ATE195125T1 - Verfahren zur de-esterifikation - Google Patents

Verfahren zur de-esterifikation

Info

Publication number: ATE195125T1
Authority: AT; Austria
Prior art keywords: tetrachloride; ceph; isomer; substituted; esterification method
Prior art date: 1995-11-06

Application number

AT96938143T

Other languages

English (en)

Inventor

Vroom Eric De

Der Does Thomas Van

Original Assignee

Dsm Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-11-06

Filing date

1996-11-06

Publication date

2000-08-15

1996-11-06 Application filed by Dsm Nv filed Critical Dsm Nv

2000-08-15 Application granted granted Critical

2000-08-15 Publication of ATE195125T1 publication Critical patent/ATE195125T1/de

Links

238000000034 method Methods 0.000 title abstract 2
238000005886 esterification reaction Methods 0.000 title 1
-1 3-substituted (6R,7R)-7-phenyl-acetamido-ceph-3-em-4-carboxylic acid Chemical class 0.000 abstract 2
LSNNJFPAIWHDGA-TZMCWYRMSA-N (6r,7r)-8-oxo-7-[(2-phenylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical class N([C@H]1[C@H]2SCC=C(N2C1=O)C(=O)O)C(=O)CC1=CC=CC=C1 LSNNJFPAIWHDGA-TZMCWYRMSA-N 0.000 abstract 1
OFDISMSWWNOGFW-UHFFFAOYSA-N 1-(4-ethoxy-3-fluorophenyl)ethanamine Chemical compound CCOC1=CC=C(C(C)N)C=C1F OFDISMSWWNOGFW-UHFFFAOYSA-N 0.000 abstract 1
229910021627 Tin(IV) chloride Inorganic materials 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
HPGGPRDJHPYFRM-UHFFFAOYSA-J tin(iv) chloride Chemical compound Cl[Sn](Cl)(Cl)Cl HPGGPRDJHPYFRM-UHFFFAOYSA-J 0.000 abstract 1
XJDNKRIXUMDJCW-UHFFFAOYSA-J titanium tetrachloride Chemical compound Cl[Ti](Cl)(Cl)Cl XJDNKRIXUMDJCW-UHFFFAOYSA-J 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Cephalosporin Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT96938143T 1995-11-06 1996-11-06 Verfahren zur de-esterifikation ATE195125T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US727895P	1995-11-06	1995-11-06
EP95202992		1995-11-06
PCT/EP1996/004880 WO1997017352A1 (en)	1995-11-06	1996-11-06	De-esterification process

Publications (1)

Publication Number	Publication Date
ATE195125T1 true ATE195125T1 (de)	2000-08-15

Family

ID=8220799

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96938143T ATE195125T1 (de)	1995-11-06	1996-11-06	Verfahren zur de-esterifikation

Country Status (7)

Country	Link
US (1)	US6107481A (de)
EP (1)	EP0907654B1 (de)
AT (1)	ATE195125T1 (de)
AU (1)	AU7567596A (de)
DE (1)	DE907654T1 (de)
ES (1)	ES2128281T1 (de)
WO (1)	WO1997017352A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HRP20080478T3 (hr)	2003-04-04	2009-02-28	H. Lundbeck A/S	Derivati 4-(2-fenilsulfanil-fenil)-piperidina kaoinhibitori ponovne pohrane serotonina
RS50589B (sr)	2003-12-23	2010-05-07	H. Lundbeck A/S.	2-(1h-indolilsulfanil)-benzil amin derivati kao ssri
AR052308A1 (es)	2004-07-16	2007-03-14	Lundbeck & Co As H	Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto
AR054393A1 (es)	2005-06-17	2007-06-20	Lundbeck & Co As H	Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos.
US7629473B2 (en)	2005-06-17	2009-12-08	H. Lundbeck A/S	2-(1H-indolylsulfanyl)-aryl amine derivatives
AR054394A1 (es) *	2005-06-17	2007-06-20	Lundbeck & Co As H	Derivados de 2- (1h-indolilsulfanil)-aril amina

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS52106891A (en) *	1976-03-03	1977-09-07	Shionogi & Co Ltd	Removal of carboxyl protecting group
DE2725519A1 (de) *	1977-06-06	1978-12-21	Shionogi & Co	Verfahren zur herstellung freier carbonsaeuren durch esterspaltung
IL72412A (en) *	1983-07-22	1988-05-31	Lilly Co Eli	Deesterification of beta-lactam antibiotic esters
US4985554A (en) *	1987-07-13	1991-01-15	Gist-Brocades N.V.	Process for the preparation of 3-exomethylene cepham derivatives
US5922861A (en) *	1995-11-06	1999-07-13	Gist-Brocades B.V.	De-esterification process

1996
- 1996-11-06 AT AT96938143T patent/ATE195125T1/de not_active IP Right Cessation
- 1996-11-06 AU AU75675/96A patent/AU7567596A/en not_active Abandoned
- 1996-11-06 EP EP96938143A patent/EP0907654B1/de not_active Expired - Lifetime
- 1996-11-06 DE DE0907654T patent/DE907654T1/de active Pending
- 1996-11-06 WO PCT/EP1996/004880 patent/WO1997017352A1/en not_active Ceased
- 1996-11-06 ES ES96938143T patent/ES2128281T1/es active Pending
1999
- 1999-07-13 US US09/352,288 patent/US6107481A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE907654T1 (de)	1999-09-16
ES2128281T1 (es)	1999-05-16
WO1997017352A1 (en)	1997-05-15
EP0907654A1 (de)	1999-04-14
AU7567596A (en)	1997-05-29
US6107481A (en)	2000-08-22
EP0907654B1 (de)	2000-08-02

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Legal Events

Date	Code	Title	Description
2001-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties