ATE188963T1 - Verfahren zur herstellung eines benzothiazepinen - Google Patents

Verfahren zur herstellung eines benzothiazepinen

Info

Publication number: ATE188963T1
Authority: AT; Austria
Prior art keywords: benzothiazepine; acid; reaction; subjected; formula
Prior art date: 1996-03-22

Application number

AT97200797T

Other languages

English (en)

Inventor

Marcus Joseph Maria Plaum

Wilhelmus Hubertus Jos Boesten

Original Assignee

Dsm Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-03-22

Filing date

1997-03-17

Publication date

2000-02-15

1997-03-17 Application filed by Dsm Nv filed Critical Dsm Nv

2000-02-15 Application granted granted Critical

2000-02-15 Publication of ATE188963T1 publication Critical patent/ATE188963T1/de

Links

FHGWEHGZBUBQKL-UHFFFAOYSA-N 1,2-benzothiazepine Chemical compound S1N=CC=CC2=CC=CC=C12 FHGWEHGZBUBQKL-UHFFFAOYSA-N 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
KJFRSZASZNLCDF-UHFFFAOYSA-N 1,5-benzothiazepine Chemical class S1C=CC=NC2=CC=CC=C12 KJFRSZASZNLCDF-UHFFFAOYSA-N 0.000 abstract 1
XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Chemical class CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
238000005917 acylation reaction Methods 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
238000005804 alkylation reaction Methods 0.000 abstract 1
150000001735 carboxylic acids Chemical class 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 abstract 1
229960004166 diltiazem Drugs 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
229940127557 pharmaceutical product Drugs 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT97200797T 1996-03-22 1997-03-17 Verfahren zur herstellung eines benzothiazepinen ATE188963T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
NL1002687A NL1002687C2 (nl)	1996-03-22	1996-03-22	Werkwijze voor de bereiding van een benzothiazepine.

Publications (1)

Publication Number	Publication Date
ATE188963T1 true ATE188963T1 (de)	2000-02-15

Family

ID=19762546

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97200797T ATE188963T1 (de)	1996-03-22	1997-03-17	Verfahren zur herstellung eines benzothiazepinen

Country Status (13)

Country	Link
US (1)	US5859241A (de)
EP (1)	EP0796853B1 (de)
JP (1)	JPH107667A (de)
KR (1)	KR970065530A (de)
AT (1)	ATE188963T1 (de)
CA (1)	CA2200537A1 (de)
DE (1)	DE69701160T2 (de)
DK (1)	DK0796853T3 (de)
ES (1)	ES2143282T3 (de)
IL (1)	IL120502A (de)
NL (1)	NL1002687C2 (de)
PT (1)	PT796853E (de)
TW (1)	TW360644B (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2003252259A1 (en) *	2002-07-26	2004-02-16	Nihon Nohyaku Co., Ltd.	Novel haloalkylsulfonanilide derivatives, herbicides and usage thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3562257A (en) *	1967-10-28	1971-02-09	Tanabe Seiyaku Co	Benzothiazepine derivatives
JPS57122065A (en) *	1981-01-23	1982-07-29	Ihara Chem Ind Co Ltd	Dichloromaleimide derivative and fungicide containing the same
USRE34935E (en) *	1989-01-11	1995-05-09	Synthelabo	Method for preparing (+)-(2S,3S)-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-5H-1,5-benzothiazepine-4-one and chlorinated derivatives thereof
FR2641535B1 (fr) *	1989-01-11	1991-03-15	Synthelabo	Procede de preparation de (+) - (2s, 3s)-hydroxy-3 (methoxy-4 phenyl)-2 dihydro-2,3 5h-benzothiazepine-1,5 one-4
ATE116643T1 (de) *	1989-04-28	1995-01-15	Tanabe Seiyaku Co	Verfahren zur herstellung von 1,5- benzothiazepinderivaten.
JPH0798813B2 (ja) *	1989-04-28	1995-10-25	田辺製薬株式会社	１，５―ベンゾチアゼピン誘導体の製法
US5128469A (en) *	1989-04-28	1992-07-07	Tanabe Seiyaku Co., Ltd.	Process for preparing 1,5-benzothiazepine derivatives
JPH085869B2 (ja) *	1990-03-08	1996-01-24	田辺製薬株式会社	１，５−ベンゾチアゼピン誘導体の製法

1996
- 1996-03-22 NL NL1002687A patent/NL1002687C2/nl not_active IP Right Cessation
1997
- 1997-02-27 TW TW086102634A patent/TW360644B/zh active
- 1997-03-17 EP EP97200797A patent/EP0796853B1/de not_active Expired - Lifetime
- 1997-03-17 JP JP9062592A patent/JPH107667A/ja active Pending
- 1997-03-17 DE DE69701160T patent/DE69701160T2/de not_active Expired - Fee Related
- 1997-03-17 PT PT97200797T patent/PT796853E/pt unknown
- 1997-03-17 DK DK97200797T patent/DK0796853T3/da active
- 1997-03-17 AT AT97200797T patent/ATE188963T1/de not_active IP Right Cessation
- 1997-03-17 ES ES97200797T patent/ES2143282T3/es not_active Expired - Lifetime
- 1997-03-20 IL IL12050297A patent/IL120502A/xx not_active IP Right Cessation
- 1997-03-20 KR KR1019970010775A patent/KR970065530A/ko not_active Withdrawn
- 1997-03-20 CA CA002200537A patent/CA2200537A1/en not_active Abandoned
- 1997-03-21 US US08/821,519 patent/US5859241A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PT796853E (pt)	2000-06-30
DE69701160T2 (de)	2000-09-14
US5859241A (en)	1999-01-12
EP0796853B1 (de)	2000-01-19
DK0796853T3 (da)	2000-06-26
NL1002687C2 (nl)	1997-09-23
KR970065530A (ko)	1997-10-13
CA2200537A1 (en)	1997-09-22
IL120502A0 (en)	1997-07-13
ES2143282T3 (es)	2000-05-01
IL120502A (en)	2000-06-29
TW360644B (en)	1999-06-11
JPH107667A (ja)	1998-01-13
EP0796853A1 (de)	1997-09-24
DE69701160D1 (de)	2000-02-24

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Legal Events

Date	Code	Title	Description
2000-07-15	UEP	Publication of translation of european patent specification
2002-12-15	REN	Ceased due to non-payment of the annual fee