ATE187981T1 - Enzym und dessen verwendung zur herstellung von (s)-pipecolinsäure - Google Patents

Enzym und dessen verwendung zur herstellung von (s)-pipecolinsäure

Info

Publication number
ATE187981T1
ATE187981T1 AT94929606T AT94929606T ATE187981T1 AT E187981 T1 ATE187981 T1 AT E187981T1 AT 94929606 T AT94929606 T AT 94929606T AT 94929606 T AT94929606 T AT 94929606T AT E187981 T1 ATE187981 T1 AT E187981T1
Authority
AT
Austria
Prior art keywords
enzyme
pct
pipecolic acid
date apr
producing
Prior art date
Application number
AT94929606T
Other languages
English (en)
Inventor
Richard Anthony Station Wisdom
Caroline Susan Mill Lane Lee
Paul Maurice Ricaud
Original Assignee
Darwin Discovery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Darwin Discovery Ltd filed Critical Darwin Discovery Ltd
Application granted granted Critical
Publication of ATE187981T1 publication Critical patent/ATE187981T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • C12N1/205Bacterial isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/78Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10Nitrogen as only ring hetero atom
    • C12P17/12Nitrogen as only ring hetero atom containing a six-membered hetero ring
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • C12P41/007Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving acyl derivatives of racemic amines
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/05Alcaligenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT94929606T 1993-10-15 1994-10-14 Enzym und dessen verwendung zur herstellung von (s)-pipecolinsäure ATE187981T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939321325A GB9321325D0 (en) 1993-10-15 1993-10-15 Microorganism and its use
PCT/GB1994/002259 WO1995010604A1 (en) 1993-10-15 1994-10-14 Enzyme and its use in preparing (s)-pipecolic acid

Publications (1)

Publication Number Publication Date
ATE187981T1 true ATE187981T1 (de) 2000-01-15

Family

ID=10743624

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94929606T ATE187981T1 (de) 1993-10-15 1994-10-14 Enzym und dessen verwendung zur herstellung von (s)-pipecolinsäure

Country Status (10)

Country Link
US (1) US5733754A (de)
EP (1) EP0723586B1 (de)
JP (1) JP3512806B2 (de)
AT (1) ATE187981T1 (de)
AU (1) AU682221B2 (de)
CA (1) CA2172954C (de)
DE (1) DE69422298T2 (de)
ES (1) ES2141258T3 (de)
GB (1) GB9321325D0 (de)
WO (1) WO1995010604A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6156900A (en) * 1994-10-07 2000-12-05 Darwin Discovery Limited Racemization of precursors to levobupivacaine and analogues thereof
WO1999007873A1 (de) * 1997-08-11 1999-02-18 Lonza Ag VERFAHREN ZUR HERSTELLUNG ENANTIOMERENREINER CYCLISCHER α-AMINOSÄUREN BZW. DEREN N-GESCHÜTZTER DERIVATE MITTELS EINER D-SPEZIFISCHEN AMINOACYLASE
DE19735198A1 (de) * 1997-08-14 1999-02-18 Bayer Ag Verfahren zur Racematspaltung von cis- und trans-Pyrrolopiperidin
FR2825717B1 (fr) 2001-06-08 2005-02-18 Rhodia Chimie Sa Preparation stereoselective de l-acides amines cycliques

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63248393A (ja) * 1987-04-02 1988-10-14 Agency Of Ind Science & Technol 微生物によるd−ピペコリン酸の製造法
US5219741A (en) * 1989-09-06 1993-06-15 Degussa Ag Method of making L-proline using an N-acyl-L-protine acylase
DE3929570A1 (de) * 1989-09-06 1991-03-07 Degussa Mikrobiologisch hergestellte n-acyl-l-prolin-acylase, verfahren zu ihrer gewinnung und ihre verwendung

Also Published As

Publication number Publication date
CA2172954A1 (en) 1995-04-20
JPH09503669A (ja) 1997-04-15
GB9321325D0 (en) 1993-12-08
EP0723586A1 (de) 1996-07-31
ES2141258T3 (es) 2000-03-16
WO1995010604A1 (en) 1995-04-20
DE69422298T2 (de) 2000-04-20
US5733754A (en) 1998-03-31
JP3512806B2 (ja) 2004-03-31
DE69422298D1 (de) 2000-01-27
AU7860194A (en) 1995-05-04
EP0723586B1 (de) 1999-12-22
AU682221B2 (en) 1997-09-25
CA2172954C (en) 2008-12-09

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