ATE196294T1 - Piperazin-derivate und ihre verwendung als 5-ht1a-antagoniste - Google Patents

Piperazin-derivate und ihre verwendung als 5-ht1a-antagoniste

Info

Publication number: ATE196294T1
Authority: AT; Austria
Prior art keywords: piperazine derivatives; ht1a antagonists; ht1a; antagonists; piperazine
Prior art date: 1995-07-20

Application number

AT96924983T

Other languages

English (en)

Inventor

Andrew Fensome

Michael Gerard Kelly

Howard Langham Mansell

Original Assignee

American Home Prod

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-07-20

Filing date

1996-07-19

Publication date

2000-09-15

1996-07-19 Application filed by American Home Prod filed Critical American Home Prod

2000-09-15 Application granted granted Critical

2000-09-15 Publication of ATE196294T1 publication Critical patent/ATE196294T1/de

Links

102100022738 5-hydroxytryptamine receptor 1A Human genes 0.000 title 1
101710138638 5-hydroxytryptamine receptor 1A Proteins 0.000 title 1
GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical class C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT96924983T 1995-07-20 1996-07-19 Piperazin-derivate und ihre verwendung als 5-ht1a-antagoniste ATE196294T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9514901.9A GB9514901D0 (en)	1995-07-20	1995-07-20	Piperazine derivatives
PCT/GB1996/001714 WO1997003982A1 (en)	1995-07-20	1996-07-19	Piperazine derivatives and their use as 5-ht1a antagonists

Publications (1)

Publication Number	Publication Date
ATE196294T1 true ATE196294T1 (de)	2000-09-15

Family

ID=10778004

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96924983T ATE196294T1 (de)	1995-07-20	1996-07-19	Piperazin-derivate und ihre verwendung als 5-ht1a-antagoniste

Country Status (21)

Country	Link
EP (1)	EP0839146B1 (de)
JP (1)	JP4166824B2 (de)
KR (1)	KR100447002B1 (de)
CN (2)	CN1077889C (de)
AR (1)	AR003451A1 (de)
AT (1)	ATE196294T1 (de)
AU (1)	AU700546B2 (de)
BR (1)	BR9609694A (de)
CA (1)	CA2227386C (de)
DE (1)	DE69610316T2 (de)
DK (1)	DK0839146T3 (de)
ES (1)	ES2150684T3 (de)
GB (1)	GB9514901D0 (de)
GR (1)	GR3034408T3 (de)
HU (1)	HUP9802447A3 (de)
IL (1)	IL122981A (de)
MX (1)	MX9800483A (de)
NZ (1)	NZ313231A (de)
PT (1)	PT839146E (de)
WO (1)	WO1997003982A1 (de)
ZA (1)	ZA966048B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19730989A1 (de) *	1997-07-18	1999-01-21	Merck Patent Gmbh	Piperazin-Derivate
US6271234B1 (en) *	1997-08-01	2001-08-07	Recordati S.A., Chemical And Pharmaceutical Company	1,4-disubstituted piperazines
IT1293804B1 (it)	1997-08-01	1999-03-10	Recordati Chem Pharm	Diarilalchilpiperazine attive sulle basse vie urinarie
US6399614B1 (en)	1997-08-01	2002-06-04	Recordati S.A. Chemical And Pharmaceutical Company	1-(N-phenylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring
US20060287335A1 (en)	2000-11-28	2006-12-21	Wyeth	Serotonergic agents for treating sexual dysfunction
US6469007B2 (en)	2000-11-28	2002-10-22	Wyeth	Serotonergic agents
US20060223824A1 (en)	2000-11-28	2006-10-05	Wyeth	Serotonergic agents
DK1408976T5 (da)	2001-07-20	2011-01-10	Psychogenics Inc	Behandling af ADHD (Attention deficit hyperactivity disorder)
US7091349B2 (en)	2002-03-12	2006-08-15	Wyeth	Process for synthesizing N-aryl piperazines with chiral N′-1-[benzoyl(2-pyridyl)amino]-2-propane substitution
US7361773B2 (en)	2002-03-12	2008-04-22	Wyeth	Preparation of N1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines
JP2005527530A (ja)	2002-03-12	2005-09-15	ワイス	キラル１，４−二置換ピペラジン
TWI288642B (en)	2002-03-12	2007-10-21	Wyeth Corp	Preparation of N1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines
US6713626B2 (en) *	2002-03-12	2004-03-30	Wyeth	Process for synthesizing N-aryl piperazines with chiral N′-1-[benzoyl(2-pyridyl)amino]-2-propane substitution
US20050209245A1 (en) *	2004-03-19	2005-09-22	Wyeth	Process for preparing N-aryl-piperazine derivatives
TW200800959A (en)	2005-06-10	2008-01-01	Wyeth Corp	Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor
US7495111B2 (en)	2005-06-17	2009-02-24	Wyeth	Compounds useful as serotonin inhibitors and 5-HT1A agonists and antagonists
TW200808741A (en) *	2006-06-09	2008-02-16	Wyeth Corp	6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline hydrochloric acid salts
CL2008000119A1 (es)	2007-01-16	2008-05-16	Wyeth Corp	Compuestos derivados de pirazol, antagonistas del receptor nicotinico de acetilcolina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como demencia senil, alzheimer y esquizofrenia.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU645681B2 (en) *	1991-05-02	1994-01-20	John Wyeth & Brother Limited	Piperazine derivatives
DK0763024T3 (da) *	1994-06-03	2002-12-02	Wyeth John & Brother Ltd	Fremgangmåde og mellemprodukter til fremstilling af piperazinderivater

1995
- 1995-07-20 GB GBGB9514901.9A patent/GB9514901D0/en active Pending
1996
- 1996-07-10 AR ARP960103516A patent/AR003451A1/es active IP Right Grant
- 1996-07-16 ZA ZA9606048A patent/ZA966048B/xx unknown
- 1996-07-19 WO PCT/GB1996/001714 patent/WO1997003982A1/en not_active Ceased
- 1996-07-19 AU AU65249/96A patent/AU700546B2/en not_active Ceased
- 1996-07-19 AT AT96924983T patent/ATE196294T1/de not_active IP Right Cessation
- 1996-07-19 PT PT96924983T patent/PT839146E/pt unknown
- 1996-07-19 CA CA002227386A patent/CA2227386C/en not_active Expired - Fee Related
- 1996-07-19 NZ NZ313231A patent/NZ313231A/en unknown
- 1996-07-19 MX MX9800483A patent/MX9800483A/es unknown
- 1996-07-19 EP EP96924983A patent/EP0839146B1/de not_active Expired - Lifetime
- 1996-07-19 DE DE69610316T patent/DE69610316T2/de not_active Expired - Lifetime
- 1996-07-19 IL IL12298196A patent/IL122981A/xx not_active IP Right Cessation
- 1996-07-19 CN CN96195610A patent/CN1077889C/zh not_active Expired - Fee Related
- 1996-07-19 HU HU9802447A patent/HUP9802447A3/hu unknown
- 1996-07-19 KR KR10-1998-0700371A patent/KR100447002B1/ko not_active Expired - Fee Related
- 1996-07-19 JP JP50642797A patent/JP4166824B2/ja not_active Expired - Fee Related
- 1996-07-19 DK DK96924983T patent/DK0839146T3/da active
- 1996-07-19 BR BR9609694A patent/BR9609694A/pt not_active Application Discontinuation
- 1996-07-19 ES ES96924983T patent/ES2150684T3/es not_active Expired - Lifetime
2000
- 2000-09-14 GR GR20000402093T patent/GR3034408T3/el not_active IP Right Cessation
- 2000-12-05 CN CN00135330A patent/CN1131861C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
HUP9802447A3 (en)	1999-11-29
CA2227386A1 (en)	1997-02-06
CN1131861C (zh)	2003-12-24
HUP9802447A2 (hu)	1999-08-30
EP0839146B1 (de)	2000-09-13
CN1190968A (zh)	1998-08-19
JPH11509544A (ja)	1999-08-24
IL122981A (en)	2001-01-28
KR100447002B1 (ko)	2004-12-04
DE69610316D1 (de)	2000-10-19
JP4166824B2 (ja)	2008-10-15
BR9609694A (pt)	1999-03-23
PT839146E (pt)	2000-12-29
AU6524996A (en)	1997-02-18
GR3034408T3 (en)	2000-12-29
DK0839146T3 (da)	2000-11-20
EP0839146A1 (de)	1998-05-06
ES2150684T3 (es)	2000-12-01
DE69610316T2 (de)	2001-03-29
CN1309127A (zh)	2001-08-22
CN1077889C (zh)	2002-01-16
GB9514901D0 (en)	1995-09-20
ZA966048B (en)	1998-01-16
IL122981A0 (en)	1998-08-16
WO1997003982A1 (en)	1997-02-06
AU700546B2 (en)	1999-01-07
MX9800483A (es)	1998-04-30
AR003451A1 (es)	1998-08-05
KR19990029067A (ko)	1999-04-15
NZ313231A (en)	2001-03-30
CA2227386C (en)	2006-05-16

Legal Events

Date	Code	Title	Description
2010-04-15	REN	Ceased due to non-payment of the annual fee

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