ATE187720T1 - Diosmetin derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammenstellungen - Google Patents

Diosmetin derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammenstellungen

Info

Publication number: ATE187720T1
Authority: AT; Austria
Prior art keywords: allyl; propyl; production; pharmaceutical compositions; compositions containing
Prior art date: 1994-10-26

Application number

AT95402374T

Other languages

English (en)

Inventor

Michel Wierzbicki

Marie-Francoise Boussard

Tony Verbeuren

Marie-Odile Vallez

Emmanuel Canet

Yves Rolland

Original Assignee

Adir

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-10-26

Filing date

1995-10-25

Publication date

2000-01-15

1995-10-25 Application filed by Adir filed Critical Adir

2000-01-15 Application granted granted Critical

2000-01-15 Publication of ATE187720T1 publication Critical patent/ATE187720T1/de

Links

MBNGWHIJMBWFHU-UHFFFAOYSA-N diosmetin Chemical class C1=C(O)C(OC)=CC=C1C1=CC(=O)C2=C(O)C=C(O)C=C2O1 MBNGWHIJMBWFHU-UHFFFAOYSA-N 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
-1 2,3-dihydroxypropyl Chemical group 0.000 abstract 7
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 6
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 6
125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 abstract 3
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
QAGGICSUEVNSGH-UHFFFAOYSA-N Diosmetin Natural products C1=C(O)C(OC)=CC=C1C1=CC(=O)C2=CC=C(O)C=C2O1 QAGGICSUEVNSGH-UHFFFAOYSA-N 0.000 abstract 1
101100295741 Gallus gallus COR4 gene Proteins 0.000 abstract 1
101100134925 Gallus gallus COR6 gene Proteins 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
229960001876 diosmetin Drugs 0.000 abstract 1
235000015428 diosmetin Nutrition 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
- C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Biotechnology (AREA)
Cardiology (AREA)
Biochemistry (AREA)
Heart & Thoracic Surgery (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pyrane Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Peptides Or Proteins (AREA)

AT95402374T 1994-10-26 1995-10-25 Diosmetin derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammenstellungen ATE187720T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9412783A FR2726273B1 (fr)	1994-10-26	1994-10-26	Nouveaux derives de la diosmetine, leur procede de preparation et les compositions pharmaceutiques les contenant

Publications (1)

Publication Number	Publication Date
ATE187720T1 true ATE187720T1 (de)	2000-01-15

Family

ID=9468215

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95402374T ATE187720T1 (de)	1994-10-26	1995-10-25	Diosmetin derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammenstellungen

Country Status (17)

Country	Link
US (1)	US5629339A (de)
EP (1)	EP0709383B1 (de)
JP (1)	JP3076231B2 (de)
CN (1)	CN1058494C (de)
AT (1)	ATE187720T1 (de)
AU (1)	AU693599B2 (de)
CA (1)	CA2161297C (de)
CY (1)	CY2173B1 (de)
DE (1)	DE69513935T2 (de)
DK (1)	DK0709383T3 (de)
ES (1)	ES2145234T3 (de)
FI (1)	FI118766B (de)
FR (1)	FR2726273B1 (de)
GR (1)	GR3032168T3 (de)
NO (1)	NO311132B1 (de)
NZ (1)	NZ280330A (de)
ZA (1)	ZA959076B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2748025B1 (fr) *	1996-04-25	1998-10-30	Adir	Nouveaux acides et esters de la diosmetine, et les compositions pharmaceutiques les contenant
FR2778663B1 (fr)	1998-05-15	2001-05-18	Coletica	Nouveaux esters de flavonoides,leur utilisation en cosmetique, dermopharmacie, en pharmacie et en agro-alimentaire
JP2001122791A (ja) *	1999-10-20	2001-05-08	Boehringer Ingelheim Internatl Gmbh	下肢の慢性静脈不全の軽減および予防のための赤色ブドウ樹葉の水性抽出物よりなる食事補強剤
EP1127572A3 (de) *	2000-02-25	2003-05-02	Basf Aktiengesellschaft	Verwendung von Flavonen zur Behandlung von Cyclooxygenase-2 ermittelten Krankheiten
US20040151769A1 (en) *	2002-12-31	2004-08-05	Boehringer Ingelheim International Gmbh	Film coated tablet containing an extract of red vine leaves
US20040151794A1 (en) *	2002-12-31	2004-08-05	Boehringer Ingelheim International Gmbh	Method of improvement of blood circulation
EP1550450A1 (de) *	2003-12-29	2005-07-06	Boehringer Ingelheim International GmbH	Behandlung von chronischer venöser Insuffizienz mit einem Extrakt aus Blättern von roten Weinreben und einem Blutumlauf verbesserndes Mittel
RU2367464C2 (ru) *	2004-02-19	2009-09-20	Берингер Ингельхайм Интернациональ Гмбх	Состав для лечения хронических венозных недостаточностей, содержащий водный экстракт листьев красного винограда и противовоспалительное средство
FR2882654B1 (fr) *	2005-03-01	2007-04-27	Servier Lab	Utilisation de derives de la diosmetine pour le traitement et la prevention des pathologies thrombotiques
FR2929276B1 (fr) *	2008-04-01	2010-04-23	Servier Lab	Nouveaux derives de diosmetine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CA3017366A1 (en) *	2016-03-11	2017-09-14	H. Lee Moffitt Cancer Center And Research Institute, Inc.	Icariin and icaritin derivatives
CN109280067B (zh) *	2017-07-21	2022-07-05	南京正大天晴制药有限公司	香叶木苷衍生物、其制备方法以及医药用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB928150A (en) *	1961-02-08	1963-06-06	Upjohn Co	Topical pharmaceutical compositions comprising steroids and flavonoids
CH644374A5 (en) *	1981-05-18	1984-07-31	Espanola Prod Quimicos	Water-soluble hydroxyflavone ethers and medicaments containing them
FR2623808B1 (fr)	1987-12-01	1990-03-09	Adir	Nouveaux derives flavonoides (benzyl-4 piperazinyl-1)-2 oxo-2 ethylene substitues, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2701261B1 (fr) *	1993-02-05	1995-03-31	Adir	Nouveaux composés glucuronides de la diosmétine, leur procédé de préparation et les compositions pharmaceutiques les renfermant.

1994
- 1994-10-26 FR FR9412783A patent/FR2726273B1/fr not_active Expired - Fee Related
1995
- 1995-10-19 NO NO19954173A patent/NO311132B1/no not_active IP Right Cessation
- 1995-10-23 AU AU34404/95A patent/AU693599B2/en not_active Ceased
- 1995-10-24 CA CA002161297A patent/CA2161297C/fr not_active Expired - Fee Related
- 1995-10-24 US US08/547,650 patent/US5629339A/en not_active Expired - Lifetime
- 1995-10-24 JP JP07275292A patent/JP3076231B2/ja not_active Expired - Fee Related
- 1995-10-25 AT AT95402374T patent/ATE187720T1/de active
- 1995-10-25 EP EP95402374A patent/EP0709383B1/de not_active Expired - Lifetime
- 1995-10-25 DE DE69513935T patent/DE69513935T2/de not_active Expired - Lifetime
- 1995-10-25 CN CN95117660A patent/CN1058494C/zh not_active Expired - Fee Related
- 1995-10-25 FI FI955085A patent/FI118766B/fi not_active IP Right Cessation
- 1995-10-25 DK DK95402374T patent/DK0709383T3/da active
- 1995-10-25 ES ES95402374T patent/ES2145234T3/es not_active Expired - Lifetime
- 1995-10-25 NZ NZ280330A patent/NZ280330A/en not_active IP Right Cessation
- 1995-10-26 ZA ZA959076A patent/ZA959076B/xx unknown
1999
- 1999-12-17 GR GR990403253T patent/GR3032168T3/el unknown
2000
- 2000-05-30 CY CY0000020A patent/CY2173B1/xx unknown

Also Published As

Publication number	Publication date
US5629339A (en)	1997-05-13
FR2726273B1 (fr)	1996-12-06
NZ280330A (en)	1996-12-20
ES2145234T3 (es)	2000-07-01
GR3032168T3 (en)	2000-04-27
DK0709383T3 (da)	2000-04-25
NO954173L (no)	1996-04-29
ZA959076B (en)	1996-05-22
FR2726273A1 (fr)	1996-05-03
AU693599B2 (en)	1998-07-02
JPH08225563A (ja)	1996-09-03
CA2161297A1 (fr)	1996-04-27
EP0709383A1 (de)	1996-05-01
CA2161297C (fr)	2001-10-09
AU3440495A (en)	1996-05-09
CY2173B1 (en)	2002-08-23
CN1129701A (zh)	1996-08-28
EP0709383B1 (de)	1999-12-15
CN1058494C (zh)	2000-11-15
NO954173D0 (no)	1995-10-19
DE69513935T2 (de)	2000-07-20
NO311132B1 (no)	2001-10-15
DE69513935D1 (de)	2000-01-20
FI118766B (fi)	2008-03-14
FI955085L (fi)	1996-04-27
JP3076231B2 (ja)	2000-08-14
FI955085A0 (fi)	1995-10-25

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Legal Events

Date	Code	Title	Description
2000-07-15	UEP	Publication of translation of european patent specification