ATE193060T1 - Enzymatische ligation von 3'-aminosubstituierten oligonukleotiden - Google Patents
Enzymatische ligation von 3'-aminosubstituierten oligonukleotidenInfo
- Publication number
- ATE193060T1 ATE193060T1 AT94913937T AT94913937T ATE193060T1 AT E193060 T1 ATE193060 T1 AT E193060T1 AT 94913937 T AT94913937 T AT 94913937T AT 94913937 T AT94913937 T AT 94913937T AT E193060 T1 ATE193060 T1 AT E193060T1
- Authority
- AT
- Austria
- Prior art keywords
- aminosubstituted
- oligonucleotides
- enzymatic ligation
- ligation
- enzymatic
- Prior art date
Links
- 108091034117 Oligonucleotide Proteins 0.000 title 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
- 230000002255 enzymatic effect Effects 0.000 title 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3866393A | 1993-03-22 | 1993-03-22 | |
| US08/048,975 US5593826A (en) | 1993-03-22 | 1993-04-16 | Enzymatic ligation of 3'amino-substituted oligonucleotides |
| PCT/US1994/003087 WO1994021824A1 (en) | 1993-03-22 | 1994-03-21 | Enzymatic ligation of 3'-amino-substituted olignucleotides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE193060T1 true ATE193060T1 (de) | 2000-06-15 |
Family
ID=26715428
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94913937T ATE193060T1 (de) | 1993-03-22 | 1994-03-21 | Enzymatische ligation von 3'-aminosubstituierten oligonukleotiden |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0694079B1 (de) |
| JP (1) | JP2714719B2 (de) |
| AT (1) | ATE193060T1 (de) |
| AU (1) | AU3283595A (de) |
| DE (1) | DE69424541T2 (de) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4883750A (en) * | 1984-12-13 | 1989-11-28 | Applied Biosystems, Inc. | Detection of specific sequences in nucleic acids |
| AU3539089A (en) * | 1988-04-08 | 1989-11-03 | Salk Institute For Biological Studies, The | Ligase-based amplification method |
-
1994
- 1994-03-21 DE DE69424541T patent/DE69424541T2/de not_active Expired - Lifetime
- 1994-03-21 EP EP94913937A patent/EP0694079B1/de not_active Expired - Lifetime
- 1994-03-21 AT AT94913937T patent/ATE193060T1/de not_active IP Right Cessation
- 1994-03-21 JP JP6521324A patent/JP2714719B2/ja not_active Expired - Fee Related
-
1995
- 1995-09-22 AU AU32835/95A patent/AU3283595A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE69424541T2 (de) | 2000-12-14 |
| EP0694079B1 (de) | 2000-05-17 |
| JPH08506967A (ja) | 1996-07-30 |
| JP2714719B2 (ja) | 1998-02-16 |
| EP0694079A4 (de) | 1997-12-17 |
| AU3283595A (en) | 1997-04-10 |
| DE69424541D1 (de) | 2000-06-21 |
| EP0694079A1 (de) | 1996-01-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |