ATE194985T1 - Kondensiertes pyrazinderivat - Google Patents

Kondensiertes pyrazinderivat

Info

Publication number: ATE194985T1
Authority: AT; Austria
Prior art keywords: represent; alkyl; pyrazine derivative; nitro; cycloalkyl
Prior art date: 1990-11-06

Application number

AT91918943T

Other languages

English (en)

Inventor

Shuichi Sakamoto

Jun-Ya Ohmori

Hirokazu Kubota

Masao Sasamata

Masamichi Okada

Kazuyuki Hidaka

Original Assignee

Yamanouchi Pharma Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-11-06

Filing date

1991-11-01

Publication date

2000-08-15

1991-11-01 Application filed by Yamanouchi Pharma Co Ltd filed Critical Yamanouchi Pharma Co Ltd

2000-08-15 Application granted granted Critical

2000-08-15 Publication of ATE194985T1 publication Critical patent/ATE194985T1/de

Links

KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical class C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 5
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
-1 1,4-butylene Chemical group 0.000 abstract 1
102000018899 Glutamate Receptors Human genes 0.000 abstract 1
108010027915 Glutamate Receptors Proteins 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical class 0.000 abstract 1
125000003178 carboxy group Chemical class [H]OC(*)=O 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000002496 methyl group Chemical class [H]C([H])([H])* 0.000 abstract 1
125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003216 pyrazines Chemical class 0.000 abstract 1
125000003718 tetrahydrofuranyl group Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Liquid Crystal Substances (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

AT91918943T 1990-11-06 1991-11-01 Kondensiertes pyrazinderivat ATE194985T1 (de)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
JP30087990		1990-11-06
JP6959291		1991-01-11
JP13382891		1991-03-29
JP18324891		1991-06-27
PCT/JP1991/001498 WO1992007847A1 (fr)	1990-11-06	1991-11-01	Derive de pyrazine fusionnee

Publications (1)

Publication Number	Publication Date
ATE194985T1 true ATE194985T1 (de)	2000-08-15

Family

ID=27465151

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91918943T ATE194985T1 (de)	1990-11-06	1991-11-01	Kondensiertes pyrazinderivat

Country Status (14)

Country	Link
US (1)	US5283244A (de)
EP (1)	EP0556393B1 (de)
JP (1)	JP2550456B2 (de)
KR (1)	KR0132903B1 (de)
AT (1)	ATE194985T1 (de)
AU (1)	AU656154B2 (de)
CA (1)	CA2095444C (de)
DE (1)	DE69132340T2 (de)
DK (1)	DK0556393T3 (de)
ES (1)	ES2150417T3 (de)
GR (1)	GR3034629T3 (de)
HU (2)	HU221425B (de)
RU (1)	RU2095352C1 (de)
WO (1)	WO1992007847A1 (de)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
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DK162491D0 (da) *	1991-09-20	1991-09-20	Novo Nordisk As	Heterocycliske forbindelser, deres fremstilling og farmaceutiske praeparater indeholdende forbindelserne
US6057304A (en)	1992-10-26	2000-05-02	Schering Aktiengesellschaft	Quinoxaline-phosphonic acid derivatives
DE4217952A1 (de) *	1992-05-30	1993-12-02	Basf Ag	Chinoxalin-2,3(1H,4H)-dione
WO1994000124A1 (en) *	1992-06-22	1994-01-06	Eckard Weber	Glycine receptor antagonists and the use thereof
ATE157977T1 (de)	1992-10-13	1997-09-15	Warner Lambert Co	Chinoxalinderivate als eaa antagonisten
PH31122A (en) *	1993-03-31	1998-02-23	Eisai Co Ltd	Nitrogen-containing fused-heterocycle compounds.
IL109397A0 (en) *	1993-04-28	1994-07-31	Schering Ag	Quinoxalinedione derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
US5631373A (en) *	1993-11-05	1997-05-20	State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon	Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones
DE4340045A1 (de) *	1993-11-24	1995-06-01	Basf Ag	Neue Chinoxaline und Arzneimittel daraus
JPH09510695A (ja) *	1994-01-03	1997-10-28	エイシア・ファーマシュウティカルズ，インコーポレイテッド	８−アザ、６−アザ、および６，８−ジアザ−１，４−ジヒドロキノキサリン−２，３−ジオン類およびそのグリシン／ｎｍｄａリセプターに対するアンタゴニストとしての使用
AU688459B2 (en) *	1994-04-08	1998-03-12	Shionogi & Co., Ltd.	Oxopyridinylquinoxaline derivative
DE4428152A1 (de) *	1994-06-22	1996-01-04	Basf Ag	Neue Amido-chinoxalindione, ihrer Herstellung und Verwendung
GB9419318D0 (en) *	1994-09-24	1994-11-09	Pfizer Ltd	Therapeutic agents
DE69524246T2 (de) *	1994-09-27	2002-06-27	Yamanouchi Pharmaceutical Co., Ltd.	1,2,3,4-Tetrahydroquinoxalindion Derivate und ihre Verwendung als Glutamat Rezeptor Antagonisten
JP2865878B2 (ja)	1994-09-27	1999-03-08	山之内製薬株式会社	１，２，３，４−テトラヒドロキノキサリンジオン誘導体
DE4436852A1 (de) *	1994-10-14	1996-04-18	Basf Ag	Pyrrolyl-tetrahydrobenzochinoxalindione, ihre Herstellung und Verwendung
US5801183A (en) *	1995-01-27	1998-09-01	State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon	Aza and aza (N-oxy) analogs of glycine/NMDA receptor antagonists
US6110911A (en) *	1995-06-07	2000-08-29	Warner-Lambert Company	Cyclic amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists
DE19521058A1 (de) *	1995-06-09	1996-12-12	Basf Ag	Verfahren zur Herstellung von Aromaten enthaltenden Polyetherpolyolen
DE19532050A1 (de) *	1995-08-31	1997-03-06	Basf Ag	Pyrrolyl-tetrahydrochinoxalindione, ihre Herstellung und Verwendung zur Bekämpfung von Krankheiten
GB9605027D0 (en) *	1996-03-09	1996-05-08	Pfizer Ltd	Quinoxalinediones
ZA973884B (en)	1996-05-23	1998-11-06	Du Pont Merck Pharma	Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders
TW448171B (en) *	1996-06-06	2001-08-01	Yamanouchi Pharma Co Ltd	Imidazole-substituted quinoxalinedione derivatives
US5824662A (en) *	1996-09-27	1998-10-20	Guilford Pharmaceuticals Inc.	Treatment of global and focal ischemia using naaladase inhibitors
US6017903A (en)	1996-09-27	2000-01-25	Guilford Pharmaceuticals Inc.	Pharmaceutical compositions and methods of treating a glutamate abnormality and effecting a neuronal activity in an animal using NAALADase inhibitors
DE19624808A1 (de)	1996-06-21	1998-01-02	Basf Ag	Pyrrolylchinoxalindione, ihre Herstellung und Verwendung
PL332413A1 (en)	1996-09-27	1999-09-13	Guilford Pharm Inc	Compositions containing inhibitors of naaladase as well as methods of treating glutamatic anomaly and influencing neuronic functions among animals
CA2269807C (en) *	1996-10-24	2007-04-10	Novartis Ag	Substituted aminoalkanephosphonic acids
AP982A (en) *	1997-02-27	2001-07-16	Pfizer	Quinoxalinediones.
CN1121403C (zh) *	1997-02-27	2003-09-17	辉瑞大药厂	喹喔啉二酮
TW526195B (en)	1997-06-10	2003-04-01	Novartis Ag	Crystal modifications of 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide and their use
US6015800A (en) *	1997-09-03	2000-01-18	Warner-Lambert Company	Substituted quinoxaline-2-ones as glutamate receptor antagonists
AU9651198A (en)	1997-11-11	1999-05-31	Ono Pharmaceutical Co. Ltd.	Fused pyrazine compounds
PL344406A1 (en) *	1998-06-01	2001-11-05	Shionogi & Co	Cyanoiminoquinoxaline derivatives
EP1736468A3 (de) *	2000-01-24	2007-01-03	NeuroSearch A/S	Isatinderivate mit neurotropischer Aktivität geeignet zur Behandlung von NGF-bedingten Krankheiten
HU229604B1 (en) *	2001-02-12	2014-02-28	Hoffmann La Roche	6-substituted pyrido-pyrimidines, process for their preparation and pharmaceutical compositions containing them
CN101248060B (zh) *	2005-06-23	2014-09-10	阵列生物制药公司	用于制备苯并咪唑化合物的方法
NZ571540A (en) *	2006-04-21	2010-10-29	Pfizer Prod Inc	Pyridine[3,4-b]pyrazinones for inhibiting PDE-5
US7601716B2 (en) *	2006-05-01	2009-10-13	Cephalon, Inc.	Pyridopyrazines and derivatives thereof as ALK and c-Met inhibitors
KR101370434B1 (ko)	2007-01-16	2014-03-06	시오노기세이야쿠가부시키가이샤	Ｏｒｌ-1 리간드로서의 헤테로시클릭-치환 피페리딘
CA2686816A1 (en)	2007-01-16	2008-07-24	The Johns Hopkins University	Use of various glutamate receptor antagonists for delaying or preventing platelet activity or for treating or preventing a thrombotic disease or disorder
KR20140139125A (ko)	2007-08-31	2014-12-04	퍼듀 퍼머 엘피	치환-퀴녹살린-형 피페리딘 화합물 및 그의 용도
WO2010053757A1 (en) *	2008-10-29	2010-05-14	Gilead Palo Alto, Inc.	2 -oxoquinoxalin blockers of the late sodium channel
WO2010074807A1 (en)	2008-10-30	2010-07-01	Gilead Palo Alto, Inc.	3, 4-dihydroquinolin-2 ( 1h ) -one derivatives as sodium channel modulators
EP2338492A1 (de)	2009-12-24	2011-06-29	Universidad del Pais Vasco	Verfahren und Zusammensetzung zur Behandlung von Alzheimer
CN116615199A (zh) *	2020-11-26	2023-08-18	株式会社Lg化学	作为二酰基甘油激酶抑制剂的杂环化合物及其用途
JPWO2023042888A1 (de)	2021-09-15	2023-03-23
US20240398775A1 (en)	2021-09-15	2024-12-05	University Of The Ryukyus	Pharmaceutical composition for use in treating cognitive decline or for use in treating overweight or obesity

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE66149B1 (en) *	1986-09-16	1995-12-13	Novo Nordisk As	Quinoxaline compounds and their preparation and use
NO179551C (no) *	1987-11-10	1996-10-30	Novo Nordisk As	Analogifremgangsmåte for fremstilling av terapeutisk virksomme kinoxalinforbindelser
CA2002864C (en) *	1988-11-29	1999-11-16	Eddy J. E. Freyne	(1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives
GB8827822D0 (en) *	1988-11-29	1988-12-29	Janssen Pharmaceutica Nv	(1h-azol-1-ylmethyl)substituted quinoline derivatives
DK715888D0 (da) *	1988-12-22	1988-12-22	Ferrosan As	Quinoxalinforbindelser, deres fremstilling og anvendelse

1991
- 1991-11-01 AT AT91918943T patent/ATE194985T1/de not_active IP Right Cessation
- 1991-11-01 DE DE69132340T patent/DE69132340T2/de not_active Expired - Fee Related
- 1991-11-01 RU RU93033484/04A patent/RU2095352C1/ru not_active IP Right Cessation
- 1991-11-01 HU HU9301298A patent/HU221425B/hu unknown
- 1991-11-01 CA CA002095444A patent/CA2095444C/en not_active Expired - Fee Related
- 1991-11-01 US US08/050,225 patent/US5283244A/en not_active Expired - Lifetime
- 1991-11-01 ES ES91918943T patent/ES2150417T3/es not_active Expired - Lifetime
- 1991-11-01 DK DK91918943T patent/DK0556393T3/da active
- 1991-11-01 EP EP91918943A patent/EP0556393B1/de not_active Expired - Lifetime
- 1991-11-01 JP JP3517229A patent/JP2550456B2/ja not_active Expired - Fee Related
- 1991-11-01 AU AU87666/91A patent/AU656154B2/en not_active Ceased
- 1991-11-01 WO PCT/JP1991/001498 patent/WO1992007847A1/ja not_active Ceased
1993
- 1993-05-04 KR KR1019930701342A patent/KR0132903B1/ko not_active Expired - Fee Related
1995
- 1995-06-30 HU HU95P/P00644P patent/HU211310A9/hu unknown
2000
- 2000-10-16 GR GR20000402315T patent/GR3034629T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2095444C (en)	2001-06-19
DK0556393T3 (da)	2000-10-16
AU8766691A (en)	1992-05-26
AU656154B2 (en)	1995-01-27
RU2095352C1 (ru)	1997-11-10
DE69132340T2 (de)	2001-02-08
HU9301298D0 (en)	1993-09-28
HU221425B (en)	2002-10-28
KR0132903B1 (ko)	1998-04-17
GR3034629T3 (en)	2001-01-31
HU211310A9 (en)	1995-11-28
EP0556393B1 (de)	2000-07-26
EP0556393A4 (en)	1994-04-13
CA2095444A1 (en)	1992-05-07
DE69132340D1 (de)	2000-08-31
EP0556393A1 (de)	1993-08-25
JP2550456B2 (ja)	1996-11-06
HUT64324A (en)	1993-12-28
ES2150417T3 (es)	2000-12-01
WO1992007847A1 (fr)	1992-05-14
US5283244A (en)	1994-02-01

Legal Events

Date	Code	Title	Description
2008-08-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DK0556393T3 (da)	2000-10-16	Tilkondenseret pyrazinderivat
IL97403A0 (en)	1992-06-21	3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones,oxazolidinones,and imidazolidinones and pharmaceutical compositions containing them
DE68920556D1 (de)	1995-02-23	Substituierte Thiazole und ihre Anwendung als Fungizide.
ATE142630T1 (de)	1996-09-15	Triazin-derivate und unkrautvertilgungsmittel daraus
ES2088537T3 (es)	1996-08-16	Derivados de piranil cianoguanidina.
ES2161713T3 (es)	2001-12-16	Derivado de metotrexato.
DE69208478D1 (de)	1996-03-28	Amid derivate von vitamin d
DK0591058T3 (da)	1999-03-22	Ellipticinderivater med antitumoraktivitet
DE69617909D1 (de)	2002-01-24	2-substituierte vitamin-d3-derivate
ES2065994T3 (es)	1995-03-01	Beta-dicetonas substituidas.
DK451389D0 (da)	1989-09-13	2-substituerede 4,5-diaryl-thioimidazoler samt farmaceutisk praeparat indeholdende saadanne forbindelser
ES2156901T3 (es)	2001-08-01	Antidepresor.
DK0623131T3 (da)	1996-08-05	Alkylderivater af trazodon med CNS-aktivitet
EP0676399A4 (de)	1996-04-17	Methotrexat-derivate.
ATE84303T1 (de)	1993-01-15	Cysteinderivate.
ATE177106T1 (de)	1999-03-15	Ymidothiophosphat-derivat und insektizid, nematozid und akarizid enthalted dasselbe als aktiven bestandteil.
DE60316219D1 (de)	2007-10-25	Farbphotographisches lichtempfindliches Silberhalogenidmaterial
PL324070A1 (en)	1998-07-06	Novel compounds of ellipticin, method of obtaining them and pharmaceutical preparations containing such compounds