ATE184613T1 - Varianten des grünen fluoreszenzproteins, gfp - Google Patents

Varianten des grünen fluoreszenzproteins, gfp

Info

Publication number
ATE184613T1
ATE184613T1 AT96900890T AT96900890T ATE184613T1 AT E184613 T1 ATE184613 T1 AT E184613T1 AT 96900890 T AT96900890 T AT 96900890T AT 96900890 T AT96900890 T AT 96900890T AT E184613 T1 ATE184613 T1 AT E184613T1
Authority
AT
Austria
Prior art keywords
gfp
variants
green fluorescence
fluorescence protein
protein
Prior art date
Application number
AT96900890T
Other languages
English (en)
Inventor
Ole Thastrup
Soren Tullin
Lars Kongsbak Poulsen
Sara Petersen Bjorn
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8100600&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE184613(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Application granted granted Critical
Publication of ATE184613T1 publication Critical patent/ATE184613T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43595—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from coelenteratae, e.g. medusae
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/855—Proteins from animals other than mammals or birds
    • Y10S530/857—Fish; fish eggs; shell fish; crustacea

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
AT96900890T 1995-09-22 1996-01-31 Varianten des grünen fluoreszenzproteins, gfp ATE184613T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK106595 1995-09-22

Publications (1)

Publication Number Publication Date
ATE184613T1 true ATE184613T1 (de) 1999-10-15

Family

ID=8100600

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96900890T ATE184613T1 (de) 1995-09-22 1996-01-31 Varianten des grünen fluoreszenzproteins, gfp

Country Status (10)

Country Link
US (3) US6172188B1 (de)
EP (1) EP0851874B1 (de)
JP (2) JP3535177B2 (de)
AT (1) ATE184613T1 (de)
AU (1) AU4482996A (de)
CA (1) CA2232727C (de)
DE (1) DE69604298T2 (de)
DK (1) DK0851874T3 (de)
ES (1) ES2139329T3 (de)
WO (1) WO1997011094A1 (de)

Families Citing this family (133)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5777079A (en) * 1994-11-10 1998-07-07 The Regents Of The University Of California Modified green fluorescent proteins
US5625048A (en) 1994-11-10 1997-04-29 The Regents Of The University Of California Modified green fluorescent proteins
DE69604298T2 (de) 1995-09-22 2000-05-18 Bioimage A/S, Soeborg Varianten des grünen fluoreszenzproteins, gfp
US6803188B1 (en) 1996-01-31 2004-10-12 The Regents Of The University Of California Tandem fluorescent protein constructs
US6900304B2 (en) 1996-01-31 2005-05-31 The Regents Of The University Of California Emission ratiometric indicators of phosphorylation
US5804387A (en) * 1996-02-01 1998-09-08 The Board Of Trustees Of The Leland Stanford Junior University FACS-optimized mutants of the green fluorescent protein (GFP)
US6027881A (en) * 1996-05-08 2000-02-22 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Mutant Aequorea victoria fluorescent proteins having increased cellular fluorescence
US5912137A (en) * 1996-07-16 1999-06-15 The Regents Of The University Of California Assays for protein kinases using fluorescent
US5925558A (en) * 1996-07-16 1999-07-20 The Regents Of The University Of California Assays for protein kinases using fluorescent protein substrates
US6593135B2 (en) 1996-08-16 2003-07-15 The State Of Oregon, Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Long wavelength engineered fluorescent proteins
US6124128A (en) * 1996-08-16 2000-09-26 The Regents Of The University Of California Long wavelength engineered fluorescent proteins
WO1998021355A1 (en) 1996-11-15 1998-05-22 Life Technologies, Inc. Mutants of green fluorescent protein
US6090919A (en) * 1997-01-31 2000-07-18 The Board Of Trustees Of The Leland Stanford Junior University FACS-optimized mutants of the green fluorescent protein (GFP)
US5998204A (en) * 1997-03-14 1999-12-07 The Regents Of The University Of California Fluorescent protein sensors for detection of analytes
US6197928B1 (en) 1997-03-14 2001-03-06 The Regents Of The University Of California Fluorescent protein sensors for detection of analytes
JP2001519663A (ja) 1997-04-04 2001-10-23 ピー． ウィークス、ドナルド 遺伝子導入ジカンバ−分解生物体を製造及び使用するための方法及び材料
DK0986753T4 (da) * 1997-04-07 2005-12-19 Bioimage As Fremgangsmåde til uddragning af kvantitativ information, hvad angår en påvirkning af et cellulært respons
US6046925A (en) * 1997-04-14 2000-04-04 The Regents Of The University Of California Photochromic fluorescent proteins and optical memory storage devices based on fluorescent proteins
US6407132B1 (en) 1997-07-25 2002-06-18 James Black Foundation Limited Substituted imidazole derivatives and their use as histamine H3 receptor ligands
FR2766927B1 (fr) * 1997-07-31 1999-11-05 Centre Nat Rech Scient Methodes et kits pour le diagnostic de la maladie d'alzheimer
EP0928968A1 (de) * 1998-01-12 1999-07-14 Universität Basel Verfahren zum Screening der Apoptosis und Necrose
US6194548B1 (en) 1998-01-23 2001-02-27 Takashi Osumi Green fluorescent proteins and blue fluorescent proteins
AU765703B2 (en) * 1998-03-27 2003-09-25 Bruce J. Bryan Luciferases, fluorescent proteins, nucleic acids encoding the luciferases and fluorescent proteins and the use thereof in diagnostics, high throughput screening and novelty items
US7090976B2 (en) 1999-11-10 2006-08-15 Rigel Pharmaceuticals, Inc. Methods and compositions comprising Renilla GFP
US6495664B1 (en) 1998-07-24 2002-12-17 Aurora Biosciences Corporation Fluorescent protein sensors of post-translational modifications
EP1102976A1 (de) * 1998-08-08 2001-05-30 Imperial Cancer Research Technology Limited Mehrfrequenz-fluoreszenzlebensdauer-abbildungsverfahren
US6180343B1 (en) * 1998-10-08 2001-01-30 Rigel Pharmaceuticals, Inc. Green fluorescent protein fusions with random peptides
US7297482B2 (en) 1998-10-08 2007-11-20 Rigel Pharmaceuticals, Inc. Structurally biased random peptide libraries based on different scaffolds
US6936421B2 (en) 1998-10-08 2005-08-30 Rigel Pharmaceuticals, Inc. Structurally biased random peptide libraries based on different scaffolds
AU6189599A (en) * 1998-10-15 2000-05-08 Bioimage A/S An improved method for extracting quantitative information relating to an influence on a cellular response
EP1031630B1 (de) * 1999-02-22 2004-10-20 Matsushita Electric Industrial Co., Ltd. Verfahren zum Nachweis von Bakterien
