ATE190983T1 - Neue tetrapeptidderivate - Google Patents

Neue tetrapeptidderivate

Info

Publication number: ATE190983T1
Authority: AT; Austria
Prior art keywords: chem; tetrapeptide derivatives; new tetrapeptide; new; derivatives
Prior art date: 1991-08-09

Application number

AT92916961T

Other languages

English (en)

Inventor

Kyoichi Sakakibara

Masaaki Gondo

Koichi Miyazaki

Original Assignee

Teikoku Hormone Mfg Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-08-09

Filing date

1992-08-06

Publication date

2000-04-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26525532&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE190983(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1992-08-06 Application filed by Teikoku Hormone Mfg Co Ltd filed Critical Teikoku Hormone Mfg Co Ltd

2000-04-15 Application granted granted Critical

2000-04-15 Publication of ATE190983T1 publication Critical patent/ATE190983T1/de

Links

OFDNQWIFNXBECV-UHFFFAOYSA-N Dolastatin 10 Natural products CC(C)C(N(C)C)C(=O)NC(C(C)C)C(=O)N(C)C(C(C)CC)C(OC)CC(=O)N1CCCC1C(OC)C(C)C(=O)NC(C=1SC=CN=1)CC1=CC=CC=C1 OFDNQWIFNXBECV-UHFFFAOYSA-N 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
230000001085 cytostatic effect Effects 0.000 abstract 1
OFDNQWIFNXBECV-VFSYNPLYSA-N dolastatin 10 Chemical compound CC(C)[C@H](N(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C=1SC=CN=1)CC1=CC=CC=C1 OFDNQWIFNXBECV-VFSYNPLYSA-N 0.000 abstract 1
108010045524 dolastatin 10 Proteins 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Crystallography & Structural Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT92916961T 1991-08-09 1992-08-06 Neue tetrapeptidderivate ATE190983T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP22353491		1991-08-09
JP22539191		1991-08-12
PCT/JP1992/001005 WO1993003054A1 (fr)	1991-08-09	1992-08-06	Nouveau derive de tetrapeptide

Publications (1)

Publication Number	Publication Date
ATE190983T1 true ATE190983T1 (de)	2000-04-15

Family

ID=26525532

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT98115259T ATE215962T1 (de)	1991-08-09	1992-08-06	Tetrapeptide derivat
AT92916961T ATE190983T1 (de)	1991-08-09	1992-08-06	Neue tetrapeptidderivate

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT98115259T ATE215962T1 (de)	1991-08-09	1992-08-06	Tetrapeptide derivat

Country Status (13)

Country	Link
US (2)	US6004934A (de)
EP (2)	EP0934950B1 (de)
JP (1)	JP2618597B2 (de)
KR (2)	KR0185440B1 (de)
AT (2)	ATE215962T1 (de)
AU (2)	AU662551B2 (de)
CA (1)	CA2115355C (de)
DE (2)	DE69232552T2 (de)
DK (2)	DK0934950T3 (de)
ES (2)	ES2144421T3 (de)
GR (1)	GR3033397T3 (de)
SG (1)	SG87056A1 (de)
WO (1)	WO1993003054A1 (de)

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UA45304C2 (uk) *	1992-05-20	2002-04-15	Басф Аг	Похідні пептиду або їх солі, фармацевтична композиція
US5831002A (en) *	1992-05-20	1998-11-03	Basf Aktiengesellschaft	Antitumor peptides
DE69329425T2 (de) *	1992-12-16	2001-01-18	Basf Ag	Dolastatin analog
EP0731106B1 (de) *	1993-10-01	2004-11-17	Teikoku Hormone Mfg. Co., Ltd.	Dolastatin-derivate
US5599902A (en) *	1994-11-10	1997-02-04	Arizona Board Of Regents Acting On Behalf Of Arizona State University	Cancer inhibitory peptides
US5663149A (en) *	1994-12-13	1997-09-02	Arizona Board Of Regents Acting On Behalf Of Arizona State University	Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
EP0831100B1 (de) *	1995-04-21	2000-10-11	Teikoku Hormone Mfg. Co., Ltd.	Neuartige peptidderivate
US5807984A (en) *	1995-11-09	1998-09-15	Basf Aktienegesellschaft	Oligopeptides, the preparation and use thereof
US20010009901A1 (en)	1996-12-11	2001-07-26	Basf Aktiengesellschaft Germany	Antineoplastic peptides
US5939527A (en) *	1996-07-30	1999-08-17	Basf Aktiengesellschaft	Tetrapeptides as antitumor agents
US5741892A (en) *	1996-07-30	1998-04-21	Basf Aktiengesellschaft	Pentapeptides as antitumor agents
US5965537A (en) *	1997-03-10	1999-10-12	Basf Aktiengesellschaft	Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus
US6103698A (en)	1997-03-13	2000-08-15	Basf Aktiengesellschaft	Dolastatin-15 derivatives in combination with taxanes
US6143721A (en)	1997-07-18	2000-11-07	Basf Aktiengesellschaft	Dolastatin 15 derivatives
EP1049481B1 (de) *	1997-09-24	2005-04-20	Arizona Board Of Regents	Synthetische antineoplastische wirkstoffe abgeleitet von dolastatin 15 sowie verfahren zu ihrer herstellung
US6686445B1 (en)	1997-09-24	2004-02-03	Arizona Board Of Regents, Acting For And On Behalf Of Arizona State University	Synthetic antineoplastic agents derived from dolastatin 15 and methods of making same
US6015790A (en) *	1997-10-06	2000-01-18	Basf Aktiengesellschaft	Methods and compositions for treating rheumatoid arthritis
US5985837A (en) *	1998-07-08	1999-11-16	Basf Aktiengesellschaft	Dolastatin 15 derivatives
US6323315B1 (en)	1999-09-10	2001-11-27	Basf Aktiengesellschaft	Dolastatin peptides
JP4776843B2 (ja)	1999-10-01	2011-09-21	イムノゲンインコーポレーティッド	免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
WO2001041789A1 (fr) *	1999-12-07	2001-06-14	Santen Pharmaceutical Co., Ltd.	Medicament contre les rhumatismes contenant un derive tetrapeptidique en tant qu'ingredient actif
US6884869B2 (en)	2001-04-30	2005-04-26	Seattle Genetics, Inc.	Pentapeptide compounds and uses related thereto
US7256257B2 (en)	2001-04-30	2007-08-14	Seattle Genetics, Inc.	Pentapeptide compounds and uses related thereto
KR20010079252A (ko) *	2001-06-27	2001-08-22	홍진의	주름형 드럼을 갖는 드럼 필터
CA2460956C (en) *	2001-09-20	2010-12-21	Teikoku Hormone Mfg. Co., Ltd.	Tetrapeptide derivative crystals
ES2369542T3 (es) *	2002-07-31	2011-12-01	Seattle Genetics, Inc.	Conjugados de auristatina y su uso para tratar cáncer, una enfermedad autoinmune o una enfermedad infecciosa.
ES2605443T3 (es) *	2003-11-06	2017-03-14	Seattle Genetics, Inc.	Conjugados de auristatina con anticuerpos anti-HER2 o anti-CD22 y su uso en terapia
JP2008519863A (ja) *	2004-11-12	2008-06-12	シアトルジェネティクスインコーポレイティッド	Ｎ末端にアミノ安息香酸単位を有するオーリスタチン
WO2006122408A1 (en)	2005-05-18	2006-11-23	Aegera Therapeutics Inc.	Bir domain binding compounds
ES2708763T3 (es)	2005-07-07	2019-04-11	Seattle Genetics Inc	Compuestos de monometilvalina que tienen modificaciones de la cadena lateral de fenilalanina en el extremo C
WO2007008848A2 (en) *	2005-07-07	2007-01-18	Seattle Genetics, Inc.	Monomethylvaline compounds having phenylalanine carboxy modifications at the c-terminus
US7750116B1 (en)	2006-02-18	2010-07-06	Seattle Genetics, Inc.	Antibody drug conjugate metabolites
BRPI0711591A2 (pt)	2006-05-16	2011-11-16	Aegera Therapeutics, Inc.	composto de ligação de domìnio bir da iap
PE20140625A1 (es)	2007-07-16	2014-05-29	Genentech Inc	ANTICUERPOS ANTI-CD79b E INMUNOCONJUGADOS HUMANIZADOS
PT2474557E (pt)	2007-07-16	2014-12-03	Genentech Inc	Anticorpos e imunoconjugados anti-cd79b e métodos de utilização
US20090035848A1 (en) *	2007-08-03	2009-02-05	Robert Hickey	Moving bed biofilm reactor (mbbr) system for conversion of syngas components to liquid products
DK2657253T3 (en)	2008-01-31	2017-10-09	Genentech Inc	Anti-CD79b antibodies and immune conjugates and methods of use
WO2009117531A1 (en) *	2008-03-18	2009-09-24	Seattle Genetics, Inc.	Auristatin drug linker conjugates
NZ602368A (en)	2010-02-12	2014-10-31	Pharmascience Inc	Iap bir domain binding compounds
EP2780039B9 (de)	2011-11-17	2018-04-18	Pfizer Inc	Zytotoxische peptide und antikörperwirkstoffkonjugate dafür
US9278996B2 (en)	2012-09-20	2016-03-08	Celltrion, Inc.	Dolastatin-10 derivative, method of producing the same and anticancer drug composition containing the same
US10131682B2 (en)	2012-11-24	2018-11-20	Hangzhou Dac Biotech Co., Ltd.	Hydrophilic linkers and their uses for conjugation of drugs to a cell binding molecules
WO2015095301A2 (en)	2013-12-17	2015-06-25	Irm Llc	Cytotoxic peptides and conjugates thereof
JP6417421B2 (ja)	2014-02-28	2018-11-07	ハンジョウディーエーシーバイオテックシーオー．，エルティディ．ＨａｎｇｚｈｏｕＤａｃＢｉｏｔｅｃｈＣｏ．，Ｌｔｄ．	荷電連結体及び共役体のためのその使用
RU2747989C2 (ru) *	2014-05-28	2021-05-18	Эдженсис, Инк.	Производные пептидов долапроин-долаизолейина
US9884817B2 (en)	2014-06-13	2018-02-06	Novartis Ag	Auristatin derivatives and conjugates thereof
CA2979671C (en)	2014-09-23	2020-03-10	Genentech, Inc.	Methods of using anti-cd79b immunoconjugates
EP3307749A4 (de)	2015-06-15	2019-06-19	Hangzhou Dac Biotech Co., Ltd	Hydrophile linker für konjugation
CA2991973C (en)	2015-07-12	2021-12-07	Suzhou M-Conj Biotech Co., Ltd.	Bridge linkers for conjugation of a cell-binding molecule
US9839687B2 (en)	2015-07-15	2017-12-12	Suzhou M-Conj Biotech Co., Ltd.	Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
EP3325497B1 (de)	2015-07-24	2020-09-02	Arizona Board of Regents on behalf of Arizona State University	Quinstatinverbindungen
WO2017058808A1 (en) *	2015-10-02	2017-04-06	Sirenas Llc	Anti-cancer compounds and conjugates thereof
ES2948846T3 (es) *	2016-03-29	2023-09-20	Toray Industries	Derivado peptídico y uso del mismo
KR20220147719A (ko)	2016-11-14	2022-11-03	항저우 디에이씨 바이오테크 씨오, 엘티디	결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용
US20230000995A1 (en) *	2019-10-28	2023-01-05	Ariel Scientific Innovations Ltd.	Dolastatin 10 analog
CA3230737A1 (en)	2021-09-03	2023-03-09	Toray Industries, Inc.	Pharmaceutical composition for cancer treatment and/or prevention
CN117980327A (zh)	2021-11-03	2024-05-03	杭州多禧生物科技有限公司	抗体的特异性偶联
CN118561834A (zh) *	2023-02-28	2024-08-30	烟台大学	苯丙氨酸衍生联噻唑化合物及其用途

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Publication number	Priority date	Publication date	Assignee	Title
US5017691A (en) *	1986-07-03	1991-05-21	Schering Corporation	Mammalian interleukin-4
US4816444A (en) *	1987-07-10	1989-03-28	Arizona Board Of Regents, Arizona State University	Cell growth inhibitory substance
US4978744A (en) *	1989-01-27	1990-12-18	Arizona Board Of Regents	Synthesis of dolastatin 10
US5635483A (en) *	1992-12-03	1997-06-03	Arizona Board Of Regents Acting On Behalf Of Arizona State University	Tumor inhibiting tetrapeptide bearing modified phenethyl amides
US6034065A (en) *	1992-12-03	2000-03-07	Arizona Board Of Regents	Elucidation and synthesis of antineoplastic tetrapeptide phenethylamides of dolastatin 10

1992
- 1992-08-06 DK DK98115259T patent/DK0934950T3/da active
- 1992-08-06 EP EP98115259A patent/EP0934950B1/de not_active Expired - Lifetime
- 1992-08-06 ES ES92916961T patent/ES2144421T3/es not_active Expired - Lifetime
- 1992-08-06 CA CA002115355A patent/CA2115355C/en not_active Expired - Fee Related
- 1992-08-06 KR KR1019940700418A patent/KR0185440B1/ko not_active Expired - Fee Related
- 1992-08-06 DE DE69232552T patent/DE69232552T2/de not_active Expired - Fee Related
- 1992-08-06 AT AT98115259T patent/ATE215962T1/de not_active IP Right Cessation
- 1992-08-06 SG SG9905131A patent/SG87056A1/en unknown
- 1992-08-06 DK DK92916961T patent/DK0598129T3/da active
- 1992-08-06 JP JP5503479A patent/JP2618597B2/ja not_active Expired - Fee Related
- 1992-08-06 WO PCT/JP1992/001005 patent/WO1993003054A1/ja not_active Ceased
- 1992-08-06 DE DE69230824T patent/DE69230824T2/de not_active Expired - Lifetime
- 1992-08-06 US US08/190,194 patent/US6004934A/en not_active Expired - Fee Related
- 1992-08-06 EP EP92916961A patent/EP0598129B1/de not_active Expired - Lifetime
- 1992-08-06 AU AU24152/92A patent/AU662551B2/en not_active Ceased
- 1992-08-06 ES ES98115259T patent/ES2172069T3/es not_active Expired - Lifetime
- 1992-08-06 AT AT92916961T patent/ATE190983T1/de not_active IP Right Cessation
1995
- 1995-05-12 AU AU20010/95A patent/AU673487B2/en not_active Ceased
- 1995-07-03 US US08/498,688 patent/US5654399A/en not_active Expired - Lifetime
1998
- 1998-09-23 KR KR1019980707541A patent/KR100202474B1/ko not_active Expired - Fee Related
2000
- 2000-05-11 GR GR20000401085T patent/GR3033397T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
DK0598129T3 (da)	2000-07-03
SG87056A1 (en)	2002-03-19
EP0934950A1 (de)	1999-08-11
US5654399A (en)	1997-08-05
AU662551B2 (en)	1995-09-07
EP0934950B1 (de)	2002-04-10
EP0598129A4 (en)	1995-10-25
AU2001095A (en)	1995-07-20
WO1993003054A1 (fr)	1993-02-18
CA2115355C (en)	2007-09-11
AU673487B2 (en)	1996-11-07
DE69230824D1 (de)	2000-04-27
US6004934A (en)	1999-12-21
EP0598129B1 (de)	2000-03-22
DE69232552D1 (de)	2002-05-16
CA2115355A1 (en)	1993-02-18
ATE215962T1 (de)	2002-04-15
AU2415292A (en)	1993-03-02
JP2618597B2 (ja)	1997-06-11
DK0934950T3 (da)	2002-07-29
GR3033397T3 (en)	2000-09-29
DE69232552T2 (de)	2002-10-31
DE69230824T2 (de)	2000-07-27
EP0598129A1 (de)	1994-05-25
KR0185440B1 (ko)	1999-04-01
ES2172069T3 (es)	2002-09-16
ES2144421T3 (es)	2000-06-16
KR100202474B1 (en)	1999-06-15

Legal Events

Date	Code	Title	Description
2000-08-15	UEP	Publication of translation of european patent specification
2011-05-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69230824D1 (de)	2000-04-27	Neue tetrapeptidderivate
ATE271557T1 (de)	2004-08-15	Dc-89 derivat
DK0528678T3 (da)	2001-07-30	Pyrrolidylthiocarbapenemderivat med antibakteriel aktivitet
FI914928A0 (fi)	1991-10-18	Hydroximetyl (metylencyklopentyl) puriner och -pyrimidiner.
ATE282630T1 (de)	2004-12-15	Dolastatin-derivate
SE9003476D0 (sv)	1990-10-31	Novel isoindole derivatives and salts thereof, process for producing the same and antitumor agent comprising the same
KR950701615A (ko)	1995-04-28	혈소판 응집 저해작용을 갖는 신규한 화합물(novel compound with plate-let aggregation inhibitor activity)
DE68912438D1 (de)	1994-03-03	Antifungale Antibiotika.
ES2106058T3 (es)	1997-11-01	Derivados de benzamida.
DE69423339D1 (de)	2000-04-13	Epoxycyclohexendionderivat
ATE90685T1 (de)	1993-07-15	Disaccharidderivate.
AU621634B2 (en)	1992-03-19	Glycerin derivative and its pharmacological use
FI963568A0 (fi)	1996-09-10	Peptidijohdannaisia
ATE184282T1 (de)	1999-09-15	Cyclopropan-derivate und diese enthaltende antivirale mittel
ES2093051T3 (es)	1996-12-16	Purinil- y pirimidil-tetrahidrofuranos.
ES2149180T3 (es)	2000-11-01	Derivado de pirazolotiazolopirimidina.