ATE187716T1 - Acridonderivate von diinterkalatoren als chemotherapeutische wirkstoffe - Google Patents

Acridonderivate von diinterkalatoren als chemotherapeutische wirkstoffe

Info

Publication number: ATE187716T1
Authority: AT; Austria
Prior art keywords: double; diintercalators; chemotherapeutic agents; bond; acridone derivatives
Prior art date: 1994-03-14

Application number

AT95912887T

Other languages

English (en)

Inventor

Christopher J Michejda

Wieslaw M Cholody

Lidia Hernandez

Original Assignee

Us Health

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-03-14

Filing date

1995-03-09

Publication date

2000-01-15

1995-03-09 Application filed by Us Health filed Critical Us Health

2000-01-15 Application granted granted Critical

2000-01-15 Publication of ATE187716T1 publication Critical patent/ATE187716T1/de

Links

FZEYVTFCMJSGMP-UHFFFAOYSA-N acridone Chemical class C1=CC=C2C(=O)C3=CC=CC=C3NC2=C1 FZEYVTFCMJSGMP-UHFFFAOYSA-N 0.000 title 1
239000002246 antineoplastic agent Substances 0.000 title 1
229940127089 cytotoxic agent Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
230000001093 anti-cancer Effects 0.000 abstract 1
239000003937 drug carrier Substances 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0026—Acridine dyes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/08—Nitrogen atoms

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Oncology (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Investigating Or Analysing Biological Materials (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Saccharide Compounds (AREA)

AT95912887T 1994-03-14 1995-03-09 Acridonderivate von diinterkalatoren als chemotherapeutische wirkstoffe ATE187716T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/213,315 US5508289A (en)	1994-03-14	1994-03-14	Bis-acridone chemotherapeutic derivatives
PCT/US1995/003079 WO1995025093A1 (en)	1994-03-14	1995-03-09	Acridone-derived bisintercalators as chemotherapeutic agents

Publications (1)

Publication Number	Publication Date
ATE187716T1 true ATE187716T1 (de)	2000-01-15

Family

ID=22794610

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95912887T ATE187716T1 (de)	1994-03-14	1995-03-09	Acridonderivate von diinterkalatoren als chemotherapeutische wirkstoffe

Country Status (12)

Country	Link
US (1)	US5508289A (de)
EP (1)	EP0750612B1 (de)
JP (1)	JP3862747B2 (de)
AT (1)	ATE187716T1 (de)
AU (1)	AU684624B2 (de)
CA (1)	CA2185350C (de)
DE (1)	DE69513962T2 (de)
DK (1)	DK0750612T3 (de)
ES (1)	ES2140668T3 (de)
FI (1)	FI113369B (de)
GR (1)	GR3032836T3 (de)
WO (1)	WO1995025093A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE211471T1 (de)	1996-04-12	2002-01-15	Us Gov Health & Human Serv	Acridonderivate als antineoplastische-und antiretrovirale mittel
AU7221398A (en)	1997-04-29	1998-11-24	Nycomed Imaging As	Method of demarcating tissue
IT1293525B1 (it) *	1997-08-01	1999-03-01	Uni Degli Studi Camerino	Bis-acridincarbossiammidi aventi attivita' antitumorale
EP1085846A2 (de) *	1998-06-08	2001-03-28	Advanced Medicine, Inc.	Mehrfachbindende inhibitoren des microsomalen triglyceridtransferase-proteins
JP5408829B2 (ja)	1999-12-28	2014-02-05	ゲットナー・ファンデーション・エルエルシー	アクティブマトリックス基板の製造方法
ATE556075T1 (de) *	2001-01-31	2012-05-15	Meiji Seika Pharma Co Ltd	Triazoquinolone-derivate als pestizide
GB0208989D0 (en)	2002-04-19	2002-05-29	Amersham Biosciences Uk Ltd	Methods for measuring enzyme activity
FR2879598B1 (fr) *	2004-12-17	2007-03-30	Sod Conseils Rech Applic	Inhibiteurs de phosphatases cdc25
EP3070078B1 (de) *	2015-03-20	2017-10-04	Politechnika Gdanska	Unsymmetrische bisacridine und ihre verwendung zur behandlung von tumoren

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4626540A (en) *	1983-11-08	1986-12-02	Warner-Lambert Company	Substituted 1-amino-4-nitro-acridinones and methods of treating bacterial infections and leukemia with them
IL91673A0 (en) *	1988-09-20	1990-04-29	Us Health	Method for tagging an oligodeoxynucleotide
GB9104548D0 (en) *	1991-03-05	1991-04-17	Cholody Wienlaw M	Antineoplastic modified imidazoacridines

1994
- 1994-03-14 US US08/213,315 patent/US5508289A/en not_active Expired - Lifetime
1995
- 1995-03-09 ES ES95912887T patent/ES2140668T3/es not_active Expired - Lifetime
- 1995-03-09 JP JP52411295A patent/JP3862747B2/ja not_active Expired - Fee Related
- 1995-03-09 DK DK95912887T patent/DK0750612T3/da active
- 1995-03-09 DE DE69513962T patent/DE69513962T2/de not_active Expired - Fee Related
- 1995-03-09 AU AU19900/95A patent/AU684624B2/en not_active Ceased
- 1995-03-09 AT AT95912887T patent/ATE187716T1/de not_active IP Right Cessation
- 1995-03-09 WO PCT/US1995/003079 patent/WO1995025093A1/en not_active Ceased
- 1995-03-09 EP EP95912887A patent/EP0750612B1/de not_active Expired - Lifetime
- 1995-03-09 CA CA002185350A patent/CA2185350C/en not_active Expired - Fee Related
1996
- 1996-09-13 FI FI963626A patent/FI113369B/fi active
2000
- 2000-02-29 GR GR20000400528T patent/GR3032836T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
FI963626A0 (fi)	1996-09-13
WO1995025093A1 (en)	1995-09-21
ES2140668T3 (es)	2000-03-01
EP0750612A1 (de)	1997-01-02
FI963626A7 (fi)	1996-11-08
FI113369B (fi)	2004-04-15
CA2185350A1 (en)	1995-09-21
JP3862747B2 (ja)	2006-12-27
DE69513962T2 (de)	2000-06-21
US5508289A (en)	1996-04-16
JPH09510451A (ja)	1997-10-21
DK0750612T3 (da)	2000-05-01
AU1990095A (en)	1995-10-03
GR3032836T3 (en)	2000-07-31
EP0750612B1 (de)	1999-12-15
AU684624B2 (en)	1997-12-18
DE69513962D1 (de)	2000-01-20
CA2185350C (en)	2006-01-03

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Legal Events

Date	Code	Title	Description
2000-11-15	UEP	Publication of translation of european patent specification
2009-12-15	REN	Ceased due to non-payment of the annual fee