ATE189231T1 - Lytische peptide, verwendung als wachstumsfördernde mittel und für infektionen und krebs - Google Patents

Lytische peptide, verwendung als wachstumsfördernde mittel und für infektionen und krebs

Info

Publication number: ATE189231T1
Authority: AT; Austria
Prior art keywords: amino acid; amino acids; peptide; cancer; infections
Prior art date: 1989-04-10

Application number

AT90906453T

Other languages

English (en)

Inventor

Jesse M Jaynes

Original Assignee

Helix Biomedix Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-04-10

Filing date

1990-04-10

Publication date

2000-02-15

1990-04-10 Application filed by Helix Biomedix Inc filed Critical Helix Biomedix Inc

2000-02-15 Application granted granted Critical

2000-02-15 Publication of ATE189231T1 publication Critical patent/ATE189231T1/de

Links

108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
206010028980 Neoplasm Diseases 0.000 title abstract 2
201000011510 cancer Diseases 0.000 title abstract 2
208000015181 infectious disease Diseases 0.000 title abstract 2
230000002101 lytic effect Effects 0.000 title abstract 2
102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
150000001413 amino acids Chemical class 0.000 abstract 8
229940024606 amino acid Drugs 0.000 abstract 7
239000004475 Arginine Substances 0.000 abstract 1
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
239000004472 Lysine Substances 0.000 abstract 1
ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 abstract 1
206010052428 Wound Diseases 0.000 abstract 1
208000027418 Wounds and injury Diseases 0.000 abstract 1
239000002671 adjuvant Substances 0.000 abstract 1
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
108010062796 arginyllysine Proteins 0.000 abstract 1
229940009098 aspartate Drugs 0.000 abstract 1
230000010261 cell growth Effects 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229930195712 glutamate Natural products 0.000 abstract 1
230000035876 healing Effects 0.000 abstract 1
230000002519 immonomodulatory effect Effects 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
230000000813 microbial effect Effects 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
230000002062 proliferating effect Effects 0.000 abstract 1
230000001737 promoting effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Medicinal Chemistry (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Tropical Medicine & Parasitology (AREA)
Insects & Arthropods (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

AT90906453T 1989-04-10 1990-04-10 Lytische peptide, verwendung als wachstumsfördernde mittel und für infektionen und krebs ATE189231T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US33618189A	1989-04-10	1989-04-10
PCT/US1990/001945 WO1990012866A1 (en)	1989-04-10	1990-04-10	Lytic peptides, use for growth, infection and cancer

Publications (1)

Publication Number	Publication Date
ATE189231T1 true ATE189231T1 (de)	2000-02-15

Family

ID=23314920

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90906453T ATE189231T1 (de)	1989-04-10	1990-04-10	Lytische peptide, verwendung als wachstumsfördernde mittel und für infektionen und krebs

Country Status (6)

Country	Link
EP (2)	EP0470974B1 (de)
AT (1)	ATE189231T1 (de)
AU (1)	AU5433190A (de)
CA (1)	CA2032527C (de)
DE (2)	DE69033436T2 (de)
WO (1)	WO1990012866A1 (de)

Families Citing this family (46)

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EP0667871A1 (de) *	1991-09-13	1995-08-23	Magainin Pharmaceuticals Inc.	Biologisch aktive amphiphile peptidzusammensetzungen und ihre verwendungen
US5422108A (en) *	1991-09-19	1995-06-06	Smart Plants International Inc.	Protection of plants against plant pathogens
US5850025A (en) *	1991-09-19	1998-12-15	Sibia Neurosciences, Inc.	Protection of plants against plant pathogens
US5589452A (en) *	1992-07-14	1996-12-31	Syntex (U.S.A.) Inc.	Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
US5977070A (en) *	1992-07-14	1999-11-02	Piazza; Christin Teresa	Pharmaceutical compositions for the nasal delivery of compounds useful for the treatment of osteoporosis
US5534619A (en) *	1993-11-12	1996-07-09	The Board Of Regents Acting On Behalf Of University Of Michigan	Peptides for heparin and low molecular weight heparin anticoagulation reversal
US5614494A (en) *	1993-11-12	1997-03-25	University Of Michigan, The Board Of Regents Acting For And On Behalf Of	Peptides for heparin and low molecular weight heparin anticoagulation reversal
US5919761A (en) *	1992-08-14	1999-07-06	The Board Of Regents Of The University Of Michigan	Peptides for heparin and low molecular weight heparin anticoagulation reversal
US5955573A (en) *	1993-06-04	1999-09-21	Demegen, Inc.	Ubiquitin-lytic peptide fusion gene constructs, protein products deriving therefrom, and methods of making and using same
US5773413A (en) *	1993-06-04	1998-06-30	Demeter Biotechnologies, Ltd.	Method of combating mammalian neoplasias, and lytic peptides therefor
US5561107A (en) *	1993-06-04	1996-10-01	Demeter Biotechnologies, Ltd.	Method of enhancing wound healing by stimulating fibroblast and keratinocyte growth in vivo, utilizing amphipathic peptides
US5968904A (en) *	1993-06-04	1999-10-19	Demegen, Inc.	Modified arginine containing lytic peptides and method of making the same by glyoxylation
WO1995001424A1 (en) *	1993-06-30	1995-01-12	Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College	Transformed mammalian cells capable of expressing cecropin b
WO1995001095A1 (en) *	1993-06-30	1995-01-12	Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College	Transformed eukaryotic cells, and transposon-based transformation vectors
US6156568A (en) *	1993-06-30	2000-12-05	Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College	Transformed eukaryotic cells
US5856178A (en) *	1993-08-30	1999-01-05	Utah State University	DNA cassettes for expression of lytic peptides in mammalian cells and transgenic organisms containing same
WO1995013085A1 (en) *	1993-11-08	1995-05-18	Demeter Biotechnologies Ltd.	Methylated lysine-rich lytic peptides and method of making same by reductive alkylation
IL113244A0 (en) *	1994-04-08	1995-07-31	Demeter Biotech Ltd	Method of combating mammalian neoplasia and lytic peptides therefor
US5789542A (en) *	1994-04-22	1998-08-04	Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College	Amphipathic peptides
IL114697A0 (en) *	1994-07-22	1995-11-27	Demeter Biotech Ltd	Polypeptides comprising ubiquitin-lytic peptide fusion protein products deriving therefrom their preparation and use
US6057291A (en)	1995-06-02	2000-05-02	University Of British Columbia	Antimicrobial cationic peptides
US5877274A (en) *	1995-06-02	1999-03-02	University Of British Columbia	Antimicrobial cationic peptides
US5998698A (en) *	1995-06-07	1999-12-07	Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College	Transgenic fish capable of expressing exogenous lytic peptides
EP0932413A1 (de)	1996-10-04	1999-08-04	Demegen, Inc.	Verfahren zur behandlung einer immunschwäche virusinfektion
US6566334B1 (en)	1997-02-06	2003-05-20	Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College	Short amphipathic peptides with activity against bacteria and intracellular pathogens
AU6587998A (en) *	1997-03-27	1998-10-20	Demeter Biotechnologies, Ltd.	Ligand/lytic peptide compositions and methods of use
US6635740B1 (en)	1997-03-27	2003-10-21	Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College	Ligand/lytic peptide compositions and methods of use
US6680058B1 (en)	1997-09-03	2004-01-20	Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College	Compositions and methods for contraception in or sterilization of mammals
DE19749973C1 (de) *	1997-11-05	1998-10-22	Klaus Dr Duering	Lysozym-analoge Proteine und Peptide mit antimikrobieller Wirkung, ihre Herstellung und ihre Verwendung
AU3524700A (en) *	1999-03-10	2000-09-28	Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College, The	Prevention and treatment of viral infections
US6875744B2 (en)	2001-03-28	2005-04-05	Helix Biomedix, Inc.	Short bioactive peptides
EP2105141B1 (de) *	2001-03-28	2012-08-08	Helix Biomedix, Inc.	Kurze bioaktive Peptide und Verwendungsverfahren
JP4472998B2 (ja)	2002-04-22	2010-06-02	ダウグローバルテクノロジーズインコーポレイティド	低コストのペプチド製造
US7122621B2 (en) *	2003-06-17	2006-10-17	Academia Sinica	Anti-cellular proliferative disorder polypeptide
WO2006086321A2 (en)	2005-02-09	2006-08-17	Helix Biomedix Inc.	Antimicrobial hexapeptides
ATE533785T1 (de)	2006-06-13	2011-12-15	Helix Biomedix Inc	Peptidfragmente zur induzierung der synthese extrazellulärer matrixproteine
DK2125878T3 (da) *	2007-01-05	2013-05-27	Helix Biomedix Inc	Korte bioaktive peptider til cellulær og immunologisk modulation
US8071555B2 (en)	2007-10-29	2011-12-06	Helix Biomedix Inc.	Protective skin care peptides
GB0803352D0 (en)	2008-02-22	2008-04-02	Ntnu Technology Transfer As	Oligopeptidic compounds and uses thereof
US8461118B2 (en) *	2011-07-07	2013-06-11	Tuskegee University	Lytic peptides having anti-proliferative activity against prostate cancer cells
JP6613312B2 (ja)	2014-10-14	2019-11-27	ジユナイテッドステイツオブアメリカアズリプリゼンティッドバイザセクレタリー，デパートメントオブヘルスアンドヒューマンサービシズ	膵臓癌を処置するためのペプチドをベースとする方法
JP6840086B2 (ja) *	2015-03-20	2021-03-10	ユニベルシテ・パリ・デカルトＵｎｉｖｅｒｓｉｔｅＰａｒｉｓＤｅｓｃａｒｔｅｓ	薬物として、特に皮膚炎症性疾患において使用するためのフィブリノゲン由来の単離されたペプチドおよびそれらのフラグメント
AU2016235147B2 (en) *	2015-03-23	2019-09-19	Riptide Bioscience, Inc.	Antimicrobial peptides and methods of use thereof
US10413584B1 (en)	2018-08-29	2019-09-17	Riptide Bioscience, Inc.	Peptides having immunomodulatory properties
US10548944B1 (en)	2018-10-19	2020-02-04	Riptide Bioscience, Inc.	Antimicrobial peptides and methods of using the same
CA3134420A1 (en)	2019-04-12	2020-10-15	Riptide Bioscience, Inc.	Methods for modulating macrophage activity

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4355104A (en) *	1980-06-17	1982-10-19	Kabigen Ab	Bacteriolytic proteins
US4643988A (en) *	1984-05-15	1987-02-17	Research Corporation	Amphipathic peptides
KR970006154B1 (ko) *	1987-07-06	1997-04-24	루이지아나 스테이트 유니버시티 아그리컬춰럴 앤드 메카니칼 컬리지	용해성 펩티드에 의한 진핵 병원체와 신생물의 억제 및 섬유아세포와 임파구의 자극
WO1989004371A1 (en) *	1987-11-02	1989-05-18	Louisiana State University Agricultural And Mechan	Plants genetically enhanced for disease resistance

1990
- 1990-04-10 WO PCT/US1990/001945 patent/WO1990012866A1/en not_active Ceased
- 1990-04-10 DE DE69033436T patent/DE69033436T2/de not_active Expired - Lifetime
- 1990-04-10 EP EP90906453A patent/EP0470974B1/de not_active Expired - Lifetime
- 1990-04-10 EP EP99122942A patent/EP1004595B1/de not_active Expired - Lifetime
- 1990-04-10 AU AU54331/90A patent/AU5433190A/en not_active Abandoned
- 1990-04-10 AT AT90906453T patent/ATE189231T1/de not_active IP Right Cessation
- 1990-04-10 CA CA002032527A patent/CA2032527C/en not_active Expired - Lifetime
- 1990-04-10 DE DE69034085T patent/DE69034085T2/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
WO1990012866A1 (en)	1990-11-01
AU5433190A (en)	1990-11-16
DE69033436T2 (de)	2000-06-21
EP1004595A3 (de)	2000-11-02
DE69034085D1 (de)	2003-07-24
DE69034085T2 (de)	2004-05-27
CA2032527A1 (en)	1990-10-11
CA2032527C (en)	2002-07-02
DE69033436D1 (de)	2000-03-02
EP1004595B1 (de)	2003-06-18
EP0470974A1 (de)	1992-02-19
EP1004595A2 (de)	2000-05-31
EP0470974A4 (en)	1992-09-16
EP0470974B1 (de)	2000-01-26

Legal Events

Date	Code	Title	Description
2000-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69033436D1 (de)	2000-03-02	Lytische peptide, verwendung als wachstumsfördernde mittel und für infektionen und krebs
ES8306324A1 (es)	1983-06-01	"proceso para la produccion microbiana de interferon fibroblasto humano".
DE69434980D1 (de)	2007-07-12	Stabile bakterizide Proteine, welche die Permeabilität erhöhen und pharmazeutische Zusammensetzungen, diese enthaltend
DE68917163D1 (de)	1994-09-08	Antibakterielle Mittel.
FR2718452B1 (fr)	1996-06-28	Elément d'immunogène, agent immunogène, composition pharmaceutique et procédé de préparation.
DE3856588D1 (de)	2006-01-19	Biologisch-aktive Bakterizide/permeabilitätserhöhende Proteinbruchstücke
BR8107293A (pt)	1982-08-03	Polipetidio anti-viral dna de duplo cordao veiculo de expressao plasmidico replicavel microorganismo transformado plasmidio processo de formacao do dito dna e do dito polipeptidio composicao farmaceutica e uso do dito polipeptidio
Horst et al.	1972	The active components of crotoxin
ES8800160A1 (es)	1987-10-16	Procedimiento de obtencion de acidos quinolincarboxilicos con propiedades antibacteriales.
DE69908885D1 (de)	2003-07-24	NEUARTIGES AUS -i(PARASILURUS ASOTUS) ISOLIERTES ANTIMIKROBIELLES PEPTID UND SEINE VERWENDUNG
DK312688D0 (da)	1988-06-09	Glykkopeptid-antibiotika
EA200001124A1 (ru)	2001-08-27	Способ генной терапии
NO904251L (no)	1991-04-02	Fremgangsmaate for fremstilling av et tilnaermet rent polypeptid.
ATE11217T1 (de)	1985-02-15	Antibiotische substanzen, verfahren zu deren herstellung und deren zusammensetzungen; stamm von staphylococcus epidermidis, welcher diese antibiotische substanz produziert und deren zusammensetzungen.
FI964186A0 (fi)	1996-10-18	Ei-liittävät gp350/220-variantit
RU2004104335A (ru)	2005-03-27	Биологически активные пептиды
EP0642348A4 (de)	1997-08-20	Antibiotisches cryptdinpeptid und anwendungsmethoden.
NO177859C (no)	1995-12-06	Fremgangsmåte til produksjon av angiogen faktor
RU95101042A (ru)	1997-03-27	Рекомбинантный полипептид, антисыворотки, фармацевтическая композиция, способ ингибирования транспорта катионных аминокислот, способ ингибирования продукции окиси азота, способ лечения
DE69432724D1 (de)	2003-07-03	HST-2 Mutein, dafür kodierende DNS und Herstellung
DE69033553D1 (de)	2000-06-29	Rekombinante herstellung von laktoperoxidase
KR960704037A (ko)	1996-08-31	TGF-β군의 신규한 생장/분화 인자(NEW GROWTH/DIFFERENTIATION FACTOR OF THE TGF-β FAMILY)
RU95122751A (ru)	1998-02-27	Укороченный кератиноцитарный фактор роста с повышенной биологической активностью