ATE190619T1 - Biskonjugate, die zwei saccharide und einen spacer enthalten - Google Patents

Biskonjugate, die zwei saccharide und einen spacer enthalten

Info

Publication number
ATE190619T1
ATE190619T1 AT94202470T AT94202470T ATE190619T1 AT E190619 T1 ATE190619 T1 AT E190619T1 AT 94202470 T AT94202470 T AT 94202470T AT 94202470 T AT94202470 T AT 94202470T AT E190619 T1 ATE190619 T1 AT E190619T1
Authority
AT
Austria
Prior art keywords
spacer
saccharides
bisconjugates
saccharide
bisconjugate
Prior art date
Application number
AT94202470T
Other languages
English (en)
Inventor
Boeckel Constant Van
Peter Grootenhuis
Maurice Petitou
Pieter Westerduin
Original Assignee
Akzo Nobel Nv
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv, Sanofi Synthelabo filed Critical Akzo Nobel Nv
Application granted granted Critical
Publication of ATE190619T1 publication Critical patent/ATE190619T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT94202470T 1993-09-01 1994-08-30 Biskonjugate, die zwei saccharide und einen spacer enthalten ATE190619T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP93202562 1993-09-01

Publications (1)

Publication Number Publication Date
ATE190619T1 true ATE190619T1 (de) 2000-04-15

Family

ID=8214074

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94202470T ATE190619T1 (de) 1993-09-01 1994-08-30 Biskonjugate, die zwei saccharide und einen spacer enthalten

Country Status (19)

Country Link
US (1) US5705489A (de)
EP (1) EP0649854B1 (de)
JP (1) JP3918953B2 (de)
KR (1) KR100365578B1 (de)
AT (1) ATE190619T1 (de)
AU (1) AU679084B2 (de)
BR (1) BR1100612A (de)
CA (1) CA2131229C (de)
DE (1) DE69423414T2 (de)
DK (1) DK0649854T3 (de)
ES (1) ES2147216T3 (de)
FI (1) FI113540B (de)
GR (1) GR3033410T3 (de)
HU (1) HU227279B1 (de)
NO (1) NO301984B1 (de)
NZ (1) NZ264340A (de)
PT (1) PT649854E (de)
TW (1) TW349951B (de)
ZA (1) ZA946673B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL9201440A (nl) * 1992-08-11 1994-03-01 Univ Leiden Triantennaire clusterglycosiden, hun bereiding en toepassing.
DE19624705A1 (de) * 1996-06-20 1998-01-08 Deutsches Krebsforsch Dendrimere auf Saccharid-Basis
FR2751334B1 (fr) 1996-07-19 1998-10-16 Sanofi Sa Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2773801B1 (fr) * 1998-01-19 2000-05-12 Sanofi Sa Nouveaux pentasaccharides, procedes pour leurs preparations et compositions pharmaceutiques les contenant
ATE405580T1 (de) * 1998-06-17 2008-09-15 Organon Nv Antithrombotische verbindungen
JP4754137B2 (ja) * 1999-08-10 2011-08-24 生化学工業株式会社 グリコサミノグリカン誘導体およびその使用
TWI289566B (en) * 1999-12-07 2007-11-11 N.V.Organon Antithrombotic compound
DE10041221A1 (de) * 2000-08-22 2002-03-14 Deutsches Krebsforsch Verfahren zur Herstellung von wasserlöslichen Saccharidkonjugaten und Saccharidmimetika durch Diels-Alder-Reaktion und ihre Verwendung als Therapeutika oder Diagnostika
EP1574516A1 (de) 2004-03-05 2005-09-14 Sanofi-Aventis Antithrombotische Verbindungen
FR2874924B1 (fr) 2004-09-09 2006-12-01 Sanofi Aventis Sa Hexadecasaccharides biotinyles, leur preparation et leur utilisation therapeutique
TWI403334B (zh) 2004-12-23 2013-08-01 Merck Sharp & Dohme 包含生物素殘基之抗血栓雙重抑制劑
EP1886696A1 (de) * 2006-08-03 2008-02-13 Endotis Pharma Konjugate von antithrombin-bindende-oligosaccharid-derivate und therapeutische proteine
CN102256990B (zh) * 2008-10-03 2014-09-24 聚糖生物科学有限责任公司 阴离子寡糖轭合物
FR2949115B1 (fr) 2009-08-14 2012-11-02 Sanofi Aventis OLIGOSACCHARIDES N-SULFATES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2949114B1 (fr) 2009-08-14 2011-08-26 Sanofi Aventis OCTASACCHARIDES N-ACYLES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
JP2013537181A (ja) 2010-09-10 2013-09-30 サノフイ 抗血栓活性及び改善された代謝安定性を有するビオチン化多糖類
FR2970969B1 (fr) 2011-01-27 2013-10-18 Sanofi Aventis Oligosaccharides 3-o-alkyles activateurs des recepteurs des fgfs, leur preparation et leur application en therapeutique
EP2578594A1 (de) * 2011-10-04 2013-04-10 Sanofi Verfahren zur Herstellung von L-Iduronsäure mittels einer Decarboxylierung/intramolekulare Zyklisierungs-Tandemreaktion

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4818816A (en) * 1981-04-28 1989-04-04 Choay, S.A. Process for the organic synthesis of oligosaccharides and derivatives thereof
DE3734853A1 (de) * 1987-10-14 1989-04-27 Luitpold Werk Chem Pharm Bis-aldonsaeureamide und verfahren zu ihrer herstellung
DE3734815A1 (de) * 1987-10-14 1989-04-27 Luitpold Werk Chem Pharm Polyschwefelsaeureester von bis-aldonsaeureamiden und deren derivaten, verfahren zu ihrer herstellung und arzneimittel
EP0337327A1 (de) * 1988-04-09 1989-10-18 Bioiberica, S.A. Verfahren zur Herstellung von neuen Oligosaccharid-Fragmenten durch kontrollierte chemische Depolymerisation von Heparin
EP0347964A1 (de) * 1988-06-21 1989-12-27 Akzo N.V. Oligosaccharide mit interner Nichtsaccharid-Brücke
IE64378B1 (en) * 1990-04-23 1995-07-26 Akzo Nv Carbohydrate derivatives comprising a trisaccharide unit

Also Published As

Publication number Publication date
FI113540B (fi) 2004-05-14
HU227279B1 (en) 2011-01-28
AU679084B2 (en) 1997-06-19
DE69423414T2 (de) 2000-09-21
CA2131229C (en) 2005-04-12
JPH07304787A (ja) 1995-11-21
NZ264340A (en) 1995-04-27
ES2147216T3 (es) 2000-09-01
FI944001A0 (fi) 1994-08-31
KR950008528A (ko) 1995-04-19
ZA946673B (en) 1995-04-21
BR1100612A (pt) 2003-02-25
FI944001L (fi) 1995-03-02
HK1002009A1 (en) 1998-07-24
AU7161094A (en) 1995-03-16
NO943222D0 (no) 1994-08-31
GR3033410T3 (en) 2000-09-29
CA2131229A1 (en) 1995-03-02
US5705489A (en) 1998-01-06
DK0649854T3 (da) 2000-07-03
HU9402514D0 (en) 1994-10-28
EP0649854A1 (de) 1995-04-26
KR100365578B1 (ko) 2003-03-19
DE69423414D1 (de) 2000-04-20
PT649854E (pt) 2000-07-31
NO301984B1 (no) 1998-01-05
JP3918953B2 (ja) 2007-05-23
NO943222L (no) 1995-03-02
EP0649854B1 (de) 2000-03-15
TW349951B (en) 1999-01-11
HUT69163A (en) 1995-08-28

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