ATE185567T1 - Cephalosporine und ihre homologen, zubereitungen und pharmazeutsiche präparate - Google Patents

Cephalosporine und ihre homologen, zubereitungen und pharmazeutsiche präparate

Info

Publication number
ATE185567T1
ATE185567T1 AT91913583T AT91913583T ATE185567T1 AT E185567 T1 ATE185567 T1 AT E185567T1 AT 91913583 T AT91913583 T AT 91913583T AT 91913583 T AT91913583 T AT 91913583T AT E185567 T1 ATE185567 T1 AT E185567T1
Authority
AT
Austria
Prior art keywords
preparations
cephalosporins
homologues
pharmaceutical
pharmaceutical preparations
Prior art date
Application number
AT91913583T
Other languages
English (en)
Inventor
John Bateson
Park Brockham
George Burton
Stephen Christopher Marti Fell
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909016189A external-priority patent/GB9016189D0/en
Priority claimed from GB919109540A external-priority patent/GB9109540D0/en
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of ATE185567T1 publication Critical patent/ATE185567T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT91913583T 1990-07-24 1991-07-22 Cephalosporine und ihre homologen, zubereitungen und pharmazeutsiche präparate ATE185567T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909016189A GB9016189D0 (en) 1990-07-24 1990-07-24 Novel compounds
GB919109540A GB9109540D0 (en) 1991-05-02 1991-05-02 Novel compounds

Publications (1)

Publication Number Publication Date
ATE185567T1 true ATE185567T1 (de) 1999-10-15

Family

ID=26297372

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91913583T ATE185567T1 (de) 1990-07-24 1991-07-22 Cephalosporine und ihre homologen, zubereitungen und pharmazeutsiche präparate

Country Status (26)

Country Link
EP (2) EP0540609B1 (de)
JP (2) JPH05509089A (de)
KR (1) KR100189075B1 (de)
CN (2) CN1061046C (de)
AP (1) AP832A (de)
AT (1) ATE185567T1 (de)
AU (1) AU648329B2 (de)
CA (2) CA2087967C (de)
CZ (1) CZ6493A3 (de)
DE (2) DE122006000065I2 (de)
DK (1) DK0540609T3 (de)
ES (1) ES2137162T3 (de)
FI (1) FI930270A7 (de)
GR (1) GR3031711T3 (de)
HU (1) HUT63628A (de)
IE (1) IE912569A1 (de)
IL (1) IL98909A0 (de)
LU (1) LU91290I2 (de)
MX (1) MX9100317A (de)
MY (1) MY106399A (de)
NL (1) NL300249I2 (de)
NO (1) NO930226L (de)
NZ (1) NZ239061A (de)
PT (1) PT98426A (de)
WO (2) WO1992001696A1 (de)
YU (1) YU129691A (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
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GB9125645D0 (en) * 1991-12-03 1992-01-29 Smithkline Beecham Plc Novel compounds
US5578591A (en) * 1992-01-22 1996-11-26 Pfizer, Inc. 2-isocephem and oxacephem derivatives, and use as antibacterial agents
GB9212609D0 (en) * 1992-06-13 1992-07-29 Smithkline Beecham Plc Novel compounds
GB9213567D0 (en) * 1992-06-26 1992-08-12 Smithkline Beecham Plc Novel compounds
GB9424847D0 (en) * 1994-12-09 1995-02-08 Smithkline Beecham Plc Novel process
GB2300856A (en) * 1995-05-16 1996-11-20 Pfizer Ltd Beta-lactam preparation
AU4398297A (en) * 1996-10-02 1998-04-24 Daiichi Pharmaceutical Co., Ltd. Method for esterifying carboxylic compounds
FR2776292B1 (fr) 1998-03-20 2004-09-10 Oncopharm Cephalotaxanes porteurs de chaine laterale et leur procede de synthese
GB0019124D0 (en) * 2000-08-03 2000-09-27 Pfizer Novel process
CN1243755C (zh) * 2000-12-04 2006-03-01 辉瑞产品公司 用于制备头孢菌素的偶合方法和中间体
RU2237671C1 (ru) * 2000-12-04 2004-10-10 Пфайзер Продактс Инк. Способ и сложноэфирные производные, используемые для получения цефалоспоринов
US7378408B2 (en) * 2001-11-30 2008-05-27 Pfizer Inc. Methods of treatment and formulations of cephalosporin
KR100710555B1 (ko) 2001-12-04 2007-04-24 에스케이 주식회사 광학적으로 순수한 (ｒ)-폼 또는 (ｓ)-폼의테트라히드로퓨라닐 케톤의 제조방법
SG10201610936RA (en) 2011-12-22 2017-02-27 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
HUE029038T2 (en) 2012-05-25 2017-01-30 Janssen Sciences Ireland Uc Uracil spirooxetan nucleosides
GEP201706757B (en) 2012-12-21 2017-10-25 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
CN105254648B (zh) * 2015-11-13 2018-04-03 广东温氏大华农生物科技有限公司 一种头孢维星及其钠盐的合成方法
GB2575261B (en) 2018-07-02 2022-03-09 Norbrook Lab Ltd Intermediates in the synthesis of C3-substituted cephalosporins
BR112021003156A2 (pt) 2018-08-23 2021-05-11 Seagen, Inc. composição, anticorpo que se liga ao tigit humano, formulação farmacêutica, polinucleotídeo isolado, vetor, célula hospedeira, métodos para a produção de um anticorpo que se liga ao tigit humano e de anticorpos afucosilados que se ligam a tigit e para o tratamento de um câncer, e, kit.
MX2022006865A (es) 2019-12-06 2022-07-11 Vertex Pharma Tetrahidrofuranos sustituidos como moduladores de canales de sodio.
TWI794742B (zh) 2020-02-18 2023-03-01 美商基利科學股份有限公司 抗病毒化合物
AU2021224588B2 (en) 2020-02-18 2024-07-18 Gilead Sciences, Inc. Antiviral compounds
TWI874791B (zh) 2020-02-18 2025-03-01 美商基利科學股份有限公司 抗病毒化合物
CN111620893B (zh) * 2020-06-08 2021-12-14 重庆医药高等专科学校 C-3位四氢呋喃取代的头孢菌素-铁载体耦合物及其制备方法和应用
JP7688152B2 (ja) 2021-04-16 2025-06-03 ギリアード サイエンシーズ， インコーポレイテッド アミドを使用してカルバヌクレオシドを調製する方法
CN117794920A (zh) 2021-06-04 2024-03-29 沃泰克斯药物股份有限公司 N-(羟烷基(杂)芳基)四氢呋喃甲酰胺作为钠通道调节剂
JP7719954B2 (ja) 2021-08-18 2025-08-06 ギリアード サイエンシーズ， インコーポレイテッド リン脂質化合物並びにその製造方法及び使用方法
CN121181573B (zh) * 2025-11-24 2026-02-27 重庆汉佩生物科技有限公司 一种含c-3位四氢呋喃头孢菌素衍生物和应用
CN121181574B (zh) * 2025-11-24 2026-02-24 重庆汉佩生物科技有限公司 一种头孢维星衍生物和应用以及制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2197573A1 (en) * 1972-09-07 1974-03-29 Roussel Uclaf 7-substd-phenylacetamido-cephalosporin derivs - - antibiotics active against streptococci and staphylococci
BE793448A (fr) * 1971-12-31 1973-06-28 Roussel Uclaf Procede de preparation de nouveaux derives des cephalosporines et produits obtenus
BE791161A (fr) * 1972-01-03 1973-05-09 Beecham Group Ltd Procede pour la preparation d'analogues des cephalosporines
BE791160A (fr) * 1972-01-03 1973-05-09 Beecham Group Ltd Nouveaux cephemes substitues
NL7305936A (de) * 1972-05-05 1973-11-07
JPS5849382A (ja) * 1981-09-18 1983-03-23 Kyowa Hakko Kogyo Co Ltd β−ラクタム化合物
GB8821797D0 (en) * 1988-09-16 1988-10-19 Beecham Group Plc Novel compounds
ES2121745T3 (es) * 1989-03-30 1998-12-16 Pfizer Cefalosporinas y sus homologos, procedimiento para su preparacion y composiciones farmaceuticas.

Also Published As

Publication number Publication date
NZ239061A (en) 1993-11-25
CA2359744A1 (en) 1992-02-06
KR100189075B1 (ko) 1999-06-01
KR930701456A (ko) 1993-06-11
AP9100305A0 (en) 1991-07-31
JPH05509305A (ja) 1993-12-22
DE69131714T2 (de) 2000-02-24
CN1223859A (zh) 1999-07-28
NO930226D0 (no) 1993-01-22
EP0540609B1 (de) 1999-10-13
AP832A (en) 2000-05-03
FI930270A0 (fi) 1993-01-22
JPH05509089A (ja) 1993-12-16
GR3031711T3 (en) 2000-02-29
HUT63628A (en) 1993-09-28
WO1992001696A1 (en) 1992-02-06
MX9100317A (es) 1992-02-28
AU8222491A (en) 1992-02-18
EP0540606A1 (de) 1993-05-12
EP0540609A1 (de) 1993-05-12
NL300249I1 (nl) 2007-02-01
JP2851428B2 (ja) 1999-01-27
ES2137162T3 (es) 1999-12-16
IE912569A1 (en) 1992-01-29
LU91290I2 (fr) 2007-01-22
NO930226L (no) 1993-03-23
AU648329B2 (en) 1994-04-21
YU129691A (sh) 1994-01-20
CN1111410C (zh) 2003-06-18
DK0540609T3 (da) 1999-12-27
IL98909A0 (en) 1992-07-15
CA2087967A1 (en) 1992-01-25
DE122006000065I1 (de) 2007-03-01
DE69131714D1 (de) 1999-11-18
HU9300177D0 (en) 1993-04-28
MY106399A (en) 1995-05-30
WO1992001695A1 (en) 1992-02-06
PT98426A (pt) 1992-05-29
FI930270L (fi) 1993-03-22
DE122006000065I2 (de) 2007-09-13
FI930270A7 (fi) 1993-03-22
CZ6493A3 (en) 1994-04-13
NL300249I2 (en) 2007-02-01
CN1060469A (zh) 1992-04-22
CA2087967C (en) 2002-09-10
CA2359744C (en) 2007-02-13
CN1061046C (zh) 2001-01-24

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