ATE188475T1 - Tricyclische pteridinone und ein verfahren zu deren herstellung - Google Patents

Tricyclische pteridinone und ein verfahren zu deren herstellung

Info

Publication number: ATE188475T1
Authority: AT; Austria
Prior art keywords: production; pteridinones; tricyclic; compounds; tricyclic pteridinones
Prior art date: 1989-11-17

Application number

AT90250279T

Other languages

English (en)

Inventor

David D Davey

John William Lampe

Original Assignee

Berlex Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-11-17

Filing date

1990-11-12

Publication date

2000-01-15

1990-11-12 Application filed by Berlex Lab filed Critical Berlex Lab

2000-01-15 Application granted granted Critical

2000-01-15 Publication of ATE188475T1 publication Critical patent/ATE188475T1/de

Links

VWXIHLCLIOQWRA-UHFFFAOYSA-N 1h-pteridin-2-one Chemical class N1=CC=NC2=NC(O)=NC=C21 VWXIHLCLIOQWRA-UHFFFAOYSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
230000010339 dilation Effects 0.000 abstract 1
230000002526 effect on cardiovascular system Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000024883 vasodilation Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Heart & Thoracic Surgery (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT90250279T 1989-11-17 1990-11-12 Tricyclische pteridinone und ein verfahren zu deren herstellung ATE188475T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US43757489A	1989-11-17	1989-11-17

Publications (1)

Publication Number	Publication Date
ATE188475T1 true ATE188475T1 (de)	2000-01-15

Family

ID=23736999

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90250279T ATE188475T1 (de)	1989-11-17	1990-11-12	Tricyclische pteridinone und ein verfahren zu deren herstellung

Country Status (8)

Country	Link
EP (1)	EP0429149B1 (de)
JP (1)	JP3026020B2 (de)
AT (1)	ATE188475T1 (de)
CA (1)	CA2029651C (de)
DE (1)	DE69033414T2 (de)
DK (1)	DK0429149T3 (de)
ES (1)	ES2145733T3 (de)
GR (1)	GR3033079T3 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5602252A (en) *	1989-11-17	1997-02-11	Berlex Laboratories, Inc.	Tricyclic pteridinones and a process for their preparation
US5854419A (en) *	1989-11-17	1998-12-29	Schering Aktiengesellschaft	Tricyclic pteridinones and a process for their preparation
US6410726B1 (en)	2000-01-12	2002-06-25	Tularik Inc.	Arylsulfonic acid salts of pyrimidine-based antiviral
UA76512C2 (en) *	2001-09-04	2006-08-15	Boehringer Ingelheim Pharma	Dihydropteridinones, a method for producing thereof and use thereof as medicament
US6806272B2 (en)	2001-09-04	2004-10-19	Boehringer Ingelheim Pharma Kg	Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
EP1312365A1 (de) *	2001-11-20	2003-05-21	Jenapharm GmbH & Co. KG	Pteridinone zur Behandlung der erektilen Dysfunktion
US6861422B2 (en)	2003-02-26	2005-03-01	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
DE102004029784A1 (de)	2004-06-21	2006-01-05	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel
DE102004033670A1 (de)	2004-07-09	2006-02-02	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue Pyridodihydropyrazinone, Verfahren zu Ihrer Herstellung und Ihre Verwendung als Arzneimittel
US7759485B2 (en)	2004-08-14	2010-07-20	Boehringer Ingelheim International Gmbh	Process for the manufacture of dihydropteridinones
US20060074088A1 (en)	2004-08-14	2006-04-06	Boehringer Ingelheim International Gmbh	Dihydropteridinones for the treatment of cancer diseases
US20060035903A1 (en)	2004-08-14	2006-02-16	Boehringer Ingelheim International Gmbh	Storage stable perfusion solution for dihydropteridinones
US7728134B2 (en)	2004-08-14	2010-06-01	Boehringer Ingelheim International Gmbh	Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament
US20060058311A1 (en)	2004-08-14	2006-03-16	Boehringer Ingelheim International Gmbh	Combinations for the treatment of diseases involving cell proliferation
EP1630163A1 (de)	2004-08-25	2006-03-01	Boehringer Ingelheim Pharma GmbH & Co.KG	Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
EP1632493A1 (de)	2004-08-25	2006-03-08	Boehringer Ingelheim Pharma GmbH & Co.KG	Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
DE102004058337A1 (de)	2004-12-02	2006-06-14	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
US7439358B2 (en)	2006-02-08	2008-10-21	Boehringer Ingelheim International Gmbh	Specific salt, anhydrous and crystalline form of a dihydropteridione derivative
TWI315304B (en) *	2006-08-31	2009-10-01	Univ Taipei Medical	Indoline-sulfonamides compounds
WO2009019205A1 (en)	2007-08-03	2009-02-12	Boehringer Ingelheim International Gmbh	Crystalline form of a dihydropteridione derivative
RU2012131124A (ru) *	2009-12-23	2014-01-27	Элан Фармасьютикалз, Инк.	Птеридиноны как ингибиторы polo-подобных киназ
US9358233B2 (en)	2010-11-29	2016-06-07	Boehringer Ingelheim International Gmbh	Method for treating acute myeloid leukemia
US9370535B2 (en)	2011-05-17	2016-06-21	Boehringer Ingelheim International Gmbh	Method for treatment of advanced solid tumors
CN102408380B (zh) *	2011-12-22	2014-04-16	浙江大学	5-氨基嘧啶硫酮类化合物及其制备方法
EP3024464A1 (de)	2013-07-26	2016-06-01	Boehringer Ingelheim International GmbH	Behandlung des myelodysplastischen syndroms
US9867831B2 (en)	2014-10-01	2018-01-16	Boehringer Ingelheim International Gmbh	Combination treatment of acute myeloid leukemia and myelodysplastic syndrome

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2940654A1 (de) *	1979-10-06	1981-04-16	Bayer Ag, 5090 Leverkusen	Dimeres keten der 1,2,,-triazol-3-carbonsaeure
US4440929A (en) *	1981-07-16	1984-04-03	Usv Pharmaceutical Corporation	Imidazoquinoxaline compounds
ES2051772T3 (es) *	1986-09-30	1994-07-01	Ciba Geigy Ag	2-sustituido-e-fusionado-(1,2,4)-triazol(1,5-c)pirimidinas, composiciones farmaceuticas y sus usos.

1990
- 1990-11-09 CA CA002029651A patent/CA2029651C/en not_active Expired - Fee Related
- 1990-11-12 EP EP90250279A patent/EP0429149B1/de not_active Expired - Lifetime
- 1990-11-12 DE DE69033414T patent/DE69033414T2/de not_active Expired - Fee Related
- 1990-11-12 ES ES90250279T patent/ES2145733T3/es not_active Expired - Lifetime
- 1990-11-12 DK DK90250279T patent/DK0429149T3/da active
- 1990-11-12 AT AT90250279T patent/ATE188475T1/de not_active IP Right Cessation
- 1990-11-16 JP JP2312590A patent/JP3026020B2/ja not_active Expired - Fee Related
2000
- 2000-03-28 GR GR20000400768T patent/GR3033079T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
ES2145733T3 (es)	2000-07-16
JPH03170482A (ja)	1991-07-24
DE69033414D1 (de)	2000-02-10
JP3026020B2 (ja)	2000-03-27
CA2029651C (en)	2000-06-06
DK0429149T3 (da)	2000-06-13
DE69033414T2 (de)	2000-08-03
EP0429149B1 (de)	2000-01-05
GR3033079T3 (en)	2000-08-31
CA2029651A1 (en)	1991-05-18
EP0429149A1 (de)	1991-05-29

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Legal Events

Date	Code	Title	Description
2000-06-15	UEP	Publication of translation of european patent specification
2005-08-15	REN	Ceased due to non-payment of the annual fee