ATE193325T1 - Verbesserte thrombininhibitoren - Google Patents

Verbesserte thrombininhibitoren

Info

Publication number
ATE193325T1
ATE193325T1 AT92905748T AT92905748T ATE193325T1 AT E193325 T1 ATE193325 T1 AT E193325T1 AT 92905748 T AT92905748 T AT 92905748T AT 92905748 T AT92905748 T AT 92905748T AT E193325 T1 ATE193325 T1 AT E193325T1
Authority
AT
Austria
Prior art keywords
substituted
atoms
bond
group
backbone chain
Prior art date
Application number
AT92905748T
Other languages
English (en)
Inventor
John M Maraganore
Jo-Ann M Jablonski
Paul R Bourdon
Original Assignee
Biogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Inc filed Critical Biogen Inc
Application granted granted Critical
Publication of ATE193325T1 publication Critical patent/ATE193325T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Lighting Device Outwards From Vehicle And Optical Signal (AREA)
  • Manipulator (AREA)
  • Pyrane Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT92905748T 1991-02-08 1992-02-03 Verbesserte thrombininhibitoren ATE193325T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/652,929 US5240913A (en) 1989-08-18 1991-02-08 Inhibitors of thrombin
PCT/US1992/000836 WO1992013952A1 (en) 1991-02-08 1992-02-03 Improved inhibitors of thrombin

Publications (1)

Publication Number Publication Date
ATE193325T1 true ATE193325T1 (de) 2000-06-15

Family

ID=24618783

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92905748T ATE193325T1 (de) 1991-02-08 1992-02-03 Verbesserte thrombininhibitoren

Country Status (18)

Country Link
US (3) US5240913A (de)
EP (1) EP0529031B9 (de)
JP (1) JPH05506252A (de)
KR (1) KR100259759B1 (de)
AT (1) ATE193325T1 (de)
AU (1) AU659828B2 (de)
BG (1) BG61243B2 (de)
CA (1) CA2079778C (de)
DE (1) DE69231081T2 (de)
DK (1) DK0529031T3 (de)
ES (1) ES2149170T3 (de)
FI (2) FI120348B (de)
GR (1) GR3034257T3 (de)
HU (1) HU218831B (de)
NO (1) NO315710B1 (de)
NZ (1) NZ241557A (de)
TW (1) TW222642B (de)
WO (1) WO1992013952A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5240913A (en) * 1989-08-18 1993-08-31 Biogen, Inc. Inhibitors of thrombin
US6060451A (en) * 1990-06-15 2000-05-09 The National Research Council Of Canada Thrombin inhibitors based on the amino acid sequence of hirudin
US5458568A (en) * 1991-05-24 1995-10-17 Cortrak Medical, Inc. Porous balloon for selective dilatation and drug delivery
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5656600A (en) * 1993-03-25 1997-08-12 Corvas International, Inc. α-ketoamide derivatives as inhibitors of thrombosis
US5599307A (en) * 1993-07-26 1997-02-04 Loyola University Of Chicago Catheter and method for the prevention and/or treatment of stenotic processes of vessels and cavities
JPH09504554A (ja) * 1993-12-27 1997-05-06 ハミルトン シビック ホスピタルズ リサーチ ディベロップメント，インコーポレーテッド 血栓形成を阻止する方法及び組成物
AU1562895A (en) * 1994-01-12 1995-08-01 Massachusetts Institute Of Technology Process for making xanthene or cubane based compounds, and protease inhibitors
US5510330A (en) * 1994-03-25 1996-04-23 Boehringer Mannheim Gmbh Combinations of thrombolytically active proteins and non-heparin anticoagulants, and uses thereof.
US6759384B1 (en) 1994-04-26 2004-07-06 Aventis Pharmaceuticals Inc. Factor Xa inhibitors
US5849510A (en) * 1994-04-26 1998-12-15 Selectide Corporation Factor Xa inhibitors
DE4430205A1 (de) 1994-08-26 1996-02-29 Behringwerke Ag Zusammensetzungen, die als Gegenmittel für Blut-Antikoagulanzien geeignet sind und deren Verwendung
DE4430204A1 (de) 1994-08-26 1996-02-29 Behringwerke Ag Arzneimittel, welches als Gegenmittel für Blut-Antikoagulanzien geeignet ist und seine Verwendung
US5747453A (en) 1995-06-06 1998-05-05 Alza Corporation Method for increasing the electrotransport flux of polypeptides
DE19549118C2 (de) * 1995-12-29 2000-07-13 Thomas W Stief Hämostaseaktivierungs-Inhibitor und Verfahren zum Hemmen der Hämostaseaktivierung in Blut oder anderen biologischen Flüssigkeiten
US6333189B1 (en) 1996-06-06 2001-12-25 Alza Corporation Method of making an electrotransport device
JPH1010784A (ja) * 1996-06-27 1998-01-16 Brother Ind Ltd 正帯電性一成分現像剤並びにその現像剤を用いた画像形成装置
GB9613718D0 (en) * 1996-06-29 1996-08-28 Thrombosis Res Inst Thrombin inhibitors
GB9613719D0 (en) * 1996-06-29 1996-08-28 Thrombosis Res Inst Serine protease inhibitors
US5840733A (en) * 1996-07-01 1998-11-24 Redcell, Canada, Inc. Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes
US5985833A (en) * 1996-09-17 1999-11-16 Wisconsin Alumni Research Foundation Thrombin inhibitor
US20030077310A1 (en) 2001-10-22 2003-04-24 Chandrashekhar Pathak Stent coatings containing HMG-CoA reductase inhibitors
DE10162521A1 (de) * 2001-12-19 2003-07-17 Goetz Nowak Verwendung von molekulargewichtserweiterten Substanzen in der Tumortherapie
ES2352204T3 (es) 2004-10-19 2011-02-16 Lonza Ag Método de síntesis peptídica en fase sólida.
US7582727B1 (en) 2008-07-27 2009-09-01 The Medicinces Company Pharmaceutical formulations of bivalirudin and processes of making the same
US7598343B1 (en) 2008-07-27 2009-10-06 The Medicines Company Pharmaceutical formulations of bivalirudin and processes of making the same
AR073544A1 (es) * 2008-09-03 2010-11-17 Scinopharm Taiwan Ltd Proceso para la preparacion de pramlintida
US7803762B1 (en) 2009-08-20 2010-09-28 The Medicines Company Ready-to-use bivalirudin compositions
US7985733B1 (en) 2010-01-06 2011-07-26 The Medicines Company Buffer-based method for preparing bivalirudin drug product
GB201121513D0 (en) 2011-12-14 2012-01-25 Cambridge Entpr Ltd Thrombin-binding antibody molecules and uses thereof
US9518128B2 (en) 2011-12-14 2016-12-13 Janssen Pharmaceuticals, Inc. Thrombin-binding antibody molecules
HRP20220479T1 (hr) 2016-06-01 2022-05-27 Athira Pharma, Inc. Spojevi
WO2019030706A1 (en) 2017-08-10 2019-02-14 Janssen Pharmaceutica Nv ANTI-THROMBIN ANTIBODY MOLECULES AND METHODS OF USE IN ORTHOPEDIC SURGERY
WO2019035055A1 (en) 2017-08-16 2019-02-21 Janssen Pharmaceutica Nv ANTI-THROMBIN ANTIBODY MOLECULES AND METHODS OF USE WITH PLATELET ANTI-AGGREGATE AGENTS
US11992514B2 (en) 2019-05-20 2024-05-28 MAIA Pharmaceuticals, Inc. Ready-to-use bivalirudin compositions

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1161431A (en) * 1979-05-11 1984-01-31 Lars G. Svendsen Tripeptide derivatives
GB8305985D0 (en) * 1983-03-04 1983-04-07 Szelke M Enzyme inhibition
DE3501107A1 (de) * 1985-01-15 1986-07-17 Josef 8358 Vilshofen Paul Nutzfahrzeug mit schieberahmenwechselaufbau
CA1341032C (en) * 1987-01-23 2000-06-20 John L. Krstenansky Anticoagulant peptides
ZA883444B (de) * 1987-05-21 1988-11-16
CA1340646C (en) * 1987-05-21 1999-07-13 John L. Krstenansky Cyclic anticoagulant peptides
AU3098289A (en) * 1988-03-04 1989-09-07 Biogen, Inc. Hirudin peptides
US4971953A (en) * 1988-05-10 1990-11-20 Merrell Dow Pharmaceuticals Anticoagulant peptide alcohols
NZ228995A (en) * 1988-05-10 1992-03-26 Merrell Dow Pharma Hirudin peptide derivatives and pharmaceutical compositions
FI904330A7 (fi) * 1988-09-29 1990-09-03 Biogen Inc Hirudiinipeptidejä
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
US5240913A (en) * 1989-08-18 1993-08-31 Biogen, Inc. Inhibitors of thrombin
DE69128247T2 (de) * 1990-06-15 1998-03-19 Majesty (Her) In Right Of Canada As Represented By The National Research Council Of Canada, Ottawa, Ontario Thrombin-inhibitoren mit einer hirudin-ähnlichen sequenz

Also Published As

Publication number Publication date
AU1362192A (en) 1992-09-07
HK1005995A1 (en) 1999-02-05
US5240913A (en) 1993-08-31
US5425936A (en) 1995-06-20
NZ241557A (en) 1996-11-26
CA2079778C (en) 2002-09-03
HUT65675A (en) 1994-07-28
KR100259759B1 (ko) 2000-06-15
BG61243B2 (bg) 1997-03-31
DE69231081T2 (de) 2001-02-01
NO923889L (no) 1992-12-08
EP0529031A1 (de) 1993-03-03
JPH05506252A (ja) 1993-09-16
ES2149170T3 (es) 2000-11-01
US5514409A (en) 1996-05-07
FI924503A0 (fi) 1992-10-06
EP0529031B1 (de) 2000-05-24
DE69231081D1 (de) 2000-06-29
FI20050027L (fi) 2005-01-11
FI120348B (fi) 2009-09-30
GR3034257T3 (en) 2000-12-29
NO923889D0 (no) 1992-10-07
AU659828B2 (en) 1995-06-01
WO1992013952A1 (en) 1992-08-20
NO315710B1 (no) 2003-10-13
TW222642B (de) 1994-04-21
EP0529031B9 (de) 2007-11-21
HU218831B (hu) 2000-12-28
DK0529031T3 (da) 2000-10-09
HU9203500D0 (en) 1993-01-28
FI924503A7 (fi) 1992-10-06
FI120690B (fi) 2010-01-29
CA2079778A1 (en) 1992-08-09

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UEP Publication of translation of european patent specification