ATE194988T1 - Bicyclische nonan-und decanverbindungen mit dopamine-rezeptor-affinitaet - Google Patents

Bicyclische nonan-und decanverbindungen mit dopamine-rezeptor-affinitaet

Info

Publication number: ATE194988T1
Authority: AT; Austria
Prior art keywords: 4alkyl; dopamine receptor; compounds; nonanene; decanene
Prior art date: 1994-12-12

Application number

AT95937148T

Other languages

English (en)

Inventor

Patricia L Power

Sumanas Rakhit

Original Assignee

Allelix Biopharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-12-12

Filing date

1995-12-08

Publication date

2000-08-15

1995-12-08 Application filed by Allelix Biopharma filed Critical Allelix Biopharma

2000-08-15 Application granted granted Critical

2000-08-15 Publication of ATE194988T1 publication Critical patent/ATE194988T1/de

Links

102000015554 Dopamine receptor Human genes 0.000 title abstract 2
108050004812 Dopamine receptor Proteins 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 title abstract 2
-1 C1-9alkoxy Chemical group 0.000 abstract 3
125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 abstract 2
102000005962 receptors Human genes 0.000 abstract 2
108020003175 receptors Proteins 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
125000006545 (C1-C9) alkyl group Chemical group 0.000 abstract 1
125000003047 N-acetyl group Chemical group 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003275 alpha amino acid group Chemical group 0.000 abstract 1
125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
150000004677 hydrates Chemical class 0.000 abstract 1
239000003446 ligand Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
201000000980 schizophrenia Diseases 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT95937148T 1994-12-12 1995-12-08 Bicyclische nonan-und decanverbindungen mit dopamine-rezeptor-affinitaet ATE194988T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/354,906 US5576314A (en)	1994-12-12	1994-12-12	Bicyclic nonane and decane compounds having dopamine receptor affinity
PCT/IB1995/001110 WO1996018630A1 (en)	1994-12-12	1995-12-08	Bicyclic nonane and decane compounds having dopamine receptor affinity

Publications (1)

Publication Number	Publication Date
ATE194988T1 true ATE194988T1 (de)	2000-08-15

Family

ID=23395404

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95937148T ATE194988T1 (de)	1994-12-12	1995-12-08	Bicyclische nonan-und decanverbindungen mit dopamine-rezeptor-affinitaet

Country Status (7)

Country	Link
US (2)	US5576314A (de)
EP (1)	EP0797577B1 (de)
AT (1)	ATE194988T1 (de)
AU (1)	AU3934795A (de)
CA (1)	CA2207546A1 (de)
DE (1)	DE69518165T2 (de)
WO (1)	WO1996018630A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5576314A (en) *	1994-12-12	1996-11-19	Allelix Biopharmaceuticals Inc.	Bicyclic nonane and decane compounds having dopamine receptor affinity
ES2161377T3 (es) *	1995-12-21	2001-12-01	Pfizer	Derivados de octahidro-pirrolo(1,2-a)-pirazina 2,7-sustituidos.
CN1268949A (zh)	1997-09-02	2000-10-04	吉富制药株式会社	稠合噻吩化合物及其医药用途
US6251893B1 (en) *	1998-06-15	2001-06-26	Nps Allelix Corp.	Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity
US6107313A (en) *	1998-10-02	2000-08-22	Combichem, Inc.	Dopamine receptor antagonists
GB9926303D0 (en) *	1999-11-05	2000-01-12	Smithkline Beecham Plc	Novel compounds
US6890919B2 (en) *	2001-06-26	2005-05-10	Shitij Kapur	Atypical antipsychotic agents having low affinity for the D2 receptor
FR2928150A1 (fr) *	2008-02-29	2009-09-04	Vetoquinol Sa Sa	Nouveaux derives 7-substitues de 3-carboxy-oxadiazino-quinolones, leur preparation et leur application comme anti-bacteriens
EP2145891A1 (de) *	2008-07-09	2010-01-20	Vetoquinol S.A.	9-substierte 5-Carboxy-Oxadiazin-Chinolon-Derivate, ihre Herstellung und ihre Anwendung als antibakterielle Mittel
JP2023502087A (ja) *	2019-11-19	2023-01-20	エフ．ホフマン－ラロシュアーゲー	自己免疫疾患の処置のためのヒドロ－１Ｈ－ピロロ［１，２－ａ］ピラジン化合物

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA772160A (en) *		1967-11-21	Schmutz Jean	Diazepine and thiazepine derivatives
NL140242B (nl) *	1963-03-01	1973-11-15	Wander Ag Dr A	Werkwijze voor het bereiden van op de 11-plaats door een basische groep gesubstitueerde dibenz (b.f.)(1.4) oxazepinen.
US3908010A (en) *	1967-03-22	1975-09-23	Wander Ag Dr A	Basically substituted heterocycles as anti-emetics
US3758479A (en) *	1967-03-22	1973-09-11	Sandoz Ag	Nitro and sulphamoyl substituted dibenzodiazepines
US3539573A (en) *	1967-03-22	1970-11-10	Jean Schmutz	11-basic substituted dibenzodiazepines and dibenzothiazepines
US3751415A (en) *	1967-03-22	1973-08-07	Sandoz Ag	2-nitro-11-(1-piperazinyl)-dibenz(b,f)(1,4)oxazepines
US3983234A (en) *	1974-07-04	1976-09-28	Sandoz Ltd.	Treatment of dyskinesias
US4096261A (en) *	1977-02-23	1978-06-20	Abbott Laboratories	Dibenzodiazepines
DD151166A1 (de) *	1979-11-05	1981-10-08	Carla Rueger	Verfahren zur herstellung von in 11-stellung substituierten 5h-dibenzo eckige klammer auf b,e eckige klammer zu eckige klammer auf 1,4 eckige klammer zu diazepinen
SU1015618A1 (ru) *	1980-01-28	1986-12-15	Научно-исследовательский институт фармакологии АМН СССР	11- @ -(Диазабицикло (4. @ . @ )алканил) @ -5 @ -дибензо-( @ , @ ) (1,4)диазепины,обладающие нейролиптическим действием
CS224988B1 (cs) *	1982-08-17	1984-02-13	Jilek Jiri	Derivát oktahydropyrrolo(l,2-a)pyrazinu a jeho methansulfonát
US5393752A (en) *	1992-05-26	1995-02-28	Therabel Research S.A./N.V.	Methylpiperazinoazepine compounds, preparation and use thereof
US5354747A (en) *	1993-06-16	1994-10-11	G. D. Searle & Co.	2-, 3-, 4-, 5-, 6-, 7-, 8-, 9- and/or 10-substituted dibenzoxazepine and dibenzthiazepine compounds, pharmaceutical compositions and methods of use
US5576314A (en) *	1994-12-12	1996-11-19	Allelix Biopharmaceuticals Inc.	Bicyclic nonane and decane compounds having dopamine receptor affinity

1994
- 1994-12-12 US US08/354,906 patent/US5576314A/en not_active Expired - Lifetime
1995
- 1995-12-08 EP EP95937148A patent/EP0797577B1/de not_active Expired - Lifetime
- 1995-12-08 DE DE69518165T patent/DE69518165T2/de not_active Expired - Fee Related
- 1995-12-08 CA CA002207546A patent/CA2207546A1/en not_active Abandoned
- 1995-12-08 AU AU39347/95A patent/AU3934795A/en not_active Abandoned
- 1995-12-08 AT AT95937148T patent/ATE194988T1/de active
- 1995-12-08 WO PCT/IB1995/001110 patent/WO1996018630A1/en not_active Ceased
1996
- 1996-04-01 US US08/625,358 patent/US5703072A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
WO1996018630A1 (en)	1996-06-20
EP0797577A1 (de)	1997-10-01
US5703072A (en)	1997-12-30
US5576314A (en)	1996-11-19
AU3934795A (en)	1996-07-03
CA2207546A1 (en)	1996-06-20
EP0797577B1 (de)	2000-07-26
DE69518165D1 (de)	2000-08-31
DE69518165T2 (de)	2001-06-07

Similar Documents

Publication	Publication Date	Title
ES2173172T3 (es)	2002-10-16	Derivados de 1,3-dihidroindol-2-ona sustituidos en 3 por un grupo nitrogenado como agonistas y/o antagonistas de la vasopresina y/o de la octocina.
EA200000391A1 (ru)	2000-12-25	Производные тиенопиримидина и тиенопиридина, полезные в качестве противораковых агентов
DE3270317D1 (en)	1986-05-07	Derivatives of amino acids and their therapeutic use
ATE175198T1 (de)	1999-01-15	N-acylierte trizyklische azaheteroringe verwendbar als vasopressin-antagonisten
CA2179306A1 (en)	1995-06-29	Dopamine receptor ligands
NO308300B1 (no)	2000-08-28	Heterosykliske forbindelser med tachykininreseptorantagonistaktivitet, og preparat inneholdende disse
NO20003133D0 (no)	2000-06-16	Anilidderivater, fremstilling og anvendelse derav
AU8772691A (en)	1992-05-14	New compounds
ATE86110T1 (de)	1993-03-15	Behandlung von gastrointestinalkrankheiten durch anwendung von 5-ht3-antagonisten.
ATE194988T1 (de)	2000-08-15	Bicyclische nonan-und decanverbindungen mit dopamine-rezeptor-affinitaet
DE69433984D1 (de)	2004-10-14	Arylpiperazinderivate von indol als liganden der rezeptoren 5 ht1-like, 5 ht1b und 5 ht1d
EA199700160A1 (ru)	1998-02-26	Производные индола в качестве антагонистов eaa
YU29300A (sh)	2003-08-29	Katalizovane reakcije prelaznog metala bazirane na hiralnim amin oksazolinil ligandima
MX9200471A (es)	1992-08-01	N-(ariloxialquil)heteroaril-8-azabiciclo[3.2.1]octanos, compuestos intermedios y un procedimiento para su preparacion, asi como su uso en calidad de medicamentos
DE60014343D1 (de)	2004-11-04	N-(2-phenyl-4-amino-butyl)-1-naphthamide als neurokinin-1 rezeptorantagonisten
MA19514A1 (fr)	1982-12-31	Herbicides a fonctions amide et ester derives de la pyridine ainsi que leur procede de preparation et leur application
PL321545A1 (en)	1997-12-08	Substituted phenyl compounds and method of applying them as endoteline antagonists
DE60137451D1 (de)	2009-03-05	N-substituierte Amide als NK1 Rezeptor Antagonisten
EA199800289A1 (ru)	1998-08-27	Производные пептидов
GB9316195D0 (en)	1993-09-22	Pharmaceuticals
PH21982A (en)	1988-05-02	N-(3-triflouromethyl-phenyl)-n'-propargylpiperazine and method of use thereof
EA199800575A1 (ru)	1998-12-24	Производные пиперазина
EA199800597A1 (ru)	1999-02-25	Производные морфина с анальгетической активностью
DK293889A (da)	1989-12-15	2-amino-7-hydroxytetralinethere