ATE184281T1 - 9-hydroxy-pyrido (1,2-a> pyrimidin-4-on-ether- derivate - Google Patents

9-hydroxy-pyrido (1,2-a> pyrimidin-4-on-ether- derivate

Info

Publication number
ATE184281T1
ATE184281T1 AT95901389T AT95901389T ATE184281T1 AT E184281 T1 ATE184281 T1 AT E184281T1 AT 95901389 T AT95901389 T AT 95901389T AT 95901389 T AT95901389 T AT 95901389T AT E184281 T1 ATE184281 T1 AT E184281T1
Authority
AT
Austria
Prior art keywords
pct
novel compounds
date
4alkyl
sec
Prior art date
Application number
AT95901389T
Other languages
English (en)
Inventor
Jan Vandenberk
Ludo Edmond Josephine Kennis
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE184281T1 publication Critical patent/ATE184281T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT95901389T 1993-11-23 1994-11-16 9-hydroxy-pyrido (1,2-a> pyrimidin-4-on-ether- derivate ATE184281T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP93203270 1993-11-23

Publications (1)

Publication Number Publication Date
ATE184281T1 true ATE184281T1 (de) 1999-09-15

Family

ID=8214180

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95901389T ATE184281T1 (de) 1993-11-23 1994-11-16 9-hydroxy-pyrido (1,2-a> pyrimidin-4-on-ether- derivate

Country Status (14)

Country Link
US (1) US5688799A (de)
EP (1) EP0730594B1 (de)
JP (1) JP3553951B2 (de)
AT (1) ATE184281T1 (de)
AU (1) AU687940B2 (de)
CA (1) CA2175372C (de)
DE (1) DE69420579T2 (de)
DK (1) DK0730594T3 (de)
ES (1) ES2137486T3 (de)
FI (1) FI112483B (de)
GR (1) GR3031500T3 (de)
RU (1) RU2126406C1 (de)
SI (1) SI0730594T1 (de)
WO (1) WO1995014691A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2141671B1 (es) * 1997-12-26 2001-01-01 Vita Invest Sa Compuesto pirimidinico activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
WO2004009591A1 (en) * 2002-07-22 2004-01-29 Aurobindo Pharma Ltd. A process for the preparation of antipsychotic risperidone
WO2004020439A2 (en) * 2002-08-30 2004-03-11 Sunil Sadanand Nadkarni Improved process for preparation of risperidone
HUP0401379A3 (en) * 2004-07-08 2006-04-28 Richter Gedeon Vegyeszet Process for the preparation of risperidon
ES2546268T3 (es) * 2004-09-09 2015-09-22 Janssen Pharmaceutica Nv Preparación de 9-hidroxi-3-(2-hidroxietil)-2-metil-4H-pirido[1,2-a]pirimidin-4-ona y sus cristales
HUP0402163A2 (en) * 2004-10-25 2006-05-29 Richter Gedeon Vegyeszet Process for the preparation of risperidone
ES2304336T1 (es) * 2006-08-14 2008-10-16 Teva Pharmaceutical Industries Ltd. Formas cristalinas de 9-hidroxi-risperidona (paliperidona).
US7915412B2 (en) * 2006-08-14 2011-03-29 Teva Pharmaceutical Industries, Ltd. Process for the synthesis of 9-hydroxy risperidone (paliperidone)
US7820816B2 (en) * 2006-08-23 2010-10-26 Teva Pharmaceutical Industries Ltd. Process for the synthesis of CMHTP and intermediates thereof
CN101600716A (zh) 2007-01-08 2009-12-09 阿特维斯集团公司 用于制备9-羟基-3-(2-氯乙基)-2-甲基-4H-吡啶并[1,2-a]嘧啶-4-酮盐酸盐的改进方法
US20080171876A1 (en) * 2007-05-10 2008-07-17 Santiago Ini Pure paliperidone and processes for preparing thereof
WO2009010988A1 (en) * 2007-07-19 2009-01-22 Natco Pharma Limited An improved, industrially viable process for the preparation of high purity paliperidone
EP2178872A1 (de) * 2007-07-27 2010-04-28 Synthon B.V. Paliperidonderivate
PL2079446T3 (pl) * 2007-08-21 2012-04-30 Teva Pharma Preparat paliperidonu o przedłużonym uwalnianiu
US20090061005A1 (en) * 2007-08-21 2009-03-05 Actavis Group Ptc Ehf Paliperidone Polymorphs
WO2009044413A2 (en) * 2007-10-05 2009-04-09 Matrix Laboratories Limited Improved process for preparing paliperidone, novel polymorphic forms of the same and process thereof
US20090270620A1 (en) * 2007-11-27 2009-10-29 Santiago Ini Processes for preparing crystal forms of 9-hydroxy-risperidone (paliperidone)
CL2008003667A1 (es) * 2007-12-10 2010-06-04 Synthon Bv Proceso de preparacion de etil-6,7,8,9-tetrahidro-9-hidroxi-2-metil-4h-pirido[1,2-a]piridin-4-ona; y uno de los intermediarios considerados en el proceso descrito; util en la preparacion de paliperidona.
TWI385157B (zh) * 2008-01-16 2013-02-11 Scinopharm Taiwan Ltd 用於製備帕潘立酮（ｐａｌｉｐｅｒｉｄｏｎｅ）之新穎中間體
WO2009116071A2 (en) * 2008-02-05 2009-09-24 Watson Pharma Private Limited An improved process for preparation of paliperidone
WO2009118655A2 (en) * 2008-03-27 2009-10-01 Actavis Group Ptc Ehf Highly pure paliperidone or a pharmaceutically acceptable salt thereof substantially free of keto impurity
ES2625323T3 (es) * 2008-05-29 2017-07-19 Inke, S.A. Proceso para preparar paliperidona e intermedios de la misma
EP2300467A4 (de) 2008-06-16 2012-04-25 Msn Lab Ltd Neuartige und verbesserte verfahren zur herstellung von paliperidon
US7932385B2 (en) 2008-07-11 2011-04-26 Synthon Bv Paliperidone ketone
EP2321311B1 (de) * 2008-07-11 2012-09-19 Synthon B.V. Synthese von paliperidon
WO2010064134A2 (en) * 2008-12-05 2010-06-10 Cadila Pharmaceuticals Ltd. Process of synthesis of paliperidone
EP2202234A1 (de) 2008-12-24 2010-06-30 Laboratorios Lesvi, S.L. Reinigung von Paliperidon
WO2010136895A1 (en) 2009-05-28 2010-12-02 Actavis Group Ptc Ehf Solid state forms of paliperidone salts and process for the preparation thereof
EP2475663A2 (de) 2009-09-10 2012-07-18 Actavis Group Ptc Ehf Paliperidon oder substantiell verunreinigungsfreies pharmazeutisch akzeptables salz daraus
WO2011073997A2 (en) * 2009-12-14 2011-06-23 Cadila Healthcare Limited Process for preparing paliperidone and pharmaceutically acceptable salts thereof
US8088594B2 (en) * 2010-03-16 2012-01-03 Saladax Biomedical Inc. Risperidone immunoassay
WO2012035554A1 (en) 2010-09-14 2012-03-22 Megafine Pharma (P) Ltd. An improved process for the preparation of highly pure paliperidone
CN103387575A (zh) * 2013-07-22 2013-11-13 江苏万特制药有限公司 帕潘立酮的制备方法及其关键中间体
KR101867988B1 (ko) * 2016-11-02 2018-06-15 주식회사 엔지켐생명과학 팔리페리돈 중간체 및 이를 이용한 팔리페리돈의 제조방법
CN115260190A (zh) * 2022-08-30 2022-11-01 南开大学 一种帕利哌酮前药、制剂及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4485107A (en) * 1982-11-01 1984-11-27 Janssen Pharmaceutica N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
CA2000786C (en) * 1988-11-07 1999-01-26 Janssen Pharmaceutica, Naamloze Vennootschap 3-piperidinyl-1,2-benzisoxazoles
US5158952A (en) * 1988-11-07 1992-10-27 Janssen Pharmaceutica N.V. 3-[2-[4-(6-fluoro-1,2-benzisoxozol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9 tetrahydro-9-hydroxy-2-methyl-4H-pyrido [1,2-a]pyrimidin-4-one, compositions and method of use
GB9008850D0 (en) * 1990-04-19 1990-06-13 Janssen Pharmaceutica Nv Novel 2,9-disubstituted-4h-pyridol(1,2-a)pyrimidin-4-ones

Also Published As

Publication number Publication date
EP0730594B1 (de) 1999-09-08
GR3031500T3 (en) 2000-01-31
FI112483B (fi) 2003-12-15
AU1065495A (en) 1995-06-13
EP0730594A1 (de) 1996-09-11
JP3553951B2 (ja) 2004-08-11
DK0730594T3 (da) 2000-03-27
FI962155L (fi) 1996-05-22
CA2175372A1 (en) 1995-06-01
DE69420579D1 (de) 1999-10-14
CA2175372C (en) 2006-02-21
RU2126406C1 (ru) 1999-02-20
AU687940B2 (en) 1998-03-05
FI962155A0 (fi) 1996-05-22
SI0730594T1 (en) 1999-12-31
US5688799A (en) 1997-11-18
DE69420579T2 (de) 2000-04-27
ES2137486T3 (es) 1999-12-16
JPH09505574A (ja) 1997-06-03
WO1995014691A1 (en) 1995-06-01

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Legal Events

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UEP Publication of translation of european patent specification
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