ATE196138T1 - Halichondrine und verwandte verbindungen - Google Patents
Halichondrine und verwandte verbindungenInfo
- Publication number
- ATE196138T1 ATE196138T1 AT93907496T AT93907496T ATE196138T1 AT E196138 T1 ATE196138 T1 AT E196138T1 AT 93907496 T AT93907496 T AT 93907496T AT 93907496 T AT93907496 T AT 93907496T AT E196138 T1 ATE196138 T1 AT E196138T1
- Authority
- AT
- Austria
- Prior art keywords
- halichondrine
- related compounds
- norhalichondrin
- halichondrin
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Dental Preparations (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Furan Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84976992A | 1992-03-12 | 1992-03-12 | |
| PCT/US1993/002330 WO1993017690A1 (en) | 1992-03-12 | 1993-03-12 | Halichondrins and related compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE196138T1 true ATE196138T1 (de) | 2000-09-15 |
Family
ID=25306481
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93907496T ATE196138T1 (de) | 1992-03-12 | 1993-03-12 | Halichondrine und verwandte verbindungen |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5338865A (de) |
| EP (1) | EP0642345B1 (de) |
| JP (1) | JPH07504664A (de) |
| KR (1) | KR950700308A (de) |
| AT (1) | ATE196138T1 (de) |
| AU (1) | AU674673B2 (de) |
| CA (1) | CA2130905A1 (de) |
| DE (1) | DE69329383D1 (de) |
| FI (1) | FI944178L (de) |
| HU (1) | HUT70956A (de) |
| NO (1) | NO943347L (de) |
| NZ (1) | NZ251177A (de) |
| RU (1) | RU2112773C1 (de) |
| WO (1) | WO1993017690A1 (de) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5399717A (en) * | 1993-09-29 | 1995-03-21 | Merck & Co., Inc. | Glycosidation route to 4"-epi-methylamino-4"-deoxyavermectin B1 |
| US6653341B1 (en) * | 1998-06-17 | 2003-11-25 | Eisai Co., Ltd. | Methods and compositions for use in treating cancer |
| US8097648B2 (en) * | 1998-06-17 | 2012-01-17 | Eisai R&D Management Co., Ltd. | Methods and compositions for use in treating cancer |
| HU227912B1 (en) * | 1998-06-17 | 2012-05-29 | Eisai R & D Man Co | Halichondrin analogs and methods of their use and preparation |
| CN109180615A (zh) * | 2004-06-03 | 2019-01-11 | 卫材R&D管理有限公司 | 用于制备软海绵素b的类似物的中间体 |
| PL2522663T3 (pl) | 2004-06-03 | 2015-08-31 | Eisai R&D Man Co Ltd | Produkty pośrednie do otrzymywania halichondryny B |
| US20060045846A1 (en) * | 2004-08-30 | 2006-03-02 | Horstmann Thomas E | Reagents and methods for labeling terminal olefins |
| CN108948039B (zh) | 2007-10-03 | 2021-12-31 | 卫材R&D管理有限公司 | 用于合成软海绵素b类似物的中间体和方法 |
| CN105801599A (zh) | 2008-04-04 | 2016-07-27 | 卫材R&D管理有限公司 | 软海绵素b类似物 |
| CN102803254B (zh) * | 2010-01-26 | 2016-09-14 | 卫材R&D管理有限公司 | 用于软海绵素b类似物合成的呋喃并[3,2-b]吡喃衍生物 |
| CA2857385A1 (en) | 2011-11-30 | 2013-06-06 | Alphora Research Inc. | Process for preparation of (3r)-2,4-di-leaving group-3-methylbut-1-ene |
| US9174956B2 (en) | 2011-12-16 | 2015-11-03 | Alphora Research Inc. | Process for preparation of 3-((2S,5S)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol derivatives and intermediates useful thereof |
| JP6300030B2 (ja) | 2011-12-29 | 2018-03-28 | サンド アクツィエンゲゼルシャフト | ２−（（２ｓ，３ｓ，４ｒ，５ｒ）−５−（（ｓ）−３−アミノ−２−ヒドロキシプロプ−１−イル）−４−メトキシ−３−（フェニルスルホニルメチル）テトラヒドロフラン−２−イル）アセトアルデヒド誘導体およびこれらを調製するためのプロセス |
| US9278979B2 (en) | 2012-03-30 | 2016-03-08 | Alphora Research Inc. | Synthetic process for preparation of macrocyclic C1-keto analogs of halichondrin B and intermediates useful therein |
| AU2014268086A1 (en) | 2013-05-15 | 2015-11-05 | Alphora Research Inc. | 3-((2S,5S)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol derivatives, their preparation and intermediates useful thereof |
| US9850254B2 (en) | 2013-07-03 | 2017-12-26 | Sandoz Ag | Synthetic process for preparation of macrocyclic C1-keto analogs of Halichondrin B and intermediates useful therein including intermediates containing-SO2-(p-tolyl) groups |
| CN105683198B (zh) | 2013-11-04 | 2019-03-12 | 卫材R&D管理有限公司 | 软海绵素b的类似物合成中有用的大环化反应和中间体 |
| HUE043088T2 (hu) | 2013-12-06 | 2019-08-28 | Eisai R&D Man Co Ltd | Halikondrin B analógok szintézisében alkalmazható eljárások |
| EP3160970A4 (de) | 2014-06-30 | 2017-12-27 | President and Fellows of Harvard College | Synthese von halichondrinanaloga und verwendungen davon |
| WO2016176560A1 (en) * | 2015-04-30 | 2016-11-03 | President And Fellows Of Harvard College | Chromium-mediated coupling and application to the synthesis of halichondrins |
| RU2020141025A (ru) * | 2015-05-07 | 2020-12-28 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Реакции макроциклизации и промежуточные соединения и другие фрагменты, полезные в синтезе макролидов галихондринов |
| US10676481B2 (en) | 2016-02-12 | 2020-06-09 | Eisai R&D Management Co., Ltd. | Intermediates in the synthesis of eribulin and related methods of synthesis |
| SG11201811671XA (en) | 2016-06-30 | 2019-01-30 | Eisai R&D Man Co Ltd | Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof |
| JP6978758B2 (ja) | 2016-11-11 | 2021-12-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | パラジウム媒介ケトール化 |
| US9938288B1 (en) | 2017-04-05 | 2018-04-10 | President And Fellows Of Harvard College | Macrocyclic compound and uses thereof |
| KR102836514B1 (ko) | 2017-04-05 | 2025-07-22 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 마크로시클릭 화합물 및 그의 용도 |
| HUE061306T2 (hu) | 2017-07-06 | 2023-06-28 | Harvard College | Halikondrinok szintézise |
| JP7266267B2 (ja) * | 2017-07-06 | 2023-04-28 | プレジデント アンド フェローズ オブ ハーバード カレッジ | Ｆｅ／ｃｕ媒介ケトン合成 |
| US11498892B2 (en) | 2017-07-06 | 2022-11-15 | President And Fellows Of Harvard College | Fe/Cu-mediated ketone synthesis |
| ES2974243T3 (es) | 2017-11-15 | 2024-06-26 | Harvard College | Compuestos macrocíclicos y usos de los mismos |
| KR20250057138A (ko) | 2018-01-03 | 2025-04-28 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 할리콘드린 마크롤리드 및 그의 유사체의 합성에 유용한 프린스 반응 및 화합물 |
| CN111285894B (zh) | 2018-12-10 | 2021-03-05 | 北京天一绿甫医药科技有限公司 | 用于制备软海绵素类化合物的中间体及其制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9206244D0 (en) * | 1992-03-23 | 1992-05-06 | Pharma Mar Sa | Cytotoxic compound from a marine sponge |
-
1993
- 1993-01-29 US US08/011,104 patent/US5338865A/en not_active Expired - Lifetime
- 1993-03-12 RU RU94042393A patent/RU2112773C1/ru active
- 1993-03-12 JP JP5516045A patent/JPH07504664A/ja active Pending
- 1993-03-12 EP EP93907496A patent/EP0642345B1/de not_active Expired - Lifetime
- 1993-03-12 HU HU9402600A patent/HUT70956A/hu active IP Right Revival
- 1993-03-12 AT AT93907496T patent/ATE196138T1/de not_active IP Right Cessation
- 1993-03-12 FI FI944178A patent/FI944178L/fi unknown
- 1993-03-12 DE DE69329383T patent/DE69329383D1/de not_active Expired - Lifetime
- 1993-03-12 AU AU38082/93A patent/AU674673B2/en not_active Ceased
- 1993-03-12 CA CA002130905A patent/CA2130905A1/en not_active Abandoned
- 1993-03-12 NZ NZ251177A patent/NZ251177A/en unknown
- 1993-03-12 WO PCT/US1993/002330 patent/WO1993017690A1/en not_active Ceased
-
1994
- 1994-09-09 NO NO943347A patent/NO943347L/no unknown
- 1994-09-12 KR KR1019940703186A patent/KR950700308A/ko not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| KR950700308A (ko) | 1995-01-16 |
| RU2112773C1 (ru) | 1998-06-10 |
| NZ251177A (en) | 1996-10-28 |
| FI944178A7 (fi) | 1994-09-09 |
| AU674673B2 (en) | 1997-01-09 |
| DE69329383D1 (de) | 2000-10-12 |
| EP0642345A4 (en) | 1995-04-19 |
| AU3808293A (en) | 1993-10-05 |
| NO943347L (no) | 1994-11-09 |
| EP0642345B1 (de) | 2000-09-06 |
| FI944178A0 (fi) | 1994-09-09 |
| US5338865A (en) | 1994-08-16 |
| JPH07504664A (ja) | 1995-05-25 |
| RU94042393A (ru) | 1996-07-20 |
| HU9402600D0 (en) | 1994-12-28 |
| WO1993017690A1 (en) | 1993-09-16 |
| NO943347D0 (no) | 1994-09-09 |
| HUT70956A (en) | 1995-11-28 |
| EP0642345A1 (de) | 1995-03-15 |
| FI944178L (fi) | 1994-09-09 |
| CA2130905A1 (en) | 1993-09-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |