ATE186537T1 - Antibakterielle penem-ester derivate - Google Patents

Antibakterielle penem-ester derivate

Info

Publication number
ATE186537T1
ATE186537T1 AT91914603T AT91914603T ATE186537T1 AT E186537 T1 ATE186537 T1 AT E186537T1 AT 91914603 T AT91914603 T AT 91914603T AT 91914603 T AT91914603 T AT 91914603T AT E186537 T1 ATE186537 T1 AT E186537T1
Authority
AT
Austria
Prior art keywords
pct
ester derivatives
group
sec
aryl
Prior art date
Application number
AT91914603T
Other languages
English (en)
Inventor
Hiromitsu Iwata
Takashi Nakatsuka
Rie Tanaka
Masaji Ishiguro
Original Assignee
Suntory Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suntory Ltd filed Critical Suntory Ltd
Application granted granted Critical
Publication of ATE186537T1 publication Critical patent/ATE186537T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/86—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
  • Pens And Brushes (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT91914603T 1990-08-20 1991-08-16 Antibakterielle penem-ester derivate ATE186537T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP21854390 1990-08-20

Publications (1)

Publication Number Publication Date
ATE186537T1 true ATE186537T1 (de) 1999-11-15

Family

ID=16721580

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91914603T ATE186537T1 (de) 1990-08-20 1991-08-16 Antibakterielle penem-ester derivate

Country Status (12)

Country Link
US (1) US5703068A (de)
EP (1) EP0544906B1 (de)
JP (1) JP3148236B2 (de)
KR (1) KR0178957B1 (de)
AT (1) ATE186537T1 (de)
AU (1) AU8333991A (de)
CA (1) CA2089366C (de)
DE (1) DE69131774T2 (de)
ES (1) ES2140393T3 (de)
IE (1) IE912909A1 (de)
IL (2) IL99244A0 (de)
WO (1) WO1992003444A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6271222B1 (en) * 1998-05-28 2001-08-07 Merck & Co., Inc. Penem antibacterial compounds, compositions and methods of treatment
WO2004031196A1 (ja) * 2002-10-02 2004-04-15 Nippon Soda Co., Ltd. 有機化合物の製造方法
EP1636240A1 (de) * 2003-06-05 2006-03-22 Pfizer Products Inc. Beta-lactamasehemmer prodrug
PE20080940A1 (es) 2006-06-28 2008-07-09 Pfizer Prod Inc Profarmacos de penem
US20110118229A1 (en) * 2007-11-23 2011-05-19 Kukje Pharm. Ind. Co., Ltd. 2-arylmethylazetidine-carbapenem-3-carboxylic acid ester derivative or its salt, process for the preparation thereof and pharmaceutical composition comprising the same
US20190100534A1 (en) * 2017-10-04 2019-04-04 Gladius Pharmaceuticals, Inc. Cephem Compounds with Latent Reactive Groups

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6019908B2 (ja) * 1980-04-30 1985-05-18 カネボウ株式会社 １，３−ジオキソレン−２−オン誘導体
US4479947A (en) * 1981-07-13 1984-10-30 Merck & Co., Inc. Oral absorption enhancement of carboxylic acid pharmaceuticals using (5-alkyl-2-oxo-1,3-dioxolen-4-yl)methyl ester group
US4654331A (en) * 1981-07-13 1987-03-31 Merck & Co., Inc. Oral absorption enhancement of carboxylic acid pharmaceuticals using (5-alkyl-2-oxo-1,3-dioxolen-4-yl)methyl ester group
JPS58159496A (ja) * 1983-03-02 1983-09-21 Kyoto Yakuhin Kogyo Kk セフエム系化合物
JPH075463B2 (ja) * 1985-03-09 1995-01-25 サントリー株式会社 抗菌剤
EP0252885A1 (de) * 1986-07-10 1988-01-13 Ciba-Geigy Ag Bicyclische Thiaazaverbindungen
JP2526046B2 (ja) * 1986-12-26 1996-08-21 サントリー株式会社 ペネム誘導体、その製造法およびその用途
EP0275002A1 (de) * 1987-01-09 1988-07-20 Hoechst Aktiengesellschaft Verfahren zur Herstellung von 7-Oxo-4-thia-1-aza-bicyclo[3.2.0]-hept-2-en-Derivaten
GB8713515D0 (en) * 1987-06-10 1987-07-15 Erba Farmitalia Methoxymethyl compounds
GB2220203B (en) * 1988-07-04 1991-09-11 Erba Carlo Spa Process for penems
DE3839987A1 (de) * 1988-11-26 1990-05-31 Hoechst Ag Penemderivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
KR0178957B1 (ko) 1999-03-20
CA2089366A1 (en) 1992-02-21
AU8333991A (en) 1992-03-17
IL99244A0 (en) 1992-07-15
WO1992003444A1 (en) 1992-03-05
US5703068A (en) 1997-12-30
EP0544906B1 (de) 1999-11-10
JP3148236B2 (ja) 2001-03-19
KR930701454A (ko) 1993-06-11
JPH06503805A (ja) 1994-04-28
IE912909A1 (en) 1992-02-26
EP0544906A1 (de) 1993-06-09
DE69131774T2 (de) 2000-06-21
ES2140393T3 (es) 2000-03-01
CA2089366C (en) 2001-10-16
DE69131774D1 (de) 1999-12-16
IL99244A (en) 1996-11-14

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties