ATE190502T1 - Herstellung und verwendungen von los-verminderten aussenmembran-proteinen von gram-negativen kokken - Google Patents

Herstellung und verwendungen von los-verminderten aussenmembran-proteinen von gram-negativen kokken

Info

Publication number
ATE190502T1
ATE190502T1 AT94106827T AT94106827T ATE190502T1 AT E190502 T1 ATE190502 T1 AT E190502T1 AT 94106827 T AT94106827 T AT 94106827T AT 94106827 T AT94106827 T AT 94106827T AT E190502 T1 ATE190502 T1 AT E190502T1
Authority
AT
Austria
Prior art keywords
gram
membrane proteins
outer membrane
lot
preparation
Prior art date
Application number
AT94106827T
Other languages
English (en)
Inventor
Gary W Zlotnick
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of ATE190502T1 publication Critical patent/ATE190502T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT94106827T 1993-05-13 1994-05-02 Herstellung und verwendungen von los-verminderten aussenmembran-proteinen von gram-negativen kokken ATE190502T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6158193A 1993-05-13 1993-05-13

Publications (1)

Publication Number Publication Date
ATE190502T1 true ATE190502T1 (de) 2000-04-15

Family

ID=22036711

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94106827T ATE190502T1 (de) 1993-05-13 1994-05-02 Herstellung und verwendungen von los-verminderten aussenmembran-proteinen von gram-negativen kokken

Country Status (11)

Country Link
US (2) US6355253B1 (de)
EP (1) EP0624376B1 (de)
JP (1) JP3711289B2 (de)
KR (1) KR100355961B1 (de)
AT (1) ATE190502T1 (de)
CA (1) CA2123355C (de)
DE (1) DE69423383T2 (de)
DK (1) DK0624376T3 (de)
ES (1) ES2145072T3 (de)
GR (1) GR3033469T3 (de)
PT (1) PT624376E (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6121427A (en) * 1994-10-24 2000-09-19 Connaught Laboratories Limited Major outer membrane protein CD of branhamella
US20040087020A1 (en) 1997-05-28 2004-05-06 Chiron S.P.A. Culture medium with yeast or soy bean extract as amino acid source and no protein complexes of animal origin
ES2293681T3 (es) * 1997-05-28 2008-03-16 Novartis Vaccines And Diagnostics S.R.L. Medio de cultivo con extracto de soja como fuente de aminoacidos pero sin complejos proteinicos de origen animal.
ES2301181T3 (es) * 1997-08-21 2008-06-16 De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezondheid En Cultuur Mutantes nuevos de bacterias mucosas gram negativas y su aplicacion en vacunas.
US20070026021A1 (en) * 1998-05-01 2007-02-01 Chiron S.R.I. Neisseria meningitidis antigens and compositions
EP2261345A3 (de) 1998-05-01 2012-01-11 Novartis Vaccines and Diagnostics, Inc. Antigene und Zusammensetzungen gegen Neisseria meningitidis
DK1079857T3 (da) 1998-05-29 2007-01-29 Novartis Vaccines & Diagnostic Meningitidis B/C-kombinationsvacciner
PT2270173E (pt) 1999-05-19 2016-03-28 Glaxosmithkline Biologicals Sa Composições de neisseria de combinação
GB9928196D0 (en) * 1999-11-29 2000-01-26 Chiron Spa Combinations of B, C and other antigens
ES2588917T3 (es) * 2000-01-17 2016-11-07 Glaxosmithkline Biologicals Sa Vacuna de VME suplementada contra meningococo
MX339524B (es) 2001-10-11 2016-05-30 Wyeth Corp Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica.
US7785608B2 (en) * 2002-08-30 2010-08-31 Wyeth Holdings Corporation Immunogenic compositions for the prevention and treatment of meningococcal disease
GB0220194D0 (en) 2002-08-30 2002-10-09 Chiron Spa Improved vesicles
US7301554B2 (en) * 2002-09-20 2007-11-27 Ricoh Company, Ltd. Light scanning device, scanning line adjusting method, scanning line adjusting control method, image forming apparatus, and image forming method
HUE047780T2 (hu) 2002-10-11 2020-05-28 Glaxosmithkline Biologicals Sa Polipeptid vakcinák hipervirulens meningokokkusz vonalak elleni széles-spektrumú védelemre
AU2003298906A1 (en) * 2002-12-06 2004-06-30 Agennix Incorporated Oral lactoferrin in the treatment of sepsis
GB0316560D0 (en) 2003-07-15 2003-08-20 Chiron Srl Vesicle filtration
CA2551896A1 (en) 2003-12-30 2005-07-21 Wyeth Formulations of hydrophobic proteins in an immunogenic composition having improved tolerability
GB0416120D0 (en) 2004-07-19 2004-08-18 Health Prot Agency Stable compositions containing OMV's
GB0419627D0 (en) * 2004-09-03 2004-10-06 Chiron Srl Immunogenic bacterial vesicles with outer membrane proteins
GB0424092D0 (en) 2004-10-29 2004-12-01 Chiron Srl Immunogenic bacterial vesicles with outer membrane proteins
SG160329A1 (en) 2005-02-18 2010-04-29 Novartis Vaccines & Diagnostic Proteins and nucleic acids from meningitis/sepsis-associated escherichia coli
DK1858919T3 (da) 2005-02-18 2012-07-16 Novartis Vaccines & Diagnostic Immunogener fra uropathogen Escherichia coli
KR100612895B1 (ko) * 2005-05-04 2006-08-14 삼성전자주식회사 화학 물질을 이용한 생물학적 시료로부터 단백질의선택적인 제거 방법
EP2064230A2 (de) 2006-08-16 2009-06-03 Novartis AG Immungene aus uropathogenen escherichia coli
AR064642A1 (es) * 2006-12-22 2009-04-15 Wyeth Corp Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi
GB0700562D0 (en) 2007-01-11 2007-02-21 Novartis Vaccines & Diagnostic Modified Saccharides
WO2009158142A1 (en) * 2008-05-30 2009-12-30 The U.S.A., As Represented By The Secretary Of The Army, On Behalf Of Walter Reed Army Meningococcal multivalent native outer membrane vesicle vaccine, methods of making and use thereof
GB201009861D0 (en) 2010-06-11 2010-07-21 Novartis Ag OMV vaccines
EP3246044B2 (de) 2010-08-23 2024-04-10 Wyeth LLC Stabile formulierungen von neisseria-meningitidis-rlp2086-antigenen
ES2759484T3 (es) * 2010-09-10 2020-05-11 Glaxosmithkline Biologicals Sa Meningococo que sobreexpresa NadA y/o NHBA y vesículas de la membrana externa derivadas del mismo
ES2864635T3 (es) 2010-09-10 2021-10-14 Wyeth Llc Variantes no lipidadas de antígenos ORF2086 de Neisseria meningitidis
GB201015132D0 (en) * 2010-09-10 2010-10-27 Univ Bristol Vaccine composition
SA115360586B1 (ar) 2012-03-09 2017-04-12 فايزر انك تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
WO2013132452A2 (en) 2012-03-09 2013-09-12 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
MX363529B (es) 2012-09-18 2019-03-27 Novartis Ag Vesículas de membrana externa.
JP6446377B2 (ja) 2013-03-08 2018-12-26 ファイザー・インク 免疫原性融合ポリペプチド
KR20210002757A (ko) 2013-09-08 2021-01-08 화이자 인코포레이티드 나이세리아 메닌지티디스 조성물 및 그의 방법
AU2015304847B2 (en) * 2014-08-22 2018-10-25 Glaxosmithkline Intellectual Property Development Limited Tricyclic nitrogen containing compounds for treating Neisseria gonorrhoea infection
AU2016221318B2 (en) 2015-02-19 2020-06-25 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
PE20191107A1 (es) 2017-01-31 2019-08-26 Pfizer Composiciones de neisseria meningitidis y metodos respectivos
CN110568116A (zh) * 2019-09-17 2019-12-13 广东医科大学附属医院 一种筛选用于诊断阿尔茨海默病的生物标志物的方法
BR112022004921A2 (pt) 2019-09-27 2022-07-19 Pfizer Composições para neisseria meningitidis e métodos das mesmas

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4271147A (en) 1980-01-10 1981-06-02 Behringwerke Aktiengesellschaft Process for the isolation of membrane proteins from Neisseria meningitidis and vaccines containing same
US4386066A (en) 1981-08-20 1983-05-31 Merck & Co., Inc. Immunogenic complex from N. gonorrhoeae
WO1983003354A1 (en) 1982-03-30 1983-10-13 Us Army Neisseria gonorrhoeae vaccine
NL8403195A (nl) 1984-10-19 1986-05-16 Nederlanden Staat Immunogene complexen en vaccins die deze bevatten.
US4601903A (en) 1985-05-01 1986-07-22 The United States Of America As Represented By The Department Of Health And Human Services Vaccine against Neisseria meningitidis Group B serotype 2 invasive disease
DE3516017A1 (de) 1985-05-02 1986-11-27 Jochen 1000 Berlin Kittel Verfahren zur herstellung membranstaendiger proteine aus biologischem material zur anwendung im biologischen systemen
US4707543A (en) 1985-09-17 1987-11-17 The United States Of America As Represented By The Secretary Of The Army Process for the preparation of detoxified polysaccharide-outer membrane protein complexes, and their use as antibacterial vaccines
JPH01125328A (ja) * 1987-07-30 1989-05-17 Centro Natl De Biopreparados 髄膜炎菌ワクチン
EP0351604B1 (de) * 1988-06-29 1994-09-14 The Rockefeller University Neisseria-Vakzine
AU640118B2 (en) 1988-12-19 1993-08-19 De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezonheid En Cultuur Meningococcal class 1 outer-membrane protein vaccine
EP0462210B1 (de) 1989-03-09 1994-09-07 Praxis Biologics, Inc. Impfstoffe gegen hämophilus influenzae
ES2056378T3 (es) 1989-04-14 1994-10-01 Unilever Nv Procedimiento de extraccion.
US5552146A (en) * 1991-08-15 1996-09-03 Board Of Regents, The University Of Texas System Methods and compositions relating to useful antigens of Moraxella catarrhalis

Also Published As

Publication number Publication date
JP3711289B2 (ja) 2005-11-02
DK0624376T3 (da) 2000-07-24
JPH0819396A (ja) 1996-01-23
CA2123355A1 (en) 1994-11-14
ES2145072T3 (es) 2000-07-01
US6355253B1 (en) 2002-03-12
EP0624376B1 (de) 2000-03-15
US6921537B2 (en) 2005-07-26
DE69423383D1 (de) 2000-04-20
US20020136741A1 (en) 2002-09-26
EP0624376A1 (de) 1994-11-17
PT624376E (pt) 2000-07-31
DE69423383T2 (de) 2000-08-24
GR3033469T3 (en) 2000-09-29
KR100355961B1 (ko) 2002-12-26
CA2123355C (en) 2007-08-28

Similar Documents

Publication Publication Date Title
ATE190502T1 (de) Herstellung und verwendungen von los-verminderten aussenmembran-proteinen von gram-negativen kokken
AU533386B2 (en) Isolation of membrane proteins from neisseria meningitidis and vaccines containing same
NO913518L (no) Vaksiner for ikke typebestembar haemophilus influenzae.
LU92241I2 (fr) Combinaison de la protéine de fusion NHBA du groupe B de Neisseria meningitidis et de la protéine defusion fHbp du groupe B de Neisseria meningitidis
CA2103887A1 (en) Methods and materials for preparation of modified antibody variable domains and therapeutic uses thereof
DK98695A (da) Fremgangsmåde til solubilisering af iiie-polyanioniske polysaccharider og fremgangsmåde til modificering af neutrale polysaccharider
WO1998056901A3 (en) Live attenuated vaccines
NO943739L (no) Vaksiner inneholdende vesikler basert på ikke-ioniske overflate-aktive midler
EP0761230A2 (de) Aus Bordetella pertussis Aussenmembranprotein enthaltender Impfstoffe und Verfahren zu seiner Herstellung
DE69023648D1 (de) Herstellung eines virus und reinigung von virenüberzugsproteinen zur impfstoffverwendung.
ATE249841T1 (de) Immunogene zubereitungen
ATE95564T1 (de) Aeusseres membranprotein f von pseudomonas aeruginosa.
DK398683A (da) Fremgangsmaade til fremstilling af antistoffer
NO951750L (no) Renset "nontypable" Haemophilus influenzae P5 protein som en vaksine for "nontypable" Haemophilus influenzae stamme
PT96723A (pt) Metodo para a destoxificacao de um antigenio toxico
Novotny et al. Effect of Growth Conditions on the Composition and Stability of the Outer Membrane of
Rappaport et al. Development of a purified cholera toxoid. III. Refinements in purification of toxin and methods for the determination of residual somatic antigen
EP0090660A2 (de) Neisseria Gonorrhöe Vakzin
FR2517967B1 (de)
Hill et al. Protein fraction with immunogenic potential and low toxicity isolated from the cell wall of Neisseria meningitidis group B
Ahsan et al. Immunobiological relationships between Vibrio fluvialis and Vibrio cholerae enterotoxins
PT92807A (pt) Processo para a preparacao de uma vacina de proteina de membrana externa meningococia classe 1
Sandhu et al. Partial characterization of Yersinia intermedia bacteriocin
NO912824L (no) Fremgangsmaate for fremstilling av klasse ii-proteinet frayttermembranen til neisseria meningitidis.
AU8113691A (en) The class ii protein of the outer membrane of neisseria meningitidis having immunologic carrier and enhancement properties, and vaccines containing same

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee