ATE184599T1 - 14-beta-hydroxy-10-deacetyl-baccatin-iii und seine derivate als antitumormittel - Google Patents

14-beta-hydroxy-10-deacetyl-baccatin-iii und seine derivate als antitumormittel

Info

Publication number: ATE184599T1
Authority: AT; Austria
Prior art keywords: deacetyl; beta; hydroxy; iii; derivatives
Prior art date: 1992-03-06

Application number

AT93102633T

Other languages

English (en)

Inventor

Ezio Bombardelli

Bruno Gabetta

Original Assignee

Indena Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-03-06

Filing date

1993-02-19

Publication date

1999-10-15

1993-02-19 Application filed by Indena Spa filed Critical Indena Spa

1999-10-15 Application granted granted Critical

1999-10-15 Publication of ATE184599T1 publication Critical patent/ATE184599T1/de

Links

239000002246 antineoplastic agent Substances 0.000 title abstract 2
FNZPZCTVRVPPAB-YZSQHPIKSA-N 14beta-Hydroxy-10-deacetylbaccatin III Natural products O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](O)[C@H](O)[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 FNZPZCTVRVPPAB-YZSQHPIKSA-N 0.000 title 1
229940123237 Taxane Drugs 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
238000002955 isolation Methods 0.000 abstract 1
DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Hydrogenated Pyridines (AREA)
Saccharide Compounds (AREA)

AT93102633T 1992-03-06 1993-02-19 14-beta-hydroxy-10-deacetyl-baccatin-iii und seine derivate als antitumormittel ATE184599T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITMI920528A IT1254517B (it)	1992-03-06	1992-03-06	14-beta idrossi-10-deacetil-baccatina iii, suoi derivati, loro prepazione ed impiego terapeutico

Publications (1)

Publication Number	Publication Date
ATE184599T1 true ATE184599T1 (de)	1999-10-15

Family

ID=11362321

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93102633T ATE184599T1 (de)	1992-03-06	1993-02-19	14-beta-hydroxy-10-deacetyl-baccatin-iii und seine derivate als antitumormittel

Country Status (18)

Country	Link
US (2)	US5264591A (de)
EP (1)	EP0559019B1 (de)
JP (1)	JP2708346B2 (de)
KR (1)	KR100255525B1 (de)
CN (1)	CN1051082C (de)
AT (1)	ATE184599T1 (de)
CA (1)	CA2091001C (de)
CZ (1)	CZ284265B6 (de)
DE (1)	DE69326369T2 (de)
DK (1)	DK0559019T3 (de)
ES (1)	ES2136096T3 (de)
FI (1)	FI109904B (de)
GR (1)	GR3031280T3 (de)
HU (2)	HU218665B (de)
IT (1)	IT1254517B (de)
NO (1)	NO305080B1 (de)
PL (1)	PL171982B1 (de)
SK (1)	SK279257B6 (de)

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US5721268A (en) *	1991-09-23	1998-02-24	Florida State University	C7 taxane derivatives and pharmaceutical compositions containing them
US6018073A (en) *	1991-09-23	2000-01-25	Florida State University	Tricyclic taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US6011056A (en)	1991-09-23	2000-01-04	Florida State University	C9 taxane derivatives and pharmaceutical compositions containing them
US5710287A (en) *	1991-09-23	1998-01-20	Florida State University	Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
US5489601A (en) *	1991-09-23	1996-02-06	Florida State University	Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
US6794523B2 (en)	1991-09-23	2004-09-21	Florida State University	Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
US5698712A (en) *	1992-03-06	1997-12-16	Indena S.P.A.	Baccatine III derivatives
US5481007A (en) *	1992-06-23	1996-01-02	The Scripps Research Institute	Taxoid synthesis
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US5973160A (en)	1992-12-23	1999-10-26	Poss; Michael A.	Methods for the preparation of novel sidechain-bearing taxanes
US6710191B2 (en) *	1993-03-05	2004-03-23	Florida State University	9β-hydroxytetracyclic taxanes
DE69432140T2 (de) *	1993-03-05	2003-07-31	Florida State University, Tallahassee	Verfahren zur Herstellung von 9-Desoxotaxanen
US5475011A (en) *	1993-03-26	1995-12-12	The Research Foundation Of State University Of New York	Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
FR2711370B1 (fr) *	1993-10-18	1996-01-05	Rhone Poulenc Rorer Sa	Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2712289B1 (fr) *	1993-11-08	1996-01-05	Rhone Poulenc Rorer Sa	Nouveaux dérivés de taxicine, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2714053B1 (fr) *	1993-12-22	1996-03-08	Pf Medicament	Procédé d'extraction et d'isolement de la 10-désacétylbaccatine III.
CN1112433A (zh) *	1994-05-24	1995-11-29	郭明	红豆杉属植物提取物及其应用
IT1269862B (it) *	1994-05-30	1997-04-15	Indena Spa	Alcaloidi da mappia foetida, loro uso e formulazioni che li contengono
US5763477A (en) *	1994-07-22	1998-06-09	Dr. Reddy's Research Foundation	Taxane derivatives from 14-β-hydroxy-10 deacetylbaccatin III
FR2723094A1 (fr) *	1994-07-26	1996-02-02	Rhone Poulenc Rorer Sa	Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
CA2162759A1 (en) *	1994-11-17	1996-05-18	Kenji Tsujihara	Baccatin derivatives and processes for preparing the same
IT1275936B1 (it) *	1995-03-17	1997-10-24	Indena Spa	Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni
FR2732341A1 (fr) *	1995-03-27	1996-10-04	Rhone Poulenc Rorer Sa	Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
IT1275435B (it) *	1995-05-19	1997-08-07	Indena Spa	Derivati della 10-desacetil-14beta-idrossibaccatina iii,loro metodo di preparazione e formulazioni che li contengono
EP0747372A1 (de) *	1995-06-06	1996-12-11	Dr. Reddy's Research Foundation	Taxane Derivate aus 14-beta-hydroxy-10 Desacetylbachatin III
EP0914116B1 (de) *	1996-05-22	2000-10-11	Protarga Inc.	Zusammensetzungen die konjugate von cis-docosahexaenoic-säure und taxotere enthalten
US5919815A (en) *	1996-05-22	1999-07-06	Neuromedica, Inc.	Taxane compounds and compositions
US5795909A (en) *	1996-05-22	1998-08-18	Neuromedica, Inc.	DHA-pharmaceutical agent conjugates of taxanes
US6576636B2 (en)	1996-05-22	2003-06-10	Protarga, Inc.	Method of treating a liver disorder with fatty acid-antiviral agent conjugates
US5750736A (en) *	1996-07-11	1998-05-12	Napro Biotherapeutics, Inc.	Method for acylating 10-deacetylbaccatin III selectively at the c-10 position
US5856532A (en) *	1996-08-14	1999-01-05	Council Of Scientific & Industrial Research	Process for the production of taxol
WO1998008833A1 (en) *	1996-08-26	1998-03-05	Bristol-Myers Squibb Company	Sulfenamide taxane derivatives
WO1998013359A1 (de) *	1996-09-24	1998-04-02	Marigen S.A.	Ultramikroemulsionen aus spontan dispergierbaren konzentraten mit antitumoral und antiviral wirksamen estern von baccatin-iii-verbindungen
US5811452A (en) *	1997-01-08	1998-09-22	The Research Foundation Of State University Of New York	Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
DK1068192T3 (da) *	1998-01-14	2002-10-14	Bristol Myers Squibb Co	Hidtil ukendte krystallinske komplekser af baccatin III med imidazol, 2-methylimidazol eller isopropanol
US6124482A (en) *	1998-07-27	2000-09-26	Dabur Research Foundation	Process for isolation of 10-deacetyl baccatin-III
US6002024A (en) *	1998-07-27	1999-12-14	Dabur Research Foundation	Process for the isolation of 14β-hydroxy-10-deacetyl baccatin-III
US7235583B1 (en) *	1999-03-09	2007-06-26	Luitpold Pharmaceuticals, Inc.,	Fatty acid-anticancer conjugates and uses thereof
JP4776843B2 (ja)	1999-10-01	2011-09-21	イムノゲンインコーポレーティッド	免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
IT1318678B1 (it) *	2000-08-10	2003-08-27	Indena Spa	Procedimento per la preparazione di derivati della baccatina iii.
JP2004525860A (ja)	2000-09-22	2004-08-26	ブリストル−マイヤーズスクイブカンパニー	併用化学療法剤の毒性を低下させる方法
IT1320107B1 (it) *	2000-11-28	2003-11-18	Indena Spa	Procedimento per la preparazione di derivati tassanici.
AU2002305099A1 (en) *	2001-03-23	2002-10-08	Protarga, Inc.	Fatty alcohol drug conjugates
AU2002303164A1 (en)	2001-03-23	2002-10-08	Protarga, Inc.	Fatty amine drug conjugates
ITMI20012186A1 (it)	2001-10-19	2003-04-19	Indena Spa	Procedimento per la preparazione della 14-beta-idrossi-baccatina iii-1,14-carbonato
ITMI20012185A1 (it)	2001-10-19	2003-04-19	Indena Spa	Procedimento per la preparazione della 14beta-idrossi-baccatina iii-1,14-carbonato
ITMI20050614A1 (it) *	2005-04-12	2006-10-13	Indena Spa	Processo per la purificazione della 10-deacetilbaccatina iii dalla 10-deacetil-2-debenzoil-2-pentenoilbaccatina iii
JP5604105B2 (ja) *	2006-09-20	2014-10-08	エルジー・ケム・リミテッド	非水電解液添加剤及びこれを用いた二次電池
EP2080764B1 (de)	2008-01-18	2012-08-22	INDENA S.p.A.	Feste Formen von Ortataxel

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FR2629818B1 (fr) *	1988-04-06	1990-11-16	Centre Nat Rech Scient	Procede de preparation du taxol

1992
- 1992-03-06 IT ITMI920528A patent/IT1254517B/it active
- 1992-05-11 US US07/881,150 patent/US5264591A/en not_active Expired - Lifetime
1993
- 1993-02-19 AT AT93102633T patent/ATE184599T1/de active
- 1993-02-19 DE DE69326369T patent/DE69326369T2/de not_active Expired - Lifetime
- 1993-02-19 EP EP93102633A patent/EP0559019B1/de not_active Expired - Lifetime
- 1993-02-19 ES ES93102633T patent/ES2136096T3/es not_active Expired - Lifetime
- 1993-02-19 DK DK93102633T patent/DK0559019T3/da active
- 1993-03-02 SK SK152-93A patent/SK279257B6/sk not_active IP Right Cessation
- 1993-03-03 NO NO930774A patent/NO305080B1/no not_active IP Right Cessation
- 1993-03-04 CA CA002091001A patent/CA2091001C/en not_active Expired - Lifetime
- 1993-03-04 CN CN93102326A patent/CN1051082C/zh not_active Expired - Fee Related
- 1993-03-04 CZ CZ93336A patent/CZ284265B6/cs not_active IP Right Cessation
- 1993-03-04 FI FI930978A patent/FI109904B/fi not_active IP Right Cessation
- 1993-03-04 HU HU9300594A patent/HU218665B/hu not_active IP Right Cessation
- 1993-03-04 JP JP5067336A patent/JP2708346B2/ja not_active Expired - Lifetime
- 1993-03-04 KR KR1019930003213A patent/KR100255525B1/ko not_active Expired - Lifetime
- 1993-03-04 PL PL93297940A patent/PL171982B1/pl not_active IP Right Cessation
- 1993-07-22 US US08/094,969 patent/US5453520A/en not_active Expired - Lifetime
1995
- 1995-06-29 HU HU95P/P00594P patent/HU211824A9/hu unknown
1999
- 1999-09-22 GR GR990402378T patent/GR3031280T3/el unknown

Also Published As

Publication number	Publication date
KR930019654A (ko)	1993-10-18
FI109904B (fi)	2002-10-31
CA2091001C (en)	2003-11-04
CN1051082C (zh)	2000-04-05
GR3031280T3 (en)	1999-12-31
DE69326369D1 (de)	1999-10-21
ITMI920528A0 (it)	1992-03-06
CZ284265B6 (cs)	1998-10-14
NO930774D0 (no)	1993-03-03
CA2091001A1 (en)	1993-09-07
EP0559019B1 (de)	1999-09-15
KR100255525B1 (ko)	2000-05-01
NO305080B1 (no)	1999-03-29
NO930774L (no)	1993-09-07
HU9300594D0 (en)	1993-05-28
ITMI920528A1 (it)	1993-09-06
CN1076695A (zh)	1993-09-29
SK279257B6 (sk)	1998-08-05
DE69326369T2 (de)	2000-03-23
FI930978A0 (fi)	1993-03-04
HU218665B (hu)	2000-10-28
ES2136096T3 (es)	1999-11-16
DK0559019T3 (da)	2000-03-27
US5264591A (en)	1993-11-23
HK1011686A1 (en)	1999-07-16
PL171982B1 (pl)	1997-07-31
US5453520A (en)	1995-09-26
SK15293A3 (en)	1993-12-08
IT1254517B (it)	1995-09-25
PL297940A1 (en)	1993-11-15
CZ33693A3 (en)	1994-01-19
FI930978L (fi)	1993-09-07
JPH069599A (ja)	1994-01-18
HU211824A9 (en)	1995-12-28
EP0559019A1 (de)	1993-09-08
HUT64317A (en)	1993-12-28
JP2708346B2 (ja)	1998-02-04

Legal Events

Date	Code	Title	Description
2000-02-15	UEP	Publication of translation of european patent specification

Publication	Publication Date	Title
DE69326369D1 (de)	1999-10-21	14-Beta-Hydroxy-10-Deacetyl-Baccatin-III und seine Derivate als Antitumormittel
ATE89002T1 (de)	1993-05-15	Porphyrine und arzneimittel zur krebsbehandlung.
PT639577E (pt)	2002-10-31	Eteres fosfono-oximetilicos ou metiltiometilicos de derivados do taxano como agentes anti-tumor
PT582810E (pt)	2002-08-30	Novas 7-(substituidas)-8-(substituidas)-9-(substituidas)-6-desmetil-6-desoxitetraciclinas como agentes antibioticos
ATE71627T1 (de)	1992-02-15	Bryostatine.
NO302359B1 (no)	1998-02-23	7-(substituerte)-9-£(substituerte glycyl)amido\|-6-demetyl-6-deoksy-tetracykliner, farmasöytiske preparater inneholdende dem, og mellomprodukter
DE69432569D1 (de)	2003-05-28	Synthese von Taxol und deren Derivate
ATE170870T1 (de)	1998-09-15	2-oxoethylderivate als immunosuppressiva
IN170909B (de)	1992-06-13
NO902394L (no)	1990-12-03	Fremgangsmaate for fremstilling av pyranyl-cyanoguanidin-derivater.
ES2136887T3 (es)	1999-12-01	Derivados antifungicos de sordaridina.
FI930977A0 (fi)	1993-03-04	Taxanderivat, deras framstaellning och onkologiska anvaendning
ZA927606B (en)	1993-04-13	Antifungal agent.
ATE146179T1 (de)	1996-12-15	27 hydroxyrapamycin und derivate davon
ATE176233T1 (de)	1999-02-15	Imidazo(1,2-c)chinazolinderivate als antihypertensive und antidysurie
FI941963A0 (fi)	1994-04-28	Pyridiinijohdannaiset, niiden valmistus ja käyttö
ATE127806T1 (de)	1995-09-15	Antibiotikverbindungen und ihre herstellung.
FI911124A0 (fi)	1991-03-06	Nya pyridinderivat och foerfaranden foer deras syntetisering.
DE69417528D1 (de)	1999-05-06	Antibakterielles und als anti-tumormittel wirksames epoxidderivat dc 114-a1
ATE142201T1 (de)	1996-09-15	2- und 3-amino und azidoderivate von 1,5- iminozuckern als antivirale arzneimittel