ATE194598T1 - In der therapie verwendbare chinolin- und chinazolinverbindungen - Google Patents

In der therapie verwendbare chinolin- und chinazolinverbindungen

Info

Publication number: ATE194598T1
Authority: AT; Austria
Prior art keywords: quinoline; therapy; quinazoline compounds; compounds usable; usable
Prior art date: 1995-12-23

Application number

AT96943954T

Other languages

English (en)

Inventor

Alan John Collis

David Nathan Abraham Fox

Julie Newman

Original Assignee

Pfizer Res & Dev

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-23

Filing date

1996-12-05

Publication date

2000-07-15

1996-12-05 Application filed by Pfizer Res & Dev filed Critical Pfizer Res & Dev

2000-07-15 Application granted granted Critical

2000-07-15 Publication of ATE194598T1 publication Critical patent/ATE194598T1/de

Links

SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 2
JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical class N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 title 1
238000002560 therapeutic procedure Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D497/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Quinoline Compounds (AREA)

AT96943954T 1995-12-23 1996-12-05 In der therapie verwendbare chinolin- und chinazolinverbindungen ATE194598T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9526546.8A GB9526546D0 (en)	1995-12-23	1995-12-23	Compounds useful in therapy
PCT/EP1996/005609 WO1997023462A1 (en)	1995-12-23	1996-12-05	Quinoline and quinazoline compounds useful in therapy

Publications (1)

Publication Number	Publication Date
ATE194598T1 true ATE194598T1 (de)	2000-07-15

Family

ID=10786091

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96943954T ATE194598T1 (de)	1995-12-23	1996-12-05	In der therapie verwendbare chinolin- und chinazolinverbindungen

Country Status (34)

Country	Link
US (3)	US6103738A (de)
EP (1)	EP0877734B1 (de)
JP (1)	JP3070958B2 (de)
KR (1)	KR19990076693A (de)
AP (1)	AP715A (de)
AR (1)	AR005166A1 (de)
AT (1)	ATE194598T1 (de)
AU (1)	AU708979B2 (de)
BG (1)	BG102559A (de)
BR (1)	BR9612263A (de)
CA (1)	CA2236814C (de)
CO (1)	CO4480106A1 (de)
CZ (1)	CZ197698A3 (de)
DE (1)	DE69609353T2 (de)
DK (1)	DK0877734T3 (de)
ES (1)	ES2151192T3 (de)
GB (1)	GB9526546D0 (de)
GR (1)	GR3034225T3 (de)
HN (1)	HN1996000082A (de)
HR (1)	HRP960616A2 (de)
HU (1)	HUP9903560A3 (de)
IS (1)	IS4731A (de)
MA (1)	MA26414A1 (de)
NO (1)	NO982913L (de)
NZ (1)	NZ325248A (de)
OA (1)	OA10703A (de)
PL (1)	PL327610A1 (de)
PT (1)	PT877734E (de)
SK (1)	SK81698A3 (de)
TN (1)	TNSN96161A1 (de)
TR (1)	TR199801195T2 (de)
WO (1)	WO1997023462A1 (de)
YU (1)	YU68896A (de)
ZA (1)	ZA9610784B (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9526546D0 (en) *	1995-12-23	1996-02-28	Pfizer Ltd	Compounds useful in therapy
GB9700504D0 (en)	1997-01-11	1997-02-26	Pfizer Ltd	Pharmaceutical compounds
GB9708917D0 (en) *	1997-05-01	1997-06-25	Pfizer Ltd	Compounds useful in therapy
GB9711220D0 (en) *	1997-05-30	1997-07-23	Isis Innovation	Antiarrhythmic agents
GB9711650D0 (en) *	1997-06-05	1997-07-30	Pfizer Ltd	Compounds useful in therapy
ES2251512T3 (es) *	2000-08-31	2006-05-01	F. Hoffmann-La Roche Ag	Derivados de quinazolina como antagonista adrenergicos alfa-1.
KR100554813B1 (ko) *	2001-01-02	2006-02-22	에프. 호프만-라 로슈 아게	알파 1에이/비 아드레날린성 수용체 길항제로서의퀴나졸론 유도체
US6900220B2 (en)	2001-01-02	2005-05-31	Syntex (U.S.A.) Llc	Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists
US6734303B2 (en)	2001-05-18	2004-05-11	Pfizer Inc.	Process for the production of quinazolines
GB0206033D0 (en) *	2002-03-14	2002-04-24	Pfizer Ltd	Compounds useful in therapy
EP2280003B1 (de)	2002-07-15	2014-04-02	Symphony Evolution, Inc.	Verfahren zur Herstellung von Rezeptorkinase-Modulatoren
EP1556381B1 (de)	2002-09-26	2008-02-20	Pfizer Limited	Pyrazolamide zur behandlung von hiv-infektionen
DE602004015269D1 (de)	2003-04-23	2008-09-04	Glaxo Group Ltd	Piperazin derivate und ihre verwendung für die behandlung von neurologischen und psychiatrischen krankheiten.
US20050124562A1 (en) *	2003-09-23	2005-06-09	Joseph Guiles	Bis-quinazoline compounds for the treatment of bacterial infections
EP2392565B1 (de)	2003-09-26	2014-03-19	Exelixis, Inc.	c-Met-Modulatoren und Anwendungsverfahren
MX341797B (es)	2004-06-24	2016-09-02	Vertex Pharmaceuticals Incorporated *	Moduladores de transportadores con casete de union con atp.
LT1993360T (lt)	2005-12-28	2017-06-12	Vertex Pharmaceuticals Incorporated	N-[2,4-bis(1,1-dimetiletil)-5-hidroksifenil]-1,4-dihidro-4-oksochinolin-3-karboksamido kieta forma
US9114194B2 (en) *	2006-05-12	2015-08-25	W. L. Gore & Associates, Inc.	Immobilized biologically active entities having high biological activity following mechanical manipulation
US8496953B2 (en) *	2006-05-12	2013-07-30	W. L. Gore & Associates, Inc.	Immobilized biologically active entities having a high degree of biological activity following sterilization
US20080279909A1 (en) *	2006-05-12	2008-11-13	Cleek Robert L	Immobilized Biologically Active Entities Having A High Degree of Biological Activity Following Sterilization
US8986713B2 (en) *	2006-05-12	2015-03-24	W. L. Gore & Associates, Inc.	Medical device capable of being compacted and expanded having anti-thrombin III binding activity
US8021677B2 (en)	2006-05-12	2011-09-20	Gore Enterprise Holdings, Inc.	Immobilized biologically active entities having a high degree of biological activity
JP5577104B2 (ja) *	2007-03-14	2014-08-20	エクセリクシスパテントカンパニーエルエルシー	ヘッジホッグ経路の阻害剤
US20100074949A1 (en)	2008-08-13	2010-03-25	William Rowe	Pharmaceutical composition and administration thereof
US12458635B2 (en)	2008-08-13	2025-11-04	Vertex Pharmaceuticals Incorporated	Pharmaceutical composition and administrations thereof
AU2009315761A1 (en)	2008-11-14	2010-05-20	F. Hoffmann-La Roche Ag	Quinazoline derivatives as NK3 receptor antagonists
RS52754B2 (sr)	2009-01-16	2022-08-31	Exelixis Inc	Malat so n-(4- {[6,7-bis(metiloksi)hinolin-4-il]oksi}fenil-n'- (4-fluorofenil) ciklopropan-1,1-dikarboksamid-a, i njeni kristalni oblici za lečenje karcinoma
MX384179B (es)	2009-03-20	2025-03-14	Vertex Pharma	Proceso para producir moduladores del regulador de conductancia transmembrana de fibrosis quística.
JP5770158B2 (ja) *	2009-03-23	2015-08-26	シプラ・リミテッド	ドキサゾシン及びその塩の製造方法
UA108618C2 (uk)	2009-08-07	2015-05-25		Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку
EP3575288B1 (de) *	2009-09-03	2021-10-27	Bristol-Myers Squibb Company	Chinazoline als kaliumionenkanalhemmer
US8591932B2 (en) *	2009-09-17	2013-11-26	W. L. Gore & Associates, Inc.	Heparin entities and methods of use
US9101696B2 (en)	2011-03-11	2015-08-11	W.L. Gore & Associates, Inc.	Immobilised biological entities
US20140309184A1 (en) *	2011-09-21	2014-10-16	University Of South Alabama	Methods and compositions for the treatment of ovarian cancer
JP2015511583A (ja)	2012-02-27	2015-04-20	バーテックスファーマシューティカルズインコーポレイテッドＶｅｒｔｅｘＰｈａｒｍａｃｅｕｔｉｃａｌｓＩｎｃｏｒｐｏｒａｔｅｄ	薬学的組成物およびその投与
JP6377245B2 (ja)	2014-03-24	2018-08-22	グアンドンジョンシェンファーマシューティカルカンパニーリミテッド	Ｓｍｏ阻害剤としてのキノリン誘導体
EP3204358B1 (de)	2014-10-07	2018-09-19	Vertex Pharmaceuticals Incorporated	Cokristalle von modulatoren des transmembrankonduktanzregulators bei zystischer fibrose
EP3939591A1 (de)	2016-06-27	2022-01-19	Achillion Pharmaceuticals, Inc.	Chinazolin- und indolverbindungen zur behandlung von medizinischen leiden
RS66416B1 (sr) *	2019-01-18	2025-02-28	Astrazeneca Ab	6'-[[(1s,3s)-3-[[5-(difluorometoksi)-2-pirimidinil]amino]ciklopentil]amino][1(2h),3'-bipiridin]-2-on kao inhibitor pcsk9 i metode njegove primene

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4656174A (en) *	1982-07-24	1987-04-07	Pfizer Inc.	Quinoline therapeutic agents
GB8506174D0 (en) *	1985-03-09	1985-04-11	Pfizer Ltd	4-amino-6 7-dimethoxy-2-piperazin-1-ylquinazoline derivatives
GB8814458D0 (en) *	1988-06-17	1988-07-20	Wyeth John & Brother Ltd	Heterocyclic compounds
GB9526546D0 (en) *	1995-12-23	1996-02-28	Pfizer Ltd	Compounds useful in therapy

1995
- 1995-12-23 GB GBGB9526546.8A patent/GB9526546D0/en active Pending
- 1995-12-23 NZ NZ325248A patent/NZ325248A/en unknown
1996
- 1996-12-05 AT AT96943954T patent/ATE194598T1/de not_active IP Right Cessation
- 1996-12-05 WO PCT/EP1996/005609 patent/WO1997023462A1/en not_active Ceased
- 1996-12-05 SK SK816-98A patent/SK81698A3/sk unknown
- 1996-12-05 US US09/091,370 patent/US6103738A/en not_active Expired - Fee Related
- 1996-12-05 AU AU13719/97A patent/AU708979B2/en not_active Ceased
- 1996-12-05 PL PL96327610A patent/PL327610A1/xx unknown
- 1996-12-05 HU HU9903560A patent/HUP9903560A3/hu unknown
- 1996-12-05 DK DK96943954T patent/DK0877734T3/da active
- 1996-12-05 BR BR9612263A patent/BR9612263A/pt not_active Application Discontinuation
- 1996-12-05 ES ES96943954T patent/ES2151192T3/es not_active Expired - Lifetime
- 1996-12-05 KR KR1019980704806A patent/KR19990076693A/ko not_active Ceased
- 1996-12-05 DE DE69609353T patent/DE69609353T2/de not_active Expired - Fee Related
- 1996-12-05 CA CA002236814A patent/CA2236814C/en not_active Expired - Fee Related
- 1996-12-05 CZ CZ981976A patent/CZ197698A3/cs unknown
- 1996-12-05 TR TR1998/01195T patent/TR199801195T2/xx unknown
- 1996-12-05 EP EP96943954A patent/EP0877734B1/de not_active Expired - Lifetime
- 1996-12-05 PT PT96943954T patent/PT877734E/pt unknown
- 1996-12-05 JP JP9523272A patent/JP3070958B2/ja not_active Expired - Fee Related
- 1996-12-12 HN HN1996000082A patent/HN1996000082A/es unknown
- 1996-12-18 TN TNTNSN96161A patent/TNSN96161A1/fr unknown
- 1996-12-18 MA MA24433A patent/MA26414A1/fr unknown
- 1996-12-19 AP APAP/P/1996/000900A patent/AP715A/en active
- 1996-12-20 YU YU68896A patent/YU68896A/sh unknown
- 1996-12-20 ZA ZA9610784A patent/ZA9610784B/xx unknown
- 1996-12-20 CO CO96066994A patent/CO4480106A1/es unknown
- 1996-12-20 AR ARP960105804A patent/AR005166A1/es unknown
- 1996-12-23 HR HR9526546.8A patent/HRP960616A2/xx not_active Application Discontinuation
1998
- 1998-04-29 IS IS4731A patent/IS4731A/is unknown
- 1998-06-18 BG BG102559A patent/BG102559A/xx unknown
- 1998-06-22 NO NO982913A patent/NO982913L/no not_active Application Discontinuation
- 1998-06-23 OA OA9800092A patent/OA10703A/en unknown
2000
- 2000-08-17 GR GR20000401910T patent/GR3034225T3/el not_active IP Right Cessation
2001
- 2001-03-19 US US09/812,083 patent/US6642242B2/en not_active Expired - Fee Related
2003
- 2003-06-04 US US10/455,546 patent/US6750214B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
OA10703A (en)	2002-11-28
AP9600900A0 (en)	1997-01-31
CZ197698A3 (cs)	1999-03-17
DK0877734T3 (da)	2000-11-20
AU708979B2 (en)	1999-08-19
US20030220332A1 (en)	2003-11-27
KR19990076693A (ko)	1999-10-15
DE69609353D1 (de)	2000-08-17
BR9612263A (pt)	1999-07-13
CA2236814A1 (en)	1997-07-03
US20020049322A1 (en)	2002-04-25
WO1997023462A1 (en)	1997-07-03
NZ325248A (en)	1999-09-29
EP0877734B1 (de)	2000-07-12
YU68896A (sh)	1999-07-28
GR3034225T3 (en)	2000-12-29
BG102559A (en)	1999-03-31
EP0877734A1 (de)	1998-11-18
US6103738A (en)	2000-08-15
CA2236814C (en)	2001-09-18
GB9526546D0 (en)	1996-02-28
HUP9903560A3 (en)	2000-07-28
JPH11501668A (ja)	1999-02-09
NO982913L (no)	1998-07-30
JP3070958B2 (ja)	2000-07-31
HRP960616A2 (en)	1998-06-30
TNSN96161A1 (fr)	2005-03-15
AR005166A1 (es)	1999-04-14
PT877734E (pt)	2000-12-29
PL327610A1 (en)	1998-12-21
HN1996000082A (es)	1997-06-30
SK81698A3 (en)	2000-04-10
AU1371997A (en)	1997-07-17
MA26414A1 (fr)	2004-12-20
AP715A (en)	1998-12-30
US6642242B2 (en)	2003-11-04
US6750214B2 (en)	2004-06-15
TR199801195T2 (xx)	1998-10-21
NO982913D0 (no)	1998-06-22
CO4480106A1 (es)	1997-07-09
IS4731A (is)	1998-04-29
DE69609353T2 (de)	2000-12-07
HUP9903560A2 (hu)	2000-05-28
ES2151192T3 (es)	2000-12-16
ZA9610784B (en)	1998-06-22

Legal Events

Date	Code	Title	Description
2008-09-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE194598T1 (de)	2000-07-15	In der therapie verwendbare chinolin- und chinazolinverbindungen
HRP980010B1 (en)	2002-06-30	Quinoline and quinazoline compounds useful in therapy
EE9800459A (et)	1999-06-15	Spiro-piperidiini derivaadid ja nende kasutamine terapeutiliste toimeainetena
EE9700209A (et)	1998-04-15	Dihüdropürimidiinid ja nende kasutamine
TR199501305A2 (tr)	1996-06-21	Heterosiklik bilesikler ve bunlarin hazirlanmasi ve kullanimi
FI972546A7 (fi)	1997-07-04	Ristiinsidotut mikropartikkelit ja niiden käyttö hoitavina apuaineina
FI970990A7 (fi)	1997-03-10	Syövän toteaminen ja hoito
FI961758A7 (fi)	1996-04-24	Kinatsoliinijohdannainen
AU1886197A (en)	1997-09-10	Quinolones and their therapeutic use
ID18679A (id)	1998-04-30	Penggunaan terapi lanjutan
FI952656A0 (fi)	1995-05-31	Foerfarande och anordning vid pulsmaetning av en person
FI972245A0 (fi)	1997-05-28	Meso-monojodisubstituoidut tetramakrosykliset yhdisteet sekä niiden valmistus- ja käyttömenetelmät
FI964936L (fi)	1997-02-06	Bentsopyraaneja ja niiden käyttö terapeuttisina aineina
KR970702861A (ko)	1997-06-10	포르포시아닌 및 cnc-확장된 포르피린(porphocyanine and cnc-expanded porphyrins)
ZA985253B (en)	1999-06-17	Quinolines and their therapeutic use
DE69620243D1 (de)	2002-05-02	Haupt- und nebenstromfilter
FI971193A7 (fi)	1997-05-21	Hoidossa käyttökelpoisia kinoksaliinijohdannaisia
FI954680L (fi)	1996-04-05	Kinoloni- ja naftyridonikarboksyylihappojohdannaiset
LV11328A (lv)	1996-06-20	1-(2-fluorciklopropil)-hinolona un naftiridonkarbonskabes atvasinajumi
ZA9710000B (en)	1998-11-06	Quinolines and their therapeutic use
SE9604300D0 (sv)	1996-11-22	Therapeutical use and method
GB9611898D0 (en)	1996-08-07	Quinolones and their therapeutic use
GB9702933D0 (en)	1997-04-02	Quinolones and their therapeutic use
GB9702929D0 (en)	1997-04-02	Quinolones and their therapeutic use
GB9714298D0 (en)	1997-09-10	Quinolines and their therapeutic use