ATE195426T1 - Hirudin enthaltende stabilisierte, trockene pulver - Google Patents

Hirudin enthaltende stabilisierte, trockene pulver

Info

Publication number: ATE195426T1
Authority: AT; Austria
Prior art keywords: dry powder; powder containing; stabilized dry; containing hirudin; hirudin
Prior art date: 1994-01-26

Application number

AT95300361T

Other languages

English (en)

Inventor

Tudor Dr Arvinte

Original Assignee

Novartis Ag

Ucp Gen Pharma Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-01-26

Filing date

1995-01-20

Publication date

2000-09-15

1995-01-20 Application filed by Novartis Ag, Ucp Gen Pharma Ag filed Critical Novartis Ag

2000-09-15 Application granted granted Critical

2000-09-15 Publication of ATE195426T1 publication Critical patent/ATE195426T1/de

Links

102000007625 Hirudins Human genes 0.000 title abstract 2
108010007267 Hirudins Proteins 0.000 title abstract 2
WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 title abstract 2
229940006607 hirudin Drugs 0.000 title abstract 2
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 1
229910052791 calcium Inorganic materials 0.000 abstract 1
239000011575 calcium Substances 0.000 abstract 1
229910052749 magnesium Inorganic materials 0.000 abstract 1
239000011777 magnesium Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
- A61K38/58—Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Immunology (AREA)
Epidemiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Tropical Medicine & Parasitology (AREA)
Hematology (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Detergent Compositions (AREA)
Manufacturing Of Micro-Capsules (AREA)
Glanulating (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicinal Preparation (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Peptides Or Proteins (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
Mechanical Treatment Of Semiconductor (AREA)
Control Of Motors That Do Not Use Commutators (AREA)

AT95300361T 1994-01-26 1995-01-20 Hirudin enthaltende stabilisierte, trockene pulver ATE195426T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB9401448A GB9401448D0 (en)	1994-01-26	1994-01-26	Stable dry powders

Publications (1)

Publication Number	Publication Date
ATE195426T1 true ATE195426T1 (de)	2000-09-15

Family

ID=10749332

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95300361T ATE195426T1 (de)	1994-01-26	1995-01-20	Hirudin enthaltende stabilisierte, trockene pulver

Country Status (20)

Country	Link
US (1)	US5733874A (de)
EP (1)	EP0665019B1 (de)
JP (1)	JP3350604B2 (de)
KR (1)	KR100360784B1 (de)
AT (1)	ATE195426T1 (de)
AU (1)	AU701886B2 (de)
CA (1)	CA2140971C (de)
CY (1)	CY2259B1 (de)
DE (1)	DE69518342T2 (de)
DK (1)	DK0665019T3 (de)
ES (1)	ES2151022T3 (de)
FI (1)	FI114141B (de)
GB (1)	GB9401448D0 (de)
GR (1)	GR3034816T3 (de)
HU (1)	HU216628B (de)
IL (1)	IL112389A (de)
NO (1)	NO316883B1 (de)
NZ (1)	NZ270384A (de)
PT (1)	PT665019E (de)
ZA (1)	ZA95576B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9401447D0 (en)	1994-01-26	1994-03-23	Ciba Geigy Ag	Pharmaceutical compositions
DE19607239A1 (de)	1996-02-27	1997-08-28	Behringwerke Ag	Pharmazeutische Zusammensetzung, enthaltend Hirudin und Verfahren zu deren Herstellung
KR20000070338A (ko)	1997-01-20	2000-11-25	나가시마 카쭈시게, 노미야마 아키히코	펩티드의 안정화 방법 및 당해 방법을 이용한 펩티드 함유 동결건조 의약조성물
US7795205B2 (en) *	2004-04-12	2010-09-14	Canyon Pharmaceuticals, Inc.	Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor
WO2006138181A2 (en)	2005-06-14	2006-12-28	Amgen Inc.	Self-buffering protein formulations
ES3064802T3 (en)	2016-10-21	2026-04-29	Amgen Inc	Pharmaceutical formulations and methods of making the same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1243358B (it) *	1990-07-23	1994-06-10	Iketon Farmaceutici Srl	Composizioni farmaceutiche per la somministrazione orale di irudina
JP2965359B2 (ja) *	1991-01-07	1999-10-18	積水化学工業株式会社	血液検査用容器
AU659432B2 (en) *	1991-03-08	1995-05-18	Novartis Ag	A method for the inhibition or prevention of tumor cell metastasis with hirudin
GB9303275D0 (en) *	1993-02-18	1993-04-07	Ciba Geigy Ag	Pharmaceutical compositions

1994
- 1994-01-26 GB GB9401448A patent/GB9401448D0/en active Pending
1995
- 1995-01-19 IL IL11238995A patent/IL112389A/xx not_active IP Right Cessation
- 1995-01-20 DE DE69518342T patent/DE69518342T2/de not_active Expired - Lifetime
- 1995-01-20 AT AT95300361T patent/ATE195426T1/de active
- 1995-01-20 JP JP00690595A patent/JP3350604B2/ja not_active Expired - Fee Related
- 1995-01-20 EP EP95300361A patent/EP0665019B1/de not_active Expired - Lifetime
- 1995-01-20 PT PT95300361T patent/PT665019E/pt unknown
- 1995-01-20 AU AU11318/95A patent/AU701886B2/en not_active Expired
- 1995-01-20 DK DK95300361T patent/DK0665019T3/da active
- 1995-01-20 ES ES95300361T patent/ES2151022T3/es not_active Expired - Lifetime
- 1995-01-23 FI FI950282A patent/FI114141B/fi not_active IP Right Cessation
- 1995-01-24 NZ NZ270384A patent/NZ270384A/en not_active IP Right Cessation
- 1995-01-24 HU HU9500216A patent/HU216628B/hu unknown
- 1995-01-24 CA CA002140971A patent/CA2140971C/en not_active Expired - Lifetime
- 1995-01-25 ZA ZA95576A patent/ZA95576B/xx unknown
- 1995-01-25 NO NO19950274A patent/NO316883B1/no not_active IP Right Cessation
- 1995-01-25 US US08/378,225 patent/US5733874A/en not_active Expired - Lifetime
- 1995-01-25 KR KR1019950001264A patent/KR100360784B1/ko not_active Expired - Lifetime
2000
- 2000-11-10 GR GR20000402503T patent/GR3034816T3/el unknown
2002
- 2002-01-18 CY CY0200008A patent/CY2259B1/xx unknown

Also Published As

Publication number	Publication date
PT665019E (pt)	2001-01-31
ZA95576B (en)	1995-07-26
IL112389A0 (en)	1995-03-30
NO950274L (no)	1995-07-27
GB9401448D0 (en)	1994-03-23
ES2151022T3 (es)	2000-12-16
HUT70474A (en)	1995-10-30
AU701886B2 (en)	1999-02-11
FI114141B (fi)	2004-08-31
US5733874A (en)	1998-03-31
JP3350604B2 (ja)	2002-11-25
AU1131895A (en)	1995-08-03
NO950274D0 (no)	1995-01-25
NO316883B1 (no)	2004-06-28
JPH07267877A (ja)	1995-10-17
CY2259B1 (en)	2003-07-04
IL112389A (en)	2003-05-29
CA2140971A1 (en)	1995-07-27
GR3034816T3 (en)	2001-02-28
KR100360784B1 (ko)	2003-02-25
DE69518342D1 (de)	2000-09-21
HU216628B (hu)	1999-07-28
HU9500216D0 (en)	1995-03-28
CA2140971C (en)	2008-11-25
DE69518342T2 (de)	2001-02-01
NZ270384A (en)	1996-02-27
EP0665019B1 (de)	2000-08-16
DK0665019T3 (da)	2000-10-30
FI950282A0 (fi)	1995-01-23
EP0665019A1 (de)	1995-08-02
FI950282L (fi)	1995-07-27
KR950031105A (ko)	1995-12-18

Legal Events

Date	Code	Title	Description
2000-12-15	UEP	Publication of translation of european patent specification
2004-10-15	EEIH	Change in the person of patent owner

Publication	Publication Date	Title
PT1041972E (pt)	2003-01-31	Comprimido para a libertacao instantanea e prolongada de uma ou mais substancias activas
NO900439L (no)	1990-08-03	Fremgangsmaate for behandling av uorganisk pulver.
ITTO930610A1 (it)	1994-02-22	Composizione a base di 1, 1, 1, 3, 3, -pentafluorobutano e di cloruro di metilene per la pulitura e/o essicazione di superfici solide.
DE69518342D1 (de)	2000-09-21	Hirudin enthaltende stabilisierte, trockene Pulver
ATE216586T1 (de)	2002-05-15	Hirudin enthaltende arzneimittel
ATE201996T1 (de)	2001-06-15	Hirudin enthaltende pharmazeutische zusammensetzungen
NL192573B (nl)	1997-06-02	2,5-Digesubstitueerde tetrahydrofuran- of tetrahydrothiofeenverbindingen met werking tegen de bloedplaatjesactiverende factor en farmaceutisch preparaat dat deze verbindingen bevat.
DE69602208D1 (de)	1999-05-27	Stabilisierte pharmazeutische zusammensetzungen enthaltend dobutamine
HUP9901183A2 (hu)	1999-07-28	Készítmények és eljárások az orális mukozitisz megakadályozására és kezelésére
ES1019379Y (es)	1992-11-01	Pieza para la construccion de paredes y similares.
ES1019296Y (es)	1992-10-16	Esparciador de abonos granulados o en polvo.