ATE193448T1 - Microkapseln zur verzögerten freigabe von acetylsalicylsäure - Google Patents

Microkapseln zur verzögerten freigabe von acetylsalicylsäure

Info

Publication number
ATE193448T1
ATE193448T1 AT94420126T AT94420126T ATE193448T1 AT E193448 T1 ATE193448 T1 AT E193448T1 AT 94420126 T AT94420126 T AT 94420126T AT 94420126 T AT94420126 T AT 94420126T AT E193448 T1 ATE193448 T1 AT E193448T1
Authority
AT
Austria
Prior art keywords
salicylic acid
delayed release
acetyl salicylic
micro capsules
forming polymer
Prior art date
Application number
AT94420126T
Other languages
English (en)
Inventor
Olga Burguiere
Ahmad Yassine
Jean-Philippe Selles
Original Assignee
Flamel Tech Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Flamel Tech Sa filed Critical Flamel Tech Sa
Application granted granted Critical
Publication of ATE193448T1 publication Critical patent/ATE193448T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5052—Proteins, e.g. albumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
AT94420126T 1993-04-19 1994-04-19 Microkapseln zur verzögerten freigabe von acetylsalicylsäure ATE193448T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9304560A FR2704146B1 (fr) 1993-04-19 1993-04-19 Microcapsules d'acide acétylsalicylique à libération contrôlée.

Publications (1)

Publication Number Publication Date
ATE193448T1 true ATE193448T1 (de) 2000-06-15

Family

ID=9446180

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94420126T ATE193448T1 (de) 1993-04-19 1994-04-19 Microkapseln zur verzögerten freigabe von acetylsalicylsäure

Country Status (10)

Country Link
US (2) US5603957A (de)
EP (1) EP0624371B1 (de)
JP (2) JP4067137B2 (de)
AT (1) ATE193448T1 (de)
DE (1) DE69424718D1 (de)
DK (1) DK0624371T3 (de)
ES (1) ES2148300T3 (de)
FR (1) FR2704146B1 (de)
GR (1) GR3034231T3 (de)
PT (1) PT624371E (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2704146B1 (fr) * 1993-04-19 1995-07-13 Cripdom Microcapsules d'acide acétylsalicylique à libération contrôlée.
DE29502547U1 (de) * 1995-02-16 1995-03-30 Röhm GmbH, 64293 Darmstadt Thermoplastisches Überzugs- und Bindemittel für Arzneiformen
US6953593B2 (en) * 2000-02-01 2005-10-11 Lipoprotein Technologies, Inc. Sustained-release microencapsulated delivery system
FR2811571B1 (fr) 2000-07-11 2002-10-11 Flamel Tech Sa Composition pharmaceutique orale, permettant la liberation controlee et l'absorption prolongee d'un principe actif
US6929884B2 (en) * 2001-04-19 2005-08-16 Zinc Matrix Power, Inc. Method for manufacture of films containing insoluble solids embedded in cellulose-based films
US6663896B1 (en) * 2001-08-01 2003-12-16 Alvin S. Blum Delayed release aspirin for vascular obstruction prophylaxis
FR2830447B1 (fr) * 2001-10-09 2004-04-16 Flamel Tech Sa Forme galenique orale microparticulaire pour la liberation retardee et controlee de principes actifs pharmaceutiques
US8101209B2 (en) * 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
US20100041079A1 (en) * 2002-03-24 2010-02-18 Mcmaster University Method for predicting cardiovascular events
CN100553625C (zh) * 2002-04-09 2009-10-28 弗拉梅技术公司 活性成分微囊的口服混悬液
JP4698950B2 (ja) * 2002-04-09 2011-06-08 フラメル・テクノロジー アモキシシリンの改変された放出のための、マイクロカプセルの水性懸濁液形態での経口医薬品製剤
US7008979B2 (en) * 2002-04-30 2006-03-07 Hydromer, Inc. Coating composition for multiple hydrophilic applications
EP1888045B1 (de) * 2005-05-24 2010-09-08 Flamel Technologies Orale pharmazeutische zusammensetzung zur behandlung einer cox-2-vermittelten erkrankung
EP1726300A1 (de) * 2005-05-24 2006-11-29 Flamel Technologies Orale pharmazeutische Formulierung zur Vorbeugung und/oder Behandlung kardiovaskulärer und inflammatorischer Erkrankungen
EP1726301A1 (de) * 2005-05-24 2006-11-29 Flamel Technologies Pharmazeutische Zusammensetzung zur Behandlung COX-2 vermittelter Krankheiten
FR2886150B1 (fr) * 2005-05-24 2007-08-24 Flamel Technologies Sa Forme pharmaceutique orale a base d'au moins un principe actif dont la solubilite varie en fonction des conditions de ph gastrique
WO2006133733A1 (en) * 2005-06-13 2006-12-21 Flamel Technologies Oral dosage form comprising an antimisuse system
US8652529B2 (en) * 2005-11-10 2014-02-18 Flamel Technologies Anti-misuse microparticulate oral pharmaceutical form
BRPI0912842A8 (pt) * 2008-05-20 2019-01-29 Cerenis Therapeutics Holding composição farmacêutica, métodos para prevenir ou tratar o rubor induzido por niacina em um indivíduo, para reduzir pelo menos um sintoma de rubor relacionado com a terapia com niacina em um indivíduo, para diminuir os efeitos colaterais relacionados com a protaglandina em um indivíduo, para diminuir uma taxa de descontinuação do tratamento com niacina por um indivíduo, para aumentar a submissão do paciente ao tratamento com niacina, para tratar aterosclerose em um paciente, para tratar uma doença relacionada com um perfil de hdl baixo em um paciente, formulação do ácido nicotínico de dispensação modificada, uso da composição farmacêutica, e, microcápsula de aspirina
US9901551B2 (en) 2009-04-20 2018-02-27 Ambra Bioscience Llc Chemosensory receptor ligand-based therapies
BRPI1013856A2 (pt) 2009-04-20 2016-04-05 Elcelyx Therapeutics Inc terapias à base de ligantes de receptores quimiossensíveis
US8828953B2 (en) * 2009-04-20 2014-09-09 NaZura BioHealth, Inc. Chemosensory receptor ligand-based therapies
KR100978583B1 (ko) * 2009-09-02 2010-08-27 (주)바이오제닉스 화장품용 색조캡슐 조성물, 이의 제조방법 및 이를 이용한 화장품 제제
SG10201507554RA (en) 2010-09-13 2015-10-29 Bev Rx Inc Aqueous drug delivery system comprising off - flavor masking agent
WO2012054523A2 (en) 2010-10-19 2012-04-26 Elcelyx Therapeutics, Inc. Chemosensory receptor ligand-based therapies
LT2661266T (lt) 2011-01-07 2020-12-10 Anji Pharma (Us) Llc Gydimo būdai chemosensorinio receptoriaus ligando pagrindu
US9795792B2 (en) 2011-02-25 2017-10-24 Medtronic, Inc. Emergency mode switching for non-pacing modes
CN104254325A (zh) 2012-01-06 2014-12-31 埃尔舍利克斯治疗公司 双胍组合物和治疗代谢性病症的方法
CN110693867A (zh) 2012-01-06 2020-01-17 埃尔舍利克斯治疗公司 用于治疗代谢性病症的组合物和方法
WO2013158928A2 (en) 2012-04-18 2013-10-24 Elcelyx Therapeutics, Inc. Chemosensory receptor ligand-based therapies
CA2878625A1 (en) 2012-07-11 2014-01-16 Elcelyx Therapeutics, Inc. Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk
HK1214966A1 (zh) 2013-01-05 2016-08-12 Anji Pharmaceuticals Inc. 包含雙胍的延遲釋放組合物
WO2019027459A1 (en) * 2017-08-03 2019-02-07 Sklar Pharma Llc PROLONGED RELEASE OF NITRIC OXIDE INTO THE INTESTINAL TRACT
CN110893179A (zh) * 2019-12-13 2020-03-20 沈阳东星医药科技有限公司 一种阿司匹林缓释胶囊及其制备方法
US12029719B2 (en) 2021-04-16 2024-07-09 Allen Morgan Compounds comprising cannabinoids and other natural ingredients for alieving premenstrual, menstrual and menopausal symptoms

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3892769A (en) * 1973-07-20 1975-07-01 Merck & Co Inc Acetaminophen esters of aryl salicylic acids
US4308251A (en) * 1980-01-11 1981-12-29 Boots Pharmaceuticals, Inc. Controlled release formulations of orally-active medicaments
LU85943A1 (fr) * 1985-06-12 1987-01-13 Galephar Comprimes pharmaceutiques permettant l'administration aisee de pellets, leur preparation et leur utilisation
US4693896A (en) * 1985-10-07 1987-09-15 Fmc Corporation Ethylcellulose-coated, gastric-disintegrable aspirin tablet
DE3810757A1 (de) * 1988-03-30 1989-10-26 Freudenberg Carl Fa Verfahren zur herstellung einer mikroporoesen folie
AU632602B2 (en) * 1989-08-02 1993-01-07 John David Arnold Method and preparation for reducing risk of myocardial infarction
NZ233975A (en) * 1989-08-16 1992-06-25 Sterling Drug Inc Aspirin granules coated with a gastroprotectant
US5248516A (en) * 1989-12-19 1993-09-28 Fmc Corporation Film-forming composition: method of producing same and use for coating pharmaceuticals and foods and the like
US5206030A (en) * 1990-02-26 1993-04-27 Fmc Corporation Film-forming composition and use for coating pharmaceuticals, foods and the like
IT1246383B (it) * 1990-04-17 1994-11-18 Eurand Int Metodo per il mascheramento del sapore di farmaci
FR2704146B1 (fr) * 1993-04-19 1995-07-13 Cripdom Microcapsules d'acide acétylsalicylique à libération contrôlée.

Also Published As

Publication number Publication date
DK0624371T3 (da) 2000-10-02
US5846566A (en) 1998-12-08
JPH07138164A (ja) 1995-05-30
FR2704146A1 (fr) 1994-10-28
PT624371E (pt) 2000-11-30
EP0624371B1 (de) 2000-05-31
DE69424718D1 (de) 2000-07-06
JP2008019274A (ja) 2008-01-31
ES2148300T3 (es) 2000-10-16
FR2704146B1 (fr) 1995-07-13
EP0624371A1 (de) 1994-11-17
US5603957A (en) 1997-02-18
GR3034231T3 (en) 2000-12-29
JP4067137B2 (ja) 2008-03-26

Similar Documents

Publication Publication Date Title
ATE193448T1 (de) Microkapseln zur verzögerten freigabe von acetylsalicylsäure
ATE193799T1 (de) Landwirtschaftliche mikrokapseln und ihre herstellung
NL189464C (nl) Verknoping teweegbrengende verbinding, mengsels die zo'n verbinding bevatten, thermisch hardbare polymeermengsels, verpompbare suspensies en werkwijze voor het vormen van een geconsolideerde mantel van deeltjesvormig materiaal om de verbuizing van een boorput.
EP1647326A3 (de) Verfahren zur Herstellung von Kapseln mit einer Polyelektrolythülle
IE883810L (en) Sustained release pharmaceutical compositions
DE68910654D1 (de) Beschichtungszusammensetzung und Verfahren zu ihrer Herstellung.
BR8905340A (pt) Sistema aglutinante,composicao de revestimento a base d'agua,processo para produzir o sistema aglutinante,e substrato
DE3880762D1 (de) Orale, acetaminophen enthaltende zusammensetzung mit gesteuerter arzneistoff-freisetzung und verfahren zu ihrer herstellung.
CA2021580A1 (en) Polysiloxane-grafted copolymer topical binder composition with novel fluorochemical comonomer and method of coating therewith
DE69421799D1 (de) Mit einem trockenmittel überzogenes substrat und methode zur dessen herstellung
DK599989A (da) Hule, polymere acrylatmikrosfaerer og anvendelse deraf
DE69412295D1 (de) Verfahren zur Herstellung von Mikrogranulaten, die nach Umhüllung zur Suspendierung in flüssigen Pharmazeutika geeignet sind
DK21991D0 (da) Tryk-modtagelig belaegning samt en polymer-filmdannende sammensaetning til fremstilling af en saadan
ES2079649T3 (es) Fertilizantes encapsulados de liberacion lenta.
PT84372B (pt) Processo para a preparacao de composicoes polimericas controlavel e rapidamente degradaveis contendo um polimero vinilico e de peliculas e outros objectos que as contem
IS1620B (is) Aðferð til framleiðslu á lyfjablöndum sem innihalda nifedipine
BR9300473A (pt) Processo para a preparacao de uma composicao de polimero de multiplos estagios
EP0420988A4 (en) Cross-linked spherical particulate, production thereof, coating composition and releasable pressure-sensitive adhesive produced from said particulate, and article comprising the same as laminar component
DE3585193D1 (de) Macrophage aktivierende zusammensetzung und ein verfahren zu ihrer herstellung.
DE58904703D1 (de) Flaechengebilde aus einem substrat und einem ueberzug und verfahren zu seiner herstellung.
BR9207067A (pt) Processo para a preparação de uma dispersão aquosa de resina de poliamida modificada com acrilato curável produto dispersão aquosa de resina de poliamida modificada com acrilato curável revestimento adesivo e produto de adição de Michael de uma dispersão aquosa de resina de poliamida
ATE189492T1 (de) Zusammensetzungen aus bleichmittelvorläufern enthaltend eine beschichtete peroxysäure
AU6367990A (en) Chewable spray dried spheroidal microcapsules and polymer coated microcapsules and methods for preparing same
BR7903320A (pt) Dispersao aquosa de plastico a base de um polimero de ester vinilico,processo para a sua producao,e agente de pintura preparado a partir da mesma
DE59001713D1 (de) Verfahren und anlage zur herstellung von holzspanplatten und aehnlichen plattenwerkstoffen.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification