ATE193208T1 - Verwendung synthetischer peptide zur induktion der toleranz gegen t- und b-zell epitope von autoantigenen - Google Patents

Verwendung synthetischer peptide zur induktion der toleranz gegen t- und b-zell epitope von autoantigenen

Info

Publication number: ATE193208T1
Authority: AT; Austria
Prior art keywords: autoantigens; synthetic peptides; cell epitopes; induce tolerance; tolerance
Prior art date: 1992-02-10

Application number

AT93905870T

Other languages

English (en)

Inventor

Barton F Haynes

Original Assignee

Univ Duke

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-02-10

Filing date

1993-02-10

Publication date

2000-06-15

1993-02-10 Application filed by Univ Duke filed Critical Univ Duke

2000-06-15 Application granted granted Critical

2000-06-15 Publication of ATE193208T1 publication Critical patent/ATE193208T1/de

Links

108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
230000002163 immunogen Effects 0.000 abstract 3
241000124008 Mammalia Species 0.000 abstract 2
102000004169 proteins and genes Human genes 0.000 abstract 2
108090000623 proteins and genes Proteins 0.000 abstract 2
230000002209 hydrophobic effect Effects 0.000 abstract 1
230000001939 inductive effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Zoology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Wood Science & Technology (AREA)
Microbiology (AREA)
Cell Biology (AREA)
Pharmacology & Pharmacy (AREA)
Endocrinology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Mycology (AREA)
Plant Pathology (AREA)
Neurology (AREA)
Rheumatology (AREA)
Virology (AREA)
Physics & Mathematics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Peptides Or Proteins (AREA)

AT93905870T 1992-02-10 1993-02-10 Verwendung synthetischer peptide zur induktion der toleranz gegen t- und b-zell epitope von autoantigenen ATE193208T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US83342992A	1992-02-10	1992-02-10
PCT/US1993/001207 WO1993015750A1 (en)	1992-02-10	1993-02-10	Use of synthetic peptides to induce tolerance to pathogenic t and b cell epitopes of autoantigens

Publications (1)

Publication Number	Publication Date
ATE193208T1 true ATE193208T1 (de)	2000-06-15

Family

ID=25264393

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93905870T ATE193208T1 (de)	1992-02-10	1993-02-10	Verwendung synthetischer peptide zur induktion der toleranz gegen t- und b-zell epitope von autoantigenen

Country Status (7)

Country	Link
EP (1)	EP0652764B1 (de)
JP (1)	JPH07506810A (de)
AT (1)	ATE193208T1 (de)
AU (1)	AU679439B2 (de)
CA (1)	CA2129351A1 (de)
DE (1)	DE69328726D1 (de)
WO (1)	WO1993015750A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6210873B1 (en)	1987-08-28	2001-04-03	Board Of Regents, The University Of Texas System	Methods and compositions for the priming of specific cytotoxic T-lymphocyte response
US5128319A (en)	1987-08-28	1992-07-07	Board Of Regents, The University Of Texas System	Prophylaxis and therapy of acquired immunodeficiency syndrome
CN1111540C (zh) *	1993-06-09	2003-06-18	康诺特实验室有限公司	串联的合成hiv－1肽类
US5603933A (en) *	1993-08-31	1997-02-18	Board Of Regents, The University Of Texas	CD4 peptides for binding to viral envelope proteins
GB2290293A (en) *	1994-06-08	1995-12-20	Rupert Donald Holms	Preparation which inhibits the autoimmune response in HIV, or SLE, patients
IL115744A (en) *	1994-10-27	2000-07-16	Akzo Nobel Nv	Peptides comprising a subsequence of human cartilage glycoprotein - 39
US5869602A (en)	1995-03-17	1999-02-09	Novo Nordisk A/S	Peptide derivatives
AU6113896A (en) *	1995-06-05	1996-12-24	Brigham And Women's Hospital	Use of oral tolerance to suppress both th1 and th2 immune re sponses and to suppress antibody production
BR9912378A (pt) *	1998-07-23	2001-04-17	Akzo Nobel Nv	Peptìdeo, composição farmacêutica, uso de um ou mais dos peptìdeos, e, composição para diagnóstico.
US7311920B1 (en)	1999-10-08	2007-12-25	University Of Maryland Biotechnology Institute	Virus coat protein/receptor chimeras and methods of use
US6908612B2 (en)	1999-10-08	2005-06-21	University Of Maryland Biotechnology Institute	Virus coat protein/receptor chimeras and methods of use
PT1137786E (pt) *	1999-10-08	2007-07-13	Univ Maryland Biotech Inst	Quimeras de proteína do invólucro/receptor de vírus e métodos de utilização.
JP2004503205A (ja)	2000-02-04	2004-02-05	デューク・ユニバーシティー	ヒト免疫不全ウイルスワクチン
US7033593B2 (en)	2000-09-22	2006-04-25	Duke University	Immunogen comprising an HIV envelope protein, a ligand and H2 peptide
JP2004511444A (ja)	2000-09-22	2004-04-15	デューク・ユニバーシティー	免疫原
ES2736165T3 (es)	2001-08-23	2019-12-26	Rsr Ltd	Regiones epítopo de un receptor de tirotropina (TSH), sus usos y anticuerpos para las mismas
US7195768B2 (en)	2001-11-07	2007-03-27	Duke University	Polyvalent immunogen
WO2003039470A2 (en)	2001-11-07	2003-05-15	Duke University	Polyvalent immunogen of hiv
US7172761B2 (en)	2001-11-07	2007-02-06	Duke University	Polyvalent immunogen
US7485314B2 (en)	2002-05-06	2009-02-03	Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center	Induction of antigen specific immunologic tolerance
ES2996234T3 (en)	2014-12-24	2025-02-12	Worg Pharmaceuticals Zhejiang Co Ltd	Composition
WO2018067582A2 (en)	2016-10-03	2018-04-12	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Hiv-1 env fusion peptide immunogens and their use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU592258B2 (en) *	1986-12-30	1990-01-04	United States of America, as represented by the Secretary, U.S. Department of Commerce, The	Synthetic peptides which induce cellular immunity to the aids virus and aids viral proteins
JPH01501939A (ja) *	1987-01-28	1989-07-06	オーソ・フアーマシユーチカル・コーポレーシヨン	免疫抑制ペプチドおよび使用法
AU6523590A (en) *	1989-09-22	1991-04-18	Idec Pharmaceuticals Corporation	Novel peptides associated with the cd4 binding region of gp120 and their methods of use

1993
- 1993-02-10 JP JP5514277A patent/JPH07506810A/ja not_active Ceased
- 1993-02-10 AU AU36629/93A patent/AU679439B2/en not_active Ceased
- 1993-02-10 DE DE69328726T patent/DE69328726D1/de not_active Expired - Lifetime
- 1993-02-10 WO PCT/US1993/001207 patent/WO1993015750A1/en not_active Ceased
- 1993-02-10 CA CA002129351A patent/CA2129351A1/en not_active Abandoned
- 1993-02-10 EP EP93905870A patent/EP0652764B1/de not_active Expired - Lifetime
- 1993-02-10 AT AT93905870T patent/ATE193208T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69328726D1 (de)	2000-06-29
AU3662993A (en)	1993-09-03
EP0652764B1 (de)	2000-05-24
CA2129351A1 (en)	1993-08-19
WO1993015750A1 (en)	1993-08-19
EP0652764A4 (de)	1995-12-27
JPH07506810A (ja)	1995-07-27
EP0652764A1 (de)	1995-05-17
AU679439B2 (en)	1997-07-03

Legal Events

Date	Code	Title	Description
2000-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE193208T1 (de)	2000-06-15	Verwendung synthetischer peptide zur induktion der toleranz gegen t- und b-zell epitope von autoantigenen
ES2127829T3 (es)	1999-05-01	Expresion de proteinas recombinantes fusionadas en bacterias atenuadas.
TR199900666T2 (xx)	1999-06-21	�nsan paratormonu ile ilgili peptidlere kar�� antikor.
ES2128362T3 (es)	1999-05-16	Fragmentos de proteinas de prion.
NO894503L (no)	1989-11-10	Uretan-beskyttede aminosyre-n-karboksyanhydrider.
DE69333673D1 (de)	2004-11-25	Epitope von Stress Proteinen
NZ330897A (en)	2000-03-27	Human trk receptors and neurotropic factor inhibitors
ES2129487T3 (es)	1999-06-16	Peptidos sinteticos, anticuerpos dirigidos contra ellos y su utilizacion.
DK156592D0 (da)	1992-12-28	Human-h1-praeprorelaxin, -prorelaxin og -relaxin samt polypeptid med relaxinaktivitet og fremgangsmaade til sammenfoejning af a- og b-kaederne i human-h1-relaxin
DK461884A (da)	1984-09-27	Beskyttende peptidantigen
IL90832A0 (en)	1990-01-18	Gene leader fragment encoding a peptide leader sequence and a polypeptide sequence
ES2194836T3 (es)	2003-12-01	Peptidos para su uso en vacunacion e induccion de anticuerpos neutralizantes contra el virus de la inmunodeficiencia humana.
JPS6470498A (en)	1989-03-15	Synthetic peptide and antibody thereto
DK0625157T3 (da)	2003-06-16	Blodplade-GPIIIaP1A1- og -P1A2-epitoper og fremstilling og anvendelse deraf
DE3585370D1 (de)	1992-03-19	Kreuzreaktive und schuetzende epitope von circumsporozoit-proteinen.
DE69739062D1 (de)	2008-12-04	Verwendung von kryptischen Peptiden zur Induktion von immunologischer Toleranz
DE3884672D1 (de)	1993-11-11	Ein synthetisches Nonapeptid zur Verwendung als Adjuvant.
DE69012989D1 (de)	1994-11-03	Peptiden von retinblastoma gen produkten und antikoerper dagegen.
ATE192163T1 (de)	2000-05-15	Peptide, analoge und ihre mischungen zur detektion und erzeugung von antikörpern gegen die e1 und e2 proteine des rubella virus
ES2183376T3 (es)	2003-03-16	Uso de lbp para el tratamiento de la septicemia.
KR950032286A (ko)	1995-12-20	B형 간염 바이러스에 대한 인체면역 조절기능을 가진 펩타이드
ATE128717T1 (de)	1995-10-15	Schizosaccharomyces-spezifische polypeptide.