ATE188212T1 - 2-pyrazinylethylamin-derivate und ihre verwendung als arzneimittel. - Google Patents

2-pyrazinylethylamin-derivate und ihre verwendung als arzneimittel.

Info

Publication number: ATE188212T1
Authority: AT; Austria
Prior art keywords: alkyl; independently represent; derivatives; nr8r9; alkynyl
Prior art date: 1991-10-30

Application number

AT92922179T

Other languages

English (en)

Inventor

Ronald Conrad Griffith

Robert John Murray

Richard John Schmiesing

Original Assignee

Astra Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-10-30

Filing date

1992-10-28

Publication date

2000-01-15

1992-10-28 Application filed by Astra Ab filed Critical Astra Ab

2000-01-15 Application granted granted Critical

2000-01-15 Publication of ATE188212T1 publication Critical patent/ATE188212T1/de

Links

WJNJQSDKFXGALV-UHFFFAOYSA-N 2-pyrazin-2-ylethanamine Chemical class NCCC1=CN=CC=N1 WJNJQSDKFXGALV-UHFFFAOYSA-N 0.000 title 1
229940126601 medicinal product Drugs 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 6
229910052799 carbon Inorganic materials 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 4
125000003342 alkenyl group Chemical group 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000000304 alkynyl group Chemical group 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
229910052717 sulfur Inorganic materials 0.000 abstract 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
208000012902 Nervous system disease Diseases 0.000 abstract 1
208000025966 Neurological disease Diseases 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 abstract 1
125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/08—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/16—Halogen atoms; Nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Addiction (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Pyridine Compounds (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT92922179T 1991-10-30 1992-10-28 2-pyrazinylethylamin-derivate und ihre verwendung als arzneimittel. ATE188212T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US78559091A	1991-10-30	1991-10-30
PCT/GB1992/001971 WO1993009095A1 (en)	1991-10-30	1992-10-28	2-heterocyclicethylamine derivatives and their use as pharmaceuticals

Publications (1)

Publication Number	Publication Date
ATE188212T1 true ATE188212T1 (de)	2000-01-15

Family

ID=25135977

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92922179T ATE188212T1 (de)	1991-10-30	1992-10-28	2-pyrazinylethylamin-derivate und ihre verwendung als arzneimittel.

Country Status (20)

Country	Link
US (1)	US5607935A (de)
EP (2)	EP0540318A1 (de)
JP (1)	JP3208141B2 (de)
AT (1)	ATE188212T1 (de)
AU (2)	AU667490B2 (de)
CA (1)	CA2122633C (de)
DE (1)	DE69230498T2 (de)
DK (1)	DK0612314T3 (de)
ES (1)	ES2142320T3 (de)
FI (1)	FI105475B (de)
GR (1)	GR3032993T3 (de)
HU (1)	HU211948A9 (de)
IL (1)	IL103595A (de)
MX (1)	MX9206296A (de)
NO (1)	NO300174B1 (de)
NZ (1)	NZ244929A (de)
PT (1)	PT612314E (de)
SG (1)	SG47949A1 (de)
WO (1)	WO1993009095A1 (de)
ZA (1)	ZA928414B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9806739D0 (en) *	1998-03-28	1998-05-27	Univ Newcastle Ventures Ltd	Cyclin dependent kinase inhibitors
SE9901340D0 (sv) *	1999-04-15	1999-04-15	Astra Pharma Prod	Novel process
EP1757290A1 (de)	2005-08-16	2007-02-28	Zentaris GmbH	Triazolderivate als Liganden der Wachstumshormonrezeptoren
PE20120249A1 (es)	2008-12-24	2012-04-19	Astrazeneca Ab	Compuestos etanaminicos
EP2431035A1 (de)	2010-09-16	2012-03-21	Æterna Zentaris GmbH	Neue Triazolderivate mit verbesserter Rezeptoraktivität und Bioverfügbarkeitseigenschaften als Ghrelin-Antagonisten der Wachstumshormon-Sekretagogum-Rezeptoren
EP2822931B1 (de)	2012-03-09	2017-05-03	Inception 2, Inc.	Triazolonverbindungen und verwendungen davon
SG11201504622PA (en)	2012-12-20	2015-07-30	Inception 2 Inc	Triazolone compounds and uses thereof
CN105579440A (zh)	2013-09-06	2016-05-11	因森普深2公司	三唑酮化合物及其应用
RS58991B1 (sr)	2013-11-05	2019-08-30	Astrazeneca Ab	Prolekovi nmda antagonista
US11358935B2 (en)	2016-11-28	2022-06-14	Biohaven Pharmaceutical Holding Company Ltd.	Prodrugs of lanicemine and their method of use

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2447258A1 (de) *	1974-10-03	1976-04-08	Bayer Ag	Pyridylalkylamidine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
IE56001B1 (en) *	1982-09-30	1991-03-13	Boots Co Plc	1-arylcyclobutylmethylamine compounds
FR2558160B1 (fr) *	1984-01-18	1986-05-30	Cerm Cent Europ Rech Mauvernay	3-alkoxy 2-(n-pyrrolidino)-n-pyrimidinyl ou -pyrazinyl propylamines, leur preparation et leur application en therapeutique
DE3640247A1 (de) *	1986-11-25	1988-05-26	Basf Ag	Fungizide cyclohexylamine
US4769466A (en) *	1987-02-06	1988-09-06	Pennwalt Corporation	2-aminoacetamide pyridinyl derivatives
EP0346791B1 (de) *	1988-06-14	1994-04-06	G.D. Searle & Co.	1,2-Diarylethylamine zur Behandlung neurotoxischer Verletzungen
ATE135206T1 (de) *	1988-08-12	1996-03-15	Astra Ab	Arylalkylamine und -amide mit krampflösender und nervenschützender wirkung
CA2037123A1 (en) *	1990-02-26	1991-08-27	Jouveinal S.A.	Substituted ethylamines, their process of preparation, their use as medication and their synthetic intermediates

1992
- 1992-10-28 EP EP92309888A patent/EP0540318A1/de active Pending
- 1992-10-28 AU AU28766/92A patent/AU667490B2/en not_active Ceased
- 1992-10-28 SG SG1996005611A patent/SG47949A1/en unknown
- 1992-10-28 PT PT92922179T patent/PT612314E/pt unknown
- 1992-10-28 AT AT92922179T patent/ATE188212T1/de not_active IP Right Cessation
- 1992-10-28 JP JP50801193A patent/JP3208141B2/ja not_active Expired - Fee Related
- 1992-10-28 US US08/232,029 patent/US5607935A/en not_active Expired - Fee Related
- 1992-10-28 WO PCT/GB1992/001971 patent/WO1993009095A1/en not_active Ceased
- 1992-10-28 DK DK92922179T patent/DK0612314T3/da active
- 1992-10-28 DE DE69230498T patent/DE69230498T2/de not_active Expired - Fee Related
- 1992-10-28 EP EP92922179A patent/EP0612314B1/de not_active Expired - Lifetime
- 1992-10-28 CA CA002122633A patent/CA2122633C/en not_active Expired - Fee Related
- 1992-10-28 ES ES92922179T patent/ES2142320T3/es not_active Expired - Lifetime
- 1992-10-29 NZ NZ244929A patent/NZ244929A/en not_active IP Right Cessation
- 1992-10-29 IL IL103595A patent/IL103595A/en not_active IP Right Cessation
- 1992-10-30 ZA ZA928414A patent/ZA928414B/xx unknown
- 1992-10-30 MX MX9206296A patent/MX9206296A/es not_active IP Right Cessation
1994
- 1994-04-28 NO NO941568A patent/NO300174B1/no unknown
- 1994-04-28 FI FI941958A patent/FI105475B/fi not_active IP Right Cessation
1995
- 1995-06-27 HU HU95P/P00459P patent/HU211948A9/hu unknown
1996
- 1996-03-27 AU AU50305/96A patent/AU686934B2/en not_active Ceased
2000
- 2000-03-17 GR GR20000400693T patent/GR3032993T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
NO941568L (de)	1994-06-22
JPH07500825A (ja)	1995-01-26
MX9206296A (es)	1993-08-01
IL103595A0 (en)	1993-03-15
AU667490B2 (en)	1996-03-28
CA2122633A1 (en)	1993-05-13
EP0612314A1 (de)	1994-08-31
JP3208141B2 (ja)	2001-09-10
WO1993009095A1 (en)	1993-05-13
NO941568D0 (de)	1994-04-28
EP0540318A1 (de)	1993-05-05
GR3032993T3 (en)	2000-07-31
AU2876692A (en)	1993-06-07
DE69230498T2 (de)	2000-07-27
DK0612314T3 (da)	2000-05-29
FI941958A0 (fi)	1994-04-28
US5607935A (en)	1997-03-04
FI941958A7 (fi)	1994-04-28
IL103595A (en)	1998-02-22
HU211948A9 (en)	1996-01-29
NZ244929A (en)	1994-08-26
EP0612314B1 (de)	1999-12-29
ES2142320T3 (es)	2000-04-16
FI105475B (fi)	2000-08-31
SG47949A1 (en)	1998-04-17
ZA928414B (en)	1993-05-03
CA2122633C (en)	2003-12-16
DE69230498D1 (de)	2000-02-03
PT612314E (pt)	2000-06-30
AU686934B2 (en)	1998-02-12
AU5030596A (en)	1996-07-04
NO300174B1 (no)	1997-04-21

Legal Events

Date	Code	Title	Description
2000-06-15	UEP	Publication of translation of european patent specification
2007-07-15	REN	Ceased due to non-payment of the annual fee

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