ATE190983T1 - Neue tetrapeptidderivate - Google Patents

Neue tetrapeptidderivate

Info

Publication number: ATE190983T1
Authority: AT; Austria
Prior art keywords: chem; tetrapeptide derivatives; new tetrapeptide; new; derivatives
Prior art date: 1991-08-09

Application number

AT92916961T

Other languages

English (en)

Inventor

Kyoichi Sakakibara

Masaaki Gondo

Koichi Miyazaki

Original Assignee

Teikoku Hormone Mfg Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-08-09

Filing date

1992-08-06

Publication date

2000-04-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26525532&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE190983(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1992-08-06 Application filed by Teikoku Hormone Mfg Co Ltd filed Critical Teikoku Hormone Mfg Co Ltd

2000-04-15 Application granted granted Critical

2000-04-15 Publication of ATE190983T1 publication Critical patent/ATE190983T1/de

Links

OFDNQWIFNXBECV-UHFFFAOYSA-N Dolastatin 10 Natural products CC(C)C(N(C)C)C(=O)NC(C(C)C)C(=O)N(C)C(C(C)CC)C(OC)CC(=O)N1CCCC1C(OC)C(C)C(=O)NC(C=1SC=CN=1)CC1=CC=CC=C1 OFDNQWIFNXBECV-UHFFFAOYSA-N 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
230000001085 cytostatic effect Effects 0.000 abstract 1
OFDNQWIFNXBECV-VFSYNPLYSA-N dolastatin 10 Chemical compound CC(C)[C@H](N(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C=1SC=CN=1)CC1=CC=CC=C1 OFDNQWIFNXBECV-VFSYNPLYSA-N 0.000 abstract 1
108010045524 dolastatin 10 Proteins 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Crystallography & Structural Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT92916961T 1991-08-09 1992-08-06 Neue tetrapeptidderivate ATE190983T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP22353491		1991-08-09
JP22539191		1991-08-12
PCT/JP1992/001005 WO1993003054A1 (fr)	1991-08-09	1992-08-06	Nouveau derive de tetrapeptide

Publications (1)

Publication Number	Publication Date
ATE190983T1 true ATE190983T1 (de)	2000-04-15

Family

ID=26525532

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT98115259T ATE215962T1 (de)	1991-08-09	1992-08-06	Tetrapeptide derivat
AT92916961T ATE190983T1 (de)	1991-08-09	1992-08-06	Neue tetrapeptidderivate

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT98115259T ATE215962T1 (de)	1991-08-09	1992-08-06	Tetrapeptide derivat

Country Status (13)

Country	Link
US (2)	US6004934A (de)
EP (2)	EP0598129B1 (de)
JP (1)	JP2618597B2 (de)
KR (2)	KR0185440B1 (de)
AT (2)	ATE215962T1 (de)
AU (2)	AU662551B2 (de)
CA (1)	CA2115355C (de)
DE (2)	DE69230824T2 (de)
DK (2)	DK0934950T3 (de)
ES (2)	ES2172069T3 (de)
GR (1)	GR3033397T3 (de)
SG (1)	SG87056A1 (de)
WO (1)	WO1993003054A1 (de)

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US5831002A (en) *	1992-05-20	1998-11-03	Basf Aktiengesellschaft	Antitumor peptides
EP0642530B1 (de) *	1992-05-20	1998-08-12	BASF Aktiengesellschaft	Derivate des Dolastatin
PL178766B1 (pl) *	1992-12-16	2000-06-30	Basf Ag	Nowe peptydy
CA2173150C (en) *	1993-10-01	2004-11-30	Kyoichi Sakakibara	Novel peptide derivatives
US5599902A (en) *	1994-11-10	1997-02-04	Arizona Board Of Regents Acting On Behalf Of Arizona State University	Cancer inhibitory peptides
US5663149A (en) *	1994-12-13	1997-09-02	Arizona Board Of Regents Acting On Behalf Of Arizona State University	Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
AU704973B2 (en) *	1995-04-21	1999-05-13	Teikoku Hormone Mfg. Co., Ltd.	Novel peptide derivatives
US5807984A (en) *	1995-11-09	1998-09-15	Basf Aktienegesellschaft	Oligopeptides, the preparation and use thereof
US20010009901A1 (en)	1996-12-11	2001-07-26	Basf Aktiengesellschaft Germany	Antineoplastic peptides
US5741892A (en) *	1996-07-30	1998-04-21	Basf Aktiengesellschaft	Pentapeptides as antitumor agents
US5939527A (en) *	1996-07-30	1999-08-17	Basf Aktiengesellschaft	Tetrapeptides as antitumor agents
US5965537A (en) *	1997-03-10	1999-10-12	Basf Aktiengesellschaft	Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus
US6103698A (en)	1997-03-13	2000-08-15	Basf Aktiengesellschaft	Dolastatin-15 derivatives in combination with taxanes
US6143721A (en)	1997-07-18	2000-11-07	Basf Aktiengesellschaft	Dolastatin 15 derivatives
CA2298639C (en) *	1997-09-24	2005-07-05	Erik J. Flahive	Synthetic antineoplastic agents derived from dolastatin 15 and methods of making same
US6686445B1 (en)	1997-09-24	2004-02-03	Arizona Board Of Regents, Acting For And On Behalf Of Arizona State University	Synthetic antineoplastic agents derived from dolastatin 15 and methods of making same
US6015790A (en) *	1997-10-06	2000-01-18	Basf Aktiengesellschaft	Methods and compositions for treating rheumatoid arthritis
US5985837A (en) *	1998-07-08	1999-11-16	Basf Aktiengesellschaft	Dolastatin 15 derivatives
US6323315B1 (en) *	1999-09-10	2001-11-27	Basf Aktiengesellschaft	Dolastatin peptides
HK1049787B (en)	1999-10-01	2014-07-25	Immunogen, Inc.	Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
WO2001041789A1 (fr) *	1999-12-07	2001-06-14	Santen Pharmaceutical Co., Ltd.	Medicament contre les rhumatismes contenant un derive tetrapeptidique en tant qu'ingredient actif
US6884869B2 (en)	2001-04-30	2005-04-26	Seattle Genetics, Inc.	Pentapeptide compounds and uses related thereto
US7256257B2 (en)	2001-04-30	2007-08-14	Seattle Genetics, Inc.	Pentapeptide compounds and uses related thereto
KR20010079252A (ko) *	2001-06-27	2001-08-22	홍진의	주름형 드럼을 갖는 드럼 필터
US7008928B2 (en) *	2001-09-20	2006-03-07	Teikoku Hormone Mfg. Co., Ltd.	Tetrapeptide derivative TZT-1027 crystal
DK1545613T3 (da)	2002-07-31	2011-11-14	Seattle Genetics Inc	Auristatinkonjugater og deres anvendelse til behandling af cancer, en autoimmun sygdom eller en infektiøs sygdom
CN107213469A (zh) *	2003-11-06	2017-09-29	西雅图基因公司	能够与配体偶联的单甲基缬氨酸化合物
EP3505191A1 (de) *	2004-11-12	2019-07-03	Seattle Genetics, Inc.	Auristatine mit einer aminobenzoesäureeinheit am n-ende
EP1883627B1 (de)	2005-05-18	2018-04-18	Pharmascience Inc.	An die bir-domäne bindende verbindungen
WO2007008603A1 (en)	2005-07-07	2007-01-18	Seattle Genetics, Inc.	Monomethylvaline compounds having phenylalanine side-chain modifications at the c-terminus
US8871720B2 (en)	2005-07-07	2014-10-28	Seattle Genetics, Inc.	Monomethylvaline compounds having phenylalanine carboxy modifications at the C-terminus
US7750116B1 (en)	2006-02-18	2010-07-06	Seattle Genetics, Inc.	Antibody drug conjugate metabolites
WO2007131366A1 (en)	2006-05-16	2007-11-22	Aegera Therapeutics Inc.	Iap bir domain binding compounds
CL2008002083A1 (es)	2007-07-16	2008-11-21	Genentech Inc	Anticuerpo humanizado anti-cd79b/igbeta/b29; inmunoconjugado; metodo in vitro para determinar presencia de cd79b, inhibir crecimiento de celula con cd79b, o para detectara celula b; metodo para elaborar dicho anticyerpo humanizado; acido nucleico; celula huesped; composicion; metodo de elaboracion de inmunoconjugado; uso medico
NZ583367A (en)	2007-07-16	2012-10-26	Genentech Inc	Anti-cd79b antibodies and immunoconjugates and methods of use
US20090035848A1 (en) *	2007-08-03	2009-02-05	Robert Hickey	Moving bed biofilm reactor (mbbr) system for conversion of syngas components to liquid products
ES2643239T3 (es)	2008-01-31	2017-11-21	Genentech, Inc.	Anticuerpos anti-CD79b e inmunoconjugados y métodos de uso
DK2265283T3 (da) *	2008-03-18	2014-10-20	Seattle Genetics Inc	Auristatin-lægemiddel-linker-konjugater
SG182724A1 (en)	2010-02-12	2012-08-30	Pharmascience Inc	Iap bir domain binding compounds
CN104185477B (zh)	2011-11-17	2017-05-24	辉瑞公司	细胞毒性肽及其抗体‑药物缀合物
WO2014046441A1 (ko) *	2012-09-20	2014-03-27	(주)셀트리온	돌라스타틴 10 유도체, 그의 제조방법 및 그를 포함하는 항암제 조성물
CA2891280C (en)	2012-11-24	2018-03-20	Hangzhou Dac Biotech Co., Ltd.	Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
US9988420B2 (en)	2013-12-17	2018-06-05	Novartis Ag	Cytotoxic peptides and conjugates thereof
CN106414465B (zh)	2014-02-28	2021-11-16	杭州多禧生物科技有限公司	带电荷链接体及其在共轭反应上的应用
JP2017519740A (ja) *	2014-05-28	2017-07-20	アジェンシス，インコーポレイテッド	ドラプロイン‐ドライソロイインペプチド誘導体
SG11201609462RA (en)	2014-06-13	2016-12-29	Novartis Ag	Auristatin derivatives and conjugates thereof
DK3262071T3 (da)	2014-09-23	2020-06-15	Hoffmann La Roche	Fremgangsmåde til anvendelse af anti-CD79b-immunkonjugater
WO2015151078A2 (en)	2015-06-15	2015-10-08	Suzhou M-Conj Biotech Co., Ltd	Hydrophilic linkers for conjugation
NZ739830A (en)	2015-07-12	2021-12-24	Hangzhou Dac Biotech Co Ltd	Bridge linkers for conjugation of cell-binding molecules
US9839687B2 (en)	2015-07-15	2017-12-12	Suzhou M-Conj Biotech Co., Ltd.	Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
US10435435B2 (en)	2015-07-24	2019-10-08	The Arizona Board Of Regents On Behalf Of Arizona State University	Quinstatin compounds
WO2017058808A1 (en) *	2015-10-02	2017-04-06	Sirenas Llc	Anti-cancer compounds and conjugates thereof
BR112018016008A2 (pt)	2016-03-29	2018-12-18	Toray Industries, Inc.	derivado de peptídeo ou o sal farmaceuticamente aceitável do mesmo, conjugado ou um sal farmaceuticamente aceitável do mesmo, e, agente citotóxico.
CN116143678A (zh)	2016-11-14	2023-05-23	杭州多禧生物科技有限公司	偶联连接体，含有此连接体的细胞结合分子-药物偶联物及其制备和应用
WO2021084532A1 (en) *	2019-10-28	2021-05-06	Ariel Scientific Innovations Ltd.	Dolastatin 10 analog
CA3230737A1 (en)	2021-09-03	2023-03-09	Toray Industries, Inc.	Pharmaceutical composition for cancer treatment and/or prevention
WO2022078524A2 (en)	2021-11-03	2022-04-21	Hangzhou Dac Biotech Co., Ltd.	Specific conjugation of an antibody

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5017691A (en) *	1986-07-03	1991-05-21	Schering Corporation	Mammalian interleukin-4
US4816444A (en) *	1987-07-10	1989-03-28	Arizona Board Of Regents, Arizona State University	Cell growth inhibitory substance
US4978744A (en) *	1989-01-27	1990-12-18	Arizona Board Of Regents	Synthesis of dolastatin 10
US5635483A (en) *	1992-12-03	1997-06-03	Arizona Board Of Regents Acting On Behalf Of Arizona State University	Tumor inhibiting tetrapeptide bearing modified phenethyl amides
US6034065A (en) *	1992-12-03	2000-03-07	Arizona Board Of Regents	Elucidation and synthesis of antineoplastic tetrapeptide phenethylamides of dolastatin 10

1992
- 1992-08-06 AU AU24152/92A patent/AU662551B2/en not_active Ceased
- 1992-08-06 EP EP92916961A patent/EP0598129B1/de not_active Expired - Lifetime
- 1992-08-06 EP EP98115259A patent/EP0934950B1/de not_active Expired - Lifetime
- 1992-08-06 DK DK98115259T patent/DK0934950T3/da active
- 1992-08-06 ES ES98115259T patent/ES2172069T3/es not_active Expired - Lifetime
- 1992-08-06 ES ES92916961T patent/ES2144421T3/es not_active Expired - Lifetime
- 1992-08-06 SG SG9905131A patent/SG87056A1/en unknown
- 1992-08-06 DK DK92916961T patent/DK0598129T3/da active
- 1992-08-06 WO PCT/JP1992/001005 patent/WO1993003054A1/ja not_active Ceased
- 1992-08-06 DE DE69230824T patent/DE69230824T2/de not_active Expired - Lifetime
- 1992-08-06 AT AT98115259T patent/ATE215962T1/de not_active IP Right Cessation
- 1992-08-06 CA CA002115355A patent/CA2115355C/en not_active Expired - Fee Related
- 1992-08-06 US US08/190,194 patent/US6004934A/en not_active Expired - Fee Related
- 1992-08-06 KR KR1019940700418A patent/KR0185440B1/ko not_active Expired - Fee Related
- 1992-08-06 DE DE69232552T patent/DE69232552T2/de not_active Expired - Fee Related
- 1992-08-06 JP JP5503479A patent/JP2618597B2/ja not_active Expired - Fee Related
- 1992-08-06 AT AT92916961T patent/ATE190983T1/de not_active IP Right Cessation
1995
- 1995-05-12 AU AU20010/95A patent/AU673487B2/en not_active Ceased
- 1995-07-03 US US08/498,688 patent/US5654399A/en not_active Expired - Lifetime
1998
- 1998-09-23 KR KR1019980707541A patent/KR100202474B1/ko not_active Expired - Fee Related
2000
- 2000-05-11 GR GR20000401085T patent/GR3033397T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
US6004934A (en)	1999-12-21
CA2115355C (en)	2007-09-11
EP0598129B1 (de)	2000-03-22
GR3033397T3 (en)	2000-09-29
EP0598129A4 (en)	1995-10-25
AU2001095A (en)	1995-07-20
EP0598129A1 (de)	1994-05-25
WO1993003054A1 (fr)	1993-02-18
DE69232552T2 (de)	2002-10-31
DK0598129T3 (da)	2000-07-03
DK0934950T3 (da)	2002-07-29
EP0934950B1 (de)	2002-04-10
DE69230824D1 (de)	2000-04-27
DE69230824T2 (de)	2000-07-27
KR0185440B1 (ko)	1999-04-01
DE69232552D1 (de)	2002-05-16
AU2415292A (en)	1993-03-02
JP2618597B2 (ja)	1997-06-11
CA2115355A1 (en)	1993-02-18
KR100202474B1 (en)	1999-06-15
US5654399A (en)	1997-08-05
ES2172069T3 (es)	2002-09-16
SG87056A1 (en)	2002-03-19
AU673487B2 (en)	1996-11-07
ES2144421T3 (es)	2000-06-16
AU662551B2 (en)	1995-09-07
EP0934950A1 (de)	1999-08-11
ATE215962T1 (de)	2002-04-15

Legal Events

Date	Code	Title	Description
2000-08-15	UEP	Publication of translation of european patent specification
2011-05-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69230824D1 (de)	2000-04-27	Neue tetrapeptidderivate
DE69533277D1 (de)	2004-08-26	Dc-89 derivat
DK0528678T3 (da)	2001-07-30	Pyrrolidylthiocarbapenemderivat med antibakteriel aktivitet
FI914928A0 (fi)	1991-10-18	Hydroximetyl (metylencyklopentyl) puriner och -pyrimidiner.
SE9003476L (sv)	1992-05-01	Novel isoindole derivatives and salts thereof, process for producing the same and antitumor agent comprising the same
KR950701615A (ko)	1995-04-28	혈소판 응집 저해작용을 갖는 신규한 화합물(novel compound with plate-let aggregation inhibitor activity)
ES2093037T3 (es)	1996-12-16	Derivados de beta-lactama y su preparacion.
ATE100459T1 (de)	1994-02-15	Antifungale antibiotika.
ES2106058T3 (es)	1997-11-01	Derivados de benzamida.
DE69423339D1 (de)	2000-04-13	Epoxycyclohexendionderivat
ATE90685T1 (de)	1993-07-15	Disaccharidderivate.
AU621634B2 (en)	1992-03-19	Glycerin derivative and its pharmacological use
FI963568A0 (fi)	1996-09-10	Peptidijohdannaisia
ATE184282T1 (de)	1999-09-15	Cyclopropan-derivate und diese enthaltende antivirale mittel
ES2093051T3 (es)	1996-12-16	Purinil- y pirimidil-tetrahidrofuranos.
ES2149180T3 (es)	2000-11-01	Derivado de pirazolotiazolopirimidina.