DE19915137C2 (de) * 1999-03-26 2001-10-18 Michael Schaefer Verfahren zur Quantifizierung mehrerer Fluorochrome in einer mehrfach gefärbten Probe bei der Fluoreszenzmikroskopie und Verwendungen des Verfahrens
US6410255B1 (en) 1999-05-05 2002-06-25 Aurora Biosciences Corporation Optical probes and assays
US7151847B2 (en) 2001-02-20 2006-12-19 Cytokinetics, Inc. Image analysis of the golgi complex
JP4845073B2 (ja) * 1999-07-30 2011-12-28 全国農業協同組合連合会 再構築受精卵の作製方法及びそれを用いたトランスジェニック胚の作製方法
US6716614B1 (en) * 1999-09-02 2004-04-06 Lexicon Genetics Incorporated Human calcium dependent proteases, polynucleotides encoding the same, and uses thereof
US6541252B1 (en) 2000-05-19 2003-04-01 Lexicon Genetics Incorporated Human kinases and polynucleotides encoding the same
US7109315B2 (en) 2000-03-15 2006-09-19 Bruce J. Bryan Renilla reniformis fluorescent proteins, nucleic acids encoding the fluorescent proteins and the use thereof in diagnostics, high throughput screening and novelty items
ATE439373T1 (de) * 2000-06-19 2009-08-15 Fisher Bioimage Aps Fluoreszierende proteine
EP1624062A3 (de) * 2000-10-27 2006-02-22 Lexicon Genetics Incorporated Humane 7tm Proteine und dafür kodierende Polynukleotide
US7016787B2 (en) 2001-02-20 2006-03-21 Cytokinetics, Inc. Characterizing biological stimuli by response curves
US6956961B2 (en) 2001-02-20 2005-10-18 Cytokinetics, Inc. Extracting shape information contained in cell images
JP3929250B2 (ja) * 2001-03-08 2007-06-13 株式会社ルネサステクノロジ 半導体装置
WO2002077011A2 (en) 2001-03-12 2002-10-03 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Oxidation-reduction sensitive green fluorescent protein variants
EP1392864A4 (de) * 2001-04-23 2005-11-23 Lifesensors Inc Zusammensetzungen und verfahren zur geschlechtertrennung
GB0109858D0 (en) * 2001-04-23 2001-06-13 Amersham Pharm Biotech Uk Ltd Fluorscent proteins
JP3829252B2 (ja) 2001-06-08 2006-10-04 独立行政法人理化学研究所 蛍光蛋白質
US6894205B2 (en) * 2001-06-22 2005-05-17 Vanderbilt University Assay for toxin induced neuronal degeneration and viability in C. elegans
TWI252847B (en) * 2001-07-10 2006-04-11 Synta Pharmaceuticals Corp Synthesis of taxol enhancers
TWI297335B (en) 2001-07-10 2008-06-01 Synta Pharmaceuticals Corp Taxol enhancer compounds
TWI332943B (en) * 2001-07-10 2010-11-11 Synta Pharmaceuticals Corp Taxol enhancer compounds
US6924312B2 (en) * 2001-07-10 2005-08-02 Synta Pharmaceuticals Corp. Taxol enhancer compounds
GB0123314D0 (en) * 2001-09-28 2001-11-21 Amersham Pharm Biotech Uk Ltd Fluorescent proteins
WO2003029827A2 (en) * 2001-10-01 2003-04-10 Bioimage A/S A method of detecting intracellular protein-protein interactions using three heterologous conjugates
AU2002226244A1 (en) * 2002-02-04 2003-09-02 Hemolytics Ag High throughput screening method for compounds with non-, pro-, or anti-apoptotic or proliferative or necrotic activity
WO2009095742A1 (en) * 2008-01-31 2009-08-06 Cellectis New i-crei derived single-chain meganuclease and uses thereof
US7335488B2 (en) 2002-04-05 2008-02-26 The Chinese University Of Hong Kong Fluorescent proteins
US7271241B2 (en) * 2002-04-24 2007-09-18 Los Alamos National Security, Llc Directed evolution methods for improving polypeptide folding and solubility and superfolder fluorescent proteins generated thereby
ES2338111T3 (es) 2002-08-21 2010-05-04 Revivicor, Inc. Animales porcinos que carecen de cualquier expresion de alfa 1,3 galactosiltransferasa funcional.
US9453251B2 (en) 2002-10-08 2016-09-27 Pfenex Inc. Expression of mammalian proteins in Pseudomonas fluorescens
AU2003285844A1 (en) * 2002-11-12 2004-06-03 Zakrytoe Aktsionernoe Obschestvo "Evrogen" Fluorescent proteins and chromoproteins from non-aequorea hydrozoa species and methods for using same
US7413874B2 (en) 2002-12-09 2008-08-19 University Of Miami Nucleic acid encoding fluorescent proteins from aquatic species
TWI330079B (en) * 2003-01-15 2010-09-11 Synta Pharmaceuticals Corp Treatment for cancers
WO2004090115A2 (en) * 2003-04-04 2004-10-21 Stratagene Renilla gfp mutants with increased fluorescent intensity and special shift
EP1646926A2 (de) 2003-07-18 2006-04-19 Cytokinetics, Inc. Charakterisierung biologischer stimuli durch ansprechkurven
WO2005074436A2 (en) 2003-10-24 2005-08-18 The Regents Of The University Of California Self-assembling split-fluorescent protein systems
GB0329353D0 (en) * 2003-12-19 2004-01-21 Amersham Biosciences Uk Ltd Cytochrome C protein and assay
US8586294B2 (en) 2004-05-18 2013-11-19 The Board Of Trustees Of The Leland Stanford Junior University Detection of protein translocation by beta-galactosidase reporter fragment complementation
PL1781604T3 (pl) * 2004-06-23 2014-01-31 Synta Pharmaceuticals Corp Sole bis(tiohydrazydoamidu) do leczenia nowotworów
US7323318B2 (en) 2004-07-15 2008-01-29 Cytokinetics, Inc. Assay for distinguishing live and dead cells
EP1774017B1 (de) 2004-07-26 2013-05-15 Pfenex Inc. Verfahren zur verbesserten proteinexpression durch strain-engineering
US20060024833A1 (en) * 2004-07-27 2006-02-02 Molecular Probes, Inc. Fluorescent metal ion indicators with large stokes shift
US20060031020A1 (en) * 2004-08-09 2006-02-09 Yang Jenny J Computational approach for constructing an analyte binding motif
EP1827410A2 (de) * 2004-11-19 2007-09-05 Synta Pharmaceuticals Corporation Bis(thio-hydrazid-amide) zur erhöhung der hsp70-expression
US20090263821A1 (en) * 2004-12-01 2009-10-22 Proteologics, Inc. Ubiquitin Ligase Assays And Related Reagents
BRPI0610219A2 (pt) * 2005-04-15 2010-06-08 Synta Pharmaceuticals Corp métodos de tratamento de um ser humano com cáncer e composição de farmacêutica
KR20080008399A (ko) 2005-05-16 2008-01-23 신타 파마슈티칼스 코프. 비스(티오-히드라지드 아미드) 염의 합성 방법
AU2006249144B2 (en) 2005-05-18 2011-11-17 Ablynx Nv Improved NanobodiesTM against Tumor Necrosis Factor-alpha
MX2007014564A (es) 2005-05-20 2008-02-07 Ablynx Nv Anticuerpos de vhh de dominio unico contra el factor de von willebrand.
US8362250B2 (en) 2005-05-24 2013-01-29 Enzo Biochem, Inc. Fluorescent dyes and compounds, methods and kits useful for identifying specific organelles and regions in cells of interest
US20090186097A1 (en) 2005-08-09 2009-07-23 David Lee Ayares Transgenic Ungulates Expressing CTLA4-IG and Uses Thereof
WO2007021881A1 (en) * 2005-08-16 2007-02-22 Synta Pharmaceuticals Corp. Bis(thio-hydrazide amide) formulation
US7417131B2 (en) * 2005-11-04 2008-08-26 Evrogen Joint Stock Company Modified green fluorescent proteins and methods for using same
EP1785434A1 (de) 2005-11-11 2007-05-16 Ludwig-Maximilians-Universität München Zielen und Folgen von Antigenen in lebenden Zellen
WO2008018905A2 (en) * 2006-01-17 2008-02-14 Cellumen, Inc. Method for predicting biological systems responses
GB0606430D0 (en) * 2006-03-31 2006-05-10 Ge Healthcare Uk Ltd Method for cell based assays
WO2007127428A2 (en) * 2006-04-28 2007-11-08 University Of Florida Research Foundation, Inc. Double-stranded/self-complementary vectors with a truncated cba promoter and methods of gene delivery
US8114615B2 (en) 2006-05-17 2012-02-14 Cernostics, Inc. Method for automated tissue analysis
US20080004410A1 (en) * 2006-06-30 2008-01-03 Yu-Chin Lai Hydrophilic macromonomers having alpha,beta-conjugated carboxylic terminal group and medical devices incorporating same
WO2008019123A2 (en) 2006-08-04 2008-02-14 Georgia State University Research Foundation, Inc. Enzyme sensors, methods for preparing and using such sensors, and methods of detecting protease activity
US8609720B2 (en) 2006-08-21 2013-12-17 Synta Pharmaceuticals Corp. Compounds for treating proliferative disorders
US7939564B2 (en) * 2006-08-31 2011-05-10 Synta Pharmaceuticals Corp. Combination with bis(thiohydrazide amides) for treating cancer
WO2008033494A2 (en) * 2006-09-15 2008-03-20 Synta Pharmaceuticals Corp. Purification of bis(thiohydrazide amides)
US20100112602A1 (en) * 2006-11-10 2010-05-06 Taylor Lansing D Protein-Protein Interaction Biosensors and Methods of Use Thereof
GB0624462D0 (en) * 2006-12-07 2007-01-17 Ge Healthcare Ltd Method for determining gentoxicity
CA2673331A1 (en) 2006-12-19 2008-06-26 Ablynx N.V. Amino acid sequences directed against gpcrs and polypeptides comprising the same for the treatment of gpcr-related diseases and disorders
AU2007336243B2 (en) 2006-12-19 2012-07-26 Ablynx N.V. Amino acid sequences directed against a metalloproteinase from the ADAM family and polypeptides comprising the same for the treatment of ADAM-related diseases and disorders
US9394571B2 (en) 2007-04-27 2016-07-19 Pfenex Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
US9580719B2 (en) 2007-04-27 2017-02-28 Pfenex, Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
US8727554B2 (en) 2007-06-25 2014-05-20 Yorktown Technologies, L.P. Aquarium with adjustable lighting
US20090006219A1 (en) * 2007-06-29 2009-01-01 Alan Blake Method for distribution of an aquarium kit
JPWO2009020197A1 (ja) * 2007-08-03 2010-11-04 国立大学法人北海道大学 群青色蛍光タンパク質
ES2606706T3 (es) 2008-01-09 2017-03-27 Ludwig-Maximilians-Universitat München Un ensayo de doble híbrido fluorescente (F2H) para la visualización directa de interacciones de proteínas en células vivas
GB0800938D0 (en) * 2008-01-18 2008-02-27 Ge Healthcare Uk Ltd Multiplex cell signalling assay
AU2009235467A1 (en) 2008-04-07 2009-10-15 Ablynx Nv Single variable domains against the Notch pathways
EP2128259A1 (de) * 2008-05-27 2009-12-02 Koninklijke Philips Electronics N.V. Therapieverabreichung und Überwachung mittels eines Fusionsproteins eines relevanten Reportergens und optischer Bildgebung
US9334281B2 (en) * 2008-09-08 2016-05-10 Enzo Life Sciences, Inc. Fluorochromes for organelle tracing and multi-color imaging
US9250249B2 (en) 2008-09-08 2016-02-02 Enzo Biochem, Inc. Autophagy and phospholipidosis pathway assays
AU2009329501B2 (en) 2008-12-19 2015-11-26 Ablynx N.V. Genetic immunization for producing immunoglobulins against cell-associated antigens such as P2X7, CXCR7 or CXCR4
US8748581B2 (en) 2009-04-10 2014-06-10 Ablynx N.V. Anti-IL-6R polypeptides and pharmaceutical compositions thereof
KR101852204B1 (ko) 2009-06-05 2018-04-26 아블린쓰 엔.브이. 기도 감염의 예방 및/또는 치료를 위한 일가, 이가 및 삼가 항 인간 호흡기 세포융합 바이러스 (ｈｒｓｖ) 나노바디 구조물
EP2275442A1 (de) 2009-07-06 2011-01-19 Ludwig-Maximilians-Universität München Erkennung und Visualisierung des Zellzyklus von lebenden Zellen
WO2011064382A1 (en) 2009-11-30 2011-06-03 Ablynx N.V. Improved amino acid sequences directed against human respiratory syncytial virus (hrsv) and polypeptides comprising the same for the prevention and/or treatment of respiratory tract infections
WO2011083141A2 (en) 2010-01-08 2011-07-14 Ablynx Nv Method for generation of immunoglobulin sequences by using lipoprotein particles
WO2012043826A1 (ja) 2010-10-01 2012-04-05 国立大学法人九州大学 ストラメノパイルの形質転換方法
ES2739623T3 (es) 2011-03-17 2020-02-03 Cernostics Inc Sistemas y composiciones para diagnosticar el esófago de Barrett y métodos para usarlos
EP2737070A1 (de) 2011-07-27 2014-06-04 GBiotech SARL Herstellung eines rekombinanten proteins in insektenzellen mittels eines baculovirenexpressionssystems
EP2685260A1 (de) 2012-07-09 2014-01-15 Ludwig-Maximilians-Universität München Direkte und quantitative Erkennung von Zielen in lebenden Zellen
TW201538518A (zh) 2014-02-28 2015-10-16 Dow Agrosciences Llc 藉由嵌合基因調控元件所賦予之根部特異性表現
NL2013661B1 (en) 2014-10-21 2016-10-05 Ablynx Nv KV1.3 Binding immunoglobulins.
US10690661B2 (en) 2014-07-11 2020-06-23 Northwestern University Yeast-based biosensor
DE102014012130B3 (de) 2014-08-13 2015-03-05 Alfred-Wegener-Institut, Helmholtz-Zentrum für Polar- und Meeresforschung Nachweisverfahren unter Verwendung von rekombinanten lebenden Zellen zum Nachweis von xenobiotischen Stoffen sowie Anordnung und Testkit zur Durchführung des Nachweisverfahrens
US9920102B2 (en) 2015-05-15 2018-03-20 Albert Einstein College Of Medicine, Inc. Fusion tags for protein expression
IL317416A (en) 2016-11-16 2025-02-01 Ablynx Nv T cell-recruiting polypeptides capable of binding CD123 and TCR alpha/beta
EP3420811A1 (de) 2017-06-29 2019-01-02 Paris Sciences et Lettres - Quartier Latin Nicht-menschliches neurofibromatosis typ 1 model
TW202000238A (zh) 2018-02-26 2020-01-01 比利時商艾伯林克斯公司 編碼肽連接子之經改良核苷酸序列
EP3553080A1 (de) 2018-04-12 2019-10-16 ETH Zürich Piezo1-basierter fluoreszenzreporter
US11834698B2 (en) 2018-05-02 2023-12-05 Indian Institute Of Science Education And Research Process for determining enzyme activity in a cell by activity-based reporter gene technology (ABRGT)
US20210238236A1 (en) 2018-06-20 2021-08-05 Dwi-Leibniz-Institut Für Interaktive Materialien E.V. Fusion peptides or proteins, their use, and systems and kits based thereupon, for the separation and/or detection of plastics, particularly of microplastics
GB201904697D0 (en) 2019-04-03 2019-05-15 Vib Vzw Means and methods for single molecule peptide sequencing
EP3962932A4 (de) 2019-05-02 2023-05-10 Board of Regents, The University of Texas System System und verfahren zur erhöhung der stabilität von synthetisierten proteinen
IL297237B2 (en) 2020-04-17 2025-08-01 Regeneron Pharma Detection assays for coronavirus neutralizing antibodies
US12624071B2 (en) 2023-03-30 2026-05-12 Triad National Security, Llc Bright and stable red fluorescent protein

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU694745B2 (en) * 1993-09-10 1998-07-30 Trustees Of Columbia University In The City Of New York, The Uses of green fluorescent protein
US5491084A (en) * 1993-09-10 1996-02-13 The Trustees Of Columbia University In The City Of New York Uses of green-fluorescent protein
US5610031A (en) * 1993-10-27 1997-03-11 The General Hospital Corporation B1k chain of laminin and methods of use
WO1995021191A1 (en) * 1994-02-04 1995-08-10 William Ward Bioluminescent indicator based upon the expression of a gene for a modified green-fluorescent protein
US5625048A (en) * 1994-11-10 1997-04-29 The Regents Of The University Of California Modified green fluorescent proteins
DE69604298T2 (de) 1995-09-22 2000-05-18 Bioimage A/S, Soeborg Varianten des grünen fluoreszenzproteins, gfp
US5804387A (en) 1996-02-01 1998-09-08 The Board Of Trustees Of The Leland Stanford Junior University FACS-optimized mutants of the green fluorescent protein (GFP)
US6124128A (en) 1996-08-16 2000-09-26 The Regents Of The University Of California Long wavelength engineered fluorescent proteins
US6090919A (en) 1997-01-31 2000-07-18 The Board Of Trustees Of The Leland Stanford Junior University FACS-optimized mutants of the green fluorescent protein (GFP)

Also Published As

Publication number Publication date
US6818443B2 (en) 2004-11-16
WO1997011094A1 (en) 1997-03-27
EP0851874A1 (de) 1998-07-08
US20050054050A1 (en) 2005-03-10
JPH11512441A (ja) 1999-10-26
EP0851874B1 (de) 1999-09-15
AU4482996A (en) 1997-04-09
US6172188B1 (en) 2001-01-09
DE69604298T2 (de) 2000-05-18
DE69604298D1 (de) 1999-10-21
US7314915B2 (en) 2008-01-01
CA2232727C (en) 2002-03-26
JP3535177B2 (ja) 2004-06-07
US20020107362A1 (en) 2002-08-08
JP2004024258A (ja) 2004-01-29
CA2232727A1 (en) 1997-03-27
DK0851874T3 (da) 2000-03-06
ES2139329T3 (es) 2000-02-01

Similar Documents

Publication Publication Date Title
DE69604298D1 (de) Varianten des grünen fluoreszenzproteins, gfp
ATE411082T1 (de) Neue verwendung von kurzkettigen carbonsäuren
BR9808491A (pt) Compostos calcilìticos
GR960100438A (el) Νεα παρασιτοκτονα.
MXPA02004666A (es) Gelatinas recombinantes.
TR199900239T2 (de)
EA200300464A1 (ru) ГУМАНИЗИРОВАННОЕ АНТИТЕЛО ПРОТИВ РЕЦЕПТОРА ЛИМФОТОКСИНА-β (ВАРИАНТЫ), КОМПОЗИЦИЯ, СПОСОБ ЛЕЧЕНИЯ ИЛИ СНИЖЕНИЯ РИСКА РАЗВИТИЯ, ТЯЖЕСТИ ИЛИ ПОСЛЕДСТВИЙ НЕОПЛАЗИИ У ЧЕЛОВЕКА, ВЫДЕЛЕННАЯ НУКЛЕИНОВАЯ КИСЛОТА (ВАРИАНТЫ), КЛЕТКА КЛЕТОЧНОЙ ЛИНИИ
CY1112101T1 (el) Νευροτροφικοι παραγοντες
WO2001064835A8 (en) Novel nucleic acids and polypeptides
CY1108567T1 (el) Αντιθρομβωτικες ενωσεις
ES2163638T3 (es) Nuevas n-(1-alquil-5-fenil-2,3,4,5-tetrahidro-1h-benzo(b)(1,5)diacepin-3-il)acetamidas.
DE69919700D1 (de) Überbrückte indenopyrrolocarbazole
BG99177A (bg) Нови 7 бета-заместени-4-аза-5 алфа-холестанони като инхибитори на 5 алфа-редуктаза
ATE435648T1 (de) Derivaten von nodulisporen säure
CY1111567T1 (el) Ενδιαμεσα διβενζο (b,f) αζεπινης
AR004357A1 (es) Compuestos de 1-fenil-2-dimetilaminometil-ciclohexan-1-ol, y procedimiento de preparacion para dichos compuestos.
FI973571A0 (fi) Uusi kasvutekijä ja sitä koodaava geneettinen sekvenssi
BR0206697A (pt) Fio tingido espacialmente
BR9710919A (pt) Proteina purificada sr-p70
TR200402030T4 (tr) İkame edilen I-aminobutan-3-ol-türevleri
DK0942992T3 (da) O-fucosyltransferase
PT1206452E (pt) Processo de preparacao de compostos benzoper-hidroisoindole
TR200003203T2 (tr) Karboksaldehitin saflaştırılması
AU6832498A (en) Substituted benzyl oximino compounds
DE69826029D1 (de) Acetyl-coa-carboxylase von candida albicans

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties