ATE195320T1 - Neue polymerträger zur nukleinsäuresynthese - Google Patents

Neue polymerträger zur nukleinsäuresynthese

Info

Publication number: ATE195320T1
Authority: AT; Austria
Prior art keywords: nucleic acid; acid synthesis; polymer carrier; new polymer; processes
Prior art date: 1995-11-27

Application number

AT96941507T

Other languages

English (en)

Inventor

Jin-Yan Tang

Jimmy X Tang

Original Assignee

Hybridon Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-11-27

Filing date

1996-11-27

Publication date

2000-08-15

1996-11-27 Application filed by Hybridon Inc filed Critical Hybridon Inc

2000-08-15 Application granted granted Critical

2000-08-15 Publication of ATE195320T1 publication Critical patent/ATE195320T1/de

Links

238000001668 nucleic acid synthesis Methods 0.000 title 1
229920000642 polymer Polymers 0.000 title 1
238000000034 method Methods 0.000 abstract 2
108091034117 Oligonucleotide Proteins 0.000 abstract 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
238000002515 oligonucleotide synthesis Methods 0.000 abstract 1
229920000620 organic polymer Polymers 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
238000010532 solid phase synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Saccharide Compounds (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)

AT96941507T 1995-11-27 1996-11-27 Neue polymerträger zur nukleinsäuresynthese ATE195320T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/562,841 US5668268A (en)	1995-11-27	1995-11-27	Passivated polymer supports for nucleic acid synthesis
PCT/US1996/019050 WO1997019951A1 (en)	1995-11-27	1996-11-27	Novel polymer supports for nucleic acid synthesis

Publications (1)

Publication Number	Publication Date
ATE195320T1 true ATE195320T1 (de)	2000-08-15

Family

ID=24248010

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96941507T ATE195320T1 (de)	1995-11-27	1996-11-27	Neue polymerträger zur nukleinsäuresynthese

Country Status (11)

Country	Link
US (2)	US5668268A (de)
EP (1)	EP0863912B1 (de)
AT (1)	ATE195320T1 (de)
AU (1)	AU1062997A (de)
CA (1)	CA2238865A1 (de)
DE (1)	DE69609725T2 (de)
DK (1)	DK0863912T3 (de)
ES (1)	ES2150702T3 (de)
GR (1)	GR3034534T3 (de)
PT (1)	PT863912E (de)
WO (1)	WO1997019951A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5668268A (en) *	1995-11-27	1997-09-16	Hybridon, Inc.	Passivated polymer supports for nucleic acid synthesis
DE19943374A1 (de) *	1999-09-10	2001-03-29	Max Planck Gesellschaft	Verfahren zum Anbinden von Nukleinsäuren an eine Festphase
AU2001275091A1 (en) *	2000-06-02	2001-12-17	Blue Heron Biotechnology, Inc.	Methods for improving the sequence fidelity of synthetic double-stranded oligonucleotides
EP1322710B2 (de) *	2000-09-29	2015-02-18	Life Technologies Corporation	Modifizierte carbocyaninfarbstoffe und deren konjugate
US20030072689A1 (en) *	2001-08-15	2003-04-17	Third Wave Technologies, Inc.	Polymer synthesizer
US7435390B2 (en) *	2001-01-26	2008-10-14	Third Wave Technologies, Inc.	Nucleic acid synthesizers
US6932943B1 (en)	2001-01-26	2005-08-23	Third Wave Technologies	Nucleic acid synthesizers
US7709544B2 (en) *	2005-10-25	2010-05-04	Massachusetts Institute Of Technology	Microstructure synthesis by flow lithography and polymerization
JP5560039B2 (ja) *	2006-10-05	2014-07-23	マサチューセッツインスティテュートオブテクノロジー	ハイスループット分析のための多機能のコード化された粒子
JP2009280544A (ja) *	2008-05-26	2009-12-03	Nitto Denko Corp	核酸固相合成用担体
US8431416B2 (en)	2009-04-01	2013-04-30	Becton, Dickinson And Company	Reactive heterocycle-substituted 7-hydroxycoumarins and their conjugates
US8309059B2 (en) *	2009-08-31	2012-11-13	Promega Corporation	Reactive cyanine compounds
EP2576839B1 (de)	2010-06-07	2017-05-10	Firefly Bioworks, Inc.	Nukleinsäurenachweis und -quantifizierung durch posthybridisierungs-kennzeichnung und universelle kodierung
US8623324B2 (en)	2010-07-21	2014-01-07	Aat Bioquest Inc.	Luminescent dyes with a water-soluble intramolecular bridge and their biological conjugates
US9051441B2 (en)	2012-03-29	2015-06-09	Xerox Corporation	Process for chemical passivation of polymer surfaces
CN107873054B (zh) *	2014-09-09	2022-07-12	博德研究所	用于复合单细胞核酸分析的基于微滴的方法和设备
WO2017172608A1 (en)	2016-03-28	2017-10-05	Aat Bioquest, Inc.	Polyfluoreno[4,5-cde]oxepine conjugates and their use in methods of analyte detection
US11220628B2 (en)	2019-02-20	2022-01-11	Aat Bioquest, Inc.	Condensed polycyclic conjugated polymers and their use for biological detection
CN115280147A (zh)	2020-01-30	2022-11-01	阿特生物探索公司	可紫外激发的基于聚芴的缀合物及其在分析物检测方法中的用途
CN120174630B (zh) *	2025-05-21	2025-09-12	天津中合基因科技有限公司	一种编织型dna合成固定相的制备方法及应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4458066A (en) *	1980-02-29	1984-07-03	University Patents, Inc.	Process for preparing polynucleotides
US4638032A (en) *	1983-12-12	1987-01-20	Genetics Institute, Inc.	Magnetic particles as supports for organic synthesis
US5262530A (en) *	1988-12-21	1993-11-16	Applied Biosystems, Inc.	Automated system for polynucleotide synthesis and purification
US5049656A (en) *	1988-12-21	1991-09-17	Board Of Regents Of The University Of Nebraska	Sequential peptide and oligonucleotide syntheses using immunoaffinity techniques
US5112962A (en) *	1989-04-19	1992-05-12	Northwestern University	Labile anchors for solid phase polynucleotide synthesis
US5204455A (en) *	1989-06-15	1993-04-20	Froehler Brian C	Monomethoxytrityl protected oligonucleotides bound to a solid support
US5470463A (en) *	1992-06-19	1995-11-28	Sepracor Inc.	Passivated porous supports and methods for the preparation and use of same
US5668268A (en) *	1995-11-27	1997-09-16	Hybridon, Inc.	Passivated polymer supports for nucleic acid synthesis

1995
- 1995-11-27 US US08/562,841 patent/US5668268A/en not_active Expired - Fee Related
1996
- 1996-11-27 DK DK96941507T patent/DK0863912T3/da active
- 1996-11-27 CA CA002238865A patent/CA2238865A1/en not_active Abandoned
- 1996-11-27 DE DE69609725T patent/DE69609725T2/de not_active Expired - Fee Related
- 1996-11-27 AT AT96941507T patent/ATE195320T1/de not_active IP Right Cessation
- 1996-11-27 WO PCT/US1996/019050 patent/WO1997019951A1/en not_active Ceased
- 1996-11-27 AU AU10629/97A patent/AU1062997A/en not_active Abandoned
- 1996-11-27 ES ES96941507T patent/ES2150702T3/es not_active Expired - Lifetime
- 1996-11-27 EP EP96941507A patent/EP0863912B1/de not_active Expired - Lifetime
- 1996-11-27 PT PT96941507T patent/PT863912E/pt unknown
1997
- 1997-09-10 US US08/926,755 patent/US6392031B1/en not_active Expired - Fee Related
2000
- 2000-10-02 GR GR20000402224T patent/GR3034534T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0863912B1 (de)	2000-08-09
GR3034534T3 (en)	2001-01-31
DK0863912T3 (da)	2000-11-06
US5668268A (en)	1997-09-16
AU1062997A (en)	1997-06-19
EP0863912A1 (de)	1998-09-16
DE69609725D1 (de)	2000-09-14
PT863912E (pt)	2000-12-29
DE69609725T2 (de)	2001-04-05
ES2150702T3 (es)	2000-12-01
CA2238865A1 (en)	1997-06-05
US6392031B1 (en)	2002-05-21
WO1997019951A1 (en)	1997-06-05

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Legal Events

Date	Code	Title	Description
2001-01-15	UEP	Publication of translation of european patent specification
2002-08-15	REN	Ceased due to non-payment of the annual fee