ATE191847T1 - Verwendung von aminoguamidin zur herstellung eines arzneimittels zur unterdrückung der stickoxidbildung - Google Patents

Verwendung von aminoguamidin zur herstellung eines arzneimittels zur unterdrückung der stickoxidbildung

Info

Publication number: ATE191847T1
Authority: AT; Austria
Prior art keywords: aminoguamidine; production; oxide formation; nitrogen oxide; medicinal product
Prior art date: 1991-12-16

Application number

AT92121318T

Other languages

English (en)

Inventor

Joseph Robert Williamson

John Andrew Corbett

Michael Lynn Mcdaniel

Ronald Gene Tilton

Original Assignee

Univ Washington

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-12-16

Filing date

1992-12-15

Publication date

2000-05-15

1992-12-15 Application filed by Univ Washington filed Critical Univ Washington

2000-05-15 Application granted granted Critical

2000-05-15 Publication of ATE191847T1 publication Critical patent/ATE191847T1/de

Links

MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 title abstract 7
230000015572 biosynthetic process Effects 0.000 title abstract 2
229940126601 medicinal product Drugs 0.000 title 1
241000124008 Mammalia Species 0.000 abstract 2
230000002401 inhibitory effect Effects 0.000 abstract 2
HAMNKKUPIHEESI-UHFFFAOYSA-N aminoguanidine Chemical compound NNC(N)=N HAMNKKUPIHEESI-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Immunology (AREA)
Urology & Nephrology (AREA)
Epidemiology (AREA)
Vascular Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Ophthalmology & Optometry (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Transplantation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT92121318T 1991-12-16 1992-12-15 Verwendung von aminoguamidin zur herstellung eines arzneimittels zur unterdrückung der stickoxidbildung ATE191847T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US80791291A	1991-12-16	1991-12-16

Publications (1)

Publication Number	Publication Date
ATE191847T1 true ATE191847T1 (de)	2000-05-15

Family

ID=25197413

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92121318T ATE191847T1 (de)	1991-12-16	1992-12-15	Verwendung von aminoguamidin zur herstellung eines arzneimittels zur unterdrückung der stickoxidbildung

Country Status (5)

Country	Link
EP (1)	EP0547558B1 (de)
JP (1)	JP3251673B2 (de)
AT (1)	ATE191847T1 (de)
CA (1)	CA2085399A1 (de)
DE (1)	DE69230928T2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5358969A (en) *	1991-12-16	1994-10-25	Washington University	Method of inhibiting nitric oxide formation
AU5533094A (en) *	1992-11-27	1994-06-22	Wellcome Foundation Limited, The	Enzyme inhibitors
US5807885A (en) *	1993-08-12	1998-09-15	Astra Aktiebolag	Amidine derivatives with nitric oxide synthetase activities
CA2176747A1 (en) *	1993-11-17	1995-05-26	J. Brice Weinberg	Use of nitric oxide synthase inhibitors in the treatment of autoimmune diseases
WO1996001817A1 (en) *	1994-05-07	1996-01-25	Astra Aktiebolag	Bicyclic amidine derivatives as inhibitors of nitric oxide synthetase
WO1996021445A1 (en) *	1995-01-13	1996-07-18	The General Hospital Corporation	Methods of inhibiting neurodegenerative diseases
US5929063A (en) *	1995-03-24	1999-07-27	Children's Hospital Medical Center	Mercapto and seleno derivatives as inhibitors of nitric oxide synthase
US5674907A (en) *	1995-03-24	1997-10-07	Children's Hospital Medical Center	Mercapto derivatives as inhibitors of nitric oxide synthase
US5780513A (en) *	1996-08-22	1998-07-14	Washington University	Method of inhibiting the release of bioactive IL-1

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3541218A (en) *	1969-06-18	1970-11-17	Lilly Co Eli	Omicron-fluorobenzylaminoguanidine for diabetes
US4758583A (en) *	1984-03-19	1988-07-19	The Rockefeller University	Method and agents for inhibiting protein aging
EP0339496A3 (de) *	1988-04-26	1991-05-08	Ono Pharmaceutical Co., Ltd.	Aminoguanidine Derivate

1992
- 1992-12-15 AT AT92121318T patent/ATE191847T1/de not_active IP Right Cessation
- 1992-12-15 CA CA002085399A patent/CA2085399A1/en not_active Abandoned
- 1992-12-15 JP JP33418592A patent/JP3251673B2/ja not_active Expired - Fee Related
- 1992-12-15 DE DE69230928T patent/DE69230928T2/de not_active Expired - Fee Related
- 1992-12-15 EP EP92121318A patent/EP0547558B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE69230928T2 (de)	2001-01-11
JP3251673B2 (ja)	2002-01-28
CA2085399A1 (en)	1993-06-17
EP0547558B1 (de)	2000-04-19
JPH05255079A (ja)	1993-10-05
DE69230928D1 (de)	2000-05-25
EP0547558A1 (de)	1993-06-23

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Legal Events

Date	Code	Title	Description
2000-10-15	UEP	Publication of translation of european patent specification
2003-09-15	REN	Ceased due to non-payment of the annual fee