15	Univ Nottingham	N-Acyl homoserine lactones for the treatment of cardiac tachyarrhythmias Ischaemic heart disease or congestive heart failure
GB0004530D0 (en) *	2000-02-25	2000-04-19	Univ Nottingham	Adjuvants
GB0007588D0 (en) *	2000-03-30	2000-05-17	Univ Nottingham	N-Acyl homoserine lactones
US6703513B1 (en)	2000-06-02	2004-03-09	K-Quay Enterprises Llc	Production and use of derivatized homoserine lactones
AU2001286976A1 (en) *	2000-08-31	2002-03-13	East Carolina University	Novel autoinducer molecules and uses therefor
US7651699B2 (en) *	2001-01-08	2010-01-26	Pathway Intermediates Limited	Autoinducer compounds and their uses
GB0116312D0 (en)	2001-07-04	2001-08-29	Univ Nottingham	"Compositions containing N-acyl homoserine lactones"
AU2002322720B2 (en)	2001-07-25	2008-11-13	Raptor Pharmaceutical Inc.	Compositions and methods for modulating blood-brain barrier transport
US6569887B2 (en) *	2001-08-24	2003-05-27	Dov Pharmaceuticals Inc.	(−)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake
GB0122026D0 (en) *	2001-09-12	2001-10-31	Univ Nottingham	Insulitis
EP1450802A2 (de) *	2001-10-30	2004-09-01	The General Hospital Corporation	Verfahren zur prävention oder behandlung von bakteriellen und pilzinfektionen
US7338969B2 (en)	2002-03-08	2008-03-04	Quonova, Llc	Modulation of pathogenicity
WO2006115509A2 (en)	2004-06-24	2006-11-02	Novartis Vaccines And Diagnostics Inc.	Small molecule immunopotentiators and assays for their detection
GB2418427A (en)	2004-09-02	2006-03-29	Univ Cambridge Tech	Ligands for G-protein coupled receptors
CA2589537A1 (en) *	2004-12-02	2006-06-08	Stephen Craig Dyar	Pharmaceutical compositions of amorphous atorvastatin and process for preparing same
JP5133067B2 (ja) *	2005-02-04	2013-01-30	ウイスコンシンアラムナイリサーチファウンデーシヨン	クオラムセンシング細菌におけるコミュニケーション及び毒性を変更するための化合物及び方法
CN102379684B (zh)	2005-04-28	2014-11-19	普罗透斯数字保健公司	药物信息系统
GB0512238D0 (en) *	2005-06-15	2005-07-27	Univ Cambridge Tech	Anti-inflammatory agents
GB0610042D0 (en)	2006-05-22	2006-06-28	Univ Nottingham	Substituted n-acyl homoserine lactones
KR20090071598A (ko)	2006-09-18	2009-07-01	랩터 파마슈티컬 인코포레이티드	수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
US7910622B2 (en) *	2007-03-19	2011-03-22	Wisconsin Alumni Research Foundation	Modulation of bacterial quorum sensing with synthetic ligands
GB2452696B (en) *	2007-08-02	2009-09-23	Cambridge Entpr Ltd	3-(2',2'-dimethylpropanoylamino)-tetrahydropyridin-2-one and its use in pharmaceutical compositions
US7662967B2 (en)	2007-08-02	2010-02-16	Cambridge Enterprise Limited	Anti-inflammatory compounds and compositions
EP2078713A1 (de)	2007-12-28	2009-07-15	QuoNova GmbH	Hemmer der Biofilmbildung grampositiver und gramnegativer Bakterien
ES2942923T3 (es)	2009-05-06	2023-06-07	Laboratory Skin Care Inc	Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
US8624063B2 (en)	2009-06-30	2014-01-07	Wisconsin Alumni Research Foundation	Non-lactone carbocyclic and heterocyclic antagonists and agonists of bacterial quorum sensing
US20120077778A1 (en)	2010-09-29	2012-03-29	Andrea Bourdelais	Ladder-Frame Polyether Conjugates
US10195177B2 (en) *	2015-10-01	2019-02-05	The University Of Toledo	Use of acyl-homoserine lactone derivatives as anti-thrombotic agents
US11247976B2 (en)	2016-04-29	2022-02-15	Wisconsin Alumni Research Foundation	Synthetic ligands that modulate the activity of the RhlR quorum sensing receptor
US10526278B2 (en)	2017-10-19	2020-01-07	Wisconsin Alumni Research Foundation	Inhibitors of quorum sensing receptor LasR
FR3102357B1 (fr) *	2019-10-23	2022-06-24	Univ Sorbonne	Analogues de n-acyl-homoserine lactones et composition pharmaceutique les comprenant

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2265355B1 (de) *	1974-03-28	1977-11-04	Blum Jean
FR2502153A1 (fr) *	1981-03-19	1982-09-24	Rech Pharmaceutiq Medicale	Acides (2-oxo-3-tetrahydrothienylcarbamoyl)-alkylthio) acetiques, leurs sels et leurs esters, leur procede de preparation et les compositions pharmaceutiques en contenant
IT1216556B (it) *	1988-04-07	1990-03-08	Poli Ind Chimica Spa	Derivati peptidici del3_aminodiidrotiofen_2_one, loro preparazione e impiego terapeutico.
GB9108307D0 (en) *	1991-04-18	1991-06-05	Univ Nottingham	Autoinducer
US5591872A (en) *	1993-08-09	1997-01-07	The University Of Iowa Research Foundation	Autoinducer molecule

1994
- 1994-07-01 AU AU70778/94A patent/AU7077894A/en not_active Abandoned
- 1994-07-01 JP JP50337495A patent/JP3434824B2/ja not_active Expired - Fee Related
- 1994-07-01 WO PCT/GB1994/001437 patent/WO1995001175A1/en not_active Ceased
- 1994-07-01 ES ES94919750T patent/ES2139079T3/es not_active Expired - Lifetime
- 1994-07-01 DE DE69420564T patent/DE69420564T2/de not_active Expired - Fee Related
- 1994-07-01 US US08/569,257 patent/US5776974A/en not_active Expired - Fee Related
- 1994-07-01 AT AT94919750T patent/ATE184194T1/de not_active IP Right Cessation
- 1994-07-01 EP EP94919750A patent/EP0706393B1/de not_active Expired - Lifetime
- 1994-07-01 DK DK94919750T patent/DK0706393T3/da active
- 1994-07-01 CA CA002166289A patent/CA2166289A1/en not_active Abandoned
1998
- 1998-06-15 US US09/097,371 patent/US5969158A/en not_active Expired - Lifetime
1999
- 1999-12-08 GR GR990403174T patent/GR3032083T3/el unknown

Also Published As

Publication number	Publication date
WO1995001175A1 (en)	1995-01-12
US5969158A (en)	1999-10-19
ES2139079T3 (es)	2000-02-01
DE69420564T2 (de)	2000-05-04
JPH08512048A (ja)	1996-12-17
EP0706393B1 (de)	1999-09-08
US5776974A (en)	1998-07-07
DK0706393T3 (da)	2000-04-03
GR3032083T3 (en)	2000-03-31
JP3434824B2 (ja)	2003-08-11
EP0706393A1 (de)	1996-04-17
DE69420564D1 (de)	1999-10-14
CA2166289A1 (en)	1995-01-12
AU7077894A (en)	1995-01-24

Legal Events

Date	Code	Title	Description
2005-04-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69420564D1 (de)	1999-10-14	Immunsuppressive und antiallergische verbindungen; z.b. n-(3-oxohexanoyl)-homoserinlacton
ATE168677T1 (de)	1998-08-15	Retroviralproteasehemmende verbindungen
YU20199A (sh)	2001-09-28	Heterociklični sukcinimidi i njihova primena kao metaloproteinaznih inhibitora
PT705833E (pt)	2004-11-30	Derivado de dc-89
ES2146741T3 (es)	2000-08-16	Derivados de rapamicina utiles como inmunosupresores.
NL1002835A1 (nl)	1996-10-14	Synergistisch stabilisatormengsel.
FI931888A0 (fi)	1993-04-27	Kramploesande cykliska fruktopyranossulfiter -och sulfater
PT810209E (pt)	2002-09-30	Hidroxietilamino-sulfonamidas de alfa- e beta-aminoacidos uteis como inibidores de protease retroviral
YU11997A (sh)	1999-09-27	Laktamski derivati i njihove farmaceutske kompozicije
TR200102957T2 (tr)	2004-12-21	Sitalopram hazırlanması için metod.
ES2088537T3 (es)	1996-08-16	Derivados de piranil cianoguanidina.
CY2488B1 (en)	2005-06-03	New 4-(oxyalkoxyphenyl)-3-oxy-piperidines for trea.
ATE383861T1 (de)	2008-02-15	Vasopressin antagonist und oxytocin antagonist
NZ314003A (en)	2000-12-22	Medicaments for treating osteoporosis containing thiazolidine compounds
ES2161713T3 (es)	2001-12-16	Derivado de metotrexato.
DE69328366D1 (de)	2000-05-18	Benzopyran und benzoxazin-derivate
YU83993A (sh)	1996-10-09	Novi derivati piridon organske kiseline
TW333532B (en)	1998-06-11	Benzopyrans
MX9300361A (es)	1994-06-30	Derivado de 4-aril-3-heteroarilureidoquinolina como agentes antihipercolesterolemicos y antiateroscleroticos.
WO2001062709A3 (de)	2002-04-18	Verwendung von 2-phenylendiaminderivaten zur behandlung von infektionen
DE69426620D1 (de)	2001-03-01	Antidepressiva
ATE190334T1 (de)	2000-03-15	Azlacton-derivatisierte polyamide
ATE170862T1 (de)	1998-09-15	5-ht3 pyrrolopyrazinderivate
NO982879L (no)	1998-08-20	Vannlöselige antibiotika
TW221988B (de)	1994-04-01