ATE190983T1 - Neue tetrapeptidderivate - Google Patents

Neue tetrapeptidderivate

Info

Publication number: ATE190983T1
Authority: AT; Austria
Prior art keywords: chem; tetrapeptide derivatives; new tetrapeptide; new; derivatives
Prior art date: 1991-08-09

Application number

AT92916961T

Other languages

English (en)

Inventor

Kyoichi Sakakibara

Masaaki Gondo

Koichi Miyazaki

Original Assignee

Teikoku Hormone Mfg Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-08-09

Filing date

1992-08-06

Publication date

2000-04-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26525532&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE190983(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1992-08-06 Application filed by Teikoku Hormone Mfg Co Ltd filed Critical Teikoku Hormone Mfg Co Ltd

2000-04-15 Application granted granted Critical

2000-04-15 Publication of ATE190983T1 publication Critical patent/ATE190983T1/de

Links

OFDNQWIFNXBECV-UHFFFAOYSA-N Dolastatin 10 Natural products CC(C)C(N(C)C)C(=O)NC(C(C)C)C(=O)N(C)C(C(C)CC)C(OC)CC(=O)N1CCCC1C(OC)C(C)C(=O)NC(C=1SC=CN=1)CC1=CC=CC=C1 OFDNQWIFNXBECV-UHFFFAOYSA-N 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
230000001085 cytostatic effect Effects 0.000 abstract 1
OFDNQWIFNXBECV-VFSYNPLYSA-N dolastatin 10 Chemical compound CC(C)[C@H](N(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C=1SC=CN=1)CC1=CC=CC=C1 OFDNQWIFNXBECV-VFSYNPLYSA-N 0.000 abstract 1
108010045524 dolastatin 10 Proteins 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Crystallography & Structural Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT92916961T 1991-08-09 1992-08-06 Neue tetrapeptidderivate ATE190983T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP22353491		1991-08-09
JP22539191		1991-08-12
PCT/JP1992/001005 WO1993003054A1 (fr)	1991-08-09	1992-08-06	Nouveau derive de tetrapeptide

Publications (1)

Publication Number	Publication Date
ATE190983T1 true ATE190983T1 (de)	2000-04-15

Family

ID=26525532

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT98115259T ATE215962T1 (de)	1991-08-09	1992-08-06	Tetrapeptide derivat
AT92916961T ATE190983T1 (de)	1991-08-09	1992-08-06	Neue tetrapeptidderivate

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT98115259T ATE215962T1 (de)	1991-08-09	1992-08-06	Tetrapeptide derivat

Country Status (13)

Country	Link
US (2)	US6004934A (de)
EP (2)	EP0598129B1 (de)
JP (1)	JP2618597B2 (de)
KR (2)	KR0185440B1 (de)
AT (2)	ATE215962T1 (de)
AU (2)	AU662551B2 (de)
CA (1)	CA2115355C (de)
DE (2)	DE69230824T2 (de)
DK (2)	DK0934950T3 (de)
ES (2)	ES2144421T3 (de)
GR (1)	GR3033397T3 (de)
SG (1)	SG87056A1 (de)
WO (1)	WO1993003054A1 (de)

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* Cited by examiner, † Cited by third party
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US5831002A (en) *	1992-05-20	1998-11-03	Basf Aktiengesellschaft	Antitumor peptides
CA2136339C (en) *	1992-05-20	2008-02-05	Andreas Haupt	Derivatives of dolastatin
PL178766B1 (pl) *	1992-12-16	2000-06-30	Basf Ag	Nowe peptydy
EP0731106B1 (de) *	1993-10-01	2004-11-17	Teikoku Hormone Mfg. Co., Ltd.	Dolastatin-derivate
US5599902A (en) *	1994-11-10	1997-02-04	Arizona Board Of Regents Acting On Behalf Of Arizona State University	Cancer inhibitory peptides
US5663149A (en) *	1994-12-13	1997-09-02	Arizona Board Of Regents Acting On Behalf Of Arizona State University	Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
CN1113066C (zh) *	1995-04-21	2003-07-02	帝国脏器制药株式会社	新型肽衍生物
US5807984A (en) *	1995-11-09	1998-09-15	Basf Aktienegesellschaft	Oligopeptides, the preparation and use thereof
US20010009901A1 (en)	1996-12-11	2001-07-26	Basf Aktiengesellschaft Germany	Antineoplastic peptides
US5939527A (en) *	1996-07-30	1999-08-17	Basf Aktiengesellschaft	Tetrapeptides as antitumor agents
US5741892A (en) *	1996-07-30	1998-04-21	Basf Aktiengesellschaft	Pentapeptides as antitumor agents
US5965537A (en) *	1997-03-10	1999-10-12	Basf Aktiengesellschaft	Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus
US6103698A (en)	1997-03-13	2000-08-15	Basf Aktiengesellschaft	Dolastatin-15 derivatives in combination with taxanes
US6143721A (en)	1997-07-18	2000-11-07	Basf Aktiengesellschaft	Dolastatin 15 derivatives
ATE293638T1 (de) *	1997-09-24	2005-05-15	Univ Arizona	Synthetische antineoplastische wirkstoffe abgeleitet von dolastatin 15 sowie verfahren zu ihrer herstellung
US6686445B1 (en)	1997-09-24	2004-02-03	Arizona Board Of Regents, Acting For And On Behalf Of Arizona State University	Synthetic antineoplastic agents derived from dolastatin 15 and methods of making same
US6015790A (en) *	1997-10-06	2000-01-18	Basf Aktiengesellschaft	Methods and compositions for treating rheumatoid arthritis
US5985837A (en) *	1998-07-08	1999-11-16	Basf Aktiengesellschaft	Dolastatin 15 derivatives
US6323315B1 (en) *	1999-09-10	2001-11-27	Basf Aktiengesellschaft	Dolastatin peptides
AU775373B2 (en)	1999-10-01	2004-07-29	Immunogen, Inc.	Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
WO2001041789A1 (fr) *	1999-12-07	2001-06-14	Santen Pharmaceutical Co., Ltd.	Medicament contre les rhumatismes contenant un derive tetrapeptidique en tant qu'ingredient actif
US7256257B2 (en) *	2001-04-30	2007-08-14	Seattle Genetics, Inc.	Pentapeptide compounds and uses related thereto
US6884869B2 (en)	2001-04-30	2005-04-26	Seattle Genetics, Inc.	Pentapeptide compounds and uses related thereto
KR20010079252A (ko) *	2001-06-27	2001-08-22	홍진의	주름형 드럼을 갖는 드럼 필터
US7008928B2 (en) *	2001-09-20	2006-03-07	Teikoku Hormone Mfg. Co., Ltd.	Tetrapeptide derivative TZT-1027 crystal
DK1545613T3 (da)	2002-07-31	2011-11-14	Seattle Genetics Inc	Auristatinkonjugater og deres anvendelse til behandling af cancer, en autoimmun sygdom eller en infektiøs sygdom
EP2478912B1 (de)	2003-11-06	2016-08-31	Seattle Genetics, Inc.	Konjugate von Auristatin mit gegen HER2- oder CD22-gerichtete Antikörper und deren therapeutische Verwendung
US8288352B2 (en) *	2004-11-12	2012-10-16	Seattle Genetics, Inc.	Auristatins having an aminobenzoic acid unit at the N terminus
JP4954983B2 (ja)	2005-05-18	2012-06-20	ファーマサイエンス・インコーポレイテッド	Ｂｉｒドメイン結合化合物
WO2007008848A2 (en)	2005-07-07	2007-01-18	Seattle Genetics, Inc.	Monomethylvaline compounds having phenylalanine carboxy modifications at the c-terminus
ES2708763T3 (es)	2005-07-07	2019-04-11	Seattle Genetics Inc	Compuestos de monometilvalina que tienen modificaciones de la cadena lateral de fenilalanina en el extremo C
US7750116B1 (en) *	2006-02-18	2010-07-06	Seattle Genetics, Inc.	Antibody drug conjugate metabolites
CN101535300B (zh)	2006-05-16	2014-05-28	埃格拉医疗公司	Iap bir域结合化合物
EP2176295B1 (de)	2007-07-16	2014-11-19	Genentech, Inc.	Humanisierte anti-cd79b-antikörper und immunkonjugate und anwendungsverfahren
PE20090943A1 (es)	2007-07-16	2009-08-05	Genentech Inc	Anticuerpos anti-cd79b e inmunoconjugados
US20090035848A1 (en) *	2007-08-03	2009-02-05	Robert Hickey	Moving bed biofilm reactor (mbbr) system for conversion of syngas components to liquid products
KR101607346B1 (ko)	2008-01-31	2016-03-29	제넨테크, 인크.	항-ｃｄ７９ｂ 항체 및 면역접합체 및 사용 방법
DK2265283T3 (da)	2008-03-18	2014-10-20	Seattle Genetics Inc	Auristatin-lægemiddel-linker-konjugater
US9284350B2 (en)	2010-02-12	2016-03-15	Pharmascience Inc.	IAP BIR domain binding compounds
CN104185477B (zh)	2011-11-17	2017-05-24	辉瑞公司	细胞毒性肽及其抗体‑药物缀合物
JP6089108B2 (ja) *	2012-09-20	2017-03-01	セルトリオン，インク．	ドラスタチン１０誘導体、その製造方法およびそれを含む抗癌剤組成物
CA2891280C (en)	2012-11-24	2018-03-20	Hangzhou Dac Biotech Co., Ltd.	Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
JP6636925B2 (ja)	2013-12-17	2020-01-29	ノバルティスアーゲー	細胞障害性ペプチドおよびその抱合体
US10464955B2 (en)	2014-02-28	2019-11-05	Hangzhou Dac Biotech Co., Ltd.	Charged linkers and their uses for conjugation
WO2015183978A1 (en) *	2014-05-28	2015-12-03	Agensys, Inc.	Derivatives of dolaproine-dolaisoleuine peptides
CA2951368A1 (en)	2014-06-13	2015-12-17	Novartis Ag	Auristatin derivatives and conjugates thereof
HUE049175T2 (hu)	2014-09-23	2020-09-28	Hoffmann La Roche	Eljárás anti-CD79b immunkonjugátumok alkalmazására
CA2989269C (en)	2015-06-15	2020-09-22	Robert Yongxin Zhao	Hydrophilic linkers for conjugation of a cytotoxic agent or chromophore molecule to a cell-binding molecule
NZ739830A (en)	2015-07-12	2021-12-24	Hangzhou Dac Biotech Co Ltd	Bridge linkers for conjugation of cell-binding molecules
US9839687B2 (en)	2015-07-15	2017-12-12	Suzhou M-Conj Biotech Co., Ltd.	Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
US10435435B2 (en)	2015-07-24	2019-10-08	The Arizona Board Of Regents On Behalf Of Arizona State University	Quinstatin compounds
WO2017058808A1 (en) *	2015-10-02	2017-04-06	Sirenas Llc	Anti-cancer compounds and conjugates thereof
CN108779146B (zh) *	2016-03-29	2022-03-18	东丽株式会社	肽衍生物及其用途
KR20220150408A (ko)	2016-11-14	2022-11-10	항저우 디에이씨 바이오테크 씨오, 엘티디	결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용
US20230000995A1 (en) *	2019-10-28	2023-01-05	Ariel Scientific Innovations Ltd.	Dolastatin 10 analog
CN118119409A (zh)	2021-09-03	2024-05-31	东丽株式会社	癌的治疗和/或预防用药物组合物
EP4426727A2 (de)	2021-11-03	2024-09-11	Hangzhou Dac Biotech Co., Ltd.	Spezifische konjugation eines antikörpers

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5017691A (en) *	1986-07-03	1991-05-21	Schering Corporation	Mammalian interleukin-4
US4816444A (en) *	1987-07-10	1989-03-28	Arizona Board Of Regents, Arizona State University	Cell growth inhibitory substance
US4978744A (en) *	1989-01-27	1990-12-18	Arizona Board Of Regents	Synthesis of dolastatin 10
US6034065A (en) *	1992-12-03	2000-03-07	Arizona Board Of Regents	Elucidation and synthesis of antineoplastic tetrapeptide phenethylamides of dolastatin 10
US5635483A (en) *	1992-12-03	1997-06-03	Arizona Board Of Regents Acting On Behalf Of Arizona State University	Tumor inhibiting tetrapeptide bearing modified phenethyl amides

1992
- 1992-08-06 WO PCT/JP1992/001005 patent/WO1993003054A1/ja not_active Ceased
- 1992-08-06 US US08/190,194 patent/US6004934A/en not_active Expired - Fee Related
- 1992-08-06 DK DK98115259T patent/DK0934950T3/da active
- 1992-08-06 EP EP92916961A patent/EP0598129B1/de not_active Expired - Lifetime
- 1992-08-06 CA CA002115355A patent/CA2115355C/en not_active Expired - Fee Related
- 1992-08-06 DE DE69230824T patent/DE69230824T2/de not_active Expired - Lifetime
- 1992-08-06 SG SG9905131A patent/SG87056A1/en unknown
- 1992-08-06 DK DK92916961T patent/DK0598129T3/da active
- 1992-08-06 AT AT98115259T patent/ATE215962T1/de not_active IP Right Cessation
- 1992-08-06 DE DE69232552T patent/DE69232552T2/de not_active Expired - Fee Related
- 1992-08-06 JP JP5503479A patent/JP2618597B2/ja not_active Expired - Fee Related
- 1992-08-06 KR KR1019940700418A patent/KR0185440B1/ko not_active Expired - Fee Related
- 1992-08-06 EP EP98115259A patent/EP0934950B1/de not_active Expired - Lifetime
- 1992-08-06 ES ES92916961T patent/ES2144421T3/es not_active Expired - Lifetime
- 1992-08-06 AT AT92916961T patent/ATE190983T1/de not_active IP Right Cessation
- 1992-08-06 AU AU24152/92A patent/AU662551B2/en not_active Ceased
- 1992-08-06 ES ES98115259T patent/ES2172069T3/es not_active Expired - Lifetime
1995
- 1995-05-12 AU AU20010/95A patent/AU673487B2/en not_active Ceased
- 1995-07-03 US US08/498,688 patent/US5654399A/en not_active Expired - Lifetime
1998
- 1998-09-23 KR KR1019980707541A patent/KR100202474B1/ko not_active Expired - Fee Related
2000
- 2000-05-11 GR GR20000401085T patent/GR3033397T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP2618597B2 (ja)	1997-06-11
DE69232552T2 (de)	2002-10-31
GR3033397T3 (en)	2000-09-29
EP0598129A4 (en)	1995-10-25
AU673487B2 (en)	1996-11-07
US6004934A (en)	1999-12-21
WO1993003054A1 (fr)	1993-02-18
US5654399A (en)	1997-08-05
EP0598129B1 (de)	2000-03-22
KR0185440B1 (ko)	1999-04-01
CA2115355C (en)	2007-09-11
ES2172069T3 (es)	2002-09-16
DE69230824T2 (de)	2000-07-27
CA2115355A1 (en)	1993-02-18
EP0934950A1 (de)	1999-08-11
DK0934950T3 (da)	2002-07-29
EP0598129A1 (de)	1994-05-25
SG87056A1 (en)	2002-03-19
AU2415292A (en)	1993-03-02
DE69232552D1 (de)	2002-05-16
KR100202474B1 (en)	1999-06-15
AU662551B2 (en)	1995-09-07
EP0934950B1 (de)	2002-04-10
DK0598129T3 (da)	2000-07-03
AU2001095A (en)	1995-07-20
DE69230824D1 (de)	2000-04-27
ATE215962T1 (de)	2002-04-15
ES2144421T3 (es)	2000-06-16

Legal Events

Date	Code	Title	Description
2000-08-15	UEP	Publication of translation of european patent specification
2011-05-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE190983T1 (de)	2000-04-15	Neue tetrapeptidderivate
DE69533277D1 (de)	2004-08-26	Dc-89 derivat
DK0528678T3 (da)	2001-07-30	Pyrrolidylthiocarbapenemderivat med antibakteriel aktivitet
FI914928A0 (fi)	1991-10-18	Hydroximetyl (metylencyklopentyl) puriner och -pyrimidiner.
SE9003476D0 (sv)	1990-10-31	Novel isoindole derivatives and salts thereof, process for producing the same and antitumor agent comprising the same
TW269687B (de)	1996-02-01
DE68912438D1 (de)	1994-03-03	Antifungale Antibiotika.
ES2106058T3 (es)	1997-11-01	Derivados de benzamida.
DE69423339D1 (de)	2000-04-13	Epoxycyclohexendionderivat
ATE90685T1 (de)	1993-07-15	Disaccharidderivate.
AU621634B2 (en)	1992-03-19	Glycerin derivative and its pharmacological use
FI963568A0 (fi)	1996-09-10	Peptidijohdannaisia
ATE184282T1 (de)	1999-09-15	Cyclopropan-derivate und diese enthaltende antivirale mittel
ES2093051T3 (es)	1996-12-16	Purinil- y pirimidil-tetrahidrofuranos.
ES2149180T3 (es)	2000-11-01	Derivado de pirazolotiazolopirimidina.