ATE190501T1 - Bereitstellung einer für krebszellen cytotoxischen verbindung unter verwendung des weges von plasminogenaktivatormaterial - Google Patents
Bereitstellung einer für krebszellen cytotoxischen verbindung unter verwendung des weges von plasminogenaktivatormaterialInfo
- Publication number
- ATE190501T1 ATE190501T1 AT93914191T AT93914191T ATE190501T1 AT E190501 T1 ATE190501 T1 AT E190501T1 AT 93914191 T AT93914191 T AT 93914191T AT 93914191 T AT93914191 T AT 93914191T AT E190501 T1 ATE190501 T1 AT E190501T1
- Authority
- AT
- Austria
- Prior art keywords
- cancer cell
- providing
- compound
- cytotoxic compound
- activation material
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 4
- 201000011510 cancer Diseases 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 231100000433 cytotoxic Toxicity 0.000 title abstract 2
- 230000001472 cytotoxic effect Effects 0.000 title abstract 2
- 239000000463 material Substances 0.000 title abstract 2
- 230000033885 plasminogen activation Effects 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 5
- 102000010752 Plasminogen Inactivators Human genes 0.000 abstract 3
- 108010077971 Plasminogen Inactivators Proteins 0.000 abstract 3
- 239000002797 plasminogen activator inhibitor Substances 0.000 abstract 3
- 102000013566 Plasminogen Human genes 0.000 abstract 1
- 108010051456 Plasminogen Proteins 0.000 abstract 1
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 abstract 1
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 231100000167 toxic agent Toxicity 0.000 abstract 1
- 239000003440 toxic substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88978392A | 1992-05-28 | 1992-05-28 | |
| US5981393A | 1993-05-10 | 1993-05-10 | |
| PCT/US1993/005034 WO1993024141A1 (en) | 1992-05-28 | 1993-05-27 | Delivery of a cytotoxic compound to a cancer cell using a pathway of plasminogen activator material |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE190501T1 true ATE190501T1 (de) | 2000-04-15 |
Family
ID=26739215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93914191T ATE190501T1 (de) | 1992-05-28 | 1993-05-27 | Bereitstellung einer für krebszellen cytotoxischen verbindung unter verwendung des weges von plasminogenaktivatormaterial |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0643584B1 (de) |
| AT (1) | ATE190501T1 (de) |
| AU (1) | AU4394293A (de) |
| DE (1) | DE69328092T2 (de) |
| ES (1) | ES2143504T3 (de) |
| WO (1) | WO1993024141A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997024453A1 (en) * | 1995-12-28 | 1997-07-10 | Chiron Corporation | Receptor specific chimeric viral surface polypeptides for viral and particle incorporation and internalization in target cells |
| US6277818B1 (en) | 1998-10-29 | 2001-08-21 | Angstrom Pharmaceuticals, Inc. | Cyclic peptide ligands that target urokinase plasminogen activator receptor |
| US5994309A (en) | 1997-07-25 | 1999-11-30 | Angstrom Pharmaceuticals, Inc. | Anti-invasive and anti-angiogenic compositions and methods |
| US20050232924A1 (en) * | 2003-11-18 | 2005-10-20 | Attenuon Llc | Antibodies and/or conjugates thereof which bind to the amino terminal fragment of urokinase, compositions and uses thereof |
| US20070190068A1 (en) * | 2005-10-10 | 2007-08-16 | Richard Hart | uPAR-binding molecule-drug conjugates and uses thereof |
| PL2117571T3 (pl) | 2006-12-08 | 2017-08-31 | Monopar Therapeutics Inc. | Epitop receptora aktywatora plazminogenu typu urokinazy |
| US8877156B2 (en) | 2007-06-26 | 2014-11-04 | New York University | Contrast agents anchored by thiols on nanoparticles |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN165717B (de) * | 1986-08-07 | 1989-12-23 | Battelle Memorial Institute | |
| DE69033653T2 (de) * | 1989-04-07 | 2001-06-07 | Cancerforskningsfonden Af 1989 (Fonden Til Fremme Af Eksperimental Cancerforskning), Kopenhagen | Plasminogen-aktivator-rezeptor vom urokinasetyp |
-
1993
- 1993-05-27 AT AT93914191T patent/ATE190501T1/de not_active IP Right Cessation
- 1993-05-27 EP EP93914191A patent/EP0643584B1/de not_active Expired - Lifetime
- 1993-05-27 AU AU43942/93A patent/AU4394293A/en not_active Abandoned
- 1993-05-27 ES ES93914191T patent/ES2143504T3/es not_active Expired - Lifetime
- 1993-05-27 WO PCT/US1993/005034 patent/WO1993024141A1/en not_active Ceased
- 1993-05-27 DE DE69328092T patent/DE69328092T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU4394293A (en) | 1993-12-30 |
| DE69328092D1 (de) | 2000-04-20 |
| WO1993024141A1 (en) | 1993-12-09 |
| DE69328092T2 (de) | 2000-07-20 |
| EP0643584A4 (de) | 1995-07-26 |
| EP0643584A1 (de) | 1995-03-22 |
| EP0643584B1 (de) | 2000-03-15 |
| ES2143504T3 (es) | 2000-05-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |