ATE194710T1 - Verfahren und vorrichtung zur zählung und klassifizierung von zellen - Google Patents

Verfahren und vorrichtung zur zählung und klassifizierung von zellen

Info

Publication number
ATE194710T1
ATE194710T1 AT95302975T AT95302975T ATE194710T1 AT E194710 T1 ATE194710 T1 AT E194710T1 AT 95302975 T AT95302975 T AT 95302975T AT 95302975 T AT95302975 T AT 95302975T AT E194710 T1 ATE194710 T1 AT E194710T1
Authority
AT
Austria
Prior art keywords
container
cells
scanned images
data
neighborhood
Prior art date
Application number
AT95302975T
Other languages
English (en)
Inventor
Ning L Sizto
Louis J Dietz
Original Assignee
Biometric Imaging Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biometric Imaging Inc filed Critical Biometric Imaging Inc
Application granted granted Critical
Publication of ATE194710T1 publication Critical patent/ATE194710T1/de

Links

Classifications

    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06VIMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00Scenes; Scene-specific elements
    • G06V20/60Type of objects
    • G06V20/69Microscopic objects, e.g. biological cells or cellular parts
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/968High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/973Simultaneous determination of more than one analyte
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/805Optical property

Landscapes

  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Multimedia (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Theoretical Computer Science (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Image Processing (AREA)
  • Image Analysis (AREA)
AT95302975T 1994-05-02 1995-05-02 Verfahren und vorrichtung zur zählung und klassifizierung von zellen ATE194710T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/236,645 US5556764A (en) 1993-02-17 1994-05-02 Method and apparatus for cell counting and cell classification

Publications (1)

Publication Number Publication Date
ATE194710T1 true ATE194710T1 (de) 2000-07-15

Family

ID=22890377

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95302975T ATE194710T1 (de) 1994-05-02 1995-05-02 Verfahren und vorrichtung zur zählung und klassifizierung von zellen

Country Status (6)

Country Link
US (2) US5556764A (de)
EP (2) EP0987535A3 (de)
JP (1) JP3591911B2 (de)
AT (1) ATE194710T1 (de)
CA (1) CA2148204A1 (de)
DE (1) DE69517864T2 (de)

Families Citing this family (143)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5556764A (en) * 1993-02-17 1996-09-17 Biometric Imaging, Inc. Method and apparatus for cell counting and cell classification
DE69530323T2 (de) * 1994-09-02 2004-02-12 BD Biosciences, Systems and Reagents, Inc., San Jose Verfahren und vorrichtung zur eichung eines optischen abtasters
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US6143247A (en) * 1996-12-20 2000-11-07 Gamera Bioscience Inc. Affinity binding-based system for detecting particulates in a fluid
DE19621312A1 (de) 1996-05-28 1997-12-04 Bayer Ag Maskierung der Hintergrundfluoreszenz und Signalverstärkung bei der optischen Analyse biologisch medizinischer Assays
EP1562035B1 (de) 1997-01-31 2017-01-25 Xy, Llc Optischer Apparat und optisches Verfahren
AU739824B2 (en) 1997-05-05 2001-10-18 Chemometec A/S A method and a system for determination of particles in a liquid sample
EP0985142A4 (de) * 1997-05-23 2006-09-13 Lynx Therapeutics Inc System und gerät zur sequentiellen behandlung von analyten
US5876946A (en) * 1997-06-03 1999-03-02 Pharmacopeia, Inc. High-throughput assay
US6710871B1 (en) 1997-06-09 2004-03-23 Guava Technologies, Inc. Method and apparatus for detecting microparticles in fluid samples
US5834203A (en) * 1997-08-25 1998-11-10 Applied Spectral Imaging Method for classification of pixels into groups according to their spectra using a plurality of wide band filters and hardwire therefore
US6316215B1 (en) 1999-12-27 2001-11-13 Edwin L. Adair Methods of cancer screening utilizing fluorescence detection techniques and selectable imager charge integration periods
US6149867A (en) 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
US6071689A (en) 1997-12-31 2000-06-06 Xy, Inc. System for improving yield of sexed embryos in mammals
US20030036855A1 (en) * 1998-03-16 2003-02-20 Praelux Incorporated, A Corporation Of New Jersey Method and apparatus for screening chemical compounds
US6388788B1 (en) 1998-03-16 2002-05-14 Praelux, Inc. Method and apparatus for screening chemical compounds
US20030153023A1 (en) * 1999-05-13 2003-08-14 Starzl Timothy W. Enumeration method of analyte detection
JP3946444B2 (ja) * 1998-05-14 2007-07-18 ルミネックス コーポレイション フローサイトメータのデッドタイムをゼロにする構成および方法
JP3662850B2 (ja) 1998-06-24 2005-06-22 イルミナ インコーポレイテッド 微小球を有するアレイセンサーのデコード
US6873719B1 (en) * 1998-08-19 2005-03-29 Oxoid Limited Image acquisition apparatus
US6603537B1 (en) 1998-08-21 2003-08-05 Surromed, Inc. Optical architectures for microvolume laser-scanning cytometers
US6423505B1 (en) * 1998-12-03 2002-07-23 Becton Dickinson And Company Methods and reagents for quantitation of HLA-DR and CD11b expression on peripheral blood cells
US6200766B1 (en) 1998-12-03 2001-03-13 Becton Dickinson And Company Methods and reagents for quantitation of HLA-DR expression on peripheral blood cells
US6130745A (en) * 1999-01-07 2000-10-10 Biometric Imaging, Inc. Optical autofocus for use with microtiter plates
US6355934B1 (en) 1999-02-26 2002-03-12 Packard Biochip Technologies Imaging system for an optical scanner
US6937330B2 (en) 1999-04-23 2005-08-30 Ppd Biomarker Discovery Sciences, Llc Disposable optical cuvette cartridge with low fluorescence material
WO2000071991A1 (en) * 1999-05-25 2000-11-30 Biometric Imaging, Inc. Apparatus and method for optical detection in a limited depth of field
AU4491100A (en) * 1999-07-21 2001-02-13 Surromed, Inc. System for microvolume laser scanning cytometry
US6687395B1 (en) 1999-07-21 2004-02-03 Surromed, Inc. System for microvolume laser scanning cytometry
US20040209376A1 (en) * 1999-10-01 2004-10-21 Surromed, Inc. Assemblies of differentiable segmented particles
US7045049B1 (en) * 1999-10-01 2006-05-16 Nanoplex Technologies, Inc. Method of manufacture of colloidal rod particles as nanobar codes
US20040178076A1 (en) * 1999-10-01 2004-09-16 Stonas Walter J. Method of manufacture of colloidal rod particles as nanobarcodes
US7208265B1 (en) 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
US6750037B2 (en) 1999-12-27 2004-06-15 Edwin L. Adair Method of cancer screening primarily utilizing non-invasive cell collection, fluorescence detection techniques, and radio tracing detection techniques
US6984498B2 (en) * 1999-12-27 2006-01-10 Adair Edwin L Method of cancer screening primarily utilizing non-invasive cell collection, fluorescence detection techniques, and radio tracing detection techniques
US6190877B1 (en) 1999-12-27 2001-02-20 Edwin L. Adair Method of cancer screening primarily utilizing non-invasive cell collection and fluorescence detection techniques
US6924114B2 (en) 2000-09-20 2005-08-02 Surromed, Inc. Method for monitoring resting and activated platelets in unfixed blood samples
WO2002044695A1 (en) * 2000-11-16 2002-06-06 Burstein Technologies, Inc. Methods and apparatus for detecting and quantifying lymphocytes with optical biodiscs
US6787761B2 (en) * 2000-11-27 2004-09-07 Surromed, Inc. Median filter for liquid chromatography-mass spectrometry data
US20020095260A1 (en) * 2000-11-28 2002-07-18 Surromed, Inc. Methods for efficiently mining broad data sets for biological markers
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
AU2002237689B2 (en) 2000-11-29 2008-01-10 Xy, Llc. System to separate frozen-thawed spermatozoa into X-chromosome bearing and Y-chromosome bearing populations
US20020146745A1 (en) * 2001-04-03 2002-10-10 Surromed, Inc. Methods and reagents for multiplexed analyte capture, surface array self-assembly, and analysis of complex biological samples
US7016087B2 (en) * 2001-08-08 2006-03-21 Becton Dickinson And Company Photon efficient scanner
US6873915B2 (en) * 2001-08-24 2005-03-29 Surromed, Inc. Peak selection in multidimensional data
US6750457B2 (en) * 2001-08-29 2004-06-15 Becton Dickinson And Company System for high throughput analysis
WO2003021222A2 (en) * 2001-08-31 2003-03-13 Burstein Technologies, Inc. Capture layer assemblies for cellular assays including related optical analysis discs and methods
EP1423699A4 (de) * 2001-09-07 2006-01-18 Burstein Technologies Inc Auf zellkernmorphologie beruhende identifizierung und quantifizierung weisser blutzelltypen unter verwendung optischer bio-disc-systeme
US20030078739A1 (en) * 2001-10-05 2003-04-24 Surromed, Inc. Feature list extraction from data sets such as spectra
CA2468041A1 (en) * 2001-11-20 2003-05-30 Burstein Technologies, Inc. Optical bio-discs and microfluidic devices for analysis of cells
EP1474772A4 (de) * 2002-02-14 2005-11-09 Immunivest Corp Verfahren und algorithmen zur zellenaufzählung in einem kostengünstigen zytometer
US7764821B2 (en) * 2002-02-14 2010-07-27 Veridex, Llc Methods and algorithms for cell enumeration in a low-cost cytometer
US6846311B2 (en) * 2002-04-02 2005-01-25 Acueity, Inc. Method and apparatus for in VIVO treatment of mammary ducts by light induced fluorescence
WO2003095978A2 (en) * 2002-05-09 2003-11-20 Surromed, Inc. Methods for time-alignment of liquid chromatography-mass spectrometry data
JPWO2003102224A1 (ja) * 2002-05-30 2005-09-29 富士電機ホールディングス株式会社 微生物または細胞の計数方法
ATE336266T1 (de) * 2002-06-21 2006-09-15 Adair Edwin Lloyd Anwendung von metalloporphyrinen zur behandlung von arteriosklerose
RU2246606C2 (ru) * 2002-07-09 2005-02-20 Самгин Юрий Сергеевич Установка для депарафинизации нефтедобывающих скважин
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
CN1674780A (zh) 2002-08-01 2005-09-28 Xy公司 低压精子分离系统
US7855078B2 (en) 2002-08-15 2010-12-21 Xy, Llc High resolution flow cytometer
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
US7326573B2 (en) * 2003-01-10 2008-02-05 Beckman Coulter, Inc. Assay procedures and apparatus
EP2305173B1 (de) 2003-03-28 2016-05-11 Inguran, LLC Vorrichtung und Verfahren zur Bereitstellung von sortierten Partikeln
WO2004104178A2 (en) 2003-05-15 2004-12-02 Xy, Inc. Efficient haploid cell sorting for flow cytometer systems
US20050019556A1 (en) * 2003-06-17 2005-01-27 Surromed, Inc. Labeling and authentication of metal objects
DE10327839A1 (de) * 2003-06-20 2005-01-05 Arvinmeritor Gmbh Fahrzeugdachmodul
EP1649066A4 (de) * 2003-07-11 2006-10-11 Surromed Inc Molecular beacon-multiplex-assay zum nachweis von krankheitserregern
US20120077206A1 (en) 2003-07-12 2012-03-29 Accelr8 Technology Corporation Rapid Microbial Detection and Antimicrobial Susceptibility Testing
US7341841B2 (en) * 2003-07-12 2008-03-11 Accelr8 Technology Corporation Rapid microbial detection and antimicrobial susceptibility testing
ES2661168T3 (es) 2003-07-12 2018-03-27 Accelerate Diagnostics, Inc. Biodetección sensible y rápida
JP2007537727A (ja) 2004-03-29 2007-12-27 モンサント テクノロジー エルエルシー 受精で用いられる精子分散液
JP4598426B2 (ja) * 2004-03-30 2010-12-15 富士通株式会社 境界抽出方法、プログラムおよびこれを用いた装置
US7248360B2 (en) 2004-04-02 2007-07-24 Ppd Biomarker Discovery Sciences, Llc Polychronic laser scanning system and method of use
ATE479918T1 (de) * 2004-06-17 2010-09-15 Koninkl Philips Electronics Nv Autofocus-mechanismus für ein spektroskopisches system
JP2006003653A (ja) * 2004-06-17 2006-01-05 Olympus Corp 生体試料観察システム
MX2007000888A (es) 2004-07-22 2007-04-02 Monsanto Technology Llc Procedimiento para enriquecer una poblacion de celulas de esperma.
US8189899B2 (en) * 2004-07-30 2012-05-29 Veridex, Llc Methods and algorithms for cell enumeration in a low-cost cytometer
WO2006057768A2 (en) * 2004-11-24 2006-06-01 Battelle Memorial Institute Optical system for cell imaging
US7554663B2 (en) * 2005-02-08 2009-06-30 Northrop Grumman Corporation Systems and methods for use in detecting harmful aerosol particles
US7995202B2 (en) * 2006-02-13 2011-08-09 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7804594B2 (en) * 2006-12-29 2010-09-28 Abbott Laboratories, Inc. Method and apparatus for rapidly counting and identifying biological particles in a flow stream
CA2683134A1 (en) * 2007-05-07 2008-11-13 Ge Healthcare Bio-Sciences Corp. System and method for the automated analysis of cellular assays and tissues
US8159670B2 (en) * 2007-11-05 2012-04-17 Abbott Laboratories Method and apparatus for rapidly counting and identifying biological particles in a flow stream
US9658222B2 (en) 2009-03-02 2017-05-23 Mbio Diagnostics, Inc. Planar waveguide based cartridges and associated methods for detecting target analyte
US9212995B2 (en) 2009-03-02 2015-12-15 Mbio Diagnostics, Inc. System and method for detecting multiple molecules in one assay
US8331751B2 (en) * 2009-03-02 2012-12-11 mBio Diagnositcs, Inc. Planar optical waveguide with core of low-index-of-refraction interrogation medium
NL1038359C2 (en) 2010-03-31 2012-06-27 Aquamarijn Res B V Device and method for separation of circulating tumor cells.
US8717568B2 (en) 2010-07-16 2014-05-06 Luminex Corporation Analyzing particle quantity and/or distribution within an assay analysis system
JP2013541767A (ja) * 2010-09-16 2013-11-14 ユニバーシティ・オブ・カンザス セルブロック調製物のデジタル評価のためのシステム及び方法
US10114020B2 (en) 2010-10-11 2018-10-30 Mbio Diagnostics, Inc. System and device for analyzing a fluidic sample
CA2815951A1 (en) 2010-11-03 2012-05-10 Reametrix Inc. Measurement system for fluorescent detection, and method therefor
US10254204B2 (en) 2011-03-07 2019-04-09 Accelerate Diagnostics, Inc. Membrane-assisted purification
WO2012122314A2 (en) 2011-03-07 2012-09-13 Accelr8 Technology Corporation Rapid cell purification systems
CN103608664B (zh) 2011-06-24 2016-09-07 贝克顿·迪金森公司 吸收光谱扫描流动血细胞计数
CN103917870B (zh) 2011-11-16 2016-04-13 贝克顿·迪金森公司 用于检测样品中的分析物的方法和系统
WO2014070235A1 (en) 2012-10-29 2014-05-08 Mbio Diagnostics, Inc. Biological particle identification system, cartridge and associated methods
BR112015010695B1 (pt) 2013-01-11 2023-03-07 Becton, Dickinson And Company Dispositivo microfluídico e método para realizar um ensaio de uma amostra líquida, método para formar um dispositivo microfluídico, sistema e kit
US9677109B2 (en) 2013-03-15 2017-06-13 Accelerate Diagnostics, Inc. Rapid determination of microbial growth and antimicrobial susceptibility
US9595092B2 (en) * 2013-05-10 2017-03-14 The Boeing Company Methods and systems for inspection of composite irregularities
US10088407B2 (en) 2013-05-17 2018-10-02 Becton, Dickinson And Company Systems and methods for efficient contours and gating in flow cytometry
US9545471B2 (en) 2013-08-06 2017-01-17 Viatar LLC Extracorporeal fluidic device for collecting circulating tumor cells and method of use thereof
KR101463005B1 (ko) 2013-10-15 2014-11-18 (주)한국해양기상기술 특정 파장에 대한 형광 특성을 갖는 미생물 검사방법
CN113477149B (zh) 2013-11-06 2023-09-12 贝克顿·迪金森公司 微流体性装置和制造和使用其的方法
US10018640B2 (en) 2013-11-13 2018-07-10 Becton, Dickinson And Company Optical imaging system and methods for using the same
US9945848B2 (en) 2014-04-14 2018-04-17 Becton, Dickinson And Company Reagent calibration system and method
JP2017506340A (ja) 2014-10-14 2017-03-02 ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company オープンセル発泡体を用いた血液サンプルの管理
EP3692914B1 (de) 2014-10-14 2023-12-27 Becton, Dickinson and Company Blutprobenverwaltung mittels offenzelligem schaumstoff
US10616219B2 (en) 2014-12-11 2020-04-07 FlowJo, LLC Single cell data management and analysis systems and methods
EP3154697B1 (de) 2015-03-10 2018-06-20 Becton, Dickinson and Company Vorrichtung zur bearbeitung biologischer flüssigproben
US10277906B2 (en) * 2015-03-23 2019-04-30 Arris Enterprises Llc System and method for selectively compressing images
US10253355B2 (en) 2015-03-30 2019-04-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
AU2016243656A1 (en) 2015-03-30 2017-11-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
US10876953B2 (en) 2015-07-15 2020-12-29 Becton, Dickinson And Company System and method for label selection
WO2017040650A1 (en) 2015-09-01 2017-03-09 Becton, Dickinson And Company Depth filtration device for separating specimen phases
US9830720B2 (en) 2015-09-02 2017-11-28 Becton, Dickinson And Company Graphics control during flow cytometry event gating
FI3469338T3 (fi) * 2016-06-10 2025-05-06 Univ California Kuvapohjaisia solunlajittelujärjestelmiä ja -menetelmiä
US12300357B2 (en) 2016-12-14 2025-05-13 FlowJo, LLC Applied computer technology for management, synthesis, visualization, and exploration of parameters in large multi-parameter data sets
ES2980676T3 (es) 2017-05-25 2024-10-02 Flowjo Llc Visualización, análisis comparativo y detección de diferencias automatizada para grandes conjuntos de datos multiparamétricos
US11029242B2 (en) 2017-06-12 2021-06-08 Becton, Dickinson And Company Index sorting systems and methods
US10593082B2 (en) 2017-07-18 2020-03-17 Becton, Dickinson And Company Dynamic display of multi-parameter quantitative biological data
US10636182B2 (en) 2017-07-18 2020-04-28 Becton, Dickinson And Company Dynamic interactive display of multi-parameter quantitative biological data
CN110770571B (zh) 2017-07-18 2022-09-20 贝克顿·迪金森公司 多参数定量生物学数据的动态交互显示
US10883912B2 (en) 2018-06-04 2021-01-05 Becton, Dickinson And Company Biexponential transformation for graphics display
US11327003B2 (en) 2018-08-30 2022-05-10 Becton, Dickinson And Company Characterization and sorting for particle analyzers
EP3908824B1 (de) 2019-01-11 2025-09-10 Becton, Dickinson and Company Optimierte sortiergitter
EP3948221A4 (de) 2019-03-27 2022-12-21 Becton, Dickinson and Company Systeme zur zellsortierung auf basis von frequenzcodierten bildern und verfahren zur verwendung davon
WO2020205089A1 (en) 2019-04-02 2020-10-08 Becton, Dickinson And Company Compensation editor
WO2020219347A1 (en) 2019-04-21 2020-10-29 Becton, Dickinson And Company Cytometric bead array analysis
WO2021155057A1 (en) 2020-01-29 2021-08-05 Becton, Dickinson And Company Barcoded wells for spatial mapping of single cells through sequencing
JP7663587B2 (ja) 2020-01-31 2025-04-16 ベクトン・ディキンソン・アンド・カンパニー 訓練ゲートを調整してフローサイトメータデータに適応させるための方法およびシステム
CN111507956B (zh) * 2020-04-15 2023-04-07 广西科技大学 一种纳米线数量统计方法及系统
WO2021236339A1 (en) 2020-05-18 2021-11-25 Becton, Dickinson And Company Resolution indices for detecting heterogeneity in data and methods of use thereof
JP7766690B2 (ja) 2020-11-19 2025-11-10 ベクトン・ディキンソン・アンド・カンパニー 機械学習分析のためのサイトメトリックデータの最適なスケーリング方法及びそのシステム
CN112597852B (zh) * 2020-12-15 2024-05-24 深圳大学 细胞分类方法、装置、电子设备及存储介质
CN113029919B (zh) * 2021-03-13 2024-04-02 长春长光辰英生物科学仪器有限公司 一种细胞富集与荧光计数的检测装置以及检测、计数方法
WO2024137527A1 (en) 2022-12-19 2024-06-27 Becton, Dickinson And Company Sorting method using barcoded chambers for single cell workflow
US20240377325A1 (en) 2023-05-09 2024-11-14 Becton, Dickinson And Company Methods for assessing cell mitochondrial morphology and systems for same
US20240377311A1 (en) 2023-05-09 2024-11-14 Becton, Dickinson And Company Methods for image-based detection and sorting and systems for same
US20250308080A1 (en) 2024-04-02 2025-10-02 Becton, Dickinson And Company Methods for label-free cell sorting and systems for same
US20250314573A1 (en) 2024-04-05 2025-10-09 Becton, Dickinson And Company Gate/population naming in flow cytometry data analysis based on geometry and data distribution
US20250314577A1 (en) 2024-04-09 2025-10-09 Becton, Dickinson And Company Methods for assessing cell nuclei morphology and systems for same
US20250321179A1 (en) 2024-04-10 2025-10-16 Becton, Dickinson And Company Quantitative flow cytometry light scatter detector alignment
CN120125562B (zh) * 2025-03-10 2025-08-26 江苏诺鬲生物科技有限公司 基于深度神经网络的呼吸道肿瘤细胞智能识别系统及方法

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4060713A (en) * 1971-06-23 1977-11-29 The Perkin-Elmer Corporation Analysis of images
US3999047A (en) * 1972-09-05 1976-12-21 Green James E Method and apparatus utilizing color algebra for analyzing scene regions
US3918812A (en) * 1973-05-07 1975-11-11 Us Energy Diagnoses of disease states by fluorescent measurements utilizing scanning laser beams
US3900265A (en) * 1974-03-08 1975-08-19 Intec Corp Laser scanner flaw detection system
US4045772A (en) * 1974-04-29 1977-08-30 Geometric Data Corporation Automatic focusing system
US4122518A (en) * 1976-05-17 1978-10-24 The United States Of America As Represented By The Administrator Of The National Aeronautics & Space Administration Automated clinical system for chromosome analysis
JPS594058B2 (ja) * 1976-07-23 1984-01-27 株式会社日立製作所 白血球像処理方法
US4129854A (en) * 1976-10-25 1978-12-12 Hitachi, Ltd. Cell classification method
US4199748A (en) * 1976-11-01 1980-04-22 Rush-Presbyterian-St. Luke's Medical Center Automated method and apparatus for classification of cells with application to the diagnosis of anemia
US4097845A (en) * 1976-11-01 1978-06-27 Rush-Presbyterian-St. Luke's Medical Center Method of and an apparatus for automatic classification of red blood cells
US4191940A (en) * 1978-01-09 1980-03-04 Environmental Research Institute Of Michigan Method and apparatus for analyzing microscopic specimens and the like
US4282412A (en) * 1978-08-21 1981-08-04 Florin Robert E Mercury switch for monitoring position of patient
US4229797A (en) * 1978-09-06 1980-10-21 National Biomedical Research Foundation Method and system for whole picture image processing
DE2903855A1 (de) * 1979-02-01 1980-08-14 Bloss Werner H Prof Dr Ing Verfahren zum automatischen markieren von zellen und bestimmung der merkmale von zellen aus zytologischen abstrichpraeparaten
US4318886A (en) * 1979-11-19 1982-03-09 Nippon Kogaku K.K. Automatic HLA typing apparatus
JPS58154064A (ja) * 1982-03-08 1983-09-13 Mitsubishi Rayon Co Ltd リンパ球t細胞百分率測定方法
US4513438A (en) * 1982-04-15 1985-04-23 Coulter Electronics, Inc. Automated microscopy system and method for locating and re-locating objects in an image
US4647531A (en) * 1984-02-06 1987-03-03 Ortho Diagnostic Systems, Inc. Generalized cytometry instrument and methods of use
US4665553A (en) * 1984-05-01 1987-05-12 Ortho Diagnostics Systems Inc. Methods and apparatus for analysis of particles and cells
US4700298A (en) * 1984-09-14 1987-10-13 Branko Palcic Dynamic microscope image processing scanner
US4672559A (en) * 1984-12-26 1987-06-09 E. I. Du Pont De Nemours And Company Method for operating a microscopical mapping system
US4727020A (en) * 1985-02-25 1988-02-23 Becton, Dickinson And Company Method for analysis of subpopulations of blood cells
US4741043B1 (en) * 1985-11-04 1994-08-09 Cell Analysis Systems Inc Method of and apparatus for image analyses of biological specimens
US5121436A (en) * 1987-08-14 1992-06-09 International Remote Imaging Systems, Inc. Method and apparatus for generating a plurality of parameters of an object in a field of view
US4845552A (en) * 1987-08-20 1989-07-04 Bruno Jaggi Quantitative light microscope using a solid state detector in the primary image plane
US5068909A (en) * 1989-05-18 1991-11-26 Applied Imaging Corporation Method and apparatus for generating quantifiable video displays
US5072382A (en) * 1989-10-02 1991-12-10 Kamentsky Louis A Methods and apparatus for measuring multiple optical properties of biological specimens
US5107422A (en) * 1989-10-02 1992-04-21 Kamentsky Louis A Method and apparatus for measuring multiple optical properties of biological specimens
US5556764A (en) * 1993-02-17 1996-09-17 Biometric Imaging, Inc. Method and apparatus for cell counting and cell classification
USD366938S (en) 1994-09-02 1996-02-06 Biometric Imaging, Inc. Cartridge for processing laboratory samples

Also Published As

Publication number Publication date
CA2148204A1 (en) 1995-11-03
US5962238A (en) 1999-10-05
DE69517864D1 (de) 2000-08-17
EP0681177B1 (de) 2000-07-12
EP0987535A3 (de) 2001-03-21
JP3591911B2 (ja) 2004-11-24
DE69517864T2 (de) 2001-03-15
JPH0854333A (ja) 1996-02-27
EP0681177A1 (de) 1995-11-08
EP0987535A2 (de) 2000-03-22
US5556764A (en) 1996-09-17

Similar Documents

Publication Publication Date Title
DE69517864D1 (de) Verfahren und Vorrichtung zur Zählung und Klassifizierung von Zellen
EP1234280B1 (de) Verfahren zur untersuchung von zellproben durch bildherstellung und analysen
EP0713086B1 (de) Vorrichtung und Verfahren zum Erkennen und Zählen von selten vorkommenden Säugerzellen
US8698881B2 (en) Apparatus, method and article to perform assays using assay strips
EP0245466B1 (de) Analyseverfahren und vorrichtung für biologische specimen
EP0713087B1 (de) Vorrichtung und Verfahren zum schnellen und hochempfindlichen Erkennen und Zählen von Mikroorganismen mittels Fluoreszenz
CN108627656B (zh) 医疗样本检测系统、方法及装置
ATE194431T1 (de) Optisches probe-analysesystem und verfahren
ATE236386T1 (de) Verfahren zur automatischen bildanalyse biologischer proben
DE69824174D1 (de) Ein system zur zellbasierten reihenuntersuchung
DE69720505D1 (de) Verfahren und vorrichtung zur identifizierung und charakterisierung von biomolekuelen
ATE245278T1 (de) Verfahren zur automatischen analyse von mikroskopaufnahmen
EP4375669A3 (de) Direkter nachweis von einzelmolekülen auf mikropartikeln
US20040243318A1 (en) Microbe examining device and method
US6535624B1 (en) Gel electrophoresis image combining for improved dynamic range
US8041086B2 (en) Method of detecting specific polymer crystal
US8229196B2 (en) Method of detecting specific polymer crystal
EP1439384A3 (de) System für Screening biologischer Zellen
JP2005291795A (ja) 蛍光検出装置および画像処理システム
Günther et al. Facilitated gate setting by sequential dot plot scanning
JP2000157298A (ja) 染色体異常の解析方法および装置
Laws et al. SignalViewer: analyzing microarray images
CN121595427A (zh) 基于多模态数据融合的细胞智能分选方法、设备及介质
Manzur Imaging System and Method for Biomedical Analysis
WO2001032913A1 (en) Method of analysing cell samples, by creating and analysing a resultant image

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties