ATE196733T1 - Zusammensetzung auf der basis von mikrokristalliner zellulose für die herstellung von kugelförmigen teilchen - Google Patents

Zusammensetzung auf der basis von mikrokristalliner zellulose für die herstellung von kugelförmigen teilchen

Info

Publication number
ATE196733T1
ATE196733T1 AT93900553T AT93900553T ATE196733T1 AT E196733 T1 ATE196733 T1 AT E196733T1 AT 93900553 T AT93900553 T AT 93900553T AT 93900553 T AT93900553 T AT 93900553T AT E196733 T1 ATE196733 T1 AT E196733T1
Authority
AT
Austria
Prior art keywords
microcrystalline cellulose
composition
production
spherical particles
hydrocolloid
Prior art date
Application number
AT93900553T
Other languages
English (en)
Inventor
David Frank Erkoboni
Scott Allan Fiore
Thomas Albert Wheatley
Original Assignee
Fmc Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fmc Corp filed Critical Fmc Corp
Application granted granted Critical
Publication of ATE196733T1 publication Critical patent/ATE196733T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/005—Processes for mixing polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
    • C08L1/02—Cellulose; Modified cellulose
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2300/00—Characterised by the use of unspecified polymers
    • C08J2300/14—Water soluble or water swellable polymers, e.g. aqueous gels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2301/00—Characterised by the use of cellulose, modified cellulose or cellulose derivatives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
    • C08L1/08—Cellulose derivatives
    • C08L1/26—Cellulose ethers
    • C08L1/28—Alkyl ethers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT93900553T 1991-12-30 1992-11-18 Zusammensetzung auf der basis von mikrokristalliner zellulose für die herstellung von kugelförmigen teilchen ATE196733T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81602791A 1991-12-30 1991-12-30
PCT/US1992/009983 WO1993012768A1 (en) 1991-12-30 1992-11-18 Microcrystalline cellulose spheronization composition

Publications (1)

Publication Number Publication Date
ATE196733T1 true ATE196733T1 (de) 2000-10-15

Family

ID=25219497

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93900553T ATE196733T1 (de) 1991-12-30 1992-11-18 Zusammensetzung auf der basis von mikrokristalliner zellulose für die herstellung von kugelförmigen teilchen

Country Status (16)

Country Link
US (1) US5725886A (de)
EP (1) EP0619731B1 (de)
JP (1) JP2628230B2 (de)
CN (1) CN1074228A (de)
AT (1) ATE196733T1 (de)
AU (1) AU663146B2 (de)
BR (1) BR9206996A (de)
CA (1) CA2126441C (de)
DE (1) DE69231499T2 (de)
ES (1) ES2150438T3 (de)
FI (1) FI943121L (de)
IL (1) IL104087A (de)
MX (1) MX9207438A (de)
NO (1) NO942457D0 (de)
WO (1) WO1993012768A1 (de)
ZA (1) ZA929161B (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5567439A (en) * 1994-06-14 1996-10-22 Fuisz Technologies Ltd. Delivery of controlled-release systems(s)
US6471994B1 (en) 1995-01-09 2002-10-29 Edward Mendell Co., Inc. Pharmaceutical excipient having improved compressibility
IL116674A (en) * 1995-01-09 2003-05-29 Mendell Co Inc Edward Microcrystalline cellulose-based excipient having improved compressibility, pharmaceutical compositions containing the same and methods for the preparation of said excipient and of solid dosage form thereof
US5585115A (en) 1995-01-09 1996-12-17 Edward H. Mendell Co., Inc. Pharmaceutical excipient having improved compressability
US5948438A (en) * 1995-01-09 1999-09-07 Edward Mendell Co., Inc. Pharmaceutical formulations having improved disintegration and/or absorptivity
US6395303B1 (en) 1996-06-10 2002-05-28 Edward Mendell Co., Inc. Process for preparing a directly compressible solid dosage form containing microcrystalline cellulose
US6936277B2 (en) 1995-01-09 2005-08-30 J. Rettenmaier & Soehne Gmbh & Co. Kg Pharmaceutical excipient having improved compressibility
US5733578A (en) 1995-11-15 1998-03-31 Edward Mendell Co., Inc. Directly compressible high load acetaminophen formulations
US6852336B2 (en) 1995-11-15 2005-02-08 J. Rettenmaier & Soehne Gmbh + Co. Kg Directly compressible high load acetaminophen formulations
US6391337B2 (en) 1995-11-15 2002-05-21 Edward Mendell Co., Inc. Directly compressible high load acetaminophen formulations
TR199900296T2 (xx) * 1996-08-14 1999-06-21 Yamanouchi Europe B.V. Suda ��z�n�r bir bile�ik ve sel�loz i�eren gran�ler �r�nler
CN1086189C (zh) * 1997-06-12 2002-06-12 食品机械和化工公司 超细微晶纤维素组合物及其制备方法
US5904937A (en) * 1997-10-03 1999-05-18 Fmc Corporation Taste masked pharmaceutical compositions
US7122207B2 (en) * 1998-05-22 2006-10-17 Bristol-Myers Squibb Company High drug load acid labile pharmaceutical composition
EP1233755B1 (de) 1999-09-29 2007-06-27 R.P. Scherer Technologies, Inc. Granulate von arzneistoffsalzen mit hydrolisierter cellulose
US6858725B1 (en) 1999-11-12 2005-02-22 R.P. Scherer Technologies, Inc. Microcrystalline cellulose cushioning granules
BR0109602A (pt) 2000-03-30 2004-06-29 Bristol Myers Squibb Co Glóbulos de liberação controlada contendo estavudina
BR0206979A (pt) * 2001-02-05 2004-04-20 Scherer Technologies Inc R P Métodos e composições para reduzir o paladar de agentes farmaceuticamente ativos
CA2445290A1 (en) * 2001-04-26 2002-11-07 Chenkou Wei A pharmaceutical tablet having a high api content
US7462232B2 (en) 2002-05-14 2008-12-09 Fmc Corporation Microcrystalline cellulose compositions
EP1848292B1 (de) * 2005-02-04 2015-10-14 Philip Morris Products S.A. Zigarette und filter mit cellulosischem geschmackszusatz
US20070000505A1 (en) * 2005-02-24 2007-01-04 Philip Morris Usa Inc. Smoking article with tobacco beads
US7879382B2 (en) * 2005-09-30 2011-02-01 Fmc Corporation Stabilizers and compositions and products comprising same
ZA200807571B (en) * 2006-03-01 2009-08-26 Ethypharm Sa Crush-resistant tablets intended to prevent accidental misuse and unlawful diversion
CA2657202A1 (en) * 2006-07-28 2008-01-31 Farmaprojects, S.A. Extended release pharmaceutical formulation of metoprolol and process for its preparation
US7998505B2 (en) * 2006-10-27 2011-08-16 Fmc Corporation Dry granulation binders, products, and use thereof
ATE476176T1 (de) * 2007-03-02 2010-08-15 Farnam Co Inc Wachsähnliches material enthaltende tabletten mit verzögerter freisetzung
US9888712B2 (en) 2007-06-08 2018-02-13 Philip Morris Usa Inc. Oral pouch products including a liner and tobacco beads
US20100055180A1 (en) * 2007-10-10 2010-03-04 Mallinckrodt Baker, Inc. Directly Compressible Granular Microcrystalline Cellulose Based Excipient, Manufacturing Process and Use Thereof
SG185257A1 (en) * 2007-10-10 2012-11-29 Avantor Performance Mat Inc Directly compressible high functionality granular microcrystalline cellulose based excipient, manufacturing process and use thereof
BRPI0921507A2 (pt) * 2008-11-19 2016-01-19 Avantor Performance Mat Inc composição, método de preparação de um excipiente, comprimido farmacêutico e método de preparação do mesmo
US9221963B2 (en) 2008-11-27 2015-12-29 Speciality Fibres And Materials Ltd. Absorbent material
US9144625B2 (en) 2008-11-27 2015-09-29 Speciality Fibres And Materials Ltd. Cellulose ethylsulfonate-based absorbent material
US8377215B2 (en) 2008-12-18 2013-02-19 Philip Morris Usa Inc. Moist botanical pouch processing
US8863755B2 (en) * 2009-02-27 2014-10-21 Philip Morris Usa Inc. Controlled flavor release tobacco pouch products and methods of making
US10051884B2 (en) 2010-03-26 2018-08-21 Philip Morris Usa Inc. Controlled release mentholated tobacco beads
US20110277781A1 (en) 2010-03-26 2011-11-17 Philip Morris Usa Inc. Methods for improving quality of mainstream smoke and multicomponent filters and smoking articles therefor
EP2764045B1 (de) 2011-10-05 2017-03-01 FMC Corporation Stabilisatorzusammensetzung aus koattritierter mikrokristalliner cellulose und carboxymethylcellulose, verfahren zu ihrer herstellung und anwendungen davon
US9826763B2 (en) 2011-10-05 2017-11-28 Fmc Corporation Stabilizer composition of microcrystalline cellulose and carboxymethylcellulose, method for making, and uses
WO2013085809A1 (en) 2011-12-09 2013-06-13 Fmc Corporation Co-attrited stabilizer composition having superior gel strength
CN105085992B (zh) * 2015-09-16 2017-12-29 珠海市东辰医药科技有限公司 一种改性微晶纤维素的制备工艺
CN105193738B (zh) * 2015-09-21 2018-09-04 珠海市东辰制药有限公司 一种微晶纤维素丸芯的制备工艺
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1010477A (en) * 1962-05-15 1965-11-17 Fmc Corp Method of making cellulose crystallite aggregates in particulate form and product of such method
GB1561204A (en) * 1977-06-01 1980-02-13 Ici Ltd Sustained release pharmaceutical composition
US4421778A (en) * 1982-11-04 1983-12-20 Rich Products Corporation Freezer stable whipped ice cream and milk shake food products
US4744987A (en) * 1985-03-08 1988-05-17 Fmc Corporation Coprocessed microcrystalline cellulose and calcium carbonate composition and its preparation
IL81419A0 (en) * 1986-01-30 1987-08-31 Syntex Inc Long acting sustained release pharmaceutical compositions containing dihydropyridines and their preparation
GB8705083D0 (en) * 1987-03-04 1987-04-08 Euro Celtique Sa Spheroids
CA1323833C (en) * 1987-04-28 1993-11-02 Yatindra M. Joshi Pharmaceutical compositions in the form of beadlets and method
US4837030A (en) * 1987-10-06 1989-06-06 American Cyanamid Company Novel controlled release formulations of tetracycline compounds

Also Published As

Publication number Publication date
CA2126441A1 (en) 1993-07-08
CN1074228A (zh) 1993-07-14
ZA929161B (en) 1993-05-25
ES2150438T3 (es) 2000-12-01
EP0619731A4 (de) 1995-05-03
DE69231499T2 (de) 2001-05-03
US5725886A (en) 1998-03-10
FI943121A7 (fi) 1994-06-29
EP0619731B1 (de) 2000-10-04
FI943121A0 (fi) 1994-06-29
DE69231499D1 (de) 2000-11-09
NO942457L (no) 1994-06-29
JPH06511255A (ja) 1994-12-15
JP2628230B2 (ja) 1997-07-09
CA2126441C (en) 1999-12-21
IL104087A0 (en) 1993-05-13
IL104087A (en) 1998-10-30
FI943121L (fi) 1994-06-29
NO942457D0 (no) 1994-06-29
AU663146B2 (en) 1995-09-28
AU3179393A (en) 1993-07-28
EP0619731A1 (de) 1994-10-19
BR9206996A (pt) 1995-12-05
MX9207438A (es) 1993-06-01
WO1993012768A1 (en) 1993-07-08

Similar Documents

Publication Publication Date Title
ATE196733T1 (de) Zusammensetzung auf der basis von mikrokristalliner zellulose für die herstellung von kugelförmigen teilchen
SE8503092D0 (sv) Forfarande for framstellning av en guar-gum produkt
NO20004980D0 (no) Partikulær virkestoffbærer for pulmonær anvendelse
ATE175732T1 (de) Silikondioxid enthaltendes produkt und seine herstellung
GB1498086A (en) High bulking clay pigments and methods of making same
US2798838A (en) Method of preparing acetophenetidin tablets
HUP0000141A2 (hu) Eljárás legfeljebb 90 tömeg% gyógyhatású anyagot tartalmazó pelletek előállítására
KR890003292A (ko) 안정화된 사료 첨가제 및 이의 제조방법
ATE75602T1 (de) Spruehgetrocknetes acetaminophen.
IE41923L (en) Suspension of xanthan gum
ES422710A1 (es) Procedimiento para la produccion de granulos pesticidas dispersables en agua.
IE41924L (en) Suspension of alginate
JPH11147902A5 (ja) 吸水剤、吸水性物品および吸水性樹脂の製造方法
ES8604134A1 (es) Procedimiento para preparar derivados de acidos insaturados sustituidos con carboxialquiltio o carboxiamidoalquiltio.
JPS5455054A (en) Water-despersible compound
JPS5474855A (en) Preparation of finely divided soluble cellulose derivative
ES526874A0 (es) Procedimiento de trituracion de compuestos esteroides
GB896439A (en) Cellulose derivatives useful as anion-exchange materials and their application
ES225054A1 (es) PROCEDIMIENTO DE OBTENCIoN DE PERoXIDO DE HIDRoGENO
JPS5763303A (en) Spherical particles of crosslinked porous amylopectin and its production
SU614558A1 (ru) Способ изготовлени диффузора электродинамического громкоговорител
GB2619237A (en) Composition of cellulose nanocrystals and carboxymethyl cellulose
KR930001932A (ko) 정화제 겸 탈취제의 제조방법
RU94038767A (ru) Способ получения гранулированных органоминеральных сорбентов
DE3777570D1 (de) Agglomeriertes produkt, seine herstellung und seine anwendung.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties