ATE196294T1 - Piperazin-derivate und ihre verwendung als 5-ht1a-antagoniste - Google Patents

Piperazin-derivate und ihre verwendung als 5-ht1a-antagoniste

Info

Publication number: ATE196294T1
Authority: AT; Austria
Prior art keywords: piperazine derivatives; ht1a antagonists; ht1a; antagonists; piperazine
Prior art date: 1995-07-20

Application number

AT96924983T

Other languages

English (en)

Inventor

Andrew Fensome

Michael Gerard Kelly

Howard Langham Mansell

Original Assignee

American Home Prod

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-07-20

Filing date

1996-07-19

Publication date

2000-09-15

1996-07-19 Application filed by American Home Prod filed Critical American Home Prod

2000-09-15 Application granted granted Critical

2000-09-15 Publication of ATE196294T1 publication Critical patent/ATE196294T1/de

Links

102100022738 5-hydroxytryptamine receptor 1A Human genes 0.000 title 1
101710138638 5-hydroxytryptamine receptor 1A Proteins 0.000 title 1
GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical class C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT96924983T 1995-07-20 1996-07-19 Piperazin-derivate und ihre verwendung als 5-ht1a-antagoniste ATE196294T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9514901.9A GB9514901D0 (en)	1995-07-20	1995-07-20	Piperazine derivatives
PCT/GB1996/001714 WO1997003982A1 (en)	1995-07-20	1996-07-19	Piperazine derivatives and their use as 5-ht1a antagonists

Publications (1)

Publication Number	Publication Date
ATE196294T1 true ATE196294T1 (de)	2000-09-15

Family

ID=10778004

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96924983T ATE196294T1 (de)	1995-07-20	1996-07-19	Piperazin-derivate und ihre verwendung als 5-ht1a-antagoniste

Country Status (21)

Country	Link
EP (1)	EP0839146B1 (de)
JP (1)	JP4166824B2 (de)
KR (1)	KR100447002B1 (de)
CN (2)	CN1077889C (de)
AR (1)	AR003451A1 (de)
AT (1)	ATE196294T1 (de)
AU (1)	AU700546B2 (de)
BR (1)	BR9609694A (de)
CA (1)	CA2227386C (de)
DE (1)	DE69610316T2 (de)
DK (1)	DK0839146T3 (de)
ES (1)	ES2150684T3 (de)
GB (1)	GB9514901D0 (de)
GR (1)	GR3034408T3 (de)
HU (1)	HUP9802447A3 (de)
IL (1)	IL122981A (de)
MX (1)	MX9800483A (de)
NZ (1)	NZ313231A (de)
PT (1)	PT839146E (de)
WO (1)	WO1997003982A1 (de)
ZA (1)	ZA966048B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19730989A1 (de) *	1997-07-18	1999-01-21	Merck Patent Gmbh	Piperazin-Derivate
US6271234B1 (en) *	1997-08-01	2001-08-07	Recordati S.A., Chemical And Pharmaceutical Company	1,4-disubstituted piperazines
IT1293804B1 (it)	1997-08-01	1999-03-10	Recordati Chem Pharm	Diarilalchilpiperazine attive sulle basse vie urinarie
US6399614B1 (en)	1997-08-01	2002-06-04	Recordati S.A. Chemical And Pharmaceutical Company	1-(N-phenylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring
US20060287335A1 (en)	2000-11-28	2006-12-21	Wyeth	Serotonergic agents for treating sexual dysfunction
US20060223824A1 (en)	2000-11-28	2006-10-05	Wyeth	Serotonergic agents
US6469007B2 (en)	2000-11-28	2002-10-22	Wyeth	Serotonergic agents
ES2323451T7 (es)	2001-07-20	2011-08-01	Psychogenics Inc.	Tratamiento para el trastorno de hiperactividad con deficit de atencion.
BR0308347A (pt)	2002-03-12	2005-01-25	Wyeth Corp	Processo para fabricação de piperazinas 1,4-dissubstituìdas quirais
US7361773B2 (en)	2002-03-12	2008-04-22	Wyeth	Preparation of N1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines
JP4397693B2 (ja) *	2002-03-12	2010-01-13	ワイス	Ｎ１−（２’−ピリジル）−１，２−アルカンジアミンスルファミン酸の合成および生物学的に活性なピペラジンの合成におけるその使用
US7091349B2 (en)	2002-03-12	2006-08-15	Wyeth	Process for synthesizing N-aryl piperazines with chiral N′-1-[benzoyl(2-pyridyl)amino]-2-propane substitution
ES2329122T3 (es) *	2002-03-12	2009-11-23	Wyeth	Procedimiento para sintetizar n-aril piperazinas quirales.
US20050209245A1 (en) *	2004-03-19	2005-09-22	Wyeth	Process for preparing N-aryl-piperazine derivatives
TW200800959A (en)	2005-06-10	2008-01-01	Wyeth Corp	Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor
BRPI0611948A2 (pt)	2005-06-17	2010-10-13	Wyeth Corp	compostos úteis como inibidores de serotonina e agonistas de antagonista de 5-ht1a
TW200808741A (en) *	2006-06-09	2008-02-16	Wyeth Corp	6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline hydrochloric acid salts
TW200901974A (en)	2007-01-16	2009-01-16	Wyeth Corp	Compounds, compositions, and methods of making and using them

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MX9201991A (es) *	1991-05-02	1992-11-01	Jonh Wyeth & Brother Limited	Derivados de piperazina y procedimiento para su preparacion.
JPH10504275A (ja) *	1994-06-03	1998-04-28	ジョン・ワイス・アンド・ブラザー・リミテッド	ピペラジン誘導体を製造するための新規な方法および中間体

1995
- 1995-07-20 GB GBGB9514901.9A patent/GB9514901D0/en active Pending
1996
- 1996-07-10 AR ARP960103516A patent/AR003451A1/es active IP Right Grant
- 1996-07-16 ZA ZA9606048A patent/ZA966048B/xx unknown
- 1996-07-19 MX MX9800483A patent/MX9800483A/es unknown
- 1996-07-19 DE DE69610316T patent/DE69610316T2/de not_active Expired - Lifetime
- 1996-07-19 IL IL12298196A patent/IL122981A/xx not_active IP Right Cessation
- 1996-07-19 CA CA002227386A patent/CA2227386C/en not_active Expired - Fee Related
- 1996-07-19 WO PCT/GB1996/001714 patent/WO1997003982A1/en not_active Ceased
- 1996-07-19 AU AU65249/96A patent/AU700546B2/en not_active Ceased
- 1996-07-19 EP EP96924983A patent/EP0839146B1/de not_active Expired - Lifetime
- 1996-07-19 ES ES96924983T patent/ES2150684T3/es not_active Expired - Lifetime
- 1996-07-19 CN CN96195610A patent/CN1077889C/zh not_active Expired - Fee Related
- 1996-07-19 DK DK96924983T patent/DK0839146T3/da active
- 1996-07-19 NZ NZ313231A patent/NZ313231A/en unknown
- 1996-07-19 JP JP50642797A patent/JP4166824B2/ja not_active Expired - Fee Related
- 1996-07-19 BR BR9609694A patent/BR9609694A/pt not_active Application Discontinuation
- 1996-07-19 KR KR10-1998-0700371A patent/KR100447002B1/ko not_active Expired - Fee Related
- 1996-07-19 HU HU9802447A patent/HUP9802447A3/hu unknown
- 1996-07-19 PT PT96924983T patent/PT839146E/pt unknown
- 1996-07-19 AT AT96924983T patent/ATE196294T1/de not_active IP Right Cessation
2000
- 2000-09-14 GR GR20000402093T patent/GR3034408T3/el not_active IP Right Cessation
- 2000-12-05 CN CN00135330A patent/CN1131861C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69610316T2 (de)	2001-03-29
EP0839146A1 (de)	1998-05-06
MX9800483A (es)	1998-04-30
DE69610316D1 (de)	2000-10-19
NZ313231A (en)	2001-03-30
CA2227386A1 (en)	1997-02-06
KR19990029067A (ko)	1999-04-15
IL122981A0 (en)	1998-08-16
ES2150684T3 (es)	2000-12-01
AR003451A1 (es)	1998-08-05
WO1997003982A1 (en)	1997-02-06
AU700546B2 (en)	1999-01-07
BR9609694A (pt)	1999-03-23
CA2227386C (en)	2006-05-16
CN1077889C (zh)	2002-01-16
PT839146E (pt)	2000-12-29
AU6524996A (en)	1997-02-18
CN1190968A (zh)	1998-08-19
CN1131861C (zh)	2003-12-24
GR3034408T3 (en)	2000-12-29
HUP9802447A3 (en)	1999-11-29
EP0839146B1 (de)	2000-09-13
IL122981A (en)	2001-01-28
GB9514901D0 (en)	1995-09-20
HUP9802447A2 (hu)	1999-08-30
DK0839146T3 (da)	2000-11-20
JP4166824B2 (ja)	2008-10-15
JPH11509544A (ja)	1999-08-24
ZA966048B (en)	1998-01-16
KR100447002B1 (ko)	2004-12-04
CN1309127A (zh)	2001-08-22

Legal Events

Date	Code	Title	Description
2010-04-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69332898D1 (de)	2003-05-22	4-Carboxamidopiperidinderivate und ihre Verwendung als Neurokinin Antagonisten
DE69509765D1 (de)	1999-06-24	N-heterocyclyl sulphonamid-derivate und ihre verwendung als endothelin-antagonisten
FI964815L (fi)	1996-12-02	Piperatsiinijohdoksia 5-HT1A antagonisteina
DE60036803D1 (de)	2007-11-29	Arylmethyl-carbonylamino-thiazolderivate und ihre verwendung als antitumormittel
DE59710422D1 (de)	2003-08-14	Acylmercapto-triazolyl-derivate und ihre verwendung als mikrobizide
ATA38799A (de)	2001-06-15	1-alkoxypolyalkylpiperidinderivate und ihre verwendung als polymerisationsregler
DE59611304D1 (de)	2005-12-29	Pyrazol-4-yl-benzoylderivate und ihre verwendung als herbizide
DE59710580D1 (de)	2003-09-18	Thiocyano-triazolyl-derivate und ihre verwendung als mikrobizide
ATE196294T1 (de)	2000-09-15	Piperazin-derivate und ihre verwendung als 5-ht1a-antagoniste
ATE299503T1 (de)	2005-07-15	Pyridin-3-carbonsäurederivate und ihre verwendung als zwischenprodukte
DE59712887D1 (de)	2007-11-22	Substituierte phenylketoenole und ihre verwendung als schädlingsbekämpfungsmittel
ATE205185T1 (de)	2001-09-15	Benzamid-derivate und deren verwendung als vasopressin-antagonisten
DE69637691D1 (de)	2008-11-06	Azeotropähnliche zusammensetzungen und ihre verwendung
DE69638056D1 (de)	2009-11-26	Azeotropähnliche zusammensetzungen und ihre verwendung
DE69836346D1 (de)	2006-12-14	Heteroaryl aminoguanidin- und alkoxyguanidinderivate und ihre verwendung als proteasehemmer
DE69430279D1 (de)	2002-05-08	Pyrimidinverbindungen und ihre Verwendung als Pharmazeutika
ATE209200T1 (de)	2001-12-15	N-heteroaryl-pyridinsulfonamidderivate und deren verwendung als endothelinantagonisten
ATE268761T1 (de)	2004-06-15	Substituierte quinazolin-derivate und ihre verwendung als tyrosin-kinase inhibitoren
ATE129497T1 (de)	1995-11-15	Bicyclische pyranderivate und ihre verwendung als 5-lipoxygenasehemmer.
DE69608551D1 (de)	2000-06-29	Bicyclische amin-derivate und ihre verwendung als antipsychotische wirkstoffe
DE69510228D1 (de)	1999-07-15	Piperidinessigsäurederivate und ihre verwendung als fibrinogenantagonistmittel
DE69613805D1 (de)	2001-08-16	Diiminoquinonderivate und ihre Verwendung als Elektronübertragungsmittel
DE69708629D1 (de)	2002-01-10	Alkyloxyamin-substituierte fluorenonderivate und ihre verwendung als proteinkinase-c-inhibitoren
DE69821988D1 (de)	2004-04-01	Substituierte isochinoline derivate und ihre verwendung als anticonvulsiva
DE69832902D1 (de)	2006-01-26	Oromukosal-zytokin-zusammensetzungen und ihre verwendung