ATE195126T1 - Bioverfügbare kristalline form des cefuroxim- axetils - Google Patents

Bioverfügbare kristalline form des cefuroxim- axetils

Info

Publication number: ATE195126T1
Authority: AT; Austria
Prior art keywords: crystalline form; cefuroxim; axetil; bioavailable; bioavailable crystalline
Prior art date: 1995-08-03

Application number

AT96109665T

Other languages

English (en)

Inventor

Maurizio Zenoni

Mario Leone

Angelo Cattaneo

Leonardo Marsili

Original Assignee

Acs Dobfar Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-08-03

Filing date

1996-06-17

Publication date

2000-08-15

1996-06-17 Application filed by Acs Dobfar Spa filed Critical Acs Dobfar Spa

2000-08-15 Application granted granted Critical

2000-08-15 Publication of ATE195126T1 publication Critical patent/ATE195126T1/de

Links

KEJCWVGMRLCZQQ-YJBYXUATSA-N Cefuroxime axetil Chemical compound N([C@@H]1C(N2C(=C(COC(N)=O)CS[C@@H]21)C(=O)OC(C)OC(C)=O)=O)C(=O)\C(=N/OC)C1=CC=CO1 KEJCWVGMRLCZQQ-YJBYXUATSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
- C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

AT96109665T 1995-08-03 1996-06-17 Bioverfügbare kristalline form des cefuroxim- axetils ATE195126T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT95MI001716A IT1277426B1 (it)	1995-08-03	1995-08-03	Forma cristallina biodisponibile del cefuroxima axetil

Publications (1)

Publication Number	Publication Date
ATE195126T1 true ATE195126T1 (de)	2000-08-15

Family

ID=11372130

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96109665T ATE195126T1 (de)	1995-08-03	1996-06-17	Bioverfügbare kristalline form des cefuroxim- axetils

Country Status (24)

Country	Link
US (1)	US5677443A (de)
EP (1)	EP0757991B1 (de)
JP (1)	JPH09104685A (de)
KR (1)	KR970010776A (de)
CN (1)	CN1055693C (de)
AR (1)	AR003973A1 (de)
AT (1)	ATE195126T1 (de)
BR (1)	BR9603270A (de)
CA (1)	CA2179359A1 (de)
DE (1)	DE69609576T2 (de)
DK (1)	DK0757991T3 (de)
ES (1)	ES2150052T3 (de)
FI (1)	FI962937A7 (de)
GR (1)	GR3034663T3 (de)
IL (1)	IL118822A (de)
IT (1)	IT1277426B1 (de)
MX (1)	MX9603110A (de)
PT (1)	PT757991E (de)
RU (1)	RU2155767C2 (de)
SI (1)	SI0757991T1 (de)
TR (1)	TR199600691A2 (de)
TW (1)	TW413635B (de)
UA (1)	UA46727C2 (de)
ZA (1)	ZA965234B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2725382B1 (fr) *	1994-10-05	1997-01-03	Commissariat Energie Atomique	Polyazacycloalcanes, complexes tri-, tetra- ou pentaazamacrocycliques, procede de fabrication de ces polyazacycloalcanes substitues ou non et greffes sur un support et utilisations des polyazacycloalcanes
NZ299077A (en) *	1996-07-26	1998-06-26	Apotex Inc	Preparation of amorphous cefuroxime axetil (a cephalosporin derivative) by dissolving crystalline cefuroxim axetil in a highly polar solvent, typically dmso and/or dmf
KR100401284B1 (ko) *	1997-06-03	2004-01-31	주식회사유한양행	1-브로모에틸 아세테이트의 제조방법
CA2209868C (en) *	1997-08-15	2001-08-14	Bernard Charles Sherman	Pharmaceutical compositions comprising cefuroxime axetil
IN186539B (de) *	1997-09-29	2001-09-29	Ranbaxy Lab Ltd
DE19907521A1 (de) *	1998-02-20	1999-11-04	Fako Ilaclari A S	Lösliches kristallines Cefuroxim axetil
US6384213B1 (en)	1998-10-23	2002-05-07	Ranbaxy Laboratories Limited	Process for preparing a pure, pharmacopoeial grade amorphous form of cefuroxime axetil
IN190849B (de) *	2000-07-17	2003-08-23	Ranbaxy Lab Ltd
ITMI20011763A1 (it) *	2001-08-10	2003-02-10	Antibioticos Spa	Processo di preparazione di cefuroxime axelite ad elevata purezza
ITMI20011925A1 (it) *	2001-09-14	2003-03-14	Antibioticos Spa	Metodo applicabile su scala industriale per la preparazione di cefuroxime axetile cristallino
ES2201932B2 (es) *	2001-11-23	2005-03-16	Glaxo Group Limited	Composicion farmaceutica.
US20090175952A1 (en) *	2004-01-09	2009-07-09	Jong Soo Woo	Cefuroxime axetil granule and process for the preparation thereof
CN100448879C (zh) *	2004-07-22	2009-01-07	北京化工大学	一种无定型头孢呋辛酯的制备方法
DE102005019458A1 (de) *	2005-04-25	2006-10-26	Grünenthal GmbH	Darreichungsform mit verbesserter Freisetzung von Cefuroximaxetil
WO2007063552A1 (en) *	2005-12-02	2007-06-07	Lupin Limited	Stable taste masked formulations of cephalosporins
DE102006019619A1 (de) *	2006-04-25	2007-10-31	Grünenthal GmbH	Kristalline Modifikation von Cefuroximaxetil
CN102417451B (zh) *	2011-12-20	2013-12-04	浙江国邦药业有限公司	一种合成（r，s）1-溴代乙基乙酸酯的制备方法
CN103717607A (zh) *	2012-09-12	2014-04-09	海南卫康制药(潜山)有限公司	头孢呋辛钠新晶型化合物及其组合物粉针
CN106554361B (zh) *	2016-09-30	2018-10-09	华北制药河北华民药业有限责任公司	一种头孢呋辛酯口服制剂的制备方法
CN115594583A (zh) *	2022-10-13	2023-01-13	浙江东盈药业有限公司（Cn）	一种1-溴乙基乙酸酯的合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1094545A (en) *	1976-02-16	1981-01-27	Michael Gregson	Cephalosporin antibiotics
GB1571683A (en) *	1976-02-16	1980-07-16	Glaxo Operations Ltd	Ester derivatives of cefuroxime
YU44680B (en) *	1982-07-30	1990-12-31	Glaxo Lab Ltd	Process for obtaining very pure amorphous form of cephuroxim axetile
GB8320521D0 (en) *	1983-07-29	1983-09-01	Glaxo Group Ltd	Chemical process
US5063224A (en) *	1990-07-09	1991-11-05	Eli Lilly And Company	R-cefuroxime axetil

1995
- 1995-08-03 IT IT95MI001716A patent/IT1277426B1/it active IP Right Grant
1996
- 1996-06-17 SI SI9630229T patent/SI0757991T1/xx unknown
- 1996-06-17 AT AT96109665T patent/ATE195126T1/de not_active IP Right Cessation
- 1996-06-17 ES ES96109665T patent/ES2150052T3/es not_active Expired - Lifetime
- 1996-06-17 US US08/664,552 patent/US5677443A/en not_active Expired - Fee Related
- 1996-06-17 PT PT96109665T patent/PT757991E/pt unknown
- 1996-06-17 DE DE69609576T patent/DE69609576T2/de not_active Expired - Fee Related
- 1996-06-17 DK DK96109665T patent/DK0757991T3/da active
- 1996-06-17 EP EP96109665A patent/EP0757991B1/de not_active Expired - Lifetime
- 1996-06-18 CA CA002179359A patent/CA2179359A1/en not_active Abandoned
- 1996-06-20 ZA ZA965234A patent/ZA965234B/xx unknown
- 1996-06-25 TW TW085107604A patent/TW413635B/zh not_active IP Right Cessation
- 1996-07-09 IL IL11882296A patent/IL118822A/xx not_active IP Right Cessation
- 1996-07-23 FI FI962937A patent/FI962937A7/fi unknown
- 1996-07-30 KR KR1019960031374A patent/KR970010776A/ko not_active Ceased
- 1996-07-31 MX MX9603110A patent/MX9603110A/es unknown
- 1996-08-01 CN CN96109271A patent/CN1055693C/zh not_active Expired - Fee Related
- 1996-08-01 AR ARP960103834A patent/AR003973A1/es unknown
- 1996-08-02 RU RU96115329/04A patent/RU2155767C2/ru active
- 1996-08-02 BR BR9603270A patent/BR9603270A/pt not_active Application Discontinuation
- 1996-08-02 UA UA96083116A patent/UA46727C2/uk unknown
- 1996-08-02 JP JP8205098A patent/JPH09104685A/ja active Pending
- 1996-08-28 TR TR96/00691A patent/TR199600691A2/xx unknown
2000
- 2000-10-23 GR GR20000402353T patent/GR3034663T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
JPH09104685A (ja)	1997-04-22
MX9603110A (es)	1997-06-28
DE69609576T2 (de)	2001-01-04
TW413635B (en)	2000-12-01
FI962937L (fi)	1997-02-04
PT757991E (pt)	2000-11-30
IT1277426B1 (it)	1997-11-10
TR199600691A3 (tr)	1998-03-21
AU6083396A (en)	1997-02-06
IL118822A (en)	1999-11-30
AR003973A1 (es)	1998-09-30
CN1055693C (zh)	2000-08-23
US5677443A (en)	1997-10-14
EP0757991A1 (de)	1997-02-12
CN1147516A (zh)	1997-04-16
KR970010776A (ko)	1997-03-27
TR199600691A2 (xx)	1998-03-21
CA2179359A1 (en)	1997-02-04
BR9603270A (pt)	1998-04-28
FI962937A0 (fi)	1996-07-23
IL118822A0 (en)	1996-10-31
EP0757991B1 (de)	2000-08-02
DK0757991T3 (da)	2000-09-04
ES2150052T3 (es)	2000-11-16
DE69609576D1 (de)	2000-09-07
ITMI951716A1 (it)	1997-02-03
SI0757991T1 (en)	2000-12-31
RU2155767C2 (ru)	2000-09-10
ITMI951716A0 (it)	1995-08-03
AU700214B2 (en)	1998-12-24
UA46727C2 (uk)	2002-06-17
GR3034663T3 (en)	2001-01-31
ZA965234B (en)	1997-03-06
FI962937A7 (fi)	1997-02-04

Legal Events

Date	Code	Title	Description
2000-11-15	UEP	Publication of translation of european patent specification
2004-03-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
FI962937A7 (fi)	1997-02-04	Kefuroksiimiaksetiilin biohyödynnettävä kidemuoto
PT1445259E (pt)	2006-10-31	Utilizacao de formas cristalinas de 2-metil-tieno-benzodiazepina
BR9711151A (pt)	1999-08-17	Forma cristalina de 4-¬5-metil-3-fenilsoxazol-4-il¾benzenossulfonamida
BR9611130A (pt)	1999-03-30	Derivados de 3-aril-5-halógeno-pirona
CZ111799A3 (cs)	1999-07-14	Způsob modifikace obrazového signálu
BR9606613A (pt)	1997-10-28	Pó de alvejamento substancialmente isento de poeira
DE69602086D1 (de)	1999-05-20	Festes waschmittelstück
BR9611475A (pt)	1999-07-13	5-aminoisotiaz is acilados
IL117016A0 (en)	1996-06-18	Purification of melamine
KR970000222A (ko)	1997-01-21	팩리택셀 유도체의 전구약물
NO940912D0 (no)	1994-03-14	Rensing av kuldemedium
MA23970A1 (fr)	1997-04-01	Derives de cephalosporine
PL327580A1 (en)	1998-12-21	Derivatives of thioles exhibiting metallopepsidase inhibiting activity
GB9621852D0 (en)	1996-12-11	Inhibition of scale
FI973500A0 (fi)	1997-08-26	3-pyrrolidylideeni-2-oni-kefalosporiinien johdannaiset
FR2733976B1 (fr)	1997-06-20	Purification du pentafluoroethane
AU700214C (en)	2000-02-10	Bioavailable crystalline form of cefuroxime axetil
BR9610540A (pt)	1999-07-06	Determinação de microorganismos não-parafinofílicos
PT761766E (pt)	2002-09-30	Compostos assimetricos de trifenilenodioxazina
PL325602A1 (en)	1998-08-03	Alternative crystalline form of thazophenelone
GB9525144D0 (en)	1996-02-07	Purification of esters
DE59603343D1 (de)	1999-11-18	Kristallines Silikatpulver
KR0110698Y1 (en)	1997-12-06	Suspension of autoseat
FR2731438B1 (fr)	1997-05-16	Hydrolise enzymatique des 4-methylthiobutyronitriles
KR970004613U (ko)	1997-02-19	박스제함기의 낱장박스 공급장